{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:48:34Z","timestamp":1773269314555,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.surg.2020.03.031","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T07:30:56Z","timestamp":1590823856000},"page":"27-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of thyroidectomy on circulating angiogenic cytokines in papillary thyroid carcinoma and benign goiter: Potential for new biomarkers?"],"prefix":"10.1016","volume":"169","author":[{"given":"Roberto","family":"Ria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-8752","authenticated-orcid":false,"given":"Francesco","family":"Prete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assunta","family":"Melaccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Di Meo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Saltarella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio G.","family":"Solimando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Gurrado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pasculli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6087-4119","authenticated-orcid":false,"given":"Lucia I.","family":"Sgaramella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Racanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Vacca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Testini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2020.03.031_bib1","unstructured":"Howlader N, Noone A, Krapcho M, et al, eds. SEER cancer statistics review, 1975-2014, 2017. National Cancer Institute. Available at: https:\/\/seer.cancer.gov\/csr\/1975_2014\/, based on November 2016 SEER data submission, posted to the SEER web site, April 2017."},{"key":"10.1016\/j.surg.2020.03.031_bib2","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1001\/jama.2017.2719","article-title":"Trends in thyroid cancer incidence and mortality in the United States, 1974-2013","volume":"317","author":"Lim","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.surg.2020.03.031_bib3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11864-005-0035-9","article-title":"Papillary thyroid cancer: surgical management of lymph node metastases","volume":"6","author":"Caron","year":"2005","journal-title":"Curr TreatOptions Oncol"},{"key":"10.1016\/j.surg.2020.03.031_bib4","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nrendo.2011.1","article-title":"Thyroid nodule guidelines: agreement, disagreement and need for future research","volume":"7","author":"Paschke","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.surg.2020.03.031_bib5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1476-4598-8-79","article-title":"Discovery and identification of potential biomarkers of papillary thyroid carcinoma","volume":"8","author":"Fan","year":"2009","journal-title":"Mol Cancer"},{"key":"10.1016\/j.surg.2020.03.031_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2020.03.031_bib7","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1089\/thy.2017.0322","article-title":"Circulating BRAFV600E levels correlate with treatment in patients with thyroid carcinoma","volume":"28","author":"Lubitz","year":"2018","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2020.03.031_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ceb.2015.06.004","article-title":"Modes of cancer cell invasion and the role of the microenvironment","volume":"36","author":"Clark","year":"2015","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.surg.2020.03.031_bib9","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/jso.21844","article-title":"Vascular endothelial growth factors and angiopoietins in presentations and prognosis of papillary thyroid carcinoma","volume":"103","author":"Hsueh","year":"2011","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.surg.2020.03.031_bib10","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.3892\/or.2013.2659","article-title":"Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells","volume":"30","author":"Ota","year":"2013","journal-title":"Oncol Rep"},{"key":"10.1016\/j.surg.2020.03.031_bib11","doi-asserted-by":"crossref","first-page":"8601","DOI":"10.1007\/s13277-015-3548-2","article-title":"Thyroid carcinoma cells produce PLGF to enhance metastasis","volume":"36","author":"He","year":"2015","journal-title":"Tumour Biol"},{"key":"10.1016\/j.surg.2020.03.031_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ccr.2004.08.034","article-title":"PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis","volume":"6","author":"Cao","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.surg.2020.03.031_bib13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/jsre.2002.6510","article-title":"PDGF(BB) increases myocardial production of VEGF: shift in VEGF mRNA splice variants after direct injection of bFGF, PDGF(BB), and PDGF(AB)","volume":"107","author":"Affleck","year":"2002","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.surg.2020.03.031_bib14","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1210\/er.2002-0008","article-title":"Angiogenesis in endocrine tumors","volume":"24","author":"Turner","year":"2003","journal-title":"Endocr Rev"},{"key":"10.1016\/j.surg.2020.03.031_bib15","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1158\/2326-6066.CIR-14-0160","article-title":"Chemokines in cancer","volume":"2","author":"Chow","year":"2014","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.surg.2020.03.031_bib16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/clinchem\/47.4.617","article-title":"Pitfalls in the measurement of circulating vascular endothelial growth factor","volume":"47","author":"Jelkmann","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.surg.2020.03.031_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fonc.2017.00053","article-title":"Association between Hashimoto\u2019s thyroiditis and thyroid cancer in 64,628 patients","volume":"7","author":"Resende de Paiva","year":"2017","journal-title":"Front Oncol"},{"key":"10.1016\/j.surg.2020.03.031_bib18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1089\/thy.2013.0133","article-title":"Higher incidence of tall cell variant\u00a0of\u00a0papillary thyroid carcinoma in Graves' disease","volume":"24","author":"Boutzios","year":"2014","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2020.03.031_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.31557\/APJCP.2019.20.1.277","article-title":"Expression of vascular endothelial growth factor and its receptors in thyroid nodular hyperplasia and papillary thyroid carcinoma: a tertiary health care centre based study","volume":"20","author":"Mohamad Pakarul Razy","year":"2019","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.surg.2020.03.031_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.33549\/physiolres.930314","article-title":"Serum levels of IGF-I, HGF, TGFbeta1, bFGF and VEGF in thyroid gland tumors","volume":"53","author":"Vesel\u00fd","year":"2004","journal-title":"Physiol Res"},{"key":"10.1016\/j.surg.2020.03.031_bib21","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/SLA.0b013e31815fa447","article-title":"Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma","volume":"247","author":"Yu","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2020.03.031_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mce.2010.01.007","article-title":"Molecular prognostic markers in papillary and follicular thyroid cancer: current status and future directions","volume":"322","author":"Handkiewicz-Junak","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.surg.2020.03.031_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1046\/j.1087-0024.2000.00014.x","article-title":"Angiogenesis in wound healing","volume":"5","author":"Tonnesen","year":"2000","journal-title":"J\u00a0Investig Dermatol Symp Proc"},{"key":"10.1016\/j.surg.2020.03.031_bib24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1530\/EJE-07-0252","article-title":"The comparison of serum vascular endothelial growth factor levels between patients with metastatic and non-metastatic thyroid cancer, and patients with nontoxic multinodular goiter","volume":"157","author":"Klubo-Gwiezdzinska","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.surg.2020.03.031_bib25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10238-008-0170-2","article-title":"Serum levels of angiogenic cytokines decrease after radiotherapy in non-Hodgkin lymphomas","volume":"8","author":"Ria","year":"2008","journal-title":"Clin Exp Med"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003960602030177X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003960602030177X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:54:30Z","timestamp":1758538470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003960602030177X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S003960602030177X"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2020.03.031","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of thyroidectomy on circulating angiogenic cytokines in papillary thyroid carcinoma and benign goiter: Potential for new biomarkers?","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2020.03.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}