{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:57:43Z","timestamp":1791899863915,"version":"4.3.4"},"reference-count":127,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surveyophthalmol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Survey of Ophthalmology"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.survophthal.2005.06.002","type":"journal-article","created":{"date-parts":[[2005,10,28]],"date-time":"2005-10-28T07:22:43Z","timestamp":1130484163000},"page":"S16-S31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"S","title":["In Vitro and In Vivo Potency of Moxifloxacin and Moxifloxacin Ophthalmic Solution 0.5%, A New Topical Fluoroquinolone"],"prefix":"10.1016","volume":"50","author":[{"given":"David W.","family":"Stroman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Dajcs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gale A.","family":"Cupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A.","family":"Schlech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.survophthal.2005.06.002_bib1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0149-2918(04)90018-5","article-title":"Topical antibacterial therapy for mycobacterial keratitis: potential for surgical prophylaxis and treatment","volume":"26","author":"Abshire","year":"2004","journal-title":"Clin Ther"},{"key":"10.1016\/j.survophthal.2005.06.002_bib2","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1128\/AAC.48.12.4562-4565.2004","article-title":"Comparative in vitro activities of linezolid, telithromycin, clarithromycin, levofloxacin, moxifloxacin, and four conventional antimycobacterial drugs against Mycobacterium kansasii","volume":"48","author":"Alcaide","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib3","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/S0161-6420(00)00179-2","article-title":"Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolones","volume":"107","author":"Alexandrakis","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.survophthal.2005.06.002_bib4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01.ico.0000134462.88535.d0","article-title":"Comparative efficacy of topical moxifloxacin versus ciprofloxacin and vancomycin in the treatment of P. aeruginosa and ciprofloxacin-resistant MRSA keratitis in rabbits","volume":"24","author":"Aliprandis","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.survophthal.2005.06.002_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1300\/J100v06n01_02","article-title":"The mutant prevention concentration (MPC): a review","volume":"6","author":"Allen","year":"2003","journal-title":"J Infect Dis Phamacother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archopht.122.1.65","article-title":"Treatment of experimental bacterial keratitis with topical trovafloxacin","volume":"122","author":"Barequet","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/jac\/40.5.639","article-title":"Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin","volume":"40","author":"Bauernfeind","year":"1997","journal-title":"J Antimicrob Chemother"},{"issue":"Pt 3a","key":"10.1016\/j.survophthal.2005.06.002_bib8","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/eye.1998.92","article-title":"The effect of intracameral, pre-operative antibiotics on microbial contamination of anterior chamber aspirates during phacoemulsification","volume":"12","author":"Beigi","year":"1998","journal-title":"Eye"},{"key":"10.1016\/j.survophthal.2005.06.002_bib9","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1128\/AAC.40.12.2714","article-title":"Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerases","volume":"40","author":"Blanche","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 2","key":"10.1016\/j.survophthal.2005.06.002_bib10","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.survophthal.2004.01.005","article-title":"Fluoroquinolones: mechanism of action, classification, and development of resistance","volume":"49","author":"Blondeau","year":"2004","journal-title":"Surv Ophthalmol"},{"issue":"Suppl B","key":"10.1016\/j.survophthal.2005.06.002_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/43.suppl_2.1","article-title":"A review of the comparative in-vitro activities of 12 antimicrobial agents, with a focus on five new respiratory quinolones","volume":"43","author":"Blondeau","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0924-8579(99)00143-0","article-title":"Comparative in vitro activity of gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin and trovafloxacin against 4151 Gram-negative and Gram-positive organisms","volume":"14","author":"Blondeau","year":"2000","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.survophthal.2005.06.002_bib13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1128\/AAC.45.2.433-438.2001","article-title":"Mutant prevention concentrations of fluoroquinolones for clinical isolates of Streptococcus pneumoniae","volume":"45","author":"Blondeau","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib14","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/infdis\/163.6.1279","article-title":"Rapid development of ciprofloxacin resistance in methicillin-susceptible and -resistant Staphylococcus aureus","volume":"163","author":"Blumberg","year":"1991","journal-title":"J Infect Dis"},{"key":"10.1016\/j.survophthal.2005.06.002_bib15","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/jac\/dkf152","article-title":"Comparison of the in vitro activities of several new fluoroquinolones against respiratory pathogens and their abilities to select fluoroquinolone resistance","volume":"50","author":"Boswell","year":"2002","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl B","key":"10.1016\/j.survophthal.2005.06.002_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/jac\/43.suppl_2.43","article-title":"Bactericidal properties of moxifloxacin and post-antibiotic effect","volume":"43","author":"Boswell","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1128\/AAC.41.1.175","article-title":"Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV","volume":"41","author":"Breines","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3928\/1542-8877-19990601-09","article-title":"Penetration of ofloxacin and ciprofloxacin in aqueous humor after topical administration","volume":"30","author":"Ceki\u00e7","year":"1999","journal-title":"Ophthalmic Surg Lasers"},{"key":"10.1016\/j.survophthal.2005.06.002_bib19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0002-9394(99)00196-8","article-title":"Emerging ciprofloxacin-resistant Pseudomonas aeruginosa","volume":"128","author":"Chaudhry","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0008-4182(00)80124-6","article-title":"Effect of prophylactic antibiotics and incision type on the incidence of endophthalmitis after cataract surgery","volume":"35","author":"Colleaux","year":"2000","journal-title":"Can J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib21","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1128\/AAC.48.5.1699-1707.2004","article-title":"Mutant selection window in levofloxacin and moxifloxacin treatments of experimental pneumococcal pneumonia in a rabbit model of human therapy","volume":"48","author":"Croisier","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1076\/ceyr.23.1.60.5417","article-title":"The effectiveness of tobramycin and Ocuflox in a prophylaxis model of Staphylococcus keratitis","volume":"23","author":"Dajcs","year":"2001","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.survophthal.2005.06.002_bib23","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1097\/00003226-200111000-00020","article-title":"Effectiveness of ciprofloxacin and ofloxacin in a prophylaxis model of Staphylococcus keratitis","volume":"20","author":"Dajcs","year":"2001","journal-title":"Cornea"},{"key":"10.1016\/j.survophthal.2005.06.002_bib24","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1128\/AAC.48.6.1948-1952.2004","article-title":"Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis","volume":"48","author":"Dajcs","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 1","key":"10.1016\/j.survophthal.2005.06.002_bib25","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1086\/319371","article-title":"Comparative in vitro and in vivo activity of the C-8 methoxy quinolone moxifloxacin and the C-8 chlorine quinolone BAY y 3118","volume":"32","author":"Dalhoff","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.survophthal.2005.06.002_bib26","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1159\/000239474","article-title":"In vitro activity of BAY 12-8039, a new 8-methoxyquinolone","volume":"42","author":"Dalhoff","year":"1996","journal-title":"Chemotherapy"},{"key":"10.1016\/j.survophthal.2005.06.002_bib27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijantimicag.2004.01.012","article-title":"In vitro activity of older and newer fluoroquinolones against efflux-mediated high-level ciprofloxacin-resistant Streptococcus pneumoniae","volume":"24","author":"Daporta","year":"2004","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.survophthal.2005.06.002_bib28","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1128\/AAC.34.9.1862","article-title":"Increasing resistance of Staphylococcus aureus to ciprofloxacin","volume":"34","author":"Daum","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib29","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1128\/AAC.43.7.1756","article-title":"Effect of fluoroquinolone concentration on selection of resistant mutants of Mycobacterium bovis BCG and Staphylococcus aureus","volume":"43","author":"Dong","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/jac\/dkg269","article-title":"The mutant selection window and antimicrobial resistance","volume":"52","author":"Drlica","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib31","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S1369-5274(99)00008-9","article-title":"Mechanism of fluoroquinolone action","volume":"2","author":"Drlica","year":"1999","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib32","series-title":"Quinolone Antimicrobial Agents","article-title":"Mechanisms of quinolone action","author":"Drlica","year":"2003"},{"key":"10.1016\/j.survophthal.2005.06.002_bib33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/1568026033452537","article-title":"Fluoroquinolones: action and resistance","volume":"3","author":"Drlica","year":"2003","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.survophthal.2005.06.002_bib34","first-page":"435","article-title":"DNA topoisomerase IV as a quinolone target","volume":"1","author":"Drlica","year":"1999","journal-title":"Curr Opin Antiinfect Drugs"},{"key":"10.1016\/j.survophthal.2005.06.002_bib35","first-page":"377","article-title":"DNA gyrase, topoisomerase IV, and the 4-quinolones","volume":"61","author":"Drlica","year":"1997","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.survophthal.2005.06.002_bib36","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1128\/AAC.39.7.1554","article-title":"Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus","volume":"39","author":"Ferrero","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib37","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1365-2958.1994.tb00458.x","article-title":"Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones","volume":"13","author":"Ferrero","year":"1994","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib38","doi-asserted-by":"crossref","unstructured":"Fisher LM, Heaton VJ: Dual activity of fluoroquinolones against Streptococcus pneumoniae. J Antimicrob Chemother 51:463\u20134;author reply 464\u20135, 2003","DOI":"10.1093\/jac\/dkg059"},{"key":"10.1016\/j.survophthal.2005.06.002_bib39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1128\/AAC.42.1.121","article-title":"Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activity","volume":"42","author":"Fournier","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib40","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1128\/AAC.44.8.2160-2165.2000","article-title":"Selective targeting of topoisomerase IV and DNA gyrase in Staphylococcus aureus: different patterns of quinolone-induced inhibition of DNA synthesis","volume":"44","author":"Fournier","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib41","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1128\/AAC.44.12.3351-3356.2000","article-title":"Antibacterial spectrum of a novel des-fluoro(6) quinolone, BMS-284756","volume":"44","author":"Fung-Tomc","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1358\/dot.2000.36.4.570200","article-title":"The microbiology of moxifloxacin","volume":"36","author":"Garc\u00eda-Rodr\u00edguez","year":"2000","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.survophthal.2005.06.002_bib43","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0161-6420(99)00717-4","article-title":"Ciprofloxacin-resistant Pseudomonas keratitis","volume":"106","author":"Garg","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.survophthal.2005.06.002_bib44","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/jac\/44.3.393","article-title":"Activity of moxifloxacin against mycobacteria","volume":"44","author":"Gillespie","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib45","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1128\/AAC.41.7.1552","article-title":"In vitro activity of Bay 12-8039, a new 8-methoxyquinolone, compared to the activities of 11 other oral antimicrobial agents against 390 aerobic and anaerobic bacteria isolated from human and animal bite wound skin and soft tissue infections in humans","volume":"41","author":"Goldstein","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib46","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0161-6420(99)00716-2","article-title":"Emerging fluoroquinolone resistance in bacterial keratitis: a 5-year review","volume":"106","author":"Goldstein","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.survophthal.2005.06.002_bib47","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/00003226-199110010-00010","article-title":"Lid flora in blepharitis","volume":"10","author":"Groden","year":"1991","journal-title":"Cornea"},{"key":"10.1016\/j.survophthal.2005.06.002_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0002-9394(14)71959-2","article-title":"Spectrum and susceptibilities of microbiologic isolates in the Endophthalmitis Vitrectomy Study","volume":"122","author":"Han","year":"1996","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/112067219800800108","article-title":"The penetration of ofloxacin into human aqueous humor given by various routes","volume":"8","author":"Hanioglu-Kargi","year":"1998","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/archopht.123.1.39","article-title":"Penetration pharmacokinetics of topically administered 0.5% moxifloxacin ophthalmic solution in human aqueous and vitreous","volume":"123","author":"Hariprasad","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib51","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1128\/AAC.44.11.3112-3117.2000","article-title":"Potent antipneumococcal activity of gemifloxacin is associated with dual targeting of gyrase and topoisomerase IV, an in vivo target preference for gyrase, and enhanced stabilization of cleavable complexes in vitro","volume":"44","author":"Heaton","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib52","doi-asserted-by":"crossref","first-page":"26424","DOI":"10.1074\/jbc.271.42.26424","article-title":"DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex","volume":"271","author":"Hiasa","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.survophthal.2005.06.002_bib53","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1128\/AAC.29.3.535","article-title":"Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli","volume":"29","author":"Hirai","year":"1985","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib54","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/jac\/45.1.31","article-title":"Comparative in vitro activity of moxifloxacin against Gram-positive clinical isolates","volume":"45","author":"Hoogkamp-Korstanje","year":"2000","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib55","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1054\/drup.1998.0068","article-title":"Mechanisms of fluoroquinolone resistance","volume":"2","author":"Hooper","year":"1999","journal-title":"Drug Resist Update"},{"key":"10.1016\/j.survophthal.2005.06.002_bib56","series-title":"Quinolone Antimicrobial Agents","year":"2003"},{"issue":"Suppl 2","key":"10.1016\/j.survophthal.2005.06.002_bib57","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/j.survophthal.2004.01.004","article-title":"Fluoroquinolone resistance in ophthalmology and the potential role for newer ophthalmic fluoroquinolones","volume":"49","author":"Hwang","year":"2004","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib58","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0140-6736(88)92799-7","article-title":"Ciprofloxacin resistance in epidemic methicillin-resistant Staphylococcus aureus","volume":"2","author":"Isaacs","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/j.survophthal.2005.06.002_bib59","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1128\/AAC.44.10.2645-2652.2000","article-title":"Benchmarking the in vitro activities of moxifloxacin and comparator agents against recent respiratory isolates from 377 medical centers throughout the United States","volume":"44","author":"Jones","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib60","series-title":"Manual of Clinical Microbiology","first-page":"1108","article-title":"Susceptibility test methods: Dilution and disk diffusion methods","author":"Jorgensen","year":"2003"},{"key":"10.1016\/j.survophthal.2005.06.002_bib61","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0161-6420(02)01760-8","article-title":"Infectious keratitis after LASIK","volume":"110","author":"Karp","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.survophthal.2005.06.002_bib62","unstructured":"Katz HR, Masket S, Lane SS, et al.: Absorption of topical moxifloxacin ophthalmic solution into human aqueous humor. Cornea (in press)"},{"key":"10.1016\/j.survophthal.2005.06.002_bib63","doi-asserted-by":"crossref","first-page":"11801","DOI":"10.1073\/pnas.92.25.11801","article-title":"Topoisomerase IV is a target of quinolones in Escherichia coli","volume":"92","author":"Khodursky","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.survophthal.2005.06.002_bib64","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00003226-199601000-00012","article-title":"Susceptibility of corneal and conjunctival pathogens to ciprofloxacin","volume":"15","author":"Knauf","year":"1996","journal-title":"Cornea"},{"key":"10.1016\/j.survophthal.2005.06.002_bib65","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000069128","article-title":"Penetration of levofloxacin into human aqueous humor","volume":"35","author":"Kobayakawa","year":"2003","journal-title":"Ophthalmic Res"},{"key":"10.1016\/j.survophthal.2005.06.002_bib66","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/infdis\/161.1.41","article-title":"Emergence of ciprofloxacin-resistant coagulase-negative staphylococcal skin flora in immunocompromised patients receiving ciprofloxacin","volume":"161","author":"Kotilainen","year":"1990","journal-title":"J Infect Dis"},{"key":"10.1016\/j.survophthal.2005.06.002_bib67","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0002-9394(03)00294-0","article-title":"Gatifloxacin and moxifloxacin: an in vitro susceptibility comparison to levofloxacin, ciprofloxacin, and ofloxacin using bacterial keratitis isolates","volume":"136","author":"Kowalski","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib68","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/S0161-6420(01)00724-2","article-title":"An in vitro resistance study of levofloxacin, ciprofloxacin, and ofloxacin using keratitis isolates of Staphylococcus aureus and Pseudomonas aeruginosa","volume":"108","author":"Kowalski","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.survophthal.2005.06.002_bib69","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ajo.2004.02.051","article-title":"Topical prophylaxis with moxifloxacin prevents endophthalmitis in a rabbit model","volume":"138","author":"Kowalski","year":"2004","journal-title":"Am J Ophthalmol"},{"issue":"Suppl 1","key":"10.1016\/j.survophthal.2005.06.002_bib70","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000310889","article-title":"Prophylactic use of topical anti-infectives in ophthalmology","volume":"211","author":"Kramer","year":"1997","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.survophthal.2005.06.002_bib71","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0021-5155(02)00543-9","article-title":"Increasing ofloxacin resistance of bacterial flora from conjunctival sac of preoperative ophthalmic patients in Japan","volume":"46","author":"Kurokawa","year":"2001","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib72","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.jcrs.2004.06.048","article-title":"Comparative penetration of moxifloxacin and gatifloxacin in rabbit aqueous humor after topical dosing","volume":"30","author":"Levine","year":"2004","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.survophthal.2005.06.002_bib73","series-title":"Quinolone Antimicrobial Agents","first-page":"355","article-title":"Quinolone resistance and its clinical relevance","author":"Low","year":"2003"},{"key":"10.1016\/j.survophthal.2005.06.002_bib74","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/BF01968141","article-title":"Ciprofloxacin resistance in methicillin- and gentamicin-resistant Staphylococcus aureus","volume":"8","author":"Maple","year":"1989","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.survophthal.2005.06.002_bib75","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ajo.2003.10.026","article-title":"Ciprofloxacin and levofloxacin resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis","volume":"137","author":"Marangon","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib76","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0140-6736(97)07322-4","article-title":"Quinolone resistance from a transferable plasmid","volume":"351","author":"Mart\u00ednez-Mart\u00ednez","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.survophthal.2005.06.002_bib77","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0886-3350(98)80116-8","article-title":"Preventing, diagnosing, and treating endophthalmitis","volume":"24","author":"Masket","year":"1998","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.survophthal.2005.06.002_bib78","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0002-9394(02)01334-X","article-title":"Fourth generation fluoroquinolones: new weapons in the arsenal of ophthalmic antibiotics","volume":"133","author":"Mather","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib79","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ajo.2004.05.011","article-title":"The effect of cataract surgery on ocular levels of topical moxifloxacin","volume":"138","author":"Mather","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib80","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ajo.2004.03.008","article-title":"Endophthalmitis caused by Streptococcus pneumoniae","volume":"138","author":"Miller","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib81","series-title":"Quinolone Antimicrobial Agents","first-page":"291","article-title":"Treatment of eye infections","author":"Miller","year":"2003"},{"key":"10.1016\/j.survophthal.2005.06.002_bib82","first-page":"843","article-title":"Ciprofloxacin resistance in epidemic methicillin-resistant Staphylococcus aureus","volume":"2","author":"Milne","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/j.survophthal.2005.06.002_bib83","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1073\/pnas.77.4.1847","article-title":"DNA gyrase action involves the introduction of transient double-strand breaks into DNA","volume":"77","author":"Mizuuchi","year":"1980","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.survophthal.2005.06.002_bib84","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0886-3350(02)01483-9","article-title":"Bacterial endophthalmitis after small-incision cataract surgery. effect of incision placement and intraocular lens type","volume":"29","author":"Nagaki","year":"2003","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.survophthal.2005.06.002_bib85","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1128\/AAC.40.8.1881","article-title":"Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus","volume":"40","author":"Ng","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 2","key":"10.1016\/j.survophthal.2005.06.002_bib86","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.survophthal.2004.01.002","article-title":"Reducing the risk of postoperative endophthalmitis","volume":"49","author":"Olson","year":"2004","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib87","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1128\/AAC.43.5.1129","article-title":"Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolones","volume":"43","author":"Pan","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib88","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1128\/AAC.42.11.2810","article-title":"DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae","volume":"42","author":"Pan","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib89","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/jac\/45.5.583","article-title":"Intracellular targets of moxifloxacin: a comparison with other fluoroquinolones","volume":"45","author":"Pestova","year":"2000","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib90","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1128\/AAC.43.8.2000","article-title":"Contribution of topoisomerase IV and DNA gyrase mutations in Streptococcus pneumoniae to resistance to novel fluoroquinolones","volume":"43","author":"Pestova","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"issue":"33S3","key":"10.1016\/j.survophthal.2005.06.002_bib91","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.1086\/321846","article-title":"Quinolone molecular structure-activity relationships: what we have learned about improving antimicrobial activity","volume":"15","author":"Peterson","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.survophthal.2005.06.002_bib92","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/jac\/18.4.547","article-title":"The effect of altered porin expression in Escherichia coli upon susceptibility to 4-quinolones","volume":"18","author":"Piddock","year":"1986","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib93","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ajo.2004.03.016","article-title":"A laboratory evaluation of antibiotic therapy for ciprofloxacin-resistant Pseudomonas aeruginosa","volume":"138","author":"Rhee","year":"2004","journal-title":"Am J Ophthalmol"},{"issue":"Suppl 1","key":"10.1016\/j.survophthal.2005.06.002_bib94","article-title":"Ocular pharmacokinetics of moxifloxacin after topical treatment of animals and humans","volume":"50","author":"Robertson","year":"2005","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib95","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/jac\/dkg388","article-title":"Detection of the plasmid-mediated quinolone resistance determinant qnr among clinical isolates of Klebsiella pneumoniae producing AmpC-type beta-lactamase","volume":"52","author":"Rodr\u00edguez-Mart\u00ednez","year":"2003","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl 2","key":"10.1016\/j.survophthal.2005.06.002_bib96","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2165\/00003495-199958002-00139","article-title":"Comparative antimycobacterial activity of Bay 12-8039 and gatifloxacin","volume":"58","author":"Saito","year":"1999","journal-title":"Drugs"},{"key":"10.1016\/j.survophthal.2005.06.002_bib97","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1136\/bjo.85.7.842","article-title":"Bacterial keratitis: a prospective clinical and microbiological study","volume":"85","author":"Schaefer","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib98","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1128\/jcm.27.2.335-336.1989","article-title":"Methicillin-resistant strains of Staphylococcus aureus resistant to quinolones","volume":"27","author":"Schaefler","year":"1989","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib99","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.3201\/eid0901.020277","article-title":"Maintaining fluoroquinolone class efficacy: review of influencing factors","volume":"9","author":"Scheld","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.survophthal.2005.06.002_bib100","unstructured":"Schlech BA, Wilhelmus KR, Crider JY, et al: Review: Nontuberculous mycobacterial (NTM) infections of the eye and treatment with topical antibacterial agents. Current Med Res Opinion (in press)"},{"key":"10.1016\/j.survophthal.2005.06.002_bib101","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10096-002-0788-z","article-title":"Activity of quinolones against Gram-positive cocci: mechanisms of drug action and bacterial resistance","volume":"21","author":"Schmitz","year":"2002","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.survophthal.2005.06.002_bib102","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0886-3350(03)00617-5","article-title":"Effect of prophylactic antibiotics on antimicrobial resistance of viridans streptococci in the normal flora of cataract surgery patients","volume":"30","author":"Sepp\u00e4l\u00e4","year":"2004","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.survophthal.2005.06.002_bib103","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/AAC.33.4.593","article-title":"Widespread quinolone resistance among methicillin-resistant Staphylococcus aureus isolates in a general hospital","volume":"33","author":"Shalit","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib104","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ophtha.2004.09.029","article-title":"Penetration of topically applied gatifloxacin 0.3%, moxifloxacin 0.5%, and ciprofloxacin 0.3% into the aqueous humor","volume":"112","author":"Solomon","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.survophthal.2005.06.002_bib105","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0161-6420(91)32239-5","article-title":"Role of external bacterial flora in the pathogenesis of acute postoperative endophthalmitis","volume":"98","author":"Speaker","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.survophthal.2005.06.002_bib106","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1086\/379518","article-title":"Serum bactericidal activity of the methoxyfluoroquinolones gatifloxacin and moxifloxacin against clinical isolates of Staphylococcus species: are the susceptibility breakpoints too high?","volume":"37","author":"Stein","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.survophthal.2005.06.002_bib107","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/S0161-6420(02)01236-8","article-title":"Prospective randomized comparison of 3-day versus 1-hour preoperative ofloxacin prophylaxis for cataract surgery","volume":"109","author":"Ta","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.survophthal.2005.06.002_bib108","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1128\/AAC.45.1.312-315.2001","article-title":"In vitro and in vivo efficacies of T-3811ME (BMS-284756) against Mycoplasma pneumoniae","volume":"45","author":"Takahata","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib109","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1128\/AAC.45.12.3544-3547.2001","article-title":"Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition","volume":"45","author":"Takei","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl B","key":"10.1016\/j.survophthal.2005.06.002_bib110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/jac\/43.suppl_2.19","article-title":"In-vitroactivity of moxifloxacin against fluoroquinolone-resistant strains of aerobic Gram-negative bacilli and Enterococcus faecalis","volume":"43","author":"Tankovic","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib111","series-title":"Quinolone Antimicrobial Agents","article-title":"Activity in vitro of the quionolones","author":"Thauvin-Eliopoulos","year":"2003"},{"key":"10.1016\/j.survophthal.2005.06.002_bib112","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1076\/ceyr.28.5.337.28676","article-title":"Quantitative comparison of fluoroquinolone therapies of experimental Gram-negative bacterial keratitis","volume":"28","author":"Thibodeaux","year":"2004","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.survophthal.2005.06.002_bib113","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1073\/pnas.082092899","article-title":"Mechanism of plasmid-mediated quinolone resistance","volume":"99","author":"Tran","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.survophthal.2005.06.002_bib114","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1136\/bjo.84.7.687","article-title":"In vitro antibiotic resistance in bacterial keratitis in London","volume":"84","author":"Tuft","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0002-9394(02)02280-8","article-title":"Fluoroquinolone therapy in multiple-drug resistant staphylococcal keratitis after lamellar keratectomy in a rabbit model","volume":"136","author":"Tungsiripat","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib116","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev.bi.65.070196.003223","article-title":"DNA topoisomerases","volume":"65","author":"Wang","year":"1996","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.survophthal.2005.06.002_bib117","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000055659","article-title":"Methicillin-resistant staphylococci and ofloxacin-resistant bacteria from clinically healthy conjunctivas","volume":"33","author":"Watanabe","year":"2001","journal-title":"Ophthalmic Res"},{"key":"10.1016\/j.survophthal.2005.06.002_bib118","series-title":"Quinolone Antimicrobial Agents","first-page":"387","article-title":"Veterinary use of quinolones and impact on human infections","author":"Wegener","year":"2003"},{"key":"10.1016\/j.survophthal.2005.06.002_bib119","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1128\/aem.63.11.4272-4281.1997","article-title":"Degradation of the fluoroquinolone enrofloxacin by the brown rot fungus Gloeophyllum striatum: identification of metabolites","volume":"63","author":"Wetzstein","year":"1997","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.survophthal.2005.06.002_bib120","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1128\/AAC.37.1.126","article-title":"A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex","volume":"37","author":"Willmott","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl","key":"10.1016\/j.survophthal.2005.06.002_bib121","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1093\/jac\/dkg210","article-title":"Maximizing efficacy and reducing the emergence of resistance","volume":"51","author":"Wise","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib122","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1128\/AAC.46.2.413-419.2002","article-title":"Cleavable-complex formation by wild-type and quinolone-resistant Streptococcus pneumoniae type II topoisomerases mediated by gemifloxacin and other fluoroquinolones","volume":"46","author":"Yague","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib123","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0886-3350(02)01538-9","article-title":"Penetration of topically applied ciprofloxacin and ofloxacin into the aqueous humor and vitreous","volume":"29","author":"Yalvac","year":"2003","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.survophthal.2005.06.002_bib124","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1128\/AAC.47.6.1958-1962.2003","article-title":"High prevalence of antimicrobial resistance in rapidly growing mycobacteria in Taiwan","volume":"47","author":"Yang","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib125","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1128\/AAC.35.8.1647","article-title":"Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli","volume":"35","author":"Yoshida","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.survophthal.2005.06.002_bib126","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1128\/AAC.34.6.1271","article-title":"Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli","volume":"34","author":"Yoshida","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 3","key":"10.1016\/j.survophthal.2005.06.002_bib127","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1086\/321841","article-title":"Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoro\u2014 quinolone studies","volume":"33","author":"Zhao","year":"2001","journal-title":"Clin Infect Dis"}],"container-title":["Survey of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039625705000767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039625705000767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T11:28:44Z","timestamp":1758540524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039625705000767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":127,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0039625705000767"],"URL":"https:\/\/doi.org\/10.1016\/j.survophthal.2005.06.002","relation":{},"ISSN":["0039-6257"],"issn-type":[{"value":"0039-6257","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In Vitro and In Vivo Potency of Moxifloxacin and Moxifloxacin Ophthalmic Solution 0.5%, A New Topical Fluoroquinolone","name":"articletitle","label":"Article Title"},{"value":"Survey of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.survophthal.2005.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}