{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:24:04Z","timestamp":1787955844494,"version":"build-2784847793"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Surgeon"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.surge.2011.11.002","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T18:05:09Z","timestamp":1322935509000},"page":"107-113","source":"Crossref","is-referenced-by-count":56,"title":["Serotonin: A double-edged sword for the liver?"],"prefix":"10.1016","volume":"10","author":[{"given":"M.","family":"Lesurtel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Soll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Humar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.-A.","family":"Clavien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.surge.2011.11.002_bib1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0091-3057(01)00746-8","article-title":"Molecular, pharmacological and functional diversity of 5-HT receptors","volume":"71","author":"Hoyer","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"issue":"4","key":"10.1016\/j.surge.2011.11.002_bib2","first-page":"687","article-title":"Serotonin and the alimentary tract","volume":"2","author":"Thompson","year":"1971","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1016\/j.surge.2011.11.002_bib3","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/172910a0","article-title":"5-hydroxytryptamine in a carcinoid tumor","volume":"172","author":"Lembeck","year":"1953","journal-title":"Nature"},{"issue":"3 Pt 2","key":"10.1016\/j.surge.2011.11.002_bib4","first-page":"H1173","article-title":"Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats","volume":"272","author":"Eddahibi","year":"1997","journal-title":"Am J Physiol"},{"issue":"5 Pt 1","key":"10.1016\/j.surge.2011.11.002_bib5","first-page":"L795","article-title":"A new role for an old molecule: serotonin as a mitogen","volume":"272","author":"Fanburg","year":"1997","journal-title":"Am J Physiol"},{"issue":"2","key":"10.1016\/j.surge.2011.11.002_bib6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1534-5807(04)00022-X","article-title":"Serotonin regulates mammary gland development via an autocrine-paracrine loop","volume":"6","author":"Matsuda","year":"2004","journal-title":"Dev Cell"},{"issue":"5770","key":"10.1016\/j.surge.2011.11.002_bib7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1123842","article-title":"Platelet-derived serotonin mediates liver regeneration","volume":"312","author":"Lesurtel","year":"2006","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.surge.2011.11.002_bib8","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s00018-007-7377-3","article-title":"Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectives","volume":"65","author":"Lesurtel","year":"2008","journal-title":"Cell Mol Life Sci"},{"issue":"Suppl. 3","key":"10.1016\/j.surge.2011.11.002_bib9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00005344-199000163-00002","article-title":"Origin and metabolism of serotonin","volume":"16","author":"Tyce","year":"1990","journal-title":"J Cardiovasc Pharmacol"},{"issue":"9","key":"10.1016\/j.surge.2011.11.002_bib10","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0006-2952(03)00556-2","article-title":"A unique central tryptophan hydroxylase isoform","volume":"66","author":"Walther","year":"2003","journal-title":"Biochem Pharmacol"},{"issue":"5603","key":"10.1016\/j.surge.2011.11.002_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.1078197","article-title":"Synthesis of serotonin by a second tryptophan hydroxylase isoform","volume":"299","author":"Walther","year":"2003","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.surge.2011.11.002_bib12","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","article-title":"A review of central 5-HT receptors and their function","volume":"38","author":"Barnes","year":"1999","journal-title":"Neuropharmacology"},{"issue":"2\u20133","key":"10.1016\/j.surge.2011.11.002_bib13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0163-7258(01)00169-3","article-title":"Multiplicity of mechanisms of serotonin receptor signal transduction","volume":"92","author":"Raymond","year":"2001","journal-title":"Pharmacol Ther"},{"issue":"15","key":"10.1016\/j.surge.2011.11.002_bib14","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1056\/NEJMra065156","article-title":"Strategies for safer liver surgery and partial liver transplantation","volume":"356","author":"Clavien","year":"2007","journal-title":"N Engl J Med"},{"issue":"2 Suppl. 1","key":"10.1016\/j.surge.2011.11.002_bib15","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/hep.20969","article-title":"Liver regeneration","volume":"43","author":"Fausto","year":"2006","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.surge.2011.11.002_bib16","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1365-2036.2008.03674.x","article-title":"Review article: blood platelet number and function in chronic liver disease and cirrhosis","volume":"27","author":"Witters","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"issue":"Suppl. 1","key":"10.1016\/j.surge.2011.11.002_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2036.2007.03510.x","article-title":"Review article: thrombocytopenia in chronic liver disease","volume":"26","author":"Poordad","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"issue":"1\u20132","key":"10.1016\/j.surge.2011.11.002_bib18","first-page":"27","article-title":"Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions","volume":"3","author":"Matsumoto","year":"1992","journal-title":"Crit Rev Oncog"},{"key":"10.1016\/j.surge.2011.11.002_bib19","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0076-6879(85)09128-5","article-title":"Purification of human platelet-derived growth factor","volume":"109","author":"Raines","year":"1985","journal-title":"Methods Enzymol"},{"issue":"5971","key":"10.1016\/j.surge.2011.11.002_bib20","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/309804a0","article-title":"Cellular transformation by coordinated action of three peptide growth factors from human platelets","volume":"309","author":"Assoian","year":"1984","journal-title":"Nature"},{"issue":"6\u20137","key":"10.1016\/j.surge.2011.11.002_bib21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1349-7006.1990.tb02616.x","article-title":"Hepatocyte regeneration after partial hepatectomy occurs even under severely thrombocytopenic conditions in the rat","volume":"81","author":"Kuwashima","year":"1990","journal-title":"Jpn J Cancer Res"},{"issue":"1","key":"10.1016\/j.surge.2011.11.002_bib22","first-page":"12","article-title":"The role of the spleen, platelets, and plasma hepatocyte growth factor activity on hepatic regeneration in rats","volume":"182","author":"Tomikawa","year":"1996","journal-title":"J Am Coll Surg"},{"issue":"4","key":"10.1016\/j.surge.2011.11.002_bib23","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s00268-006-0772-3","article-title":"Platelets promote liver regeneration in early period after hepatectomy in mice","volume":"31","author":"Murata","year":"2007","journal-title":"World J Surg"},{"issue":"2","key":"10.1016\/j.surge.2011.11.002_bib24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jss.2007.02.035","article-title":"Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in\u00a0vitro","volume":"145","author":"Matsuo","year":"2008","journal-title":"J Surg Res"},{"issue":"6","key":"10.1016\/j.surge.2011.11.002_bib25","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1007\/s00268-008-9493-0","article-title":"Platelets promote liver regeneration under conditions of Kupffer cell depletion after hepatectomy in mice","volume":"32","author":"Murata","year":"2008","journal-title":"World J Surg"},{"issue":"3","key":"10.1016\/j.surge.2011.11.002_bib26","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jhep.2008.04.019","article-title":"Role of platelets on liver regeneration after 90% hepatectomy in mice","volume":"49","author":"Myronovych","year":"2008","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.surge.2011.11.002_bib27","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/SLA.0b013e318211caf8","article-title":"Platelet administration via the portal vein promotes liver regeneration in rats after 70% hepatectomy","volume":"253","author":"Matsuo","year":"2011","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.surge.2011.11.002_bib28","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/SLA.0b013e3181b76557","article-title":"Immediate postoperative low platelet count is associated with delayed liver function recovery after partial liver resection","volume":"251","author":"Alkozai","year":"2010","journal-title":"Ann Surg"},{"issue":"5","key":"10.1016\/j.surge.2011.11.002_bib29","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s00268-010-0464-x","article-title":"Platelet transfusion can be related to liver regeneration after living donor liver transplantation","volume":"34","author":"Kim","year":"2010","journal-title":"World J Surg"},{"issue":"3","key":"10.1016\/j.surge.2011.11.002_bib30","first-page":"324","article-title":"Cyclic nucleotide levels in the regenerating liver of rats following irradiation and protection by serotonin","volume":"25","author":"Aslamova","year":"1985","journal-title":"Radiobiologiia"},{"issue":"2","key":"10.1016\/j.surge.2011.11.002_bib31","first-page":"92","article-title":"Effect of substances altering the metabolism of endogenous serotonin on mitotic activity in the regenerating liver of mice","volume":"46","author":"Kulinskii","year":"1983","journal-title":"Farmakol Toksikol"},{"issue":"3","key":"10.1016\/j.surge.2011.11.002_bib32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1478-3231.2005.01230.x","article-title":"Effect of serotonin receptor 2 blockage on liver regeneration after partial hepatectomy in the rat liver","volume":"26","author":"Papadimas","year":"2006","journal-title":"Liver Int"},{"issue":"1","key":"10.1016\/j.surge.2011.11.002_bib33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/hep.23960","article-title":"Activation of serotonin receptor-2B rescues small-for-size liver graft failure in mice","volume":"53","author":"Tian","year":"2011","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.surge.2011.11.002_bib34","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1073\/pnas.1012531108","article-title":"Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway","volume":"108","author":"Furrer","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.surge.2011.11.002_bib35","doi-asserted-by":"crossref","first-page":"G963","DOI":"10.1152\/ajpgi.90709.2008","article-title":"Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration","volume":"296","author":"Matondo","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.surge.2011.11.002_bib36","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu Rev Pathol"},{"issue":"9615","key":"10.1016\/j.surge.2011.11.002_bib37","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","article-title":"Liver cirrhosis","volume":"371","author":"Schuppan","year":"2008","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.surge.2011.11.002_bib38","doi-asserted-by":"crossref","first-page":"H692","DOI":"10.1152\/ajpheart.00634.2005","article-title":"Activated platelets contribute importantly to myocardial reperfusion injury","volume":"290","author":"Xu","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"10.1016\/j.surge.2011.11.002_bib39","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/00007890-199709270-00002","article-title":"Accumulation of platelets in rat syngeneic lung transplants: a potential factor responsible for preservation-reperfusion injury","volume":"64","author":"Okada","year":"1997","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.surge.2011.11.002_bib40","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/0016-5085(94)90238-0","article-title":"Effects of leukocyte and platelet depletion on ischemia\u2013reperfusion injury to dog pancreas","volume":"107","author":"Kuroda","year":"1994","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.surge.2011.11.002_bib41","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00024382-200212000-00008","article-title":"P-selectin mediates platelet-endothelial cell interactions and reperfusion injury in the mouse liver in\u00a0vivo","volume":"18","author":"Khandoga","year":"2002","journal-title":"Shock"},{"issue":"5","key":"10.1016\/j.surge.2011.11.002_bib42","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/hep.510290505","article-title":"P-Selectin mediates reperfusion injury through neutrophil and platelet sequestration in the warm ischemic mouse liver","volume":"29","author":"Yadav","year":"1999","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.surge.2011.11.002_bib43","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/00007890-200209150-00016","article-title":"Platelet adhesion mediated by fibrinogen-intercelllular adhesion molecule-1 binding induces tissue injury in the postischemic liver in\u00a0vivo","volume":"74","author":"Khandoga","year":"2002","journal-title":"Transplantation"},{"issue":"6","key":"10.1016\/j.surge.2011.11.002_bib44","first-page":"567","article-title":"Serotonin activity and liver dysfunction following hepatic ischemia and reperfusion","volume":"17","author":"Murata","year":"2003","journal-title":"In\u00a0Vivo"},{"issue":"2","key":"10.1016\/j.surge.2011.11.002_bib45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/hep.21516","article-title":"Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice","volume":"45","author":"Nocito","year":"2007","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.surge.2011.11.002_bib46","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/j.gastro.2004.10.002","article-title":"Autocrine\/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin","volume":"128","author":"Marzioni","year":"2005","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.surge.2011.11.002_bib47","doi-asserted-by":"crossref","first-page":"G303","DOI":"10.1152\/ajpgi.00368.2010","article-title":"Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults","volume":"300","author":"Omenetti","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"10.1016\/j.surge.2011.11.002_bib48","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S1089-3261(03)00105-3","article-title":"Pruritus and fatigue in primary biliary cirrhosis","volume":"7","author":"Bergasa","year":"2003","journal-title":"Clin Liver Dis"},{"issue":"2","key":"10.1016\/j.surge.2011.11.002_bib49","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hep.510250206","article-title":"Improvement in cholestasis-associated fatigue with a serotonin receptor agonist using a novel rat model of fatigue assessment","volume":"25","author":"Swain","year":"1997","journal-title":"Hepatology"},{"issue":"76","key":"10.1016\/j.surge.2011.11.002_bib50","first-page":"1196","article-title":"Ondansetron and pruritus in chronic liver disease: a controlled study","volume":"54","author":"Jones","year":"2007","journal-title":"Hepatogastroenterology"},{"issue":"4","key":"10.1016\/j.surge.2011.11.002_bib51","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \"hits\"?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.surge.2011.11.002_bib52","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1053\/j.gastro.2007.05.019","article-title":"Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis","volume":"133","author":"Nocito","year":"2007","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.surge.2011.11.002_bib53","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nm1780","article-title":"Aggravation of viral hepatitis by platelet-derived serotonin","volume":"14","author":"Lang","year":"2008","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.surge.2011.11.002_bib54","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2353\/ajpath.2006.050767","article-title":"A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis","volume":"169","author":"Ruddell","year":"2006","journal-title":"Am J Pathol"},{"issue":"22","key":"10.1016\/j.surge.2011.11.002_bib55","doi-asserted-by":"crossref","first-page":"9184","DOI":"10.1158\/0008-5472.CAN-08-2133","article-title":"Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth","volume":"68","author":"Alpini","year":"2008","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.surge.2011.11.002_bib56","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/hep.23441","article-title":"Serotonin promotes tumor growth in human hepatocellular cancer","volume":"51","author":"Soll","year":"2010","journal-title":"Hepatology"}],"container-title":["The Surgeon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1479666X11001521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1479666X11001521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T05:56:07Z","timestamp":1543384567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1479666X11001521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S1479666X11001521"],"URL":"https:\/\/doi.org\/10.1016\/j.surge.2011.11.002","relation":{},"ISSN":["1479-666X"],"issn-type":[{"value":"1479-666X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}