{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:05:17Z","timestamp":1791234317722,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,9]],"date-time":"2026-12-09T00:00:00Z","timestamp":1796774400000},"content-version":"am","delay-in-days":342,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA229102"],"award-info":[{"award-number":["CA229102"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.surg.2025.109707","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T02:13:34Z","timestamp":1758939214000},"page":"109707","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Surgery for normocalcemic hyperparathyroidism is safe and effective"],"prefix":"10.1016","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4323-0696","authenticated-orcid":false,"given":"C. Corbin","family":"Frye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjana","family":"Balachandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjna","family":"Swaminathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Fazendin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenessa","family":"Lindeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2025.109707_bib1","series-title":"StatPearls","article-title":"Normocalcemic hyperparathyroidism","author":"Leslie","year":"2025"},{"key":"10.1016\/j.surg.2025.109707_bib2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1590\/S0004-27302010000200004","article-title":"Normocalcemic primary hyperparathyroidism","volume":"54","author":"Bilezikian","year":"2010","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"10.1016\/j.surg.2025.109707_bib3","doi-asserted-by":"crossref","first-page":"666","DOI":"10.20945\/2359-3997000000556","article-title":"Normocalcemic primary hyperparathyroidism","volume":"66","author":"Cusano","year":"2022","journal-title":"Arch Endocrinol Metab"},{"key":"10.1016\/j.surg.2025.109707_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjsurg.2024.115812","article-title":"Normocalcemic primary hyperparathyroidism: from pathophysiology to clinical management","volume":"235","author":"Wu","year":"2024","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjsurg.2024.115941","article-title":"Temporal research trends in parathyroid surgery","volume":"237","author":"Chi","year":"2024","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjsurg.2024.115825","article-title":"Establishing the diagnosis of normocalcaemic primary hyperparathyroidism","volume":"236","author":"Mihai","year":"2024","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib7","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1210\/jc.2002-021404","article-title":"Normocalcemic primary hyperparathyroidism: evidence for a generalized target-tissue resistance to parathyroid hormone","volume":"88","author":"Maruani","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.surg.2025.109707_bib8","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1210\/jc.2003-031014","article-title":"\u201cIncipient\u201d primary hyperparathyroidism: a \u201cforme fruste\u201d of an old disease","volume":"88","author":"Silverberg","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.surg.2025.109707_bib9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.surg.2007.07.023","article-title":"Consequences of parathyroidectomy in patients with \u201cmild\u201d sporadic primary hyperparathyroidism","volume":"142","author":"Carneiro-Pla","year":"2007","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2025.109707_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jocd.2012.12.001","article-title":"Normocalcemic primary hyperparathyroidism","volume":"16","author":"Cusano","year":"2013","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.surg.2025.109707_bib11","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00268-012-1438-y","article-title":"Surgical management of normocalcemic primary hyperparathyroidism","volume":"36","author":"Wade","year":"2012","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib12","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.surg.2019.06.043","article-title":"Normocalcemic hyperparathyroidism: a collaborative endocrine surgery quality improvement program analysis","volume":"167","author":"Pandian","year":"2020","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2025.109707_bib13","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00423-019-01782-1","article-title":"Mild sporadic primary hyperparathyroidism: high rate of multiglandular disease is associated with lower surgical cure rate","volume":"404","author":"Tr\u00e9bouet","year":"2019","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.surg.2025.109707_bib14","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1007\/s13304-021-01108-1","article-title":"How should we define cure after parathyroidectomy for normocalcemic primary hyperparathyroidism? A retrospective cohort study","volume":"73","author":"Cano-Valderrama","year":"2021","journal-title":"Updat Surg"},{"key":"10.1016\/j.surg.2025.109707_bib15","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00268-022-06756-x","article-title":"Parathyroidectomy for normocalcemic primary hyperparathyroidism is associated with improved bone mineral density regardless of postoperative parathyroid hormone levels","volume":"47","author":"Lui","year":"2023","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib16","doi-asserted-by":"crossref","DOI":"10.1177\/2042018821995370","article-title":"Normocalcaemic primary hyperparathyroidism: what is the role of parathyroid surgery?","volume":"12","author":"Aojula","year":"2021","journal-title":"Ther Adv Endocrinol Metab"},{"key":"10.1016\/j.surg.2025.109707_bib17","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00423-018-1659-0","article-title":"Is parathyroidectomy safe and effective in patients with normocalcemic primary hyperparathyroidism?","volume":"403","author":"Traini","year":"2018","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.surg.2025.109707_bib18","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1002\/jbmr.4670","article-title":"The fifth International workshop on the evaluation and Management of primary hyperparathyroidism","volume":"37","author":"Bilezikian","year":"2022","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.surg.2025.109707_bib19","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jamasurg.2016.2310","article-title":"The American Association of Endocrine Surgeons guidelines for definitive management of primary hyperparathyroidism","volume":"151","author":"Wilhelm","year":"2016","journal-title":"JAMA Surg"},{"key":"10.1016\/j.surg.2025.109707_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.amjsurg.2024.02.006","article-title":"Some thoughts on surgery for primary hyperparathyroidism","volume":"234","author":"Sitges-Serra","year":"2024","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib22","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s00268-002-6623-y","article-title":"Patient-based surgical outcome tool demonstrating alleviation of symptoms following parathyroidectomy in patients with primary hyperparathyroidism","volume":"26","author":"Pasieka","year":"2002","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/JS9.0000000000000282","article-title":"Parathyroidectomy for primary hyperparathyroidism: effect on quality of life after 3 years - a prospective cohort study","volume":"109","author":"Frey","year":"2023","journal-title":"Int J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib24","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1001\/archsurg.137.9.1022","article-title":"Surgical treatment of hyperparathyroidism improves health-related quality of life","volume":"137","author":"Sheldon","year":"2002","journal-title":"Arch Surg"},{"key":"10.1016\/j.surg.2025.109707_bib25","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.amjsurg.2022.04.033","article-title":"Quantifying disease-specific symptom improvement after parathyroid and thyroid surgery using patient-reported outcome measures","volume":"224","author":"Romero-Velez","year":"2022","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.47717\/turkjsurg.2021.5156","article-title":"Quality of life assessment after parathyroidectomy in symptomatic primary hyperparathyroidism using the SF-36 questionnaire","volume":"37","author":"Mohan","year":"2021","journal-title":"Turk J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/bjs.10739","article-title":"Effect of parathyroidectomy on quality of life and non-specific symptoms in normocalcaemic primary hyperparathyroidism","volume":"105","author":"Bannani","year":"2018","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.amjsurg.2022.09.042","article-title":"Comparative utility of preoperative imaging in normocalcemic versus hypercalcemic primary hyperparathyroidism","volume":"225","author":"Montgomery","year":"2023","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjsurg.2025.116272","article-title":"Patients with normocalcemic versus hypercalcemic hyperparathyroidism: what\u2019s really the difference?","volume":"244","author":"Balachandra","year":"2025","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s001980050210","article-title":"Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Working Party for Quality of Life of the European foundation for Osteoporosis","volume":"10","author":"Lips","year":"1999","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.surg.2025.109707_bib31","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s00198-023-07005-0","article-title":"Health-related quality of life in osteoporosis: a systematic review of measurement properties of the QUALEFFO-41","volume":"35","author":"Choo","year":"2024","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.surg.2025.109707_bib32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.surg.2016.06.062","article-title":"Parathyroidectomy for asymptomatic primary hyperparathyroidism: a revised cost-effectiveness analysis incorporating fracture risk reduction","volume":"161","author":"Zanocco","year":"2017","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2025.109707_bib33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12872-019-1093-4","article-title":"Parathyroidectomy improves cardiovascular risk factors in normocalcemic and hypercalcemic primary hyperparathyroidism","volume":"19","author":"Beysel","year":"2019","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.surg.2025.109707_bib34","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.amjsurg.2008.09.009","article-title":"Surgery improves quality of life in patients with \u201cmild\u201d hyperparathyroidism","volume":"197","author":"Adler","year":"2009","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib35","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1177\/0003134820940731","article-title":"Parathyroid disease: often forgotten and undertreated","volume":"86","author":"Chen","year":"2020","journal-title":"Am Surg"},{"key":"10.1016\/j.surg.2025.109707_bib36","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1067\/j.cpsurg.2010.08.002","article-title":"New trends in parathyroid surgery","volume":"47","author":"Adler","year":"2010","journal-title":"Curr Probl Surg"},{"key":"10.1016\/j.surg.2025.109707_bib37","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.amjsurg.2023.07.010","article-title":"Thresholds for surgical referral in primary hyperparathyroidism: a conjoint analysis","volume":"226","author":"Wu","year":"2023","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib38","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.amjsurg.2018.09.010","article-title":"Degree of hypercalcemia correlates with parathyroidectomy but not with symptoms","volume":"217","author":"Yan","year":"2019","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2025.109707_bib39","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1245\/s10434-018-6998-0","article-title":"Biochemical and skeletal outcomes of parathyroidectomy for normocalcemic (incipient) primary hyperparathyroidism","volume":"26","author":"Sho","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2025.109707_bib40","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1177\/00031348211048844","article-title":"Effects of parathyroidectomy on normocalcemic primary hyperparathyroidism and the role of intraoperative PTH measurement","volume":"88","author":"Alameer","year":"2022","journal-title":"Am Surg"},{"key":"10.1016\/j.surg.2025.109707_bib41","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.surg.2008.08.026","article-title":"Long-term outcome of patients with intraoperative parathyroid level remaining above the normal range during parathyroidectomy","volume":"144","author":"Carneiro-Pla","year":"2008","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2025.109707_bib42","doi-asserted-by":"crossref","first-page":"5684","DOI":"10.62347\/UOXA2126","article-title":"Effects of bisphosphonates combined with calcitriol in treating osteoporosis induced by endocrine therapy for breast cancer","volume":"16","author":"Ou","year":"2024","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.surg.2025.109707_bib43","first-page":"288","article-title":"Psychopathological symptoms and their association with the quality of life and the sexual functioning in women affected by systemic scleroderma: a preliminary investigation","volume":"28","author":"Marcoccia","year":"2024","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.surg.2025.109707_bib44","article-title":"Relationship between blood monocyte-HDL ratio and carotid intima media thickness in with postmenopausal women","volume":"26","author":"Erden","year":"2023","journal-title":"J Clin Densitom Off J Int Soc Clin Densitom"},{"key":"10.1016\/j.surg.2025.109707_bib45","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1210\/jc.2006-2802","article-title":"Normocalcemic primary hyperparathyroidism: further characterization of a new clinical phenotype","volume":"92","author":"Lowe","year":"2007","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606025005598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606025005598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T04:28:05Z","timestamp":1780201685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606025005598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":44,"alternative-id":["S0039606025005598"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2025.109707","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surgery for normocalcemic hyperparathyroidism is safe and effective","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2025.109707","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109707"}}