{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:38:30Z","timestamp":1778632710277,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","surgjournal.com","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.surg.2025.109345","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T14:20:26Z","timestamp":1743344426000},"page":"109345","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Postoperative hepatic insufficiency despite preoperative portal vein embolization: Not just about the volumetrics"],"prefix":"10.1016","volume":"182","author":[{"given":"Amy Y.","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9797-7106","authenticated-orcid":false,"given":"M. Usman","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc C.","family":"Sofilos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shishir K.","family":"Maithel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seetharam","family":"Chadalavada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimul A.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra W.","family":"Acher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laleh G.","family":"Melstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell","family":"Kirks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio G.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Delitto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byrne","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan C.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Poultsides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2025.109345_bib1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.surg.2010.10.001","article-title":"Posthepatectomy liver failure: a definition and grading by the international study group of liver surgery (ISGLS)","volume":"149","author":"Rahbari","year":"2011","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2025.109345_bib2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jviscsurg.2018.03.005","article-title":"Liver hypertrophy: underlying mechanisms and promoting procedures before major hepatectomy","volume":"155","author":"Le Roy","year":"2018","journal-title":"J Visc Surg"},{"key":"10.1016\/j.surg.2025.109345_bib3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijsu.2018.01.042","article-title":"Assessment and optimization of liver volume before major hepatic resection: current guidelines and a narrative review","volume":"52","author":"Khan","year":"2018","journal-title":"Int J Surg"},{"key":"10.1016\/j.surg.2025.109345_bib4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jamcollsurg.2017.06.007","article-title":"Postoperative liver failure risk score: identifying patients with resectable perihilar cholangiocarcinoma who can benefit from portal vein embolization","volume":"225","author":"Olthof","year":"2017","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.surg.2025.109345_bib5","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.hpb.2018.06.1798","article-title":"Preoperative strategies to improve resectability for hepatocellular carcinoma: a systematic review and meta-analysis","volume":"20","author":"Tustumi","year":"2018","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2025.109345_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/SLA.0b013e31815f6e5b","article-title":"Preoperative portal vein embolization for major liver resection: a meta-analysis","volume":"247","author":"Abulkhir","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2025.109345_bib7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00423-017-1591-8","article-title":"Portal vein embolization in extended liver resection","volume":"402","author":"Narula","year":"2017","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.surg.2025.109345_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jamcollsurg.2012.10.018","article-title":"Kinetic growth rate after portal vein embolization predicts posthepatectomy outcomes: toward zero liver-related mortality in patients with colorectal liver metastases and small future liver remnant","volume":"216","author":"Shindoh","year":"2013","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.surg.2025.109345_bib9","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jamcollsurg.2014.04.022","article-title":"Remnant growth rate after portal vein embolization is a good early predictor of post-hepatectomy liver failure","volume":"219","author":"Leung","year":"2014","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.surg.2025.109345_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.hpb.2018.07.019","article-title":"Long-term survival after post-hepatectomy liver failure for colorectal liver metastases","volume":"21","author":"Joechle","year":"2019","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2025.109345_bib11","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/SLA.0b013e3181b674df","article-title":"Three hundred and one consecutive extended right hepatectomies: evaluation of outcome based on systematic liver volumetry","volume":"250","author":"Kishi","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2025.109345_bib12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.amsu.2017.12.003","article-title":"Impact of liver volume and liver function on posthepatectomy liver failure after portal vein embolization\u2014a multivariable cohort analysis","volume":"25","author":"Alizai","year":"2018","journal-title":"Ann Med Surg"},{"key":"10.1016\/j.surg.2025.109345_bib13","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s11605-019-04313-x","article-title":"Preoperative portal vein embolization is not associated with increased postoperative complications after major hepatectomy: a study of the National Surgical Quality Improvement database","volume":"24","author":"Snyder","year":"2020","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.surg.2025.109345_bib14","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1007\/s11605-019-04312-y","article-title":"Short-Term outcomes of patients undergoing portal vein embolization: an ACS-NSQIP procedure-targeted hepatectomy analysis","volume":"24","author":"Bagante","year":"2020","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.surg.2025.109345_bib15","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/01.sla.0000189131.90876.9e","article-title":"The \u201c50-50 criteria\u201d on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy","volume":"242","author":"Balzan","year":"2005","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2025.109345_bib16","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.jamcollsurg.2006.12.032","article-title":"Hepatic insufficiency and mortality in 1,059 noncirrhotic patients undergoing major hepatectomy","volume":"204","author":"Mullen","year":"2007","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.surg.2025.109345_bib17","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.amjsurg.2008.05.007","article-title":"Risk factors of liver dysfunction after extended hepatic resection in biliary tract malignancies","volume":"197","author":"Suda","year":"2009","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2025.109345_bib18","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1245\/s10434-010-1166-1","article-title":"Extended preoperative chemotherapy does not improve pathologic response and increases postoperative liver insufficiency after hepatic resection for colorectal liver metastases","volume":"17","author":"Kishi","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2025.109345_bib19","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1200\/JCO.2005.05.3074","article-title":"Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases","volume":"24","author":"Vauthey","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.surg.2025.109345_bib20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1053\/jlts.2002.31654","article-title":"Body surface area and body weight predict total liver volume in western adults","volume":"8","author":"Vauthey","year":"2002","journal-title":"Liver Transpl"},{"key":"10.1016\/j.surg.2025.109345_bib21","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJM198710223171717","article-title":"Simplified calculation of body-surface area","volume":"317","author":"Mosteller","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1016\/j.surg.2025.109345_bib22","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1067\/msy.2000.105294","article-title":"Standardized measurement of the future liver remnant prior to extended liver resection: methodology and clinical associations","volume":"127","author":"Vauthey","year":"2000","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2025.109345_bib23","series-title":"Updates in Liver Cancer [Internet]","article-title":"Assessment and optimization of the future liver remnant","author":"Maundura","year":"2017"},{"key":"10.1016\/j.surg.2025.109345_bib24","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/bjs.5836","article-title":"Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome","volume":"94","author":"Ribero","year":"2007","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2025.109345_bib25","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/SLA.0000000000000944","article-title":"Relevance of the ISGLS definition of posthepatectomy liver failure in early prediction of poor outcome after liver resection: study on 680 hepatectomies","volume":"260","author":"Skrzypczyk","year":"2014","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2025.109345_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jamcollsurg.2016.01.060","article-title":"Preoperative cholangitis and future liver remnant volume determine the risk of liver failure in patients undergoing resection for hilar cholangiocarcinoma","volume":"223","author":"Ribero","year":"2016","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.surg.2025.109345_bib27","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.surg.2014.04.036","article-title":"The adverse effects of preoperative cholangitis on the outcome of portal vein embolization and subsequent major hepatectomies","volume":"156","author":"Yokoyama","year":"2014","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2025.109345_bib28","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1016\/j.ejso.2019.07.033","article-title":"Major hepatectomy for intrahepatic cholangiocarcinoma or colorectal liver metastases. Are we talking about the same story?","volume":"45","author":"Doussot","year":"2019","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.surg.2025.109345_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jvir.2018.08.006","article-title":"Effect of hyperbilirubinemia on hepatic hypertrophy after portal vein embolization and liver failure after hepatectomy in primary biliary malignancy","volume":"30","author":"Yim","year":"2019","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.surg.2025.109345_bib30","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jso.25974","article-title":"Risk factors of posthepatectomy liver failure for perihilar cholangiocarcinoma","volume":"122","author":"Lee","year":"2020","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.surg.2025.109345_bib31","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/hpb.12450","article-title":"Hilar cholangiocarcinoma: expert consensus statement","volume":"17","author":"Mansour","year":"2015","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2025.109345_bib32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.14218\/JCTH.2017.00060","article-title":"Update on liver failure following hepatic resection: strategies for prediction and avoidance of post-operative liver insufficiency","volume":"6","author":"Rahnemai-Azar","year":"2018","journal-title":"J Clin Transl Hepatol"},{"key":"10.1016\/j.surg.2025.109345_bib33","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.hpb.2019.02.023","article-title":"Combined hepatic and portal vein embolization as preparation for major hepatectomy: a systematic review","volume":"21","author":"Esposito","year":"2019","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2025.109345_bib34","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1186\/s12885-020-07065-z","article-title":"Study protocol of the HYPER-LIV01 trial: a multicenter phase II, prospective and randomized study comparing simultaneous portal and hepatic vein embolization to portal vein embolization for hypertrophy of the future liver remnant before major hepatectomy","volume":"20","author":"Deshayes","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.surg.2025.109345_bib35","doi-asserted-by":"crossref","first-page":"S740","DOI":"10.1016\/j.hpb.2021.08.138","article-title":"Training, implementation, and safety evaluation of portal and hepatic vein embolization (PVE\/HVE) to accelerate FLR hypertrophy\u2014first worldwide DRAGON 1 experience","volume":"23","author":"Korenblik","year":"2021","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2025.109345_bib36","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/bjs\/znaa149","article-title":"Preoperative portal vein or portal and hepatic vein embolization: DRAGON collaborative group analysis","volume":"108","author":"Heil","year":"2021","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2025.109345_bib37","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1097\/SLA.0000000000000947","article-title":"Early survival and safety of ALPPS first report of the international ALPPS registry","volume":"260","author":"Schadde","year":"2014","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2025.109345_bib38","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/SLA.0b013e31824856f5","article-title":"Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings","volume":"255","author":"Schnitzbauer","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2025.109345_bib39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jamcollsurg.2013.03.004","article-title":"Analysis of the efficacy of portal vein embolization for patients with extensive liver malignancy and very low future liver remnant volume, including a comparison with the associating liver partition with portal vein ligation for staged hepatectomy approa","volume":"217","author":"Shindoh","year":"2013","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.surg.2025.109345_bib40","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.hpb.2016.10.008","article-title":"High mortality after ALPPS for perihilar cholangiocarcinoma: case-control analysis including the first series from the international ALPPS registry","volume":"19","author":"Olthof","year":"2017","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.surg.2025.109345_bib41","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00423-019-01838-2","article-title":"The role of ALPPS in intrahepatic cholangiocarcinoma","volume":"404","author":"Bednarsch","year":"2019","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.surg.2025.109345_bib42","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1245\/s10434-019-08192-z","article-title":"ALPPS for locally advanced intrahepatic cholangiocarcinoma: did aggressive surgery lead to the oncological benefit? An international multi-center study","volume":"27","author":"Li","year":"2020","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2025.109345_bib43","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/bjs.11346","article-title":"Value of ALPPS in surgery for Klatskin tumours","volume":"106","author":"Nagino","year":"2019","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2025.109345_bib44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijsu.2020.06.045","article-title":"Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure for cholangiocarcinoma","volume":"82","author":"Balci","year":"2020","journal-title":"Int J Surg"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606025001977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606025001977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T20:14:27Z","timestamp":1747858467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606025001977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":44,"alternative-id":["S0039606025001977"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2025.109345","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Postoperative hepatic insufficiency despite preoperative portal vein embolization: Not just about the volumetrics","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2025.109345","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109345"}}