{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:48:37Z","timestamp":1777430917226,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.surg.2021.05.006","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T19:26:49Z","timestamp":1622834809000},"page":"969-977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Heat shock protein A12B gene therapy improves perfusion, promotes neovascularization, and decreases fibrosis in a murine model of hind limb ischemia"],"prefix":"10.1016","volume":"170","author":[{"given":"Mahesh","family":"Thirunavukkarasu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Tipu Rishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seetur R.","family":"Pradeep","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh","family":"Swaminathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Accorsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Alexander","family":"Palesty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1585-1783","authenticated-orcid":false,"given":"Nilanjana","family":"Maulik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2021.05.006_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/j.tvir.2016.04.001","article-title":"Epidemiology of peripheral arterial disease and critical limb ischemia","volume":"19","author":"Dua","year":"2016","journal-title":"Techn Vascul Intervention Radiol"},{"key":"10.1016\/j.surg.2021.05.006_bib2","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/S0140-6736(11)60441-8","article-title":"Gene therapy for critical limb ischaemia: the TAMARIS trial","volume":"377","author":"Fowkes","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.surg.2021.05.006_bib3","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1161\/01.ATV.0000235720.61091.c7","article-title":"HSPA12B is predominantly expressed in endothelial cells and required for angiogenesis","volume":"26","author":"Steagall","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.surg.2021.05.006_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12265-017-9734-4","article-title":"Regulation of A-kinase-anchoring protein 12 by heat shock protein A12B to prevent ventricular dysfunction following acute myocardial infarction in diabetic rats","volume":"10","author":"Selvaraju","year":"2017","journal-title":"J\u00a0Cardiovasc Translational Res"},{"key":"10.1016\/j.surg.2021.05.006_bib5","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1158\/0008-5472.CAN-07-5619","article-title":"Loss of the SSeCKS\/Gravin\/AKAP12 gene results in prostatic hyperplasia","volume":"68","author":"Akakura","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.surg.2021.05.006_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.mvr.2014.10.009","article-title":"Deletion of prolyl hydroxylase domain proteins (PHD1, PHD3) stabilizes hypoxia inducible factor-1 alpha, promotes neovascularization, and improves perfusion in a murine model of hind-limb ischemia","volume":"97","author":"Rishi","year":"2015","journal-title":"Microvasc Res"},{"key":"10.1016\/j.surg.2021.05.006_bib7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jss.2017.04.019","article-title":"Overexpression of thioredoxin1 enhances functional recovery in a mouse model of hind limb ischemia","volume":"216","author":"Shaikh","year":"2017","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.surg.2021.05.006_bib8","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1161\/01.RES.0000141145.78900.44","article-title":"Influence of mechanical, cellular, and molecular factors on collateral artery growth (arteriogenesis)","volume":"95","author":"Heil","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.surg.2021.05.006_bib9","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1001\/archneurpsyc.1954.02320410050004","article-title":"Spinal cord compression studies. III. Time limits for recovery after gradual compression in dogs","volume":"71","author":"Tarlov","year":"1954","journal-title":"AMA Arch Neurol Psychiatr"},{"key":"10.1016\/j.surg.2021.05.006_bib10","doi-asserted-by":"crossref","first-page":"13438","DOI":"10.1073\/pnas.1016546108","article-title":"Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair","volume":"108","author":"Webber","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.surg.2021.05.006_bib11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jvs.2008.08.077","article-title":"Limb ischemia after iliac ligation in aged mice stimulates angiogenesis without arteriogenesis","volume":"49","author":"Westvik","year":"2009","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.surg.2021.05.006_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00395-020-0804-4","article-title":"Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2\/NF-\u03baB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models","volume":"115","author":"Selvaraju","year":"2020","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.surg.2021.05.006_bib13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijpharm.2019.01.001","article-title":"Evaluation of dermal tissue regeneration using resveratrol loaded fibrous matrix in a preclinical mouse model of full-thickness ischemic wound","volume":"558","author":"Lakshmanan","year":"2019","journal-title":"Int J Pharm"},{"key":"10.1016\/j.surg.2021.05.006_bib14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/ar.22641","article-title":"Quantitative analysis of histological staining and fluorescence using ImageJ","volume":"296","author":"Jensen","year":"2013","journal-title":"Anat Record (Hoboken, NJ)"},{"key":"10.1016\/j.surg.2021.05.006_bib15","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1128\/MCB.00686-12","article-title":"Multiple cancer testis antigens function to support tumor cell mitotic fidelity","volume":"32","author":"Cappell","year":"2012","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.surg.2021.05.006_bib16","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/emmm.201201584","article-title":"Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease","volume":"5","author":"Harari-Steinberg","year":"2013","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.surg.2021.05.006_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12362","article-title":"Increased survivability of ischemic skin flap tissue in Flk-1(+\/-) mice by Pellino-1 intervention","volume":"24","author":"Rednam","year":"2017","journal-title":"Microcirculation"},{"key":"10.1016\/j.surg.2021.05.006_bib18","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.surg.2018.05.045","article-title":"Thioredoxin-1 augments wound healing and promote angiogenesis in a murine ischemic full-thickness wound model","volume":"164","author":"Saad","year":"2018","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2021.05.006_bib19","article-title":"Disruption of VEGF mediated Flk-1 signaling leads to a gradual loss of vessel health and cardiac function during myocardial infarction: potential therapy with pellino-1","volume":"7","author":"Thirunavukkarasu","year":"2018","journal-title":"J\u00a0Amer Heart Assoc"},{"key":"10.1016\/j.surg.2021.05.006_bib20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.yjmcc.2010.11.002","article-title":"Thioredoxin 1 enhances neovascularization and reduces ventricular remodeling during chronic myocardial infarction: a study using thioredoxin 1 transgenic mice","volume":"50","author":"Adluri","year":"2011","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.surg.2021.05.006_bib21","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nm1075","article-title":"Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1","volume":"10","author":"Ceradini","year":"2004","journal-title":"Nature Med"},{"key":"10.1016\/j.surg.2021.05.006_bib22","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1101\/gad.291004","article-title":"The Notch target genes Hey1 and Hey2 are required for embryonic vascular development","volume":"18","author":"Fischer","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.surg.2021.05.006_bib23","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nature05571","article-title":"Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis","volume":"445","author":"Hellstr\u00f6m","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.surg.2021.05.006_bib24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrm3176","article-title":"Molecular control of endothelial cell behaviour during blood vessel morphogenesis","volume":"12","author":"Herbert","year":"2011","journal-title":"Nature Rev Mol Cell Biol"},{"key":"10.1016\/j.surg.2021.05.006_bib25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nature08995","article-title":"Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis","volume":"465","author":"Sawamiphak","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.surg.2021.05.006_bib26","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1161\/CIRCRESAHA.107.153346","article-title":"Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia","volume":"101","author":"Bosch-Marce","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.surg.2021.05.006_bib27","doi-asserted-by":"crossref","first-page":"20399","DOI":"10.1073\/pnas.0911921106","article-title":"Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia","volume":"106","author":"Rey","year":"2009","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606021004256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606021004256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:58:54Z","timestamp":1758538734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606021004256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0039606021004256"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2021.05.006","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heat shock protein A12B gene therapy improves perfusion, promotes neovascularization, and decreases fibrosis in a murine model of hind limb ischemia","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2021.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}