{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:15:09Z","timestamp":1792818909639,"version":"4.5.0"},"reference-count":115,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.surg.2021.06.033","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T18:03:25Z","timestamp":1626977005000},"page":"1732-1740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["The evolution of surgery for colorectal liver metastases: A persistent challenge to improve survival"],"prefix":"10.1016","volume":"170","author":[{"given":"Patryk","family":"Kambakamba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emir","family":"Hoti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-0556","authenticated-orcid":false,"given":"Sinead","family":"Cremen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5296-2020","authenticated-orcid":false,"given":"Felix","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0721-6811","authenticated-orcid":false,"given":"Michael","family":"Linecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2021.06.033_bib1","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.surg.2021.06.033_bib2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/01.sla.0000217629.94941.cf","article-title":"Epidemiology and management of liver metastases from colorectal cancer","volume":"244","author":"Manfredi","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib3","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/bmj.306.6880.752","article-title":"Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer","volume":"306","author":"Scheithauer","year":"1993","journal-title":"BMJ"},{"key":"10.1016\/j.surg.2021.06.033_bib4","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/00000658-198405000-00002","article-title":"The natural history of hepatic metastases from colorectal cancer: a comparison with resective treatment","volume":"199","author":"Wagner","year":"1984","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib5","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1023\/A:1008365511961","article-title":"Survival impact of chemotherapy in patients with colorectal metastases confined to the liver: a re-analysis of 1458 non-operable patients randomised in 22 trials and 4 meta-analyses","volume":"10","author":"Thirion","year":"1999","journal-title":"Ann Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib6","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/sj.bjc.6605659","article-title":"Surgery for colorectal liver metastases","volume":"102","author":"Primrose","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.surg.2021.06.033_bib7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/bjs.5719","article-title":"Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases","volume":"94","author":"Zorzi","year":"2007","journal-title":"Br J Surg"},{"issue":"suppl 4","key":"10.1016\/j.surg.2021.06.033_bib8","doi-asserted-by":"crossref","first-page":"iv103","DOI":"10.1093\/annonc\/mdh912","article-title":"Regional treatment of metastasis: surgery of colorectal liver metastases","volume":"15","author":"Adam","year":"2004","journal-title":"Ann Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib9","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S1470-2045(13)70447-9","article-title":"Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial","volume":"14","author":"Nordlinger","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/00000658-189907000-00023","article-title":"IV. Report of a case of resection of the liver for the removal of a neoplasm, with a table of seventy-six cases of resection of the liver for hepatic tumors","volume":"30","author":"Keen","year":"1899","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib11","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1001\/jama.1951.73670320001013","article-title":"Resection of primary tumor of colon three years after excision of metastatic tumor","volume":"147","author":"Trimble","year":"1951","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.surg.2021.06.033_bib12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/107327480601300105","article-title":"Resection of colorectal liver metastases: current perspectives","volume":"13","author":"McLoughlin","year":"2006","journal-title":"Cancer Control"},{"key":"10.1016\/j.surg.2021.06.033_bib13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/00000658-195611000-00013","article-title":"Right hepatic lobectomy for primary carcinoma of the liver","volume":"144","author":"Fineberg","year":"1956","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib14","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/1097-0142(197009)26:3<493::AID-CNCR2820260302>3.0.CO;2-7","article-title":"Survival after liver resection for cancer","volume":"26","author":"Foster","year":"1970","journal-title":"Cancer"},{"key":"10.1016\/j.surg.2021.06.033_bib15","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/bjs.1800771115","article-title":"Hepatic metastases from colorectal carcinoma: impact of surgical resection on the natural history","volume":"77","author":"Scheele","year":"1990","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0002-9610(63)90263-0","article-title":"Results of resection of metastatic tumors of the liver","volume":"105","author":"Woodington","year":"1963","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1001\/archsurg.1976.01360220026004","article-title":"Surgical treatment of hepatic metastases from colorectal cancers","volume":"111","author":"Wilson","year":"1976","journal-title":"Arch Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02552560","article-title":"Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of long-term survivors","volume":"31","author":"Hughes","year":"1988","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.surg.2021.06.033_bib19","first-page":"360","article-title":"Resection of liver metastases in colorectal cancer: competitive analysis of treatment results in synchronous versus metachronous metastases","volume":"16","author":"Schlag","year":"1990","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib20","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/0002-9610(64)90041-8","article-title":"The natural history of carcinoma of the colon and rectum","volume":"108","author":"Pestana","year":"1964","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib21","first-page":"697","article-title":"Survival of patients after colonic resection for carcinoma with simultaneous liver metastases","volume":"131","author":"Cady","year":"1970","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.surg.2021.06.033_bib22","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1200\/JCO.1983.1.11.720","article-title":"A\u00a0multifactorial analysis of prognostic factors in patients with liver metastases from colorectal carcinoma","volume":"1","author":"Lahr","year":"1983","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib23","first-page":"285","article-title":"A\u00a0retrospective study of the natural history of patients with liver metastases from colorectal cancer","volume":"2","author":"Wood","year":"1976","journal-title":"Clin Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib24","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0140-6736(94)92529-1","article-title":"Factors influencing the natural history of colorectal liver metastases","volume":"343","author":"Stangl","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.surg.2021.06.033_bib25","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1002\/bjs.1800821034","article-title":"Prospective study of prognostic factors in patients with unresected hepatic metastases from colorectal cancer","volume":"82","author":"Rougier","year":"1995","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib26","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s001040051345","article-title":"[Resection of colorectal liver metastases. What prognostic factors determine patient selection?]","volume":"72","author":"Scheele","year":"2001","journal-title":"Chirurg"},{"key":"10.1016\/j.surg.2021.06.033_bib27","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/BF01655817","article-title":"Resection of liver metastases:when is it worthwhile?","volume":"11","author":"Adson","year":"1987","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib28","first-page":"13","article-title":"Indicators of prognosis after hepatic resection for colorectal secondaries","volume":"110","author":"Scheele","year":"1991","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2021.06.033_bib29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/ags3.12322","article-title":"The history of liver surgery: achievements over the past 50 years","volume":"4","author":"Kokudo","year":"2020","journal-title":"Ann Gastroenterol Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/00000658-199610000-00009","article-title":"Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy","volume":"224","author":"Bismuth","year":"1996","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib31","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/bjs.1800730917","article-title":"Determinants of survival in liver resection for colorectal secondaries","volume":"73","author":"Ekberg","year":"1986","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1445-2197.2002.02230.x","article-title":"Surgery for liver metastases: how many?","volume":"72","author":"Morris","year":"2002","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib33","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/SLA.0b013e31811ea962","article-title":"The impact of margins on outcome after hepatic resection for colorectal metastasis","volume":"246","author":"Are","year":"2007","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib34","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0748-7983(98)92878-5","article-title":"Resection of liver metastases from colorectal cancer: the real impact of the surgical margin","volume":"24","author":"Elias","year":"1998","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-1-4615-2604-9_4","article-title":"Resection of hepatic metastases from colorectal carcinoma: the registry data","volume":"69","author":"Asbun","year":"1994","journal-title":"Cancer Treat Res"},{"key":"10.1016\/j.surg.2021.06.033_bib36","first-page":"77","article-title":"Management of non-resectable liver metastases from colorectal cancer","volume":"4","author":"Levitan","year":"1990","journal-title":"Oncology (Williston Park)"},{"key":"10.1016\/j.surg.2021.06.033_bib37","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1056\/NEJMra065156","article-title":"Strategies for safer liver surgery and partial liver transplantation","volume":"356","author":"Clavien","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.surg.2021.06.033_bib38","author":"Cartwright"},{"key":"10.1016\/j.surg.2021.06.033_bib39","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1084\/jem.31.5.609","article-title":"Relation of the portal blood to liver maintenance: a demonstration of liver atrophy conditional on compensation","volume":"31","author":"Rous","year":"1920","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.surg.2021.06.033_bib40","first-page":"521","article-title":"Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report","volume":"107","author":"Makuuchi","year":"1990","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2021.06.033_bib41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11605-007-0410-x","article-title":"Right portal vein ligation is as efficient as portal vein embolization to induce hypertrophy of the left liver remnant","volume":"12","author":"Aussilhou","year":"2008","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib42","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11605-012-2005-4","article-title":"Improved long-term survival after major resection for hepatocellular carcinoma: a multicenter analysis based on a new definition of major hepatectomy","volume":"17","author":"Andreou","year":"2013","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib43","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/00000658-200004000-00005","article-title":"Resection of nonresectable liver metastases from colorectal cancer after percutaneous portal vein embolization","volume":"231","author":"Azoulay","year":"2000","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib44","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/00000658-200012000-00006","article-title":"Two-stage hepatectomy: a planned strategy to treat irresectable liver tumors","volume":"232","author":"Adam","year":"2000","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib45","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/01.sla.0000145965.86383.89","article-title":"A\u00a0two-stage hepatectomy procedure combined with portal vein embolization to achieve curative resection for initially unresectable multiple and bilobar colorectal liver metastases","volume":"240","author":"Jaeck","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib46","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1072-7515(03)00334-X","article-title":"Right portal vein ligation: a new planned two-step all-surgical approach for complete resection of primary gastrointestinal tumors with multiple bilateral liver metastases","volume":"197","author":"Kianmanesh","year":"2003","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib47","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ejso.2006.10.038","article-title":"Remnant liver regeneration after two-stage hepatectomy for multiple bilobar colorectal metastases","volume":"33","author":"Tanaka","year":"2007","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib48","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1159\/000176063","article-title":"Prospective evaluation of two-stage hepatectomy combined with selective portal vein embolisation and systemic chemotherapy for patients with unresectable bilobar colorectal liver metastases","volume":"25","author":"Pamecha","year":"2008","journal-title":"Dig Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib49","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1477-2574.2010.00161.x","article-title":"Two-stage strategy for patients with extensive bilateral colorectal liver metastases","volume":"12","author":"Tsai","year":"2010","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2021.06.033_bib50","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.amjsurg.2011.07.014","article-title":"Feasibility study of two-stage hepatectomy for bilobar liver metastases","volume":"203","author":"Bowers","year":"2012","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib51","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1200\/JCO.2010.32.6132","article-title":"High survival rate after two-stage resection of advanced colorectal liver metastases: response-based selection and complete resection define outcome","volume":"29","author":"Brouquet","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib52","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1245\/s10434-011-2069-5","article-title":"Chemotherapy between the first and second stages of a two-stage hepatectomy for colorectal liver metastases: should we routinely recommend it?","volume":"19","author":"Muratore","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib53","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ejso.2011.12.009","article-title":"Two-stage hepatectomy: who will not jump over the second hurdle?","volume":"38","author":"Turrini","year":"2012","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib54","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00384-008-0620-z","article-title":"Two-stage hepatectomy (R0) with portal vein ligation: towards curing patients with extended bilobular colorectal liver metastases","volume":"24","author":"Homayounfar","year":"2009","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.surg.2021.06.033_bib55","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1001\/archsurg.143.10.978","article-title":"Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases","volume":"143","author":"Capussotti","year":"2008","journal-title":"Arch Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib56","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1097\/SLA.0b013e3181907fd9","article-title":"Long-term results of two-stage hepatectomy for irresectable colorectal cancer liver metastases","volume":"248","author":"Wicherts","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib57","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/bjs.7580","article-title":"Two-stage hepatectomy for multiple bilobar colorectal liver metastases","volume":"98","author":"Narita","year":"2011","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib58","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1245\/s10434-010-1533-y","article-title":"Two-stage resection for bilobar colorectal liver metastases: R0 resection is the key","volume":"18","author":"Tsim","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib59","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1477-2574.2012.00607.x","article-title":"A\u00a0systematic review of two-stage hepatectomy in patients with initially unresectable colorectal liver metastases","volume":"15","author":"Lam","year":"2013","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2021.06.033_bib60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jhep.2006.02.020","article-title":"Portal vein ligation and partial hepatectomy differentially influence growth of intrahepatic metastasis and liver regeneration in mice","volume":"45","author":"Heinrich","year":"2006","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.surg.2021.06.033_bib61","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1046\/j.1365-2168.1999.01154.x","article-title":"During liver regeneration following right portal embolization the growth rate of liver metastases is more rapid than that of the liver parenchyma","volume":"86","author":"Elias","year":"1999","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib62","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1245\/s10434-008-0222-6","article-title":"Induction of tumor growth after preoperative portal vein embolization: is it a real problem?","volume":"16","author":"de Graaf","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib63","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1001\/jamasurg.2013.2126","article-title":"Chemotherapy after portal vein embolization to protect against tumor growth during liver hypertrophy before hepatectomy","volume":"148","author":"Fischer","year":"2013","journal-title":"JAMA Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib64","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/jso.24139","article-title":"Neoadjuvant chemotherapy does not impair liver regeneration following hepatectomy or portal vein embolization for colorectal cancer liver metastases","volume":"113","author":"Simoneau","year":"2016","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib65","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11605-009-1073-6","article-title":"Influence of chemotherapy on liver regeneration induced by portal vein embolization or first hepatectomy of a staged procedure for colorectal liver metastases","volume":"14","author":"Tanaka","year":"2010","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib66","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1245\/s10434-008-0035-7","article-title":"Chemotherapy with bevacizumab does not affect liver regeneration after portal vein embolization in the treatment of colorectal liver metastases","volume":"15","author":"Zorzi","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib67","doi-asserted-by":"crossref","first-page":"699","DOI":"10.5009\/gnl19233","article-title":"Associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) registry: what have we learned?","volume":"14","author":"Lang","year":"2020","journal-title":"Gut Liver"},{"key":"10.1016\/j.surg.2021.06.033_bib68","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/SLA.0b013e31824856f5","article-title":"Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings","volume":"255","author":"Schnitzbauer","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib69","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/SLA.0b013e318248577d","article-title":"Playing Play-Doh to prevent postoperative liver failure: the \u201cALPPS\u201d approach","volume":"255","author":"de Santibanes","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib70","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.hpb.2016.10.008","article-title":"High mortality after ALPPS for perihilar cholangiocarcinoma: case-control analysis including the first series from the international ALPPS registry","volume":"19","author":"Olthof","year":"2017","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2021.06.033_bib71","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/bjs.9547","article-title":"Tourniquet modification of the associating liver partition and portal ligation for staged hepatectomy procedure","volume":"101","author":"Robles","year":"2014","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib72","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5604\/01.3001.0012.7937","article-title":"Laparoscopic partial ALPPS: much better than ALPPS!","volume":"18","author":"Truant","year":"2019","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.surg.2021.06.033_bib73","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12876-019-1090-1","article-title":"Partial ALPPS versus complete ALPPS for staged hepatectomy","volume":"19","author":"Wu","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.surg.2021.06.033_bib74","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.surg.2016.08.004","article-title":"How much liver needs to be transected in ALPPS? A translational study investigating the concept of less invasiveness","volume":"161","author":"Linecker","year":"2017","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2021.06.033_bib75","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1097\/SLA.0000000000001087","article-title":"Is partial-ALPPS safer than ALPPS? A single-center experience","volume":"261","author":"Petrowsky","year":"2015","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib76","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1097\/SLA.0000000000000607","article-title":"Radio-frequency-assisted Liver Partition with Portal vein ligation (RALPP) for liver regeneration","volume":"261","author":"Gall","year":"2015","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib77","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.hpb.2016.10.004","article-title":"Transition from open to laparoscopic ALPPS for patients with very small FLR: the initial experience","volume":"19","author":"Machado","year":"2017","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2021.06.033_bib78","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/SLA.0000000000002511","article-title":"ALPPS improves resectability compared with conventional two-stage hepatectomy in patients with advanced colorectal liver metastasis: results from a Scandinavian multicenter randomized controlled trial (LIGRO Trial)","volume":"267","author":"Sandstrom","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib79","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/SLA.0000000000002446","article-title":"Risk adjustment in ALPPS is associated with a dramatic decrease in early mortality and morbidity","volume":"266","author":"Linecker","year":"2017","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib80","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/SLA.0000000000001914","article-title":"The ALPPS risk score: avoiding futile use of ALPPS","volume":"264","author":"Linecker","year":"2016","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib81","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/SLA.0000000000003701","article-title":"ALPPS improves survival compared with TSH in patients affected of CRLM: survival analysis from the randomized controlled trial LIGRO","volume":"273","author":"Hasselgren","year":"2021","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib82","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1097\/SLA.0000000000004330","article-title":"First Long-term Oncologic Results of the ALPPS Procedure in a Large Cohort of Patients With Colorectal Liver Metastases","volume":"272","author":"Petrowsky","year":"2020","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib83","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.ejso.2015.01.031","article-title":"Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): short-term outcome, functional changes in the future liver remnant, and tumor growth activity","volume":"41","author":"Tanaka","year":"2015","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib84","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1245\/s10434-014-4291-4","article-title":"Strategies to increase the resectability of patients with colorectal liver metastases: a multi-center case-match analysis of ALPPS and conventional two-stage hepatectomy","volume":"22","author":"Ratti","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2021.06.033_bib85","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/bjs.10256","article-title":"Outcome after associating liver partition and portal vein ligation for staged hepatectomy and conventional two-stage hepatectomy for colorectal liver metastases","volume":"103","author":"Adam","year":"2016","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib86","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s11605-017-3523-x","article-title":"Remnant liver tumor growth activity during treatment associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS)","volume":"21","author":"Kikuchi","year":"2017","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib87","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/MLR.0b013e31820fb10c","article-title":"Continuity of care and its effect on prescription drug use among Medicare beneficiaries with hypertension","volume":"49","author":"Robles","year":"2011","journal-title":"Med Care"},{"key":"10.1016\/j.surg.2021.06.033_bib88","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s11605-019-04145-9","article-title":"Two-stage hepatectomy and ALPPS for advanced bilateral liver metastases: a tailored approach balancing risk and outcome","volume":"23","author":"Baumgart","year":"2019","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib89","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1007\/s00268-019-05031-w","article-title":"Long-term outcome after conventional two-stage hepatectomy versus tourniquet-ALPPS in colorectal liver metastases: a propensity score matching analysis","volume":"43","author":"Robles-Campos","year":"2019","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib90","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/bjs.9900","article-title":"Associating portal embolization and artery ligation to induce rapid liver regeneration in staged hepatectomy","volume":"102","author":"Dupre","year":"2015","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib91","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1007\/s00330-016-4291-9","article-title":"Simultaneous trans-hepatic portal and hepatic vein embolization before major hepatectomy: the liver venous deprivation technique","volume":"26","author":"Guiu","year":"2016","journal-title":"Eur Radiol"},{"key":"10.1016\/j.surg.2021.06.033_bib92","doi-asserted-by":"crossref","first-page":"329","DOI":"10.21037\/hbsn.2019.07.06","article-title":"Perioperative impact of liver venous deprivation compared with portal venous embolization in patients undergoing right hepatectomy: preliminary results from the pioneer center","volume":"8","author":"Panaro","year":"2019","journal-title":"Hepatobiliary Surg Nutr"},{"key":"10.1016\/j.surg.2021.06.033_bib93","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1186\/s12885-020-07065-z","volume":"20","author":"Deshayes","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.surg.2021.06.033_bib94","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00000658-200004000-00006","article-title":"Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer: long-term results","volume":"231","author":"Minagawa","year":"2000","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib95","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0002-9610(00)00560-2","article-title":"Anatomical major resection versus nonanatomical limited resection for liver metastases from colorectal carcinoma","volume":"181","author":"Kokudo","year":"2001","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib96","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jamcollsurg.2005.04.026","article-title":"\u201cRadical but conservative\u201d is the main goal for ultrasonography-guided liver resection: prospective validation of this approach","volume":"201","author":"Torzilli","year":"2005","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib97","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ijsu.2020.04.047","article-title":"Parenchyma-sparing liver resections","volume":"82S","author":"Torzilli","year":"2020","journal-title":"Int J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib98","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/bjs.7230","article-title":"Intraoperative ultrasonographic detection of communicating veins between adjacent hepatic veins during hepatectomy for tumours at the hepatocaval confluence","volume":"97","author":"Torzilli","year":"2010","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib99","article-title":"Consensus guidelines for the use of fluorescence imaging in hepatobiliary surgery","author":"Wang","year":"2020","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib100","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/s10278-018-0067-x","article-title":"A\u00a0systematic review of three-dimensional printing in liver disease","volume":"31","author":"Perica","year":"2018","journal-title":"J\u00a0Digit Imaging"},{"key":"10.1016\/j.surg.2021.06.033_bib101","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.hbpd.2018.02.002","article-title":"Augmented reality technology for preoperative planning and intraoperative navigation during hepatobiliary surgery: a review of current methods","volume":"17","author":"Tang","year":"2018","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.surg.2021.06.033_bib102","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1053\/j.gastro.2014.08.045","article-title":"Challenges to liver transplantation and strategies to improve outcomes","volume":"148","author":"Dutkowski","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.surg.2021.06.033_bib103","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1432-2277.2010.01097.x","article-title":"Liver transplantation for colorectal liver metastases: revisiting the concept","volume":"23","author":"Foss","year":"2010","journal-title":"Transpl Int"},{"key":"10.1016\/j.surg.2021.06.033_bib104","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1432-2277.2008.00735.x","article-title":"Liver transplantation for primary and metastatic liver cancers","volume":"21","author":"Hoti","year":"2008","journal-title":"Transpl Int"},{"key":"10.1016\/j.surg.2021.06.033_bib105","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/SLA.0b013e3182823957","article-title":"Liver transplantation for nonresectable liver metastases from colorectal cancer","volume":"257","author":"Hagness","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib106","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/lt.24791","article-title":"Liver transplantation for colorectal liver metastasis: Survival without recurrence can be achieved","volume":"23","author":"Toso","year":"2017","journal-title":"Liver Transpl"},{"key":"10.1016\/j.surg.2021.06.033_bib107","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/SLA.0000000000003404","article-title":"Survival following liver transplantation for patients with nonresectable liver-only colorectal metastases","volume":"271","author":"Dueland","year":"2020","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib108","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/ajt.15682","article-title":"Selection criteria related to long-term survival following liver transplantation for colorectal liver metastasis","volume":"20","author":"Dueland","year":"2020","journal-title":"Am J Transplant"},{"key":"10.1016\/j.surg.2021.06.033_bib109","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1097\/SLA.0000000000001165","article-title":"A\u00a0novel concept for partial liver transplantation in nonresectable colorectal liver metastases: the RAPID concept","volume":"262","author":"Line","year":"2015","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib110","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijsu.2020.03.078","article-title":"RAPID procedure for colorectal cancer liver metastasis","volume":"82S","author":"Nadalin","year":"2020","journal-title":"Int J Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib111","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/SLA.0000000000002861","article-title":"Paradigm shift in the management of irresectable colorectal liver metastases: living donor auxiliary partial orthotopic liver transplantation in combination with two-stage hepatectomy (LD-RAPID)","volume":"270","author":"Konigsrainer","year":"2019","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2021.06.033_bib112","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.surg.2018.05.021","article-title":"Heterotopic auxiliary segment 2-3 liver transplantation with delayed total hepatectomy: new strategies for nonresectable colorectal liver metastases","volume":"164","author":"Ravaioli","year":"2018","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2021.06.033_bib113","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/ajt.16222","article-title":"Heterotopic segmental liver transplantation on splenic vessels after splenectomy with delayed native hepatectomy after graft regeneration: a new technique to enhance liver transplantation","volume":"21","author":"Ravaioli","year":"2021","journal-title":"Am J Transplant"},{"key":"10.1016\/j.surg.2021.06.033_bib114","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/ajt.16271","article-title":"Heterotopic liver transplantation: temporary solution, permanent problem?","volume":"21","author":"Rammohan","year":"2021","journal-title":"Am J Transplant"},{"key":"10.1016\/j.surg.2021.06.033_bib115","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1001\/archsurg.1997.01430280012001","article-title":"Basic principles in surgical oncology","volume":"132","author":"Cady","year":"1997","journal-title":"Arch Surg"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606021006449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606021006449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:59:19Z","timestamp":1758538759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606021006449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":115,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0039606021006449"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2021.06.033","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The evolution of surgery for colorectal liver metastases: A persistent challenge to improve survival","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2021.06.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}