{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:56:17Z","timestamp":1761674177743,"version":"3.44.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgical Neurology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.surneu.2008.11.007","type":"journal-article","created":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T04:15:57Z","timestamp":1231992957000},"page":"490-494","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of raloxifene on cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits"],"prefix":"10.1016","volume":"72","author":[{"given":"Levent","family":"G\u00fcrses","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Se\u00e7kin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"\u015eim\u015fek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. Oytun","family":"Senel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazim","family":"Yigitkanli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evrim","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer","family":"Be\u015falt\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Belen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murad","family":"Bavbek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.surneu.2008.11.007_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/01.WCB.0000095803.98378.D8","article-title":"Molecular profile of vascular ion channels after experimental subarachnoid hemorrhage","volume":"24","author":"Aihara","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.surneu.2008.11.007_bib2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/jama.287.7.847","article-title":"Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial","volume":"287","author":"Barrett-Connor","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.surneu.2008.11.007_bib3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s007010050457","article-title":"Systemic administration of mexiletine for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage","volume":"142","author":"Caner","year":"2000","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.surneu.2008.11.007_bib4","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1196\/annals.1365.034","article-title":"The cardiovascular effects of selective estrogen receptor modulators","volume":"1092","author":"Christodoulakos","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.surneu.2008.11.007_bib5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0163-7258(94)00080-M","article-title":"Mechanisms of cerebral vasospasm in subarachnoid hemorrhage","volume":"66","author":"Cook","year":"1995","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.surneu.2008.11.007_bib6","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1001\/jama.281.23.2189","article-title":"The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation","volume":"281","author":"Cummings","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.surneu.2008.11.007_bib7","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1056\/NEJM199712043372301","article-title":"Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women","volume":"337","author":"Delmas","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.surneu.2008.11.007_bib8","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00006123-200003000-00001","article-title":"Molecular keys to the problems of cerebral vasospasm","volume":"46","author":"Dietrich","year":"2000","journal-title":"Neurosurgery"},{"key":"10.1016\/j.surneu.2008.11.007_bib9","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1161\/01.CIR.100.10.1095","article-title":"Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor\u2013dependent and nitric oxide\u2013dependent mechanism","volume":"100","author":"Figtree","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.surneu.2008.11.007_bib10","first-page":"108","article-title":"Reversal of subarachnoid hemorrhage-induced vasoconstriction with an endothelin receptor antagonist","volume":"34","author":"Foley","year":"1994","journal-title":"Neurosurgery"},{"key":"10.1016\/j.surneu.2008.11.007_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1385\/NCC:1:2:235","article-title":"Cerebral vasospasm: a consideration of the various cellular mechanisms involved in the pathophysiology","volume":"1","author":"Hansen-Schwartz","year":"2004","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.surneu.2008.11.007_bib12","doi-asserted-by":"crossref","first-page":"F137","DOI":"10.1152\/ajprenal.00353.2004","article-title":"Raloxifene relaxes rat intrarenal arteries by inhibiting Ca2+ influx","volume":"289","author":"Leung","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.surneu.2008.11.007_bib13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1527-3458.2002.tb00230.x","article-title":"Selective estrogen receptor modulators: tissue actions and potential for CNS protection","volume":"8","author":"Littleton-Kearney","year":"2002","journal-title":"CNS Drug Rev"},{"key":"10.1016\/j.surneu.2008.11.007_bib14","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/00006123-200002000-00035","article-title":"In vivo animal models of cerebral vasospasm: a review","volume":"46","author":"Megyesi","year":"2000","journal-title":"Neurosurgery"},{"key":"10.1016\/j.surneu.2008.11.007_bib15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1634\/theoncologist.5-5-388","article-title":"Raloxifene: a selective estrogen receptor modulator (SERM) with multiple target system effects","volume":"5","author":"Muchmore","year":"2000","journal-title":"Oncologist"},{"key":"10.1016\/j.surneu.2008.11.007_bib16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tcm.2004.12.002","article-title":"Signaling mechanisms in cerebral vasospasm","volume":"15","author":"Nishizawa","year":"2005","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.surneu.2008.11.007_bib17","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/00005344-200406000-00012","article-title":"Raloxifene improves coronary perfusion, cardiac contractility, and myocardial metabolism in the ischemic heart: role of phosphatidylinositol 3-kinase\/Akt pathway","volume":"43","author":"Ogita","year":"2004","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.surneu.2008.11.007_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pharmthera.2004.10.002","article-title":"Delayed cerebral vasospasm and nitric oxide: review, new hypothesis, and proposed treatment","volume":"105","author":"Pluta","year":"2005","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.surneu.2008.11.007_bib19","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.surneu.2007.07.052","article-title":"Lamotrigine attenuates cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits","volume":"70","author":"Se\u00e7kin","year":"2008","journal-title":"Surg Neurol"},{"key":"10.1016\/j.surneu.2008.11.007_bib20","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1210\/jcem.85.8.6853","article-title":"Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase","volume":"85","author":"Simoncini","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.surneu.2008.11.007_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/foc.2002.12.3.8","article-title":"Molecular mechanisms involved in development of cerebral vasospasm","volume":"12","author":"Tani","year":"2002","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.surneu.2008.11.007_bib22","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1161\/01.STR.0000131479.08005.ca","article-title":"Raloxifene relaxes rat cerebral arteries in vitro and inhibits L-type voltage-sensitive Ca2+ channels","volume":"35","author":"Tsang","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.surneu.2008.11.007_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1227\/01.NEU.0000249212.96719.95","article-title":"Persistence of the nitric oxide\u2013dependent vasodilator pathway of cerebral vessels after experimental subarachnoid hemorrhage","volume":"60","author":"Vatter","year":"2007","journal-title":"Neurosurgery"},{"key":"10.1016\/j.surneu.2008.11.007_bib24","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1001\/jama.279.18.1445","article-title":"Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women","volume":"279","author":"Walsh","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.surneu.2008.11.007_bib25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000048218","article-title":"Selective estrogen receptor modulator effects in the rat brain","volume":"75","author":"Zhou","year":"2002","journal-title":"Neuroendocrinology"}],"container-title":["Surgical Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090301908010318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090301908010318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:25:34Z","timestamp":1758763534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090301908010318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0090301908010318"],"URL":"https:\/\/doi.org\/10.1016\/j.surneu.2008.11.007","relation":{},"ISSN":["0090-3019"],"issn-type":[{"type":"print","value":"0090-3019"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of raloxifene on cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits","name":"articletitle","label":"Article Title"},{"value":"Surgical Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surneu.2008.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}