{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:59:31Z","timestamp":1790765971033,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173353"],"award-info":[{"award-number":["82173353"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["K2023002"],"award-info":[{"award-number":["K2023002"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.surg.2026.110563","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:18:54Z","timestamp":1788275934000},"page":"110563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Apixaban in preventing portal vein thrombosis after laparoscopic splenectomy and azygoportal disconnection for cirrhosis: A single-arm trial"],"prefix":"10.1016","volume":"200","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyu","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaobao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dousheng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2026.110563_bib1","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.3748\/wjg.v18.i15.1834","article-title":"Preoperative predictors of portal vein thrombosis after splenectomy with periesophagogastric devascularization","volume":"18","author":"Zhang","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.surg.2026.110563_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijsu.2016.04.047","article-title":"Predictors of portal vein system thrombosis after laparoscopic splenectomy and azygoportal disconnection: a retrospective cohort study of 75 consecutive patients with 3-months follow-up","volume":"30","author":"Jiang","year":"2016","journal-title":"Int J Surg"},{"key":"10.1016\/j.surg.2026.110563_bib3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s11605-013-2150-4","article-title":"Laparoscopic versus open splenectomy and esophagogastric devascularization for bleeding varices or severe hypersplenism: a comparative study","volume":"17","author":"Zhe","year":"2013","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.surg.2026.110563_bib4","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1053\/j.gastro.2019.01.265","article-title":"Diagnosis, development, and treatment of portal vein thrombosis in patients with and without cirrhosis","volume":"156","author":"Intagliata","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.surg.2026.110563_bib5","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jhep.2021.04.029","article-title":"Current knowledge and management of portal vein thrombosis in cirrhosis","volume":"75","author":"Senzolo","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.surg.2026.110563_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/5584_2016_119","article-title":"Portal vein thrombosis after splenic and pancreatic surgery","volume":"906","author":"Ruiz-Tovar","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.surg.2026.110563_bib7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S2468-1253(23)00438-7","article-title":"Pathophysiology and therapeutic options for cirrhotic portal hypertension","volume":"9","author":"Guix\u00e9-Muntet","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.surg.2026.110563_bib8","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1097\/TP.0b013e31826e8e53","article-title":"Management of nonneoplastic portal vein thrombosis in the setting of liver transplantation: a systematic review","volume":"94","author":"Rodr\u00edguez-Castro","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.surg.2026.110563_bib9","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1097\/JS9.0000000000001149","article-title":"Portal vein thrombosis and liver transplantation: management, matching, and outcomes. A retrospective multicenter cohort study","volume":"110","author":"Di Benedetto","year":"2024","journal-title":"Int J Surg"},{"key":"10.1016\/j.surg.2026.110563_bib10","first-page":"515","article-title":"Portal vein thrombosis","volume":"4","author":"Wang","year":"2005","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.surg.2026.110563_bib11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/hep.23259","article-title":"Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study","volume":"51","author":"Plessier","year":"2010","journal-title":"Hepatology"},{"issue":"Suppl 1","key":"10.1016\/j.surg.2026.110563_bib12","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/S0168-8278(12)60004-X","article-title":"Management of hepatic vascular diseases","volume":"56","author":"Plessier","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.surg.2026.110563_bib13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3350\/cmh.2021.0109","article-title":"Treatment of direct oral anticoagulants in patients with liver cirrhosis and portal vein thrombosis","volume":"27","author":"Chun","year":"2021","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.surg.2026.110563_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3748\/wjg.v16.i2.143","article-title":"Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment","volume":"16","author":"Ponziani","year":"2010","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.surg.2026.110563_bib15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijsu.2019.02.018","article-title":"Warfarin versus aspirin prevents portal vein thrombosis after laparoscopic splenectomy and azygoportal disconnection: a randomized clinical trial","volume":"64","author":"Bai","year":"2019","journal-title":"Int J Surg"},{"key":"10.1016\/j.surg.2026.110563_bib16","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s11239-015-1190-x","article-title":"A comparative study of two anti-coagulation plans on the prevention of PVST after laparoscopic splenectomy and esophagogastric devascularization","volume":"40","author":"Cheng","year":"2015","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.surg.2026.110563_bib17","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3324\/haematol.12682","article-title":"The postoperative splenic\/portal vein thrombosis after splenectomy and its prevention--an unresolved issue","volume":"93","author":"Krauth","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.surg.2026.110563_bib18","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1055\/a-2484-0747","article-title":"Comparison of Apixaban and aspirin in preventing portal vein thrombosis after laparoscopic splenectomy for cirrhotic hypersplenism","volume":"125","author":"Shi","year":"2025","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.surg.2026.110563_bib19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2174\/1389450116666150518100106","article-title":"Deep vein thrombosis and pulmonary embolism in the Apixaban era: from bench to bedside","volume":"19","author":"Poredos","year":"2018","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.surg.2026.110563_bib20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijcard.2021.07.005","article-title":"Upper extremities deep vein thrombosis treated with oral direct anticoagulants: a prospective cohort study","volume":"339","author":"Vedovati","year":"2021","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.surg.2026.110563_bib21","doi-asserted-by":"crossref","first-page":"e299","DOI":"10.1055\/a-1920-6224","article-title":"Apixaban prophylactic anticoagulation in patients with nephrotic syndrome","volume":"6","author":"Van Meerhaeghe","year":"2022","journal-title":"TH Open"},{"key":"10.1016\/j.surg.2026.110563_bib22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1474-4422(24)00475-7","article-title":"Apixaban versus aspirin for stroke prevention in people with subclinical atrial fibrillation and a history of stroke or transient ischaemic attack: subgroup analysis of the ARTESiA randomised controlled trial","volume":"24","author":"Shoamanesh","year":"2025","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.surg.2026.110563_bib23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00464-013-3182-2","article-title":"Modified laparoscopic and open splenectomy and azygoportal disconnection for portal hypertension","volume":"28","author":"Bai","year":"2014","journal-title":"Surg Endosc"},{"key":"10.1016\/j.surg.2026.110563_bib24","doi-asserted-by":"crossref","first-page":"18420","DOI":"10.3748\/wjg.v20.i48.18420","article-title":"Modified laparoscopic splenectomy and azygoportal disconnection combined with cell salvage is feasible and might reduce the need for blood transfusion","volume":"20","author":"Jiang","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.surg.2026.110563_bib25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11739-010-0413-6","article-title":"Splanchnic vein thrombosis: clinical presentation, risk factors and treatment","volume":"5","author":"De Stefano","year":"2010","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.surg.2026.110563_bib26","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S2468-1253(24)00155-9","article-title":"Portal vein thrombosis: diagnosis, management, and endpoints for future clinical studies","volume":"9","author":"Elkrief","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.surg.2026.110563_bib27","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jhep.2012.04.015","article-title":"Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR)","volume":"57","author":"Adam","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.surg.2026.110563_bib28","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/lt.25320","article-title":"Liver transplantation today: where we are now and where we are going","volume":"24","author":"Bodzin","year":"2018","journal-title":"Liver Transpl"},{"key":"10.1016\/j.surg.2026.110563_bib29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1089\/lap.2016.0032","article-title":"Laparoscopic splenectomy and esophagogastric devascularization for liver cirrhosis and portal hypertension is a safe, effective, and minimally invasive operation","volume":"26","author":"Yu","year":"2016","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"10.1016\/j.surg.2026.110563_bib30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/1553350612441863","article-title":"Laparoscopic splenectomy and esophagogastric devascularization is a safe, effective, minimally invasive alternative for the treatment of portal hypertension with refractory variceal bleeding","volume":"20","author":"Zheng","year":"2013","journal-title":"Surg Innov"},{"key":"10.1016\/j.surg.2026.110563_bib31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s00535-025-02317-w","article-title":"Validation of Baveno VII criteria for recompensation in patients with decompensated cirrhosis treated by laparoscopic splenectomy and azygoportal disconnection","volume":"61","author":"Zhou","year":"2025","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.surg.2026.110563_bib32","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00535-023-01982-z","article-title":"Splenectomy and azygoportal disconnection decreases the risk of hepatocellular carcinoma for cirrhosis patients with portal hypertension bleeding: a 10-year retrospective follow-up study based on the inverse probability of treatment weighting method","volume":"58","author":"Gao","year":"2023","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.surg.2026.110563_bib33","doi-asserted-by":"crossref","first-page":"8522","DOI":"10.1007\/s00464-023-10454-7","article-title":"The decreased risk of hepatocellular carcinoma in hepatitis B virus-related cirrhotic portal hypertension patients after laparoscopic splenectomy and azygoportal disconnection","volume":"37","author":"Gao","year":"2023","journal-title":"Surg Endosc"},{"key":"10.1016\/j.surg.2026.110563_bib34","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/lap.2016.0012","article-title":"Anticoagulation therapy with warfarin versus low-dose aspirin prevents portal vein thrombosis after laparoscopic splenectomy and azygoportal disconnection","volume":"26","author":"Jiang","year":"2016","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"10.1016\/j.surg.2026.110563_bib35","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.12659\/MSM.909403","article-title":"Association between changes in splanchnic hemodynamics and risk factors of portal venous System thrombosis after splenectomy with periesophagogastric devascularization","volume":"24","author":"Huang","year":"2018","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.surg.2026.110563_bib36","doi-asserted-by":"crossref","first-page":"7409","DOI":"10.1007\/s00464-022-09159-0","article-title":"Clinical effects of cluster technology optimization and innovations on laparoscopic splenectomy and azygoportal disconnection: a single-center retrospective study with 500 consecutive cases","volume":"36","author":"Wu","year":"2022","journal-title":"Surg Endosc"},{"key":"10.1016\/j.surg.2026.110563_bib37","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1177\/1553350608324931","article-title":"Portal vein thrombosis after laparoscopic splenectomy: the size of the risk","volume":"15","author":"Targarona","year":"2008","journal-title":"Surg Innov"},{"key":"10.1016\/j.surg.2026.110563_bib38","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.3390\/jcm13051517","article-title":"Portal vein thrombosis: state-of-the-art review","volume":"13","author":"Boccatonda","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.surg.2026.110563_bib39","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1365-2125.2011.03943.x","article-title":"Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy","volume":"72","author":"Warner","year":"2011","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.surg.2026.110563_bib40","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.3390\/ph3051491","article-title":"Critical overview on the benefits and harms of aspirin","volume":"3","author":"Kwok","year":"2010","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.surg.2026.110563_bib41","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11239-022-02687-5","article-title":"Pharmacokinetic and pharmacodynamic profiles of a novel phospholipid-aspirin complex liquid formulation and low dose enteric-coated aspirin: results from a prospective, randomized, crossover study","volume":"54","author":"Franchi","year":"2022","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.surg.2026.110563_bib42","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s40262-021-01090-2","article-title":"Pharmacokinetic and pharmacodynamic profile of a novel phospholipid aspirin formulation","volume":"61","author":"Angiolillo","year":"2022","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.surg.2026.110563_bib43","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3390\/biomedicines9050445","article-title":"Laboratory monitoring of direct oral anticoagulants (DOACs)","volume":"9","author":"Dunois","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.surg.2026.110563_bib44","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1093\/rheumatology\/kev445","article-title":"Non-vitamin K antagonist oral anticoagulants and antiphospholipid syndrome","volume":"55","author":"Sciascia","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.surg.2026.110563_bib45","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.2147\/TCRM.S68010","article-title":"Apixaban for the prophylaxis and treatment of deep vein thrombosis and pulmonary embolism: an evidence-based review","volume":"11","author":"Mandernach","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.surg.2026.110563_bib46","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1056\/NEJMoa1607887","article-title":"Andexanet Alfa for acute Major bleeding associated with factor Xa inhibitors","volume":"375","author":"Connolly","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.surg.2026.110563_bib47","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1001\/jamacardio.2017.0065","article-title":"Economic analysis of apixaban therapy for patients with atrial fibrillation from a US perspective: results from the ARISTOTLE randomized clinical trial","volume":"2","author":"Cowper","year":"2017","journal-title":"JAMA Cardiol"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606026004885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606026004885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:14:35Z","timestamp":1790763275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606026004885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":47,"alternative-id":["S0039606026004885"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2026.110563","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apixaban in preventing portal vein thrombosis after laparoscopic splenectomy and azygoportal disconnection for cirrhosis: A single-arm trial","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2026.110563","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110563"}}