{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:50:14Z","timestamp":1790254214936,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["surgjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.surg.2016.05.050","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T18:01:59Z","timestamp":1478800919000},"page":"230-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["SDHB mutation status and tumor size but not tumor grade are important predictors of clinical outcome in pheochromocytoma and abdominal paraganglioma"],"prefix":"10.1016","volume":"161","author":[{"given":"Yasmine","family":"Assadipour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira M.","family":"Sadowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Alimchandani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Quezado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth M.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naris","family":"Nilubol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaval","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Prodanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Pacak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Electron","family":"Kebebew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2016.05.050_bib1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.soc.2006.05.009","article-title":"Malignant pheochromocytoma","volume":"15","author":"Zarnegar","year":"2006","journal-title":"Surg Oncol Clin N Am"},{"key":"10.1016\/j.surg.2016.05.050_bib2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1055-3207(18)30244-8","article-title":"Benign and malignant pheochromocytoma: diagnosis, treatment, and follow-up","volume":"7","author":"Kebebew","year":"1998","journal-title":"Surg Oncol Clin N Am"},{"key":"10.1016\/j.surg.2016.05.050_bib3","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/jmg.39.3.178","article-title":"Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas","volume":"39","author":"Baysal","year":"2002","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.surg.2016.05.050_bib4","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1007\/s00268-008-9734-2","article-title":"Pheochromocytoma in MEN 2A syndrome. Study of 54 patients","volume":"32","author":"Rodriguez","year":"2008","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2016.05.050_bib5","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1002\/(SICI)1097-0142(19991201)86:11+<2478::AID-CNCR4>3.0.CO;2-5","article-title":"Von Hippel-Lindau syndrome. A pleomorphic condition","volume":"86","author":"Friedrich","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.surg.2016.05.050_bib6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ng.861","article-title":"Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma","volume":"43","author":"Comino-Mendez","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.surg.2016.05.050_bib7","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1210\/jc.2007-0709","article-title":"Succinate dehydrogenase B gene mutations predict survival in patients with malignant pheochromocytomas or paragangliomas","volume":"92","author":"Amar","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.surg.2016.05.050_bib8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jamcollsurg.2013.04.027","article-title":"Response after surgical resection of metastatic pheochromocytoma and paraganglioma: can postoperative biochemical remission be predicted?","volume":"217","author":"Ellis","year":"2013","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.surg.2016.05.050_bib9","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1186\/1471-2407-14-523","article-title":"The size of the primary tumor and age at initial diagnosis are independent predictors of the metastatic behavior and survival of patients with SDHB-related pheochromocytoma and paraganglioma: a retrospective cohort study","volume":"14","author":"Schovanek","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.surg.2016.05.050_bib10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/00000478-200205000-00002","article-title":"Pheochromocytoma of the adrenal gland scaled score (PASS) to separate benign from malignant neoplasms: a clinicopathologic and immunophenotypic study of 100 cases","volume":"26","author":"Thompson","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.surg.2016.05.050_bib11","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.surg.2008.02.007","article-title":"Prognostic indicators of malignancy in adrenal pheochromocytomas: clinical, histopathologic, and cell cycle\/apoptosis gene expression analysis","volume":"143","author":"Strong","year":"2008","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2016.05.050_bib12","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.7314\/APJCP.2014.15.4.1751","article-title":"Lack of correlations among histopathological parameters, Ki-67 proliferation index and prognosis in pheochromocytoma patients","volume":"15","author":"Ocal","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.surg.2016.05.050_bib13","first-page":"23","article-title":"Histological features, Ki-67 and Bcl-2 immunohistochemical expression and their correlation with the aggressiveness of pheochromocytomas","volume":"33","author":"Jovanovic","year":"2012","journal-title":"Prilozi"},{"key":"10.1016\/j.surg.2016.05.050_bib14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1055\/s-0029-1238274","article-title":"Pheochromocytomas, PASS, and immunohistochemistry","volume":"41","author":"Carlsen","year":"2009","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.surg.2016.05.050_bib15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1530\/ERC-13-0494","article-title":"Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma","volume":"21","author":"Kimura","year":"2014","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.surg.2016.05.050_bib16","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jso.24030","article-title":"Phaeochromocytomas and paragangliomas: a difference in disease behaviour and clinical outcomes","volume":"112","author":"Ezzat Abdel-Aziz","year":"2015","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.surg.2016.05.050_bib17","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.surg.2014.08.044","article-title":"Predictors of recurrence in pheochromocytoma","volume":"156","author":"Press","year":"2014","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2016.05.050_bib18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.prp.2010.01.007","article-title":"Immunohistochemical expression of Ki67, c-erbB-2, and c-kit antigens in benign and malignant pheochromocytoma","volume":"206","author":"Tavangar","year":"2010","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.surg.2016.05.050_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ctrv.2010.07.002","article-title":"Malignant pheochromocytomas and paragangliomas\u2014the importance of a multidisciplinary approach","volume":"37","author":"Andersen","year":"2011","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.surg.2016.05.050_bib20","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/jmedgenet-2015-103218","article-title":"Recommendations for somatic and germline genetic testing of single pheochromocytoma and paraganglioma based on findings from a series of 329 patients","volume":"52","author":"Curras-Freixes","year":"2015","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.surg.2016.05.050_bib21","doi-asserted-by":"crossref","first-page":"E214","DOI":"10.1210\/jc.2014-2138","article-title":"Genotype-specific differences in the tumor metabolite profile of pheochromocytoma and paraganglioma using untargeted and targeted metabolomics","volume":"100","author":"Rao","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.surg.2016.05.050_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1530\/ERC-11-0243","article-title":"False-negative (1)(2)(3)I-MIBG SPECT is most commonly found in SDHB-related pheochromocytoma or paraganglioma with high frequency to develop metastatic disease","volume":"19","author":"Fonte","year":"2012","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.surg.2016.05.050_bib23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1055\/s-0032-1331211","article-title":"Current and future therapeutic approaches for metastatic pheochromocytoma and paraganglioma: focus on SDHB tumors","volume":"45","author":"Matro","year":"2013","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.surg.2016.05.050_bib24","first-page":"1558","article-title":"Potential therapeutic target for malignant paragangliomas: ATP synthase on the surface of paraganglioma cells","volume":"5","author":"Fliedner","year":"2015","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.surg.2016.05.050_bib25","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1158\/1078-0432.CCR-14-2751","article-title":"Superiority of [68Ga]-DOTATATE PET\/CT to other functional imaging modalities in the localization of SDHB-associated metastatic pheochromocytoma and paraganglioma","volume":"21","author":"Janssen","year":"2015","journal-title":"Clin Cancer Res"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606016304986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606016304986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T18:53:06Z","timestamp":1617648786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606016304986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0039606016304986"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2016.05.050","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SDHB mutation status and tumor size but not tumor grade are important predictors of clinical outcome in pheochromocytoma and abdominal paraganglioma","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2016.05.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}