{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:09:33Z","timestamp":1787987373121,"version":"build-2784847793"},"reference-count":55,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2019A1515010143"],"award-info":[{"award-number":["2019A1515010143"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2019A1515012233"],"award-info":[{"award-number":["2019A1515012233"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701874"],"award-info":[{"award-number":["81701874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772116"],"award-info":[{"award-number":["81772116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801895"],"award-info":[{"award-number":["81801895"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.surg.2021.01.042","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T18:55:35Z","timestamp":1616180135000},"page":"239-248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["HMGB1 signaling-regulated endoplasmic reticulum stress mediates intestinal ischemia\/reperfusion-induced acute renal damage"],"prefix":"10.1016","volume":"170","author":[{"given":"Han-Jin","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Qing","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hong","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Nan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Meng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Hong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2021.01.042_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/j.2040-4603.2017.tb00741.x","article-title":"Ischemia\/reperfusion","volume":"7","author":"Kalogeris","year":"2016","journal-title":"Compr Physiol"},{"key":"10.1016\/j.surg.2021.01.042_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s10620-016-4328-6","article-title":"Intestinal ischemia-reperfusion: Rooting for the SOCS?","volume":"62","author":"Jin","year":"2017","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.surg.2021.01.042_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3233\/CH-170278","article-title":"Intestinal ischemia-reperfusion leads to early systemic micro-rheological and multiorgan microcirculatory alterations in the rat","volume":"68","author":"Mester","year":"2018","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1016\/j.surg.2021.01.042_bib4","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1096\/fj.201900817R","article-title":"HMGB1-associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia\/reperfusion in rats","volume":"34","author":"Wen","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.surg.2021.01.042_bib5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/SHK.0b013e3182662266","article-title":"Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK\/STAT signaling activation","volume":"38","author":"Wen","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.surg.2021.01.042_bib6","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1097\/SHK.0000000000001304","article-title":"Gut barrier dysfunction induced by aggressive fluid resuscitation in severe acute pancreatitis is alleviated by necroptosis inhibition in rats","volume":"52","author":"Cui","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.surg.2021.01.042_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13054-018-2040-y","article-title":"Gut-kidney crosstalk in septic acute kidney injury","volume":"22","author":"Zhang","year":"2018","journal-title":"Crit Care"},{"key":"10.1016\/j.surg.2021.01.042_bib8","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.kint.2019.05.026","article-title":"Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment","volume":"96","author":"Peerapornratana","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.surg.2021.01.042_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13054-016-1352-z","article-title":"Acute kidney injury following cardiac surgery: Current understanding and future directions","volume":"20","author":"O'Neal","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.surg.2021.01.042_bib10","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.jfma.2018.04.005","article-title":"Remote organ failure in acute kidney injury","volume":"118","author":"Kao","year":"2019","journal-title":"J\u00a0Formos Med Assoc"},{"key":"10.1016\/j.surg.2021.01.042_bib11","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1681\/ASN.2014030288","article-title":"Gut bacteria products prevent AKI induced by ischemia-reperfusion","volume":"26","author":"Andrade-Oliveira","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.surg.2021.01.042_bib12","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1681\/ASN.2016030255","article-title":"Depletion of gut microbiota protects against\u00a0renal ischemia-reperfusion injury","volume":"28","author":"Emal","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.surg.2021.01.042_bib13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00424-018-2213-1","article-title":"Probiotics ameliorate renal ischemia-reperfusion injury by modulating the phenotype of macrophages through the IL-10\/GSK-3beta\/PTEN signaling pathway","volume":"471","author":"Ding","year":"2019","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.surg.2021.01.042_bib14","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.kint.2018.10.035","article-title":"Intestinal toll-like receptor 9 deficiency leads to Paneth cell hyperplasia and exacerbates kidney, intestine, and liver injury after ischemia\/reperfusion injury","volume":"95","author":"Han","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.surg.2021.01.042_bib15","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.4049\/jimmunol.1200581","article-title":"Paneth cell-mediated multiorgan dysfunction after acute kidney injury","volume":"189","author":"Park","year":"2012","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.surg.2021.01.042_bib16","doi-asserted-by":"crossref","first-page":"F260\u2212F72","DOI":"10.1152\/ajprenal.00471.2019","article-title":"Norepinephrine released by intestinal Paneth cells exacerbates ischemic AKI","volume":"318","author":"Han","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.surg.2021.01.042_bib17","doi-asserted-by":"crossref","first-page":"e59\u221269","DOI":"10.1016\/j.jss.2010.10.014","article-title":"A\u00a0clinically applicable porcine model of septic and ischemia\/reperfusion-induced shock and multiple organ injury","volume":"166","author":"Kubiak","year":"2011","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.surg.2021.01.042_bib18","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.3390\/molecules17067195","article-title":"Ginsenoside Rb1 attenuates intestinal ischemia reperfusion induced renal injury by activating Nrf2\/ARE pathway","volume":"17","author":"Sun","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.surg.2021.01.042_bib19","first-page":"283","article-title":"The gesture life of high mobility group box 1","volume":"6","author":"Friedman","year":"2003","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.surg.2021.01.042_bib20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.surg.2021.01.042_bib21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.pharmthera.2013.11.001","article-title":"An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies","volume":"141","author":"Musumeci","year":"2014","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.surg.2021.01.042_bib22","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.4049\/jimmunol.1402490","article-title":"Intestinal epithelial TLR-4 activation is\u00a0required for the development of acute lung injury after trauma\/hemorrhagic shock via the release of HMGB1 from the gut","volume":"194","author":"Sodhi","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.surg.2021.01.042_bib23","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3389\/fphys.2019.00854","article-title":"Evidence for SIRT1 mediated HMGB1 release from kidney cells in the early stages of hemorrhagic shock","volume":"10","author":"Xu","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.surg.2021.01.042_bib24","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.immuni.2018.08.016","article-title":"The endotoxin delivery protein HMGB1 mediates caspase-11-dependent lethality in sepsis","volume":"49","author":"Deng","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.surg.2021.01.042_bib25","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/SHK.0000000000001265","article-title":"Late peaks of HMGB1 and sepsis outcome: Evidence for synergy with chronic inflammatory disorders","volume":"52","author":"Karakike","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.surg.2021.01.042_bib26","doi-asserted-by":"crossref","first-page":"46272","DOI":"10.1038\/srep46272","article-title":"Down-regulation of nuclear HMGB1 reduces ischemia-induced HMGB1 translocation and release and protects against liver ischemia-reperfusion injury","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.surg.2021.01.042_bib27","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3389\/fphar.2019.01635","article-title":"Kaempferol improves lung ischemia-reperfusion injury via antiinflammation and antioxidative stress regulated by SIRT1\/HMGB1\/NF-kappaB axis","volume":"10","author":"Yang","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.surg.2021.01.042_bib28","doi-asserted-by":"crossref","first-page":"9827312","DOI":"10.1155\/2018\/9827312","article-title":"Differential regulation of toll-like receptor-mediated cytokine production by unfolded protein response","volume":"2018","author":"Kim","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.surg.2021.01.042_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines6020058","article-title":"The crosstalk of endoplasmic reticulum (ER) stress pathways with NF-\u03baB: Complex mechanisms relevant for cancer, inflammation and infection","volume":"6","author":"Schmitz","year":"2018","journal-title":"Biomedicines"},{"key":"10.1016\/j.surg.2021.01.042_bib30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nrneurol.2017.99","article-title":"ER stress and the unfolded protein response in neurodegeneration","volume":"13","author":"Hetz","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.surg.2021.01.042_bib31","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/SHK.0000000000000425","article-title":"Endoplasmic reticulum stress in sepsis","volume":"44","author":"Khan","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.surg.2021.01.042_bib32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/MNH.0000000000000141","article-title":"Endoplasmic reticulum stress in kidney function and disease","volume":"24","author":"Taniguchi","year":"2015","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.surg.2021.01.042_bib33","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/s41374-018-0085-9","article-title":"High-mobility group box 1 induces endoplasmic reticulum stress and activates hepatic stellate cells","volume":"98","author":"He","year":"2018","journal-title":"Lab Invest"},{"key":"10.1016\/j.surg.2021.01.042_bib34","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/jcmm.12987","article-title":"Necroptosis is a key mediator of enterocytes loss in intestinal ischaemia\/reperfusion injury","volume":"21","author":"Wen","year":"2017","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.surg.2021.01.042_bib35","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/SLA.0000000000003167","article-title":"Females are more resistant to ischemia-reperfusion-induced intestinal injury than males: A human study","volume":"272","author":"Hundscheid","year":"2020","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.01.042_bib36","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jss.2017.12.043","article-title":"Age- and gender-related hemorheological alterations in intestinal ischemia-reperfusion in the rat","volume":"225","author":"Mester","year":"2018","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.surg.2021.01.042_bib37","doi-asserted-by":"crossref","first-page":"F606","DOI":"10.1152\/ajprenal.00415.2011","article-title":"Ethyl pyruvate ameliorates albuminuria and glomerular injury in the animal model of diabetic nephropathy","volume":"302","author":"Ju","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.surg.2021.01.042_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12974-019-1581-6","article-title":"Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin\/thrombomodulin system in rodents: negative impact of anticoagulants","volume":"16","author":"Tsubota","year":"2019","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.surg.2021.01.042_bib39","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch Surg"},{"key":"10.1016\/j.surg.2021.01.042_bib40","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/SLA.0b013e3182441767","article-title":"Isoflurane post-conditioning protects against intestinal ischemia-reperfusion injury and multiorgan dysfunction via transforming growth factor-beta1 generation","volume":"255","author":"Kim","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.01.042_bib41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2019.08.002","article-title":"Pursuing human-relevant gut microbiota-immune interactions","volume":"51","author":"Spencer","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.surg.2021.01.042_bib42","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.kint.2020.04.048","article-title":"Intestinal microbiota controls acute kidney injury severity by immune modulation","volume":"98","author":"Yang","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.surg.2021.01.042_bib43","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1002\/hep.24253","article-title":"Paneth cell-derived interleukin-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury","volume":"53","author":"Park","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.surg.2021.01.042_bib44","doi-asserted-by":"crossref","first-page":"G12","DOI":"10.1152\/ajpgi.00201.2012","article-title":"Critical role of interleukin-17A in murine intestinal ischemia-reperfusion injury","volume":"304","author":"Lee","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.surg.2021.01.042_bib45","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s00134-017-4755-7","article-title":"Acute kidney injury in sepsis","volume":"43","author":"Bellomo","year":"2017","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.surg.2021.01.042_bib46","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1073\/pnas.0810169106","article-title":"Donor toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation","volume":"106","author":"Kr\u00fcger","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.surg.2021.01.042_bib47","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.3389\/fimmu.2018.03052","article-title":"Effects of changes in the levels of damage-associated molecular patterns following continuous veno-venous hemofiltration therapy on outcomes in acute kidney injury patients with sepsis","volume":"9","author":"Wu","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.surg.2021.01.042_bib48","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.13869","article-title":"Circulating levels of high-mobility group box 1 protein and nucleosomes are associated with outcomes after liver transplant","author":"Faria","year":"2020","journal-title":"Clin Transplant"},{"key":"10.1016\/j.surg.2021.01.042_bib49","doi-asserted-by":"crossref","first-page":"R184","DOI":"10.1186\/ar4015","article-title":"Urine levels of HMGB1 in systemic lupus erythematosus patients with and without renal manifestations","volume":"14","author":"Abdulahad","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.surg.2021.01.042_bib50","doi-asserted-by":"crossref","first-page":"F1420","DOI":"10.1152\/ajprenal.00263.2019","article-title":"Involvement of high mobility group box 1 in the pathogenesis of severe hemolytic uremic syndrome in a murine model","volume":"317","author":"Maeda","year":"2019","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.surg.2021.01.042_bib51","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.intimp.2016.11.002","article-title":"Ethyl pyruvate inhibits the acetylation and release of HMGB1 via effects on SIRT1\/STAT signaling in LPS-activated RAW264.7 cells and peritoneal macrophages","volume":"41","author":"Kim","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.surg.2021.01.042_bib52","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.kint.2019.06.023","article-title":"Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation","volume":"96","author":"Ferre","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.surg.2021.01.042_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau5266","article-title":"Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis","volume":"11","author":"Rosen","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.surg.2021.01.042_bib54","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ebiom.2018.10.006","article-title":"Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease","volume":"37","author":"Shu","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.surg.2021.01.042_bib55","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cellsig.2013.10.002","article-title":"Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling","volume":"26","author":"Liu","year":"2014","journal-title":"Cell Signal"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606021000805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606021000805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:56:30Z","timestamp":1758538590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606021000805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0039606021000805"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2021.01.042","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HMGB1 signaling-regulated endoplasmic reticulum stress mediates intestinal ischemia\/reperfusion-induced acute renal damage","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2021.01.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}