{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:36:59Z","timestamp":1791722219970,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.surg.2020.04.062","type":"journal-article","created":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T16:08:23Z","timestamp":1593965303000},"page":"377-387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Postoperative hyperamylasemia (POH) and acute pancreatitis after pancreatoduodenectomy (POAP): State of the art and systematic review"],"prefix":"10.1016","volume":"169","author":[{"given":"Elisa","family":"Bannone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Andrianello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marchegiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Malleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6893-8618","authenticated-orcid":false,"given":"Salvatore","family":"Paiella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Salvia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2020.04.062_bib1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.surg.2020.04.062_bib2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1177\/000313481808400637","article-title":"The combination of pancreas texture and postoperative serum amylase in predicting pancreatic fistula risk","volume":"84","author":"Chen","year":"2018","journal-title":"Am Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib3","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.3748\/wjg.v23.i34.6357","article-title":"Drainage fluid and serum amylase levels accurately predict development of postoperative pancreatic fistula","volume":"23","author":"Jin","year":"2017","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.surg.2020.04.062_bib4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s11605-016-3305-x","article-title":"Pancreatitis after pancreatoduodenectomy predicts clinically relevant postoperative pancreatic fistula","volume":"21","author":"K\u00fchlbrey","year":"2017","journal-title":"J\u00a0Gastrointest Surg Off J Soc Surg Aliment Tract"},{"key":"10.1016\/j.surg.2020.04.062_bib5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.hpb.2017.03.001","article-title":"Early postoperative prediction of clinically relevant pancreatic fistula after pancreaticoduodenectomy: usefulness of C-reactive protein","volume":"19","author":"Partelli","year":"2017","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2020.04.062_bib6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1499-3872(16)60068-1","article-title":"Intraoperative acidosis is a new predictor for postoperative pancreatic fistula after pancreaticoduodenectomy","volume":"15","author":"Kinaci","year":"2016","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.surg.2020.04.062_bib7","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jamcollsurg.2015.07.005","article-title":"Drain management after pancreatoduodenectomy: reappraisal of a prospective randomized trial using risk stratification","volume":"221","author":"McMillan","year":"2015","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/bjs.9362","article-title":"Diagnostic value of abdominal drainage in individual risk assessment of pancreatic fistula following pancreaticoduodenectomy","volume":"101","author":"Ansorge","year":"2014","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib9","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s11605-013-2293-3","article-title":"Postoperative serum amylase predicts pancreatic fistula formation following pancreaticoduodenectomy","volume":"18","author":"Cloyd","year":"2014","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/bjs.10098","article-title":"Serum amylase and C-reactive protein in risk stratification of pancreas-specific complications after pancreaticoduodenectomy","volume":"103","author":"Palani Velu","year":"2016","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib11","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/hpb.12184","article-title":"Serum amylase on the night of surgery predicts clinically significant pancreatic fistula after pancreaticoduodenectomy","volume":"16","author":"Palani Velu","year":"2014","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2020.04.062_bib12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00534-007-1242-5","article-title":"Risk factors, predictors and prevention of pancreatic fistula formation after pancreatoduodenectomy","volume":"14","author":"Okabayashi","year":"2007","journal-title":"J\u00a0Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib13","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jamcollsurg.2007.01.026","article-title":"Biochemical markers predict morbidity and mortality after pancreaticoduodenectomy","volume":"204","author":"Winter","year":"2007","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/SLA.0b013e31824f24e4","article-title":"Options and limitations in applying the fistula classification by the International Study Group for Pancreatic Fistula","volume":"256","author":"Gebauer","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib15","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.surg.2007.05.005","article-title":"Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS)","volume":"142","author":"Wente","year":"2007","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2020.04.062_bib16","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/SLA.0000000000002900","article-title":"Postoperative acute pancreatitis following pancreaticoduodenectomy: A determinant of fistula potentially driven by the intraoperative fluid management","volume":"268","author":"Bannone","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib17","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.hpb.2016.05.006","article-title":"Defining post-operative pancreatitis as a new pancreatic specific complication following pancreatic resection","volume":"18","author":"Connor","year":"2016","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2020.04.062_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"10.1016\/j.surg.2020.04.062_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.surg.2005.05.001","article-title":"Postoperative pancreatic fistula: an international study group (ISGPF) definition","volume":"138","author":"Bassi","year":"2005","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2020.04.062_bib20","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.surg.2016.11.014","article-title":"The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after","volume":"161","author":"Bassi","year":"2017","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2020.04.062_bib21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.surg.2020.04.062_bib22","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.1097\/MD.0000000000000339","article-title":"The gastric\/pancreatic amylase ratio predicts postoperative pancreatic fistula with high sensitivity and specificity","volume":"94","author":"Jin","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.surg.2020.04.062_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/jhbp.11","article-title":"Multivariate logistic regression analysis for prediction of clinically relevant pancreatic fistula in the early phase after pancreaticoduodenectomy","volume":"21","author":"Kosaka","year":"2014","journal-title":"J\u00a0Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.surg.2020.04.062_bib24","first-page":"519","article-title":"Pancreatic fistula formation after pancreaticooduodenectomy; for prevention of this deep surgical site infection after pancreatic surgery","volume":"56","author":"Okabayashi","year":"2009","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.surg.2020.04.062_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/jso.21098","article-title":"Randomized clinical trial to assess the efficacy of ulinastatin for postoperative pancreatitis following pancreaticoduodenectomy","volume":"98","author":"Uemura","year":"2008","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.surg.2020.04.062_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.sla.0000218077.14035.a6","article-title":"Early removal of prophylactic drains reduces the risk of intra-abdominal infections in patients with pancreatic head resection: prospective study for 104 consecutive patients","volume":"244","author":"Kawai","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib27","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.hpb.2018.11.006","article-title":"Early postoperative pancreatitis following pancreaticoduodenectomy: what is clinically relevant postoperative pancreatitis?","volume":"21","author":"Birgin","year":"2019","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2020.04.062_bib28","first-page":"380","article-title":"Pancreatic leakage and acute postoperative pancreatitis after proximal pancreatoduodenectomy","volume":"93","author":"Rudis","year":"2014","journal-title":"Rozhl Chir"},{"key":"10.1016\/j.surg.2020.04.062_bib29","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s00268-013-1998-5","article-title":"Pancreatic anastomotic leakage after pancreaticoduodenectomy. Risk factors, clinical predictors, and management (single center experience)","volume":"37","author":"El Nakeeb","year":"2013","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/SLA.0b013e3181e61e88","article-title":"Early versus late drain removal after standard pancreatic resections: results of a prospective randomized trial","volume":"252","author":"Bassi","year":"2010","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib31","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.gassur.2006.05.012","article-title":"Postoperative acute pancreatitis as a major determinant of postoperative delayed gastric emptying after pancreaticoduodenectomy","volume":"10","author":"R\u00e4ty","year":"2006","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib32","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/s00595-018-1626-y","article-title":"The attenuation value of preoperative computed tomography as a novel predictor for pancreatic fistula after pancreaticoduodenectomy","volume":"48","author":"Hanaki","year":"2018","journal-title":"Surg Today"},{"key":"10.1016\/j.surg.2020.04.062_bib33","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1097\/MPA.0000000000000691","article-title":"The decline of amylase level of pancreatic juice after pancreaticoduodenectomy predicts postoperative pancreatic fistula","volume":"45","author":"Furukawa","year":"2016","journal-title":"Pancreas"},{"key":"10.1016\/j.surg.2020.04.062_bib34","first-page":"499","article-title":"Perioperative serum albumin correlates with postoperative pancreatic fistula after pancreaticoduodenectomy","volume":"35","author":"Fujiwara","year":"2015","journal-title":"Anticancer Res"},{"key":"10.1016\/j.surg.2020.04.062_bib35","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1007\/s00268-013-2149-8","article-title":"Usefulness of drain amylase, serum C-reactive protein levels and body temperature to predict postoperative pancreatic fistula after pancreaticoduodenectomy","volume":"37","author":"Hiyoshi","year":"2013","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib36","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/bjs.7730","article-title":"Early intraperitoneal metabolic changes and protease activation as indicators of pancreatic fistula after pancreaticoduodenectomy","volume":"99","author":"Ansorge","year":"2012","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib37","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.hpb.2017.11.003","article-title":"Acinar cell density at the pancreatic resection margin is associated with post-pancreatectomy pancreatitis and the development of postoperative pancreatic fistula","volume":"20","author":"Nahm","year":"2018","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2020.04.062_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jamcollsurg.2012.09.002","article-title":"A\u00a0prospectively validated clinical risk score accurately predicts pancreatic fistula after pancreatoduodenectomy","volume":"216","author":"Callery","year":"2013","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib39","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/MPA.0000000000000029","article-title":"Is routine imaging necessary after pancreatic resection? An appraisal of postoperative ultrasonography for the detection of pancreatic fistula","volume":"43","author":"Malleo","year":"2014","journal-title":"Pancreas"},{"key":"10.1016\/j.surg.2020.04.062_bib40","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/j.jamcollsurg.2012.11.010","article-title":"Double purse-string telescoped pancreaticogastrostomy: an expedient, safe, and easy technique","volume":"216","author":"Addeo","year":"2013","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib41","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/MPA.0b013e3182480b81","article-title":"The risk for immediate postoperative complications after pancreaticoduodenectomy is increased by high frequency of acinar cells and decreased by prevalent fibrosis of the cut edge of pancreas","volume":"41","author":"Laaninen","year":"2012","journal-title":"Pancreas"},{"key":"10.1016\/j.surg.2020.04.062_bib42","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00534-011-0393-6","article-title":"Persisting ratio of total amylase output in drain fluid can predict postoperative clinical pancreatic fistula","volume":"18","author":"Okano","year":"2011","journal-title":"J\u00a0Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.surg.2020.04.062_bib43","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/SLA.0b013e31821219af","article-title":"External pancreatic duct stent decreases pancreatic fistula rate after pancreaticoduodenectomy: prospective multicenter randomized trial","volume":"253","author":"Pessaux","year":"2011","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib44","doi-asserted-by":"crossref","first-page":"W175","DOI":"10.2214\/AJR.08.1800","article-title":"Utility of CT in the diagnosis of pancreatic fistula after pancreaticoduodenectomy in patients with soft pancreas","volume":"193","author":"Bruno","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.surg.2020.04.062_bib45","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/MPA.0b013e318175ddd0","article-title":"The gray zone between postpancreaticoduodenectomy collections and pancreatic fistula","volume":"37","author":"Barreto","year":"2008","journal-title":"Pancreas"},{"key":"10.1016\/j.surg.2020.04.062_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/SLA.0b013e3180caa42f","article-title":"Amylase value in drains after pancreatic resection as predictive factor of postoperative pancreatic fistula: results of a prospective study in 137 patients","volume":"246","author":"Molinari","year":"2007","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib47","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jamcollsurg.2007.01.018","article-title":"Risk factors of pancreatic fistula and delayed gastric emptying after pancreaticoduodenectomy with pancreaticogastrostomy","volume":"204","author":"Lermite","year":"2007","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.surg.2020.04.062_bib48","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/BF02484618","article-title":"A\u00a0prospective analysis of the factors influencing pancreaticojejunostomy performed using a single method, in 100 consecutive pancreaticoduodenectomies","volume":"28","author":"Matsusue","year":"1998","journal-title":"Surg Today"},{"key":"10.1016\/j.surg.2020.04.062_bib49","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.hpb.2019.07.016","article-title":"Postoperative acute necrotizing pancreatitis of the pancreatic remnant (POANP): a new definition of severe pancreatitis following pancreaticoduodenectomy","volume":"22","author":"Globke","year":"2020","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2020.04.062_bib50","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s11605-015-2884-2","article-title":"The characterization and prediction of ISGPF Grade C fistulas following pancreatoduodenectomy","volume":"20","author":"McMillan","year":"2016","journal-title":"J\u00a0Gastrointest Surg"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606020302762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606020302762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:54:49Z","timestamp":1758538489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606020302762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0039606020302762"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2020.04.062","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Postoperative hyperamylasemia (POH) and acute pancreatitis after pancreatoduodenectomy (POAP): State of the art and systematic review","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2020.04.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}