{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:40:50Z","timestamp":1787240450649,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.surg.2025.109890","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:58:39Z","timestamp":1764003519000},"page":"109890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Microsatellite instability\u2013high status enhances lymph node yield and reduces optimal dissection thresholds in colorectal cancer: A retrospective cohort analysis with \u03b2-binomial modeling"],"prefix":"10.1016","volume":"190","author":[{"given":"Xu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingchang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2670-0609","authenticated-orcid":false,"given":"Guanglong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2025.109890_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.surg.2025.109890_bib2","first-page":"1","article-title":"Colorectal surgery group, Surgery branch of the Chinese medical association Chinese expert consensus on the diagnosis and treatment model of multidisciplinary comprehensive treatment collaborative group for colorectal cancer (2023 edition)","volume":"44","year":"2024","journal-title":"Chin J Pract Surg"},{"key":"10.1016\/j.surg.2025.109890_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abg3551","article-title":"Tumor-draining lymph nodes: at the crossroads of metastasis and immunity","volume":"6","author":"du Bois","year":"2021","journal-title":"Sci Immunol"},{"issue":"Suppl 1","key":"10.1016\/j.surg.2025.109890_bib4","first-page":"S15","article-title":"Impact of microsatellite status on negative lymph node count and prognostic relevance after curative gastrectomy","volume":"123","author":"Cai","year":"2021","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.surg.2025.109890_bib5","first-page":"12","article-title":"Association between a high number of isolated lymph nodes in T1 to T4 N0M0 colorectal cancer and the microsatellite instability phenotype","volume":"145","author":"Eveno","year":"2010","journal-title":"Arch Surg"},{"key":"10.1016\/j.surg.2025.109890_bib6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/postmj\/qgad136","article-title":"Immunotherapy of microsatellite stable colorectal cancer: resistance mechanisms and treatment strategies","volume":"100","author":"Han","year":"2024","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.surg.2025.109890_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41571-025-01015-z","article-title":"Epidemiology, pathogenesis, biology and evolving management of MSI-H\/dMMR cancers","author":"Ambrosini","year":"2025","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.surg.2025.109890_bib8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1001\/archsurg.2012.353","article-title":"Predictors of lymph node count in colorectal cancer resections: data from US nationwide prospective cohort studies","volume":"147","author":"Morikawa","year":"2012","journal-title":"Arch Surg"},{"key":"10.1016\/j.surg.2025.109890_bib9","doi-asserted-by":"crossref","first-page":"286","DOI":"10.2119\/molmed.2013.00049","article-title":"Influence of microsatellite instability and KRAS and BRAF mutations on lymph node harvest in stage I-III colon cancers","volume":"19","author":"Berg","year":"2013","journal-title":"Mol Med"},{"key":"10.1016\/j.surg.2025.109890_bib10","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1245\/s10434-011-2091-7","article-title":"High lymph node yield is related to microsatellite instability in colon cancer","volume":"19","author":"Belt","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2025.109890_bib11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00428-017-2150-y","article-title":"The association between microsatellite instability and lymph node count in colorectal cancer","volume":"471","author":"Arnold","year":"2017","journal-title":"Virchows Arch"},{"key":"10.1016\/j.surg.2025.109890_bib12","first-page":"1977","article-title":"Mismatch repair-based stratification for immune checkpoint blockade therapy","volume":"8","author":"Zhang","year":"2018","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.surg.2025.109890_bib13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12885-021-08044-8","article-title":"A greater lymph node yield is required during pathological examination in microsatellite instability-high gastric cancer","volume":"21","author":"Cai","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.surg.2025.109890_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1200\/PO.19.00154","article-title":"International harmonization of provisional diagnostic criteria for ERBB2-Amplified metastatic colorectal cancer allowing for screening by next-generation sequencing panel","volume":"4","author":"Fujii","year":"2020","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.surg.2025.109890_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12957-025-03787-1","article-title":"Defining optimal lymph node yield in gastrectomy: a real-world cohort analysis","volume":"23","author":"Li","year":"2025","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.surg.2025.109890_bib16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrclinonc.2009.237","article-title":"Microsatellite instability in colorectal cancer-the stable evidence","volume":"7","author":"Vilar","year":"2010","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.surg.2025.109890_bib17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.21147\/j.issn.1000-9604.2019.01.07","article-title":"Chinese society of clinical oncology (CSCO) diagnosis and treatment guidelines for colorectal cancer 2018 (English version)","volume":"31","year":"2019","journal-title":"Chin J Cancer Res"},{"key":"10.1016\/j.surg.2025.109890_bib18","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.21037\/jgo-20-487","article-title":"Incidence and detection of high microsatellite instability in colorectal cancer in a Chinese population: a meta-analysis","volume":"11","author":"Zhang","year":"2020","journal-title":"J Gastrointest Oncol"},{"key":"10.1016\/j.surg.2025.109890_bib19","first-page":"703","article-title":"The application of microsatellite instability in colorectal cancer detection and challenges","volume":"22","author":"Sun","year":"2023","journal-title":"Chin digestion surg"},{"key":"10.1016\/j.surg.2025.109890_bib20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3393\/ac.2014.30.1.28","article-title":"Is microsatellite instability really a good prognostic factor of colorectal cancer?","volume":"30","author":"Shin","year":"2014","journal-title":"Ann Coloproctol"},{"key":"10.1016\/j.surg.2025.109890_bib21","first-page":"4044","article-title":"Relationship between MLH-1, MSH-2, PMS-2,MSH-6 expression and clinicopathological features in colorectal cancer","volume":"8","author":"Karahan","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.surg.2025.109890_bib22","first-page":"132","article-title":"Study on the relationship between microsatellite instability status and clinicopathological characteristics of colorectal cancer patients","volume":"10","author":"Zhang","year":"2021","journal-title":"Chin J Colorectal Dis (Electronic Edition)"},{"key":"10.1016\/j.surg.2025.109890_bib23","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.currproblcancer.2018.06.010","article-title":"The impact of microsatellite stability status in colorectal cancer","volume":"42","author":"Gupta","year":"2018","journal-title":"Curr Probl Cancer"},{"key":"10.1016\/j.surg.2025.109890_bib24","first-page":"545","article-title":"Colorectal Oncology Group, Oncology Society of the Chinese Medical Association Chinese Expert Consensus on Surgical Margins of Rectal Cancer (2024 Edition) [J]","volume":"27","year":"2024","journal-title":"Chin J Gastrointest Surg"},{"key":"10.1016\/j.surg.2025.109890_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1353787","article-title":"Involvement of tumor immune microenvironment metabolic reprogramming in colorectal cancer progression, immune escape, and response to immunotherapy","volume":"15","author":"Nicolini","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.surg.2025.109890_bib26","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1007\/s00262-023-03480-w","article-title":"Clinical trials of neoadjuvant immune checkpoint inhibitors for early-stage operable colon and rectal cancer","volume":"72","author":"Veen","year":"2023","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.surg.2025.109890_bib27","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1007\/s00262-023-03520-5","article-title":"PD-1 and PD-L1 inhibitors in cold colorectal cancer: challenges and strategies","volume":"72","author":"Lin","year":"2023","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.surg.2025.109890_bib28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3390\/genes6020185","article-title":"EMAST is a form of microsatellite instability that is initiated by inflammation and modulates colorectal cancer progression","volume":"6","author":"Carethers","year":"2015","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.surg.2025.109890_bib29","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3390\/cells9030618","article-title":"Immunotherapy, inflammation and colorectal cancer","volume":"9","author":"Lichtenstern","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.surg.2025.109890_bib30","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1245\/s10434-018-6462-1","article-title":"AJCC 8th edition","volume":"25","author":"Weiser","year":"2018","journal-title":"Colorectal Cancer Ann Surg Oncol"},{"key":"10.1016\/j.surg.2025.109890_bib31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.21147\/j.issn.1000-9604.2024.03.01","article-title":"CSCO guidelines for colorectal cancer version 2024: updates and discussions","volume":"36","author":"Chen","year":"2024","journal-title":"Chin J Cancer Res"},{"key":"10.1016\/j.surg.2025.109890_bib32","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/sim.7233","article-title":"Beta-binomial model for meta-analysis of odds ratios","volume":"36","author":"Bakbergenuly","year":"2017","journal-title":"Stat Med"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606025007421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606025007421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T08:24:19Z","timestamp":1780820659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606025007421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":32,"alternative-id":["S0039606025007421"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2025.109890","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microsatellite instability\u2013high status enhances lymph node yield and reduces optimal dissection thresholds in colorectal cancer: A retrospective cohort analysis with \u03b2-binomial modeling","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2025.109890","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109890"}}