{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:44:18Z","timestamp":1783529058750,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.surg.2021.08.024","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T07:35:52Z","timestamp":1632468952000},"page":"235-244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Inhibition of autophagy mitigates cell migration and invasion in thyroid cancer"],"prefix":"10.1016","volume":"171","author":[{"given":"Tammy M.","family":"Holm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. Christine","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-5946","authenticated-orcid":false,"given":"Kanakaraju","family":"Manupati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Lin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2021.08.024_bib1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1089\/thy.2016.0395","article-title":"Patterns of treatment failure in anaplastic thyroid carcinoma","volume":"27","author":"Rao","year":"2017","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2021.08.024_bib2","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","article-title":"Autophagy: Process and function","volume":"21","author":"Mizushima","year":"2007","journal-title":"Genes Dev"},{"key":"10.1016\/j.surg.2021.08.024_bib3","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1101\/gad.2051011","article-title":"Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis","volume":"25","author":"Wei","year":"2011","journal-title":"Genes Dev"},{"key":"10.1016\/j.surg.2021.08.024_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ceb.2009.10.008","article-title":"Autophagy and metastasis: Another double-edged sword","volume":"22","author":"Kenific","year":"2010","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.surg.2021.08.024_bib5","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.4161\/cc.20424","article-title":"Inhibition of autophagy impairs tumor cell invasion in an organotypic model","volume":"11","author":"Macintosh","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.surg.2021.08.024_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/ncb2386","article-title":"Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling","volume":"14","author":"Sandilands","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.surg.2021.08.024_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fendo.2016.00020","article-title":"Cancer stem cells in the thyroid","volume":"7","author":"Nagayama","year":"2016","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.surg.2021.08.024_bib8","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.cmet.2017.04.004","article-title":"Autophagy and tumor metabolism","volume":"25","author":"Kimmelman","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.surg.2021.08.024_bib9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fendo.2015.00022","article-title":"Autophagy in thyroid cancer: Present knowledge and future perspectives","volume":"6","author":"Netea-Maier","year":"2015","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.surg.2021.08.024_bib10","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1158\/1541-7786.MCR-10-0162","article-title":"Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer","volume":"8","author":"Lin","year":"2010","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.surg.2021.08.024_bib11","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1210\/jc.2016-1999","article-title":"Targeting autophagy sensitizes BRAF-mutant\u00a0thyroid cancer to vemurafenib","volume":"102","author":"Wang","year":"2017","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.surg.2021.08.024_bib12","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1530\/ERC-15-0402","article-title":"Glucose-deprivation increases thyroid cancer cells sensitivity to metformin","volume":"22","author":"Bikas","year":"2015","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.surg.2021.08.024_bib13","doi-asserted-by":"crossref","first-page":"E748","DOI":"10.1210\/jc.2014-1777","article-title":"A\u00a0novel dual AMPK activator\/mTOR inhibitor inhibits thyroid cancer cell growth","volume":"100","author":"Plews","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.surg.2021.08.024_bib14","doi-asserted-by":"crossref","first-page":"8253","DOI":"10.1073\/pnas.1118193109","article-title":"Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency","volume":"109","author":"McAfee","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.surg.2021.08.024_bib15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1083\/jcb.200411106","article-title":"Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control","volume":"170","author":"Gan","year":"2005","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.surg.2021.08.024_bib16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4161\/auto.5.5.8823","article-title":"In search of an \"autophagomometer","volume":"5","author":"Rubinsztein","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.surg.2021.08.024_bib17","doi-asserted-by":"crossref","first-page":"614","DOI":"10.4252\/wjsc.v6.i5.614","article-title":"Stem cell biology in thyroid cancer: Insights for novel therapies","volume":"6","author":"Bhatia","year":"2014","journal-title":"World J Stem Cells"},{"key":"10.1016\/j.surg.2021.08.024_bib18","doi-asserted-by":"crossref","first-page":"8874","DOI":"10.1158\/0008-5472.CAN-10-1994","article-title":"Tumorigenic and metastatic activity of human thyroid cancer stem cells","volume":"70","author":"Todaro","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.surg.2021.08.024_bib19","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.bbamcr.2018.02.007","article-title":"Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells","volume":"1865","author":"Alizadeh","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.surg.2021.08.024_bib20","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1111\/jcmm.13825","article-title":"Autophagy induces transforming growth factor-beta-dependent epithelial-mesenchymal transition in hepatocarcinoma cells through cAMP response element binding signalling","volume":"22","author":"Hu","year":"2018","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.surg.2021.08.024_bib21","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.1002\/jcb.26912","article-title":"Knockdown of Beclin-1 impairs epithelial-mesenchymal transition of colon cancer cells","volume":"119","author":"Shen","year":"2018","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.surg.2021.08.024_bib22","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1210\/jc.2005-2838","article-title":"Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy","volume":"91","author":"Durante","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.surg.2021.08.024_bib23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0002-9343(87)90758-3","article-title":"Papillary and follicular thyroid cancer. Prognostic factors in 1,578 patients","volume":"83","author":"Simpson","year":"1987","journal-title":"Am J Med"},{"key":"10.1016\/j.surg.2021.08.024_bib24","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1210\/er.2019-00007","article-title":"Targeted therapy for advanced thyroid cancer: Kinase inhibitors and beyond","volume":"40","author":"Cabanillas","year":"2019","journal-title":"Endocr Rev"},{"key":"10.1016\/j.surg.2021.08.024_bib25","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1089\/thy.2016.0549","article-title":"Defining radioiodine-refractory differentiated thyroid cancer: Efficacy and safety of lenvatinib by radioiodine-refractory criteria in the SELECT trial","volume":"27","author":"Kiyota","year":"2017","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2021.08.024_bib26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(14)60421-9","article-title":"Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, phase 3 trial","volume":"384","author":"Brose","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.surg.2021.08.024_bib27","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1158\/2159-8290.CD-19-0292","article-title":"Targeting autophagy in cancer: Recent advances and future directions","volume":"9","author":"Amaravadi","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.surg.2021.08.024_bib28","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.4161\/auto.20958","article-title":"Lys05: A new lysosomal autophagy inhibitor","volume":"8","author":"Amaravadi","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.surg.2021.08.024_bib29","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/s41419-018-1054-3","article-title":"Apatinib-induced protective autophagy and apoptosis through the AKT-mTOR pathway in anaplastic thyroid cancer","volume":"9","author":"Feng","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.surg.2021.08.024_bib30","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1080\/15548627.2017.1290751","article-title":"New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets","volume":"13","author":"Mokarram","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.surg.2021.08.024_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20040857","article-title":"Endoplasmic reticulum stress and unfolded protein response in breast cancer: The balance between apoptosis and autophagy and its role in drug resistance","volume":"20","author":"Sisinni","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.surg.2021.08.024_bib32","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/onc.2016.237","article-title":"Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy","volume":"36","author":"Gugnoni","year":"2017","journal-title":"Oncogene"},{"issue":"2 Suppl 1","key":"10.1016\/j.surg.2021.08.024_bib33","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0049-0172(10)80012-5","article-title":"Mechanism of action of hydroxychloroquine as an antirheumatic drug","volume":"23","author":"Fox","year":"1993","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.surg.2021.08.024_bib34","first-page":"185","article-title":"Chloroquine has not disappeared","volume":"7","author":"Cooper","year":"2007","journal-title":"Afr Health Sci"},{"key":"10.1016\/j.surg.2021.08.024_bib35","doi-asserted-by":"crossref","first-page":"59087","DOI":"10.18632\/oncotarget.10824","article-title":"Vorinostat and hydroxychloroquine improve immunity and inhibit autophagy in metastatic colorectal cancer","volume":"7","author":"Patel","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.surg.2021.08.024_bib36","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1101\/gad.2016111","article-title":"Pancreatic cancers require autophagy for tumor growth","volume":"25","author":"Yang","year":"2011","journal-title":"Genes Dev"},{"key":"10.1016\/j.surg.2021.08.024_bib37","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1245\/s10434-015-4566-4","article-title":"Safety and biologic response of pre-operative autophagy inhibition in combination with gemcitabine in patients\u00a0with pancreatic adenocarcinoma","volume":"22","author":"Boone","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2021.08.024_bib38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2125.1988.tb05281.x","article-title":"A\u00a0dose-ranging study of the pharmacokinetics of hydroxy-chloroquine following intravenous administration to healthy volunteers","volume":"26","author":"Tett","year":"1988","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.surg.2021.08.024_bib39","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1124\/jpet.117.245639","article-title":"Hydroxychloroquine: A physiologically-based pharmacokinetic model in the context of cancer-related autophagy modulation","volume":"365","author":"Collins","year":"2018","journal-title":"J\u00a0Pharmacol Exp Ther"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606021007959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606021007959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:59:00Z","timestamp":1758538740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606021007959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0039606021007959"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2021.08.024","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of autophagy mitigates cell migration and invasion in thyroid cancer","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2021.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}