{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:03:31Z","timestamp":1791140611937,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.surg.2020.03.032","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T01:09:25Z","timestamp":1590541765000},"page":"305-312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Routine histopathologic examination of the appendix after appendectomy for presumed appendicitis: Is it really necessary? A systematic review and meta-analysis"],"prefix":"10.1016","volume":"168","author":[{"given":"Vivian P.","family":"Bastiaenen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies M.","family":"Allema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.L.","family":"Klaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"van Dieren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne","family":"Koens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J.","family":"Tanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem A.","family":"Bemelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2020.03.032_bib1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/SLA.0000000000002188","article-title":"The global incidence of appendicitis: a systematic review of population-based studies","volume":"266","author":"Ferris","year":"2017","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib2","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/oxfordjournals.aje.a115734","article-title":"The epidemiology of appendicitis and appendectomy in the United States","volume":"132","author":"Addiss","year":"1990","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.surg.2020.03.032_bib3","first-page":"117","article-title":"Routine pathological evaluation of tissue from inguinal hernias in children is unnecessary","volume":"46","author":"Miller","year":"2003","journal-title":"Can J Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib4","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.amjsurg.2014.12.019","article-title":"The utility of pathologic evaluation of adult hernia specimens","volume":"209","author":"Chesley","year":"2015","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib5","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jhsa.2005.10.023","article-title":"Use of routine histologic evaluation of carpal ganglions","volume":"31","author":"McKeon","year":"2006","journal-title":"J\u00a0Hand Surg Am"},{"key":"10.1016\/j.surg.2020.03.032_bib6","doi-asserted-by":"crossref","first-page":"160e","DOI":"10.1097\/PRS.0000000000004592","article-title":"Use of routine pathologic evaluation of nonmalignant lesions in hand surgery: a national study","volume":"142","author":"Cho","year":"2018","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib7","first-page":"103","article-title":"Routine pathological evaluation after tonsillectomy: is it necessary?","volume":"2","author":"Dewil","year":"2006","journal-title":"B-ENT"},{"key":"10.1016\/j.surg.2020.03.032_bib8","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1177\/0194599810393875","article-title":"Pathologic evaluation of routine pediatric tonsillectomy specimens: analysis of cost-effectiveness","volume":"144","author":"Nelson","year":"2011","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib9","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1111\/j.1463-1318.2010.02457.x","article-title":"Is routine histopathological examination of appendectomy specimens useful? A systematic review of the literature","volume":"13","author":"Swank","year":"2011","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.surg.2020.03.032_bib10","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.surg.2020.03.032_bib11","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.surg.2020.03.032_bib12","unstructured":"Covidence systematic review software, Veritas Health Innovation, Melbourne, Australia. www.covidence.org. Accessed April 1, 2019."},{"key":"10.1016\/j.surg.2020.03.032_bib13","unstructured":"WHO Classification of Tumours Editorial Board. WHO classification of tumours: Digestive system tumours. 5th ed, vol. 1. Geneva, Switzerland: World Health Organization;\u00a02019."},{"key":"10.1016\/j.surg.2020.03.032_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/PAS.0000000000000535","article-title":"A\u00a0consensus for classification and pathologic reporting of pseudomyxoma peritonei and associated appendiceal neoplasia: the results of the Peritoneal Surface Oncology Group International (PSOGI) modified delphi process","volume":"40","author":"Carr","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.surg.2020.03.032_bib15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/XEB.0000000000000054","article-title":"Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data","volume":"13","author":"Munn","year":"2015","journal-title":"Int J Evid Based Healthc"},{"key":"10.1016\/j.surg.2020.03.032_bib16","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.ejso.2015.06.010","article-title":"Management and outcomes of appendicular neuroendocrine tumours: retrospective review with 5-year follow-up","volume":"41","author":"Amr","year":"2015","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.surg.2020.03.032_bib17","first-page":"58","article-title":"Incidence of acute appendicitis on histopathology","volume":"28","author":"Perveen","year":"2017","journal-title":"Medical Forum Mon"},{"key":"10.1016\/j.surg.2020.03.032_bib18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.amsu.2017.07.043","article-title":"Frequency, characteristics and outcomes of appendicular neuroendocrine tumors: a cross-sectional study from an academic tertiary care hospital","volume":"21","author":"Abdelaal","year":"2017","journal-title":"Ann Med Surg (Lond)"},{"key":"10.1016\/j.surg.2020.03.032_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1308\/rcsann.2017.0132","article-title":"Cost-effectiveness of routine imaging of suspected appendicitis","volume":"100","author":"D'Souza","year":"2018","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1016\/j.surg.2020.03.032_bib20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jss.2018.01.012","article-title":"Outcomes of interval appendectomy in comparison with appendectomy for acute appendicitis","volume":"225","author":"Al-Kurd","year":"2018","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.surg.2020.03.032_bib21","first-page":"1225","article-title":"[Appendix tumours and their management]","volume":"14","author":"Meyer","year":"2018","journal-title":"Rev Med Suisse"},{"key":"10.1016\/j.surg.2020.03.032_bib22","first-page":"72","article-title":"Postoperative outcomes in laparoscopic appendicectomies with histopathologically normal appendix","volume":"90","author":"Zosimas","year":"2019","journal-title":"Ann Ital Chir"},{"key":"10.1016\/j.surg.2020.03.032_bib23","article-title":"Discrepancies between intraoperative and histological evaluation of the appendix in acute appendicitis","author":"Bolmers","year":"2019","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib24","first-page":"PL01","article-title":"Do we still need to perform routine histological examination of appendectomy specimens?","volume":"9","author":"Guraya","year":"2015","journal-title":"J\u00a0Clin Diagn Res"},{"key":"10.1016\/j.surg.2020.03.032_bib25","first-page":"197","article-title":"Usefulness of histopathologic study of appendectomy and cholecystectomy specimens","volume":"23","author":"Leon","year":"2010","journal-title":"Iatreia"},{"key":"10.1016\/j.surg.2020.03.032_bib26","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.3748\/wjg.v17.i15.1961","article-title":"Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review","volume":"17","author":"Akbulut","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.surg.2020.03.032_bib27","first-page":"1292","article-title":"Spectrum of appendiceal lesions in a tertiary referral centre for a period of one year","volume":"8","author":"Kokila","year":"2019","journal-title":"J\u00a0Evol Med Dent Sci"},{"key":"10.1016\/j.surg.2020.03.032_bib28","doi-asserted-by":"crossref","first-page":"e12931","DOI":"10.5812\/ircmj.12931","article-title":"Unusual findings in appendectomy specimens of adults: retrospective analyses of 1466 patients and a review of literature","volume":"16","author":"Yabanoglu","year":"2014","journal-title":"Iran Red Crescent Med J"},{"issue":"Suppl 1","key":"10.1016\/j.surg.2020.03.032_bib29","doi-asserted-by":"crossref","first-page":"A233","DOI":"10.1093\/ajcp\/142.suppl1.233","article-title":"What can histopathology say about acute appendicitis?","volume":"142","author":"Lal","year":"2014","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.surg.2020.03.032_bib30","first-page":"S154","article-title":"A\u00a0study of histopathological findings in appendectomy specimens in Kerry General Hospital","volume":"184","author":"Nicholas","year":"2015","journal-title":"Irish J Med Sci"},{"key":"10.1016\/j.surg.2020.03.032_bib31","first-page":"S182","article-title":"Surgeon and pathologist assessment of acute appendicitis: how accurate are we?","volume":"184","author":"Stassen","year":"2015","journal-title":"Irish J Med Sci"},{"key":"10.1016\/j.surg.2020.03.032_bib32","first-page":"186A","article-title":"Unexpected histopathological findings in appendectomy specimens: An institutional experience","volume":"97","author":"Mannan","year":"2017","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.surg.2020.03.032_bib33","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s00384-009-0711-5","article-title":"Is routine pathological examination necessary in appendectomy for acute appendicitis?","volume":"24","author":"Martellucci","year":"2009","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.surg.2020.03.032_bib34","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1007\/s00268-009-0164-6","article-title":"Value of routine histopathologic examination of three common surgical specimens: appendix, gallbladder, and hemorrhoid","volume":"33","author":"Lohsiriwat","year":"2009","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib35","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1308\/003588409X12486167521677","article-title":"A\u00a0clinicopathological review of 324 appendices removed for acute appendicitis in Durban, South Africa: a retrospective analysis","volume":"91","author":"Chamisa","year":"2009","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1016\/j.surg.2020.03.032_bib36","first-page":"168","article-title":"Review of the pathologic diagnoses of appendectomy specimens","volume":"15","author":"Zulfikar","year":"2009","journal-title":"Ann King Edward Med Univ"},{"key":"10.1016\/j.surg.2020.03.032_bib37","first-page":"12","article-title":"If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies","volume":"16","author":"Ma","year":"2010","journal-title":"Hong Kong Med J"},{"key":"10.1016\/j.surg.2020.03.032_bib38","first-page":"40","article-title":"Unusual findings in appendicectomy specimens: local experience in al-Ahsa region of Saudi Arabia","volume":"2","author":"Al-Mulhim","year":"2011","journal-title":"J\u00a0Clin Pathol Forensic Med"},{"key":"10.1016\/j.surg.2020.03.032_bib39","first-page":"485","article-title":"Pathologic evaluation of appendectomy specimens in children: is routine histopatholgic examination indicated?","volume":"21","author":"Monajemzadeh","year":"2011","journal-title":"Iran J Pediatr"},{"key":"10.1016\/j.surg.2020.03.032_bib40","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00383-011-2926-0","article-title":"Routine histopathological examination of appendectomy specimens in children: is there any rationale?","volume":"27","author":"Khan","year":"2011","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.surg.2020.03.032_bib41","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1445-2197.2012.06185.x","article-title":"Pathologies of the appendix: a 10-year review of 4670 appendicectomy specimens","volume":"82","author":"Chandrasegaram","year":"2012","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib42","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.3748\/wjg.v19.i25.4015","article-title":"Unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis","volume":"19","author":"Yilmaz","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.surg.2020.03.032_bib43","doi-asserted-by":"crossref","first-page":"354","DOI":"10.9738\/INTSURG-D-13-00098.1","article-title":"Routine histopathologic examination of appendectomy specimens: retrospective analysis of 1255 patients","volume":"98","author":"Emre","year":"2013","journal-title":"Int Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12262-012-0645-y","article-title":"Routine histopathologic examination of two common surgical specimens-appendix and gallbladder: is it a waste of expertise and hospital resources?","volume":"76","author":"Ramraje","year":"2014","journal-title":"Indian J Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib45","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00384-014-1934-7","article-title":"Histopathological findings in appendectomy specimens: a study of 24,697 cases","volume":"29","author":"Charfi","year":"2014","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.surg.2020.03.032_bib46","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.jpedsurg.2014.01.005","article-title":"Incidence and outcomes of unexpected pathology findings after appendectomy","volume":"49","author":"Alemayehu","year":"2014","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib47","first-page":"119","article-title":"Histopathological correlations of appendectomies: a clinical audit of a single center","volume":"3","author":"Omiyale","year":"2015","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.surg.2020.03.032_bib48","first-page":"891","article-title":"Histopathological examination of appendicectomy specimens at a district hospital of Saudi Arabia","volume":"31","author":"Jat","year":"2015","journal-title":"Pak J Med Sci"},{"key":"10.1016\/j.surg.2020.03.032_bib49","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s12262-013-0934-0","article-title":"Unusual histopathological findings in childhood appendectomy specimens","volume":"77","author":"Buyukbese Sarsu","year":"2015","journal-title":"Indian J Surg"},{"issue":"Suppl 3","key":"10.1016\/j.surg.2020.03.032_bib50","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s12262-015-1278-8","article-title":"Unexpected histopathological findings in appendectomy specimens: a retrospective study of 1627 cases","volume":"77","author":"Limaiem","year":"2015","journal-title":"Indian J Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib51","first-page":"118","article-title":"Acute appendicitis, correlating histopathological findings with clinical-is histopathology needed for all?","volume":"10","author":"Jahan","year":"2016","journal-title":"Pak J Med Health Sci"},{"key":"10.1016\/j.surg.2020.03.032_bib52","first-page":"519","article-title":"Unexpected findings in the routine histopathological examinations of appendectomy specimens a retrospective analysis of 1,970 patients","volume":"88","author":"Dincel","year":"2017","journal-title":"Ann Ital Chir"},{"key":"10.1016\/j.surg.2020.03.032_bib53","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jpedsurg.2017.02.012","article-title":"Unexpected findings after surgery for suspected appendicitis rarely change treatment in pediatric patients; results from a cohort study","volume":"52","author":"Gorter","year":"2017","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib54","doi-asserted-by":"crossref","first-page":"117","DOI":"10.22159\/ajpcr.2018.v11i7.25432","article-title":"Surveillance of appendicectomy specimen with histomorphological evaluation","volume":"11","author":"Baisakh","year":"2018","journal-title":"Asian J Pharm Clin Res"},{"key":"10.1016\/j.surg.2020.03.032_bib55","first-page":"342","article-title":"The usefulness of routine histological examination of appendicectomy specimens in a South African tertiary centre","volume":"108","author":"Jolayemi","year":"2018","journal-title":"S\u00a0Afr Med J"},{"key":"10.1016\/j.surg.2020.03.032_bib56","first-page":"3687","article-title":"Routine histopathological examination of two common surgical specimens-appendix and gall bladder, its usefulness and impact on patient management","volume":"7","author":"Singh","year":"2018","journal-title":"J\u00a0Evol Med Dent Sci"},{"key":"10.1016\/j.surg.2020.03.032_bib57","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1177\/1066896918784650","article-title":"Unusual histopathological findings in appendectomy specimens: a retrospective analysis of 2047 cases","volume":"27","author":"Unver","year":"2019","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.surg.2020.03.032_bib58","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1053\/j.semdp.2004.12.001","article-title":"Granulomatous appendicitis and the appendix in idiopathic inflammatory bowel disease","volume":"21","author":"Bronner","year":"2004","journal-title":"Semin Diagn Pathol"},{"key":"10.1016\/j.surg.2020.03.032_bib59","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000443165","article-title":"and the Vienna Consensus Conference Participants. ENETS consensus guidelines for neuroendocrine neoplasms of the appendix (excluding goblet cell carcinomas)","volume":"103","author":"Pape","year":"2016","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.surg.2020.03.032_bib60","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1634\/theoncologist.2017-0081","article-title":"Appendiceal mucinous neoplasms: diagnosis and management","volume":"22","author":"Shaib","year":"2017","journal-title":"Oncologist"},{"key":"10.1016\/j.surg.2020.03.032_bib61","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/bjs.9964","article-title":"Prospective nationwide outcome audit of surgery for suspected acute appendicitis","volume":"103","author":"van Rossem","year":"2016","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2020.03.032_bib62","doi-asserted-by":"crossref","first-page":"e035912","DOI":"10.1136\/bmjopen-2019-035912","article-title":"Safety and cost analysis of selective histopathological examination following appendicectomy and cholecystectomy (FANCY study): protocol and statistical analysis plan of a prospective observational multicentre study","volume":"9","author":"Bastiaenen","year":"2019","journal-title":"BMJ Open"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606020301896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606020301896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:54:52Z","timestamp":1758538492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606020301896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0039606020301896"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2020.03.032","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Routine histopathologic examination of the appendix after appendectomy for presumed appendicitis: Is it really necessary? A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2020.03.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}