{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:20:10Z","timestamp":1788322810595,"version":"build-2803163510"},"reference-count":74,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surveyophthalmol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Survey of Ophthalmology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.survophthal.2020.09.008","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T11:29:50Z","timestamp":1605007790000},"page":"514-530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["A systematic review on advances in diagnostics for herpes simplex keratitis"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4631-3902","authenticated-orcid":false,"given":"Stephanie Hiu Ling","family":"Poon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Ho Lam","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Cheuk Yin","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7459-1649","authenticated-orcid":false,"given":"Chien-Fu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Jhanji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1044-2668","authenticated-orcid":false,"given":"Yau Kei","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendrick Co","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.survophthal.2020.09.008_bib1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.4103\/ijo.IJO_396_19","article-title":"Commentary: herpes keratitis: a diagnostic challenge","volume":"67","author":"Acharya","year":"2019","journal-title":"Indian J Ophthalmol"},{"issue":"2","key":"10.1016\/j.survophthal.2020.09.008_bib2","doi-asserted-by":"crossref","first-page":"e16260","DOI":"10.5812\/jjm.16260","article-title":"Designing novel and simple competitive internal amplification control for reliable PCR diagnosis of herpes simplex virus","volume":"8","author":"Akbarian","year":"2015","journal-title":"Jundishapur J Microbiol"},{"issue":"2","key":"10.1016\/j.survophthal.2020.09.008_bib3","doi-asserted-by":"crossref","first-page":"e16727","DOI":"10.5812\/jjm.16727","article-title":"Diagnosing of herpes simplex virus infections in suspected patients using real-time PCR","volume":"8","author":"Aliabadi","year":"2015","journal-title":"Jundishapur J Microbiol"},{"issue":"2","key":"10.1016\/j.survophthal.2020.09.008_bib4","doi-asserted-by":"crossref","first-page":"e14216","DOI":"10.2196\/14216","article-title":"Tools for the diagnosis of herpes simplex virus 1\/2: systematic review of studies published between 2012 and 2018","volume":"5","author":"Arshad","year":"2019","journal-title":"JMIR Public Health Surveill"},{"key":"10.1016\/j.survophthal.2020.09.008_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1586\/14737159.5.2.209","article-title":"Basic principles of real-time quantitative PCR","volume":"5","author":"Arya","year":"2005","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.survophthal.2020.09.008_bib6","first-page":"285","article-title":"Valacyclovir for the prevention of recurrent herpes simplex virus eye disease after excimer laser photokeratectomy","volume":"98","author":"Asbell","year":"2000","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.survophthal.2020.09.008_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2147\/OPTH.S80475","article-title":"Herpes simplex keratitis: challenges in diagnosis and clinical management","volume":"11","author":"Azher","year":"2017","journal-title":"Clin Ophthalmol"},{"issue":"1","key":"10.1016\/j.survophthal.2020.09.008_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jviromet.2012.08.020","article-title":"The development of a multiplex real-time PCR for the detection of herpes simplex virus 1 and 2, varizella zoster virus, adenovirus and chlamydia trachomatis from eye swabs","volume":"189","author":"Bennett","year":"2013","journal-title":"J\u00a0Virol Methods"},{"issue":"1","key":"10.1016\/j.survophthal.2020.09.008_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1128\/JCM.42.1.45-51.2004","article-title":"Multiplex real-time PCR assay for detection of influenza and human respiratory syncytial viruses","volume":"42","author":"Boivin","year":"2004","journal-title":"J\u00a0Clin Microbiol"},{"issue":"9","key":"10.1016\/j.survophthal.2020.09.008_bib10","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1099\/jmm.0.001041","article-title":"Use of a corneal impression membrane and PCR for the detection of herpes simplex virus type-1","volume":"68","author":"Brunner","year":"2019","journal-title":"J\u00a0Med Microbiol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib11","first-page":"2470","article-title":"Persistence of herpes simplex virus DNA in rabbit corneal cells","volume":"33","author":"Cantin","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.survophthal.2020.09.008_bib12","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1136\/bjophthalmol-2017-310806","article-title":"Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications","volume":"102","author":"Carnt","year":"2018","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1590\/S1516-89132008000400006","article-title":"Internal control in PCR for mycobacterium tuberculosis: usefulness and improvement of the diagnosis","volume":"51","author":"Cortez-Herrera","year":"2008","journal-title":"Braz Arch Biol Technology"},{"key":"10.1016\/j.survophthal.2020.09.008_bib14","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1136\/bjo.83.5.622","article-title":"Diagnosis of viral and chlamydial keratoconjunctivitis: which laboratory test?","volume":"83","author":"Elnifro","year":"1999","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"10.1016\/j.survophthal.2020.09.008_bib15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10792-019-01226-1","article-title":"Atypical herpes simplex keratitis: frequency, clinical presentations and treatment results","volume":"40","author":"Erdem","year":"2020","journal-title":"Int Ophthalmol"},{"issue":"5","key":"10.1016\/j.survophthal.2020.09.008_bib16","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.survophthal.2012.01.005","article-title":"Herpes simplex epithelial and stromal keratitis: an epidemiologic update","volume":"57","author":"Farooq","year":"2012","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1136\/bjo.70.8.584","article-title":"Tear and serum antibody levels in ocular herpetic infection: diagnostic precision of secretory IgA","volume":"70","author":"Fox","year":"1986","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"10.1016\/j.survophthal.2020.09.008_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/08820530802111366","article-title":"Presence of a large amount of herpes simplex virus genome in tear fluid of herpetic stromal keratitis and persistent epithelial defect patients","volume":"23","author":"Fukuda","year":"2008","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2012.07.002","article-title":"Pathogenesis of herpes stromal keratitis--a focus on corneal neovascularization","volume":"33","author":"Gimenez","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.survophthal.2020.09.008_bib20","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.ophtha.2012.01.033","article-title":"Clinical features and presentation of infectious scleritis from herpes viruses: a report of 35 cases","volume":"119","author":"Gonzalez-Gonzalez","year":"2012","journal-title":"Ophthalmology"},{"issue":"1\u20132","key":"10.1016\/j.survophthal.2020.09.008_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jviromet.2009.11.024","article-title":"Ethidium monoazide does not inhibit RT-PCR amplification of nonviable avian influenza RNA","volume":"164","author":"Graiver","year":"2010","journal-title":"J\u00a0Virol Methods"},{"issue":"12","key":"10.1016\/j.survophthal.2020.09.008_bib22","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1128\/JCM.01905-15","article-title":"Comparative evaluation of AmpliVue HSV 1+2 assay with ELVIS culture for detecting herpes simplex virus 1 (HSV-1) and HSV-2 in clinical specimens","volume":"53","author":"Granato","year":"2015","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib23","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1001\/archopht.118.12.1617","article-title":"Psychological stress and other potential triggers for recurrences of herpes simplex virus eye infections","volume":"118","year":"2000","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"10.1016\/j.survophthal.2020.09.008_bib24","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.4103\/ijo.IJO_1700_18","article-title":"Evaluation of multiplex real-time polymerase chain reaction for the detection of herpes simplex virus-1 and 2 and varicella-zoster virus in corneal cells from normal subjects and patients with keratitis in India","volume":"67","author":"Guda","year":"2019","journal-title":"Indian J Ophthalmol"},{"issue":"10","key":"10.1016\/j.survophthal.2020.09.008_bib25","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.ophtha.2010.07.010","article-title":"Corneal sensation and subbasal nerve alterations in patients with herpes simplex keratitis: an in\u00a0vivo confocal microscopy study","volume":"117","author":"Hamrah","year":"2010","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.survophthal.2020.09.008_bib26","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.ophtha.2012.03.005","article-title":"Cellular changes of the corneal epithelium and stroma in herpes simplex keratitis: an in\u00a0vivo confocal microscopy study","volume":"119","author":"Hamrah","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.survophthal.2020.09.008_bib27","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1101\/gr.6.10.986","article-title":"Real time quantitative PCR","volume":"6","author":"Heid","year":"1996","journal-title":"Genome Res"},{"key":"10.1016\/j.survophthal.2020.09.008_bib28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00003226-199903000-00002","article-title":"Classification of herpes simplex virus keratitis","volume":"18","author":"Holland","year":"1999","journal-title":"Cornea"},{"key":"10.1016\/j.survophthal.2020.09.008_bib29","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1097\/ICO.0b013e31828a8b96","article-title":"Tear HSV-specific secretory IgA as a potential indicator for recurrent stromal herpes simplex keratitis: a preliminary study","volume":"32","author":"Huang","year":"2013","journal-title":"Cornea"},{"issue":"9","key":"10.1016\/j.survophthal.2020.09.008_bib30","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1136\/bjophthalmol-2012-302254","article-title":"Multicentre clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial keratitis","volume":"97","author":"Inoue","year":"2013","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.survophthal.2020.09.008_bib31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s10384-007-0485-7","article-title":"Clinical application of real-time polymerase chain reaction for diagnosis of herpetic diseases of the anterior segment of the eye","volume":"52","author":"Kakimaru-Hasegawa","year":"2008","journal-title":"Jpn J Ophthalmol"},{"issue":"4","key":"10.1016\/j.survophthal.2020.09.008_bib32","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.preteyeres.2006.05.001","article-title":"Herpes simplex keratitis","volume":"25","author":"Kaye","year":"2006","journal-title":"Prog Retin Eye Res"},{"issue":"5","key":"10.1016\/j.survophthal.2020.09.008_bib33","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1136\/bjophthalmol-2015-307091","article-title":"Impression membrane for the diagnosis of microbial keratitis","volume":"100","author":"Kaye","year":"2016","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"10.1016\/j.survophthal.2020.09.008_bib34","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s10384-004-0081-z","article-title":"Study of a polymerase chain reaction-based method for detection of herpes simplex virus type 1 DNA among Iranian patients with ocular herpetic keratitis infection","volume":"48","author":"Khodadoost","year":"2004","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib35","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.survophthal.2008.12.004","article-title":"Management of herpes simplex virus stromal keratitis: an evidence-based review","volume":"54","author":"Knickelbein","year":"2009","journal-title":"Surv Ophthalmol"},{"issue":"Suppl 1","key":"10.1016\/j.survophthal.2020.09.008_bib36","doi-asserted-by":"crossref","first-page":"S244","DOI":"10.1097\/ICL.0000000000000393","article-title":"AmpliVue is a practical and timely test for the detection of HSV from keratitis specimens","volume":"44","author":"Kowalski","year":"2018","journal-title":"Eye Contact Lens"},{"issue":"2","key":"10.1016\/j.survophthal.2020.09.008_bib37","first-page":"164","article-title":"Cell culture isolation can miss the laboratory diagnosis of HSV ocular infection","volume":"3","author":"Kowalski","year":"2010","journal-title":"Int J Ophthalmol"},{"issue":"5","key":"10.1016\/j.survophthal.2020.09.008_bib38","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/vbz.2016.2074","article-title":"The challenges and advances in diagnosis of vector-borne diseases: where do we stand?","volume":"17","author":"Kules","year":"2017","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"5\u20136","key":"10.1016\/j.survophthal.2020.09.008_bib39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3109\/08820538.2010.518516","article-title":"Current state of in\u00a0vivo confocal microscopy in management of microbial keratitis","volume":"25","author":"Kumar","year":"2010","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib40","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.ophtha.2012.06.049","article-title":"A\u00a0highly sensitive method for molecular diagnosis of fungal keratitis: a dot hybridization assay","volume":"119","author":"Kuo","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.survophthal.2020.09.008_bib41","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1167\/iovs.15-17741","article-title":"A\u00a0multiplex dot hybridization assay for detection and differentiation of acanthamoeba and herpes keratitis","volume":"57","author":"Kuo","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.survophthal.2020.09.008_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1542-0124(12)70291-4","article-title":"Contribution of in\u00a0vivo confocal microscopy to the diagnosis and management of infectious keratitis","volume":"7","author":"Labb\u00e9","year":"2009","journal-title":"Ocul Surf"},{"key":"10.1016\/j.survophthal.2020.09.008_bib43","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s100960050466","article-title":"Evaluation of an enzyme-linked viral inducible system for the rapid detection of herpes simplex virus","volume":"19","author":"LaRocco","year":"2000","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"4","key":"10.1016\/j.survophthal.2020.09.008_bib44","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1086\/600383","article-title":"Viral loads and duration of viral shedding in adult patients hospitalized with influenza","volume":"200","author":"Lee","year":"2009","journal-title":"J\u00a0Infect Dis"},{"issue":"5","key":"10.1016\/j.survophthal.2020.09.008_bib45","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3341\/kjo.2013.27.5.316","article-title":"Comparative analysis of polymerase chain reaction assay for herpes simplex virus 1 detection in tear","volume":"27","author":"Lee","year":"2013","journal-title":"Korean J Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00003226-200101000-00001","article-title":"Herpes simplex virus epidemiology and ocular importance","volume":"20","author":"Liesegang","year":"2001","journal-title":"Cornea"},{"issue":"1","key":"10.1016\/j.survophthal.2020.09.008_bib47","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/abio.2001.5530","article-title":"A\u00a0new quantitative method of real time reverse transcription polymerase chain reaction assay based on simulation of polymerase chain reaction kinetics","volume":"302","author":"Liu","year":"2002","journal-title":"Anal Biochem"},{"issue":"1","key":"10.1016\/j.survophthal.2020.09.008_bib48","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jtos.2018.10.002","article-title":"Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation","volume":"17","author":"Lobo","year":"2019","journal-title":"Ocul Surf"},{"key":"10.1016\/j.survophthal.2020.09.008_bib49","first-page":"682","article-title":"Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis","volume":"9","author":"Ma","year":"2016","journal-title":"Int J Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1177\/104063870201400205","article-title":"Detection of bovine viral diarrhea virus by TaqMan\u00ae reverse transcription polymerase chain reaction","volume":"14","author":"Mahlum","year":"2002","journal-title":"J\u00a0Vet Diagn Invest"},{"key":"10.1016\/j.survophthal.2020.09.008_bib51","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1099\/0022-1317-74-12-2679","article-title":"Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0)","volume":"74","author":"Maul","year":"1993","journal-title":"J\u00a0Gen Virol"},{"issue":"03","key":"10.1016\/j.survophthal.2020.09.008_bib52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4236\/ojoph.2014.43011","article-title":"A\u00a0comparison of the clinical and molecular diagnosis of herpes simplex keratitis","volume":"04","author":"McGilligan","year":"2014","journal-title":"Open J Ophthalmol"},{"issue":"12","key":"10.1016\/j.survophthal.2020.09.008_bib53","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3109\/02713683.2012.707270","article-title":"In\u00a0vivo confocal microscopic evaluation of the inflammatory response in non-epithelial herpes simplex keratitis","volume":"37","author":"Mocan","year":"2012","journal-title":"Curr Eye Res"},{"issue":"6","key":"10.1016\/j.survophthal.2020.09.008_bib54","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10384-011-0091-6","article-title":"Detection of ICP0 protein in tear fluid of individuals with active herpetic epithelial keratitis","volume":"55","author":"Morishige","year":"2011","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib55","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s10384-011-0068-5","article-title":"Morphological changes of corneal subepithelial nerve plexus in different types of herpetic keratitis","volume":"55","author":"Nagasato","year":"2011","journal-title":"Jpn J Ophthalmol"},{"issue":"2","key":"10.1016\/j.survophthal.2020.09.008_bib56","doi-asserted-by":"crossref","first-page":"84","DOI":"10.5935\/0004-2749.20170021","article-title":"Detection of herpes simplex-1 and -2 and varicella zoster virus by quantitative real-time polymerase chain reaction in corneas from patients with bacterial keratitis","volume":"80","author":"Nascimento","year":"2017","journal-title":"Arq Bras Oftalmol"},{"issue":"3","key":"10.1016\/j.survophthal.2020.09.008_bib57","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jtos.2015.05.002","article-title":"In\u00a0vivo confocal microscopy of the cornea: new developments in image acquisition, reconstruction, and analysis using the HRT-rostock corneal module","volume":"13","author":"Petroll","year":"2015","journal-title":"Ocul Surf"},{"issue":"3","key":"10.1016\/j.survophthal.2020.09.008_bib58","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0008-4182(00)80006-X","article-title":"Polymerase chain reaction in the diagnosis of herpetic keratitis: experience in a developing country","volume":"35","author":"Pramod","year":"2000","journal-title":"Can J Ophthalmol"},{"issue":"7","key":"10.1016\/j.survophthal.2020.09.008_bib59","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00417-017-3653-6","article-title":"The evaluation of diagnostic efficiency for stromal herpes simplex keratitis by the combination of tear HSV-sIgA and HSV-DNA","volume":"255","author":"Qiu","year":"2017","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib60","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00003226-200204000-00006","article-title":"n vivo confocal microscopy after herpes keratitis","volume":"21","author":"Rosenberg","year":"2002","journal-title":"Cornea"},{"key":"10.1016\/j.survophthal.2020.09.008_bib61","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.preteyeres.2012.08.002","article-title":"Herpes keratitis","volume":"32","author":"Rowe","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.survophthal.2020.09.008_bib62","first-page":"571","article-title":"Diagnosis and management of neurotrophic keratitis","volume":"8","author":"Sacchetti","year":"2014","journal-title":"Clin Ophthalmol"},{"issue":"5","key":"10.1016\/j.survophthal.2020.09.008_bib63","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/cxo.12669","article-title":"A\u00a020-year experience of ocular herpes virus detection using immunofluorescence and polymerase chain reaction","volume":"101","author":"Satpathy","year":"2018","journal-title":"Clin Exp Optom"},{"issue":"3","key":"10.1016\/j.survophthal.2020.09.008_bib64","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/bjo.2010.191049","article-title":"Evaluation of tear samples for herpes simplex virus 1 (HSV) detection in suspected cases of viral keratitis using PCR assay and conventional laboratory diagnostic tools","volume":"95","author":"Satpathy","year":"2011","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib65","first-page":"2476","article-title":"HSV-1 infection of human corneal epithelial cells: receptor-mediated entry and trends of re-infection","volume":"16","author":"Shah","year":"2010","journal-title":"Mol Vis"},{"issue":"4","key":"10.1016\/j.survophthal.2020.09.008_bib66","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s10384-016-0448-y","article-title":"A\u00a0diagnostic method for herpes simplex keratitis by simultaneous measurement of viral DNA and virus-specific secretory IgA in tears: an evaluation","volume":"60","author":"Shoji","year":"2016","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib67","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/02713680490504911","article-title":"Diagnosis of herpes simplex virus-1 keratitis: comparison of Giemsa stain, immunofluorescence assay and polymerase chain reaction","volume":"29","author":"Subhan","year":"2004","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.survophthal.2020.09.008_bib68","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/08820530802111010","article-title":"Corneal endotheliitis","volume":"23","author":"Suzuki","year":"2008","journal-title":"Semin Ophthalmol"},{"issue":"12","key":"10.1016\/j.survophthal.2020.09.008_bib69","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1007\/s10792-019-01134-4","article-title":"Role of in\u00a0vivo confocal microscopy in the diagnosis of infectious keratitis","volume":"39","author":"Wang","year":"2019","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib70","series-title":"Demystifying the Ocular Herpes Simplex Virus: EyeNet Magazine","first-page":"40","author":"Weiner","year":"2013"},{"issue":"2","key":"10.1016\/j.survophthal.2020.09.008_bib71","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0002-9394(14)73071-5","article-title":"Detection of herpes simplex virus DNA in human tear film by the polymerase chain reaction","volume":"117","author":"Yamamoto","year":"1994","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.survophthal.2020.09.008_bib72","first-page":"1771","article-title":"Mapping of dendritic lesions in patients with herpes simplex keratitis using in\u00a0vivo confocal microscopy","volume":"9","author":"Yokogawa","year":"2015","journal-title":"Clin Ophthalmol"},{"issue":"06","key":"10.1016\/j.survophthal.2020.09.008_bib73","first-page":"230","article-title":"In\u00a0vivo laser scanning confocal microscopy used in herpes simplex keratitis research","volume":"03","author":"Yuan","year":"2012","journal-title":"J\u00a0Clin Exp Ophthalmol"},{"issue":"6","key":"10.1016\/j.survophthal.2020.09.008_bib74","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12250-014-3539-2","article-title":"Ocular herpes: the pathophysiology, management and treatment of herpetic eye diseases","volume":"29","author":"Zhu","year":"2014","journal-title":"Virol Sin"}],"container-title":["Survey of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039625720301387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039625720301387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T11:50:06Z","timestamp":1758541806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039625720301387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0039625720301387"],"URL":"https:\/\/doi.org\/10.1016\/j.survophthal.2020.09.008","relation":{},"ISSN":["0039-6257"],"issn-type":[{"value":"0039-6257","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A systematic review on advances in diagnostics for herpes simplex keratitis","name":"articletitle","label":"Article Title"},{"value":"Survey of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.survophthal.2020.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}