{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:07:28Z","timestamp":1790118448809,"version":"4.0.1"},"reference-count":99,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sexual Medicine Reviews"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.sxmr.2015.10.002","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T16:46:51Z","timestamp":1454431611000},"page":"85-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["The Genetic Basis of Peyronie Disease: A Review"],"prefix":"10.1093","volume":"4","author":[{"given":"Amin S.","family":"Herati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander W.","family":"Pastuszak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"10.1016\/j.sxmr.2015.10.002_bib1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/sj.ijir.3900877","article-title":"Clinical presentations of Peyronie's disease","volume":"14","author":"Pryor","year":"2002","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib2","first-page":"285","article-title":"Proposal: trauma as the cause of the Peyronie's lesion","volume":"157","author":"Devine","year":"1997","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib3","first-page":"276","article-title":"The anatomy of the tunica albuginea in the normal penis and Peyronie's disease","volume":"157","author":"Brock","year":"1997","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib4","first-page":"311","article-title":"Fibrin deposition in Peyronie\u2019s disease plaque","volume":"157","author":"Somers","year":"1997","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib5","first-page":"629","article-title":"Isolation and characterization of collagen in Peyronie's disease","volume":"141","author":"Somers","year":"1989","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib6","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.ijir.3900875","article-title":"Pathophysiology of Peyronie's disease","volume":"14","author":"Moreland","year":"2002","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/ijir.2011.18","article-title":"The association between Peyronie's and Dupuytren's disease","volume":"23","author":"Nugteren","year":"2011","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jbspin.2011.05.027","article-title":"Genetics of Dupuytren's disease","volume":"79","author":"Michou","year":"2012","journal-title":"Joint Bone Spine"},{"issue":"Suppl 4","key":"10.1016\/j.sxmr.2015.10.002_bib9","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1038\/sj.ijir.3900591","article-title":"The genetics and immunology of Peyronie's disease","volume":"12","author":"Noss","year":"2000","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib10","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.eururo.2007.06.036","article-title":"Investigation of the antifibrotic effect of IFN-gamma on fibroblasts in a cell culture model of Peyronie's disease","volume":"53","author":"Haag","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib11","first-page":"1391","article-title":"Peyronie's disease is associated with an increase in transforming growth factor-beta protein expression","volume":"158","author":"El-Sakka","year":"1997","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ajmg.1320120213","article-title":"Peyronie's disease: a newly recognized autosomal-dominant trait","volume":"12","author":"Bias","year":"1982","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.sxmr.2015.10.002_bib13","first-page":"48","article-title":"Identification of an inherited form of Peyronie's disease with autosomal dominant inheritance and association with Dupuytren\u2019s contracture and histocompatibility B7 cross-reacting antigens","volume":"128","author":"Nyberg","year":"1982","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib14","doi-asserted-by":"crossref","first-page":"44e","DOI":"10.1097\/01.prs.0000278455.63546.03","article-title":"Dupuytren's disease: history, diagnosis, and treatment","volume":"120","author":"Shaw","year":"2007","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.sxmr.2015.10.002_bib15","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1054\/jhsb.1999.0207","article-title":"Dupuytren's disease. The way forward?","volume":"24","author":"Fitzgerald","year":"1999","journal-title":"J\u00a0Hand Surg Br"},{"key":"10.1016\/j.sxmr.2015.10.002_bib16","first-page":"34","article-title":"The association of histocompatibility antigens of the B7 cross-reacting group with Peyronie's disease","volume":"122","author":"Willscher","year":"1979","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/sj.ijir.3900863","article-title":"Epidemiology of Peyronie's disease","volume":"14","author":"Sommer","year":"2002","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib18","first-page":"1007","article-title":"The incidence of Peyronie's disease in Rochester, Minnesota, 1950 through 1984","volume":"146","author":"Lindsay","year":"1991","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib19","first-page":"302","article-title":"Peyronie's disease in teenagers","volume":"9","author":"Tal","year":"2012","journal-title":"J\u00a0Sex Med"},{"key":"10.1016\/j.sxmr.2015.10.002_bib20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/sj.ijir.3900635","article-title":"Peyronie's disease in men under age 40: characteristics and outcome","volume":"13","author":"Tefekli","year":"2001","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1046\/j.1464-4096.2001.02436.x","article-title":"The prevalence of Peyronie's disease: results of a large survey","volume":"88","author":"Schwarzer","year":"2001","journal-title":"BJU Int"},{"key":"10.1016\/j.sxmr.2015.10.002_bib22","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1023\/A:1014485204205","article-title":"Peyronie's disease: epidemiology and clinical presentation of 134 cases","volume":"32","author":"Perimenis","year":"2001","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib23","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1464-410X.2006.05969.x","article-title":"Risk factors for Peyronie's disease: a case\u2013control study","volume":"97","author":"Bjekic","year":"2006","journal-title":"BJU Int"},{"key":"10.1016\/j.sxmr.2015.10.002_bib24","first-page":"1062","article-title":"Peyronie's disease and autoimmunity\u2014a real-life clinical study and comprehensive review","volume":"12","author":"Ventimiglia","year":"2015","journal-title":"J\u00a0Sex Med"},{"key":"10.1016\/j.sxmr.2015.10.002_bib25","first-page":"1223","article-title":"Non-association of Peyronie's disease with HLA B7 cross-reactive antigens","volume":"127","author":"Leffell","year":"1982","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib26","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0090-4295(84)90068-2","article-title":"HLA-A and B antigens in patients with Peyronie disease","volume":"23","author":"Deguchi","year":"1984","journal-title":"Urology"},{"key":"10.1016\/j.sxmr.2015.10.002_bib27","first-page":"1443","article-title":"Prospective analysis of HLA classes I and II antigen frequency in patients with Peyronie's disease","volume":"170","author":"Hauck","year":"2003","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib28","first-page":"672","article-title":"Chromosome abnormalities in Peyronie's disease","volume":"137","author":"Somers","year":"1987","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0165-4608(91)90461-3","article-title":"Multiple clonal chromosome abnormalities in Peyronie's disease","volume":"52","author":"Guerneri","year":"1991","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.sxmr.2015.10.002_bib30","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/sj.ijir.3901170","article-title":"Chromosomal instability is demonstrated by fibroblasts derived from the tunica of men with Peyronie's disease","volume":"16","author":"Mulhall","year":"2004","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1164\/ajrccm\/140.1.95","article-title":"Collagen synthesis by normal and fibrotic human lung fibroblasts and the effect of transforming growth factor-beta","volume":"140","author":"Raghu","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.sxmr.2015.10.002_bib32","first-page":"1221","article-title":"Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease","volume":"139","author":"Milani","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib33","first-page":"867","article-title":"Is there a role for proteomics in Peyronie's disease?","volume":"4","author":"Domes","year":"2007","journal-title":"J\u00a0Sex Med"},{"key":"10.1016\/j.sxmr.2015.10.002_bib34","first-page":"2284","article-title":"An animal model of Peyronie's-like condition associated with an increase of transforming growth factor beta mRNA and protein expression","volume":"158","author":"El-Sakka","year":"1997","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib35","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1365-2605.2007.00780.x","article-title":"Repeated intratunical injection of adenovirus expressing transforming growth factor-beta1 in a rat induces penile curvature with tunical fibrotic plaque: a useful model for the study of Peyronie's disease","volume":"31","author":"Piao","year":"2008","journal-title":"Int J Androl"},{"key":"10.1016\/j.sxmr.2015.10.002_bib36","first-page":"1284","article-title":"IN-1130, a novel transforming growth factor-beta type I receptor kinase (activin receptor-like kinase 5) inhibitor, promotes regression of fibrotic plaque and corrects penile curvature in a rat model of Peyronie's disease","volume":"6","author":"Ryu","year":"2009","journal-title":"J\u00a0Sex Med"},{"key":"10.1016\/j.sxmr.2015.10.002_bib37","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1046\/j.1523-1755.2000.07709.x","article-title":"Mechanism of transforming growth factor-beta1 signaling","volume":"77","author":"Choi","year":"2000","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.sxmr.2015.10.002_bib38","doi-asserted-by":"crossref","first-page":"e65659","DOI":"10.1371\/journal.pone.0065659","article-title":"Polymorphisms predict distant metastasis-free survival in patients with inoperable non\u2013small-cell lung cancer after definitive radiotherapy","volume":"8","author":"Yuan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.sxmr.2015.10.002_bib39","first-page":"2610","article-title":"A\u00a0transforming growth factor beta1 signal peptide variant increases secretion in\u00a0vitro and is associated with increased incidence of invasive breast cancer","volume":"63","author":"Dunning","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/rheumatology\/keg457","article-title":"The effect of transforming growth factor beta1 gene polymorphisms in ankylosing spondylitis","volume":"43","author":"Jaakkola","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.sxmr.2015.10.002_bib41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/ajmg.b.30218","article-title":"Association studies of transforming growth factor-beta 1 and Alzheimer's disease","volume":"139B","author":"Dickson","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.sxmr.2015.10.002_bib42","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/00007890-199810270-00009","article-title":"Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation","volume":"66","author":"Awad","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.sxmr.2015.10.002_bib43","first-page":"369","article-title":"Prospective analysis of single nucleotide polymorphisms of the transforming growth factor beta-1 gene in Peyronie's disease","volume":"169","author":"Hauck","year":"2003","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib44","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1056\/NEJMoa1101029","article-title":"Wnt signaling and Dupuytren's disease","volume":"365","author":"Dolmans","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.sxmr.2015.10.002_bib45","first-page":"1430","article-title":"WNT2 locus is involved in genetic susceptibility of Peyronie's disease","volume":"9","author":"Dolmans","year":"2012","journal-title":"J\u00a0Sex Med"},{"key":"10.1016\/j.sxmr.2015.10.002_bib46","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jbi.2007.01.004","article-title":"Mining pathway signatures from microarray data and relevant biological knowledge","volume":"40","author":"Panteris","year":"2007","journal-title":"J\u00a0Biomed Inform"},{"key":"10.1016\/j.sxmr.2015.10.002_bib47","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0090-4295(01)01578-3","article-title":"Gene expression profiles in the Peyronie's disease plaque","volume":"59","author":"Magee","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.sxmr.2015.10.002_bib48","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1083\/jcb.143.4.1113","article-title":"Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth\u2013associated molecule (HB-GAM)","volume":"143","author":"Imai","year":"1998","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib49","doi-asserted-by":"crossref","first-page":"e88287","DOI":"10.1371\/journal.pone.0088287","article-title":"Pleiotrophin commits human bone marrow mesenchymal stromal cells towards hypertrophy during chondrogenesis","volume":"9","author":"Bouderlique","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.sxmr.2015.10.002_bib50","first-page":"17","article-title":"Pleiotrophin\/osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation","volume":"2002","author":"Tare","year":"2009","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib51","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00011-006-5144-9","article-title":"Transforming growth factor-beta stimulates IL-1beta\u2013induced monocyte chemoattractant protein-1 expression in human synovial cells via the ERK\/AP-1 pathway","volume":"55","author":"Yoshimura","year":"2006","journal-title":"Inflamm Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib52","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00345-008-0320-x","article-title":"Upregulation of mRNA expression of MCP-1 by TGF-beta1 in fibroblast cells from Peyronie's disease","volume":"27","author":"Szardening-Kirchner","year":"2009","journal-title":"World J Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib53","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S0006-291X(02)00765-9","article-title":"Upregulation of\u00a0monocyte chemoattractant protein 1 and effects of transforming growth factor-beta 1 in Peyronie's disease","volume":"295","author":"Lin","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.sxmr.2015.10.002_bib54","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.neo.7900101","article-title":"Cell cycle and apoptosis","volume":"2","author":"Pucci","year":"2000","journal-title":"Neoplasia"},{"key":"10.1016\/j.sxmr.2015.10.002_bib55","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3109\/08830189909088492","article-title":"Ribosomal proteins in cell proliferation and apoptosis","volume":"18","author":"Chen","year":"1999","journal-title":"Int Rev Immunol"},{"issue":"Suppl 5","key":"10.1016\/j.sxmr.2015.10.002_bib56","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1038\/sj.ijir.3900771","article-title":"Perturbation of cell cycle regulators in Peyronie's disease","volume":"13","author":"Mulhall","year":"2001","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib57","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.ijir.3901183","article-title":"Peyronie's disease fibroblasts demonstrate tumorigenicity in the severe combined immunodeficient (SCID) mouse model","volume":"16","author":"Mulhall","year":"2004","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib58","doi-asserted-by":"crossref","first-page":"8317","DOI":"10.1038\/sj.onc.1205092","article-title":"Id proteins in cell cycle control and cellular senescence","volume":"20","author":"Zebedee","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.sxmr.2015.10.002_bib59","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/S0021-9258(17)42146-6","article-title":"Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts","volume":"269","author":"Hara","year":"1994","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.sxmr.2015.10.002_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.8.1.1","article-title":"bHLH factors in muscle development: deadlines and commitments, what to leave in and what to leave out","volume":"8","author":"Olson","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/j.sxmr.2015.10.002_bib61","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1042\/BJ20081715","article-title":"Proper expression of helix-loop-helix protein Id2 is important to chondrogenic differentiation of ATDC5 cells","volume":"419","author":"Yang","year":"2009","journal-title":"Biochem J"},{"key":"10.1016\/j.sxmr.2015.10.002_bib62","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0959-4388(97)80115-8","article-title":"Basic helix-loop-helix genes in neural development","volume":"7","author":"Lee","year":"1997","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib63","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/17812","article-title":"Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2","volume":"397","author":"Yokota","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.sxmr.2015.10.002_bib64","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.4049\/jimmunol.1300099","article-title":"Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation","volume":"190","author":"Masson","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib65","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1042\/BJ20060380","article-title":"Id2 leaves the chromatin of the E2F4-p130\u2013controlled c-myc promoter during hepatocyte priming for liver regeneration","volume":"398","author":"Rodriguez","year":"2006","journal-title":"Biochem J"},{"key":"10.1016\/j.sxmr.2015.10.002_bib66","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/pros.20238","article-title":"Negative acting HLH proteins Id 1, Id 2, Id 3, and Id 4 are expressed in prostate epithelial cells","volume":"64","author":"Chaudhary","year":"2005","journal-title":"Prostate"},{"key":"10.1016\/j.sxmr.2015.10.002_bib67","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1095\/biolreprod.104.035717","article-title":"The helix-loop-helix inhibitor of differentiation (ID) proteins induce post-mitotic terminally differentiated Sertoli cells to re-enter the cell cycle and proliferate","volume":"72","author":"Chaudhary","year":"2005","journal-title":"Biol Reprod"},{"key":"10.1016\/j.sxmr.2015.10.002_bib68","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.ajpath.2014.12.008","article-title":"Overexpression of inhibitor of DNA-binding 2 attenuates pulmonary fibrosis through regulation of c-Abl and Twist","volume":"185","author":"Yang","year":"2015","journal-title":"Am J Pathol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib69","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1136\/gut.2006.092460","article-title":"Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats","volume":"56","author":"Kinoshita","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.sxmr.2015.10.002_bib70","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1126\/science.274.5287.610","article-title":"Accessing genetic information with high-density DNA arrays","volume":"274","author":"Chee","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.sxmr.2015.10.002_bib71","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nm.2084","article-title":"Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth","volume":"16","author":"Houghton","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.sxmr.2015.10.002_bib72","first-page":"161","article-title":"Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines","volume":"17","author":"Wada","year":"2007","journal-title":"Oncol Rep"},{"key":"10.1016\/j.sxmr.2015.10.002_bib73","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/BJ20100427","article-title":"Regulation of TGF-beta signalling by protein phosphatases","volume":"430","author":"Liu","year":"2010","journal-title":"Biochem J"},{"key":"10.1016\/j.sxmr.2015.10.002_bib74","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1006\/excr.2000.4930","article-title":"Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-beta","volume":"258","author":"Mori","year":"2000","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.sxmr.2015.10.002_bib75","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/39369","article-title":"Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling","volume":"389","author":"Nakao","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.sxmr.2015.10.002_bib76","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S1097-2765(00)00134-9","article-title":"Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation","volume":"6","author":"Kavsak","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.sxmr.2015.10.002_bib77","article-title":"Effect of gene overexpression on TGF-beta1-induced profibrotic responses in fibroblasts derived from Peyronie's plaque","author":"Choi","year":"2014","journal-title":"Asian J Androl"},{"key":"10.1016\/j.sxmr.2015.10.002_bib78","first-page":"607","article-title":"Comparison of apoptotic gene expression profiles between Peyronie's disease plaque and tunica albuginea","volume":"21","author":"Zorba","year":"2012","journal-title":"Adv Clin Exp Med"},{"key":"10.1016\/j.sxmr.2015.10.002_bib79","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.urology.2004.04.006","article-title":"Comparison of gene expression profiles between Peyronie's disease and Dupuytren's contracture","volume":"64","author":"Qian","year":"2004","journal-title":"Urology"},{"key":"10.1016\/j.sxmr.2015.10.002_bib80","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","article-title":"Matrix metalloproteinases","volume":"274","author":"Nagase","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.sxmr.2015.10.002_bib81","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1357-2725(00)00087-X","article-title":"Beta-thymosins, small acidic peptides with multiple functions","volume":"33","author":"Huff","year":"2001","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib82","first-page":"2447","article-title":"Differential calcium independent regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by interleukin-1beta and transforming growth factor-beta in Peyronie's plaque fibroblasts","volume":"179","author":"Del Carlo","year":"2008","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib83","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1523\/JNEUROSCI.18-14-05203.1998","article-title":"Neuronal matrix metalloproteinase-2 degrades and inactivates a neurite-inhibiting chondroitin sulfate proteoglycan","volume":"18","author":"Zuo","year":"1998","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.sxmr.2015.10.002_bib84","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.cellsig.2009.12.008","article-title":"AP-1\u2014The Jun proteins: oncogenes or tumor suppressors in disguise?","volume":"22","author":"Shaulian","year":"2010","journal-title":"Cell Signal"},{"key":"10.1016\/j.sxmr.2015.10.002_bib85","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.0105-2896.2005.00332.x","article-title":"Fos\/AP-1 proteins in bone and the immune system","volume":"208","author":"Wagner","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1016\/j.sxmr.2015.10.002_bib86","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","article-title":"Histone deacetylases (HDACs): characterization of the classical HDAC family","volume":"370","author":"de Ruijter","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.sxmr.2015.10.002_bib87","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nrd3674","article-title":"Epigenetic protein families: a new frontier for drug discovery","volume":"11","author":"Arrowsmith","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.sxmr.2015.10.002_bib88","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4161\/epi.1.2.2762","article-title":"Epigenetics: a historical overview","volume":"1","author":"Holliday","year":"2006","journal-title":"Epigenetics"},{"key":"10.1016\/j.sxmr.2015.10.002_bib89","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrg3863","article-title":"RNA-mediated epigenetic regulation of gene expression","volume":"16","author":"Holoch","year":"2015","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.sxmr.2015.10.002_bib90","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1749-6632.2003.tb05964.x","article-title":"Histone deacetylases: unique players in shaping the epigenetic histone code","volume":"983","author":"Thiagalingam","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.sxmr.2015.10.002_bib91","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1124\/jpet.110.168385","article-title":"Histone deacetylase: a potential therapeutic target for fibrotic disorders","volume":"335","author":"Pang","year":"2010","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.sxmr.2015.10.002_bib92","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.urology.2009.11.022","article-title":"The effect of epigenetic therapy on congenital neurogenic bladders\u2014a pilot study","volume":"75","author":"Hodges","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.sxmr.2015.10.002_bib93","first-page":"177","article-title":"Epigenetic repression of matrix metalloproteinases in myofibroblastic hepatic stellate cells through histone deacetylases 4: implication in tissue fibrosis","volume":"2010","author":"Qin","year":"1915","journal-title":"Am J Pathol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib94","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/aja.2013.61","article-title":"Inhibition of histone deacetylase 2 mitigates profibrotic TGF-beta1 responses in fibroblasts derived from Peyronie's plaque","volume":"15","author":"Ryu","year":"2013","journal-title":"Asian J Androl"},{"key":"10.1016\/j.sxmr.2015.10.002_bib95","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/bju.12812","article-title":"Silencing histone deacetylase 2 using small hairpin RNA induces regression of fibrotic plaque in a rat model of Peyronie's disease","volume":"114","author":"Kwon","year":"2014","journal-title":"BJU Int"},{"key":"10.1016\/j.sxmr.2015.10.002_bib96","doi-asserted-by":"crossref","first-page":"17582","DOI":"10.1073\/pnas.1409700111","article-title":"Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation","volume":"111","author":"Hefetz-Sela","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.sxmr.2015.10.002_bib97","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000151747","article-title":"Transcriptional regulation of osteoblasts","volume":"189","author":"Franceschi","year":"2009","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.sxmr.2015.10.002_bib98","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s13277-010-0031-y","article-title":"Calcineurin promotes proliferation, migration, and invasion of small cell lung cancer","volume":"31","author":"Liu","year":"2010","journal-title":"Tumour Biol"},{"key":"10.1016\/j.sxmr.2015.10.002_bib99","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.mad.2011.07.005","article-title":"Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts","volume":"132","author":"Micutkova","year":"2011","journal-title":"Mech Ageing Dev"}],"container-title":["Sexual Medicine Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2050052115000037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2050052115000037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T19:36:19Z","timestamp":1672774579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2050052115000037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":99,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S2050052115000037"],"URL":"https:\/\/doi.org\/10.1016\/j.sxmr.2015.10.002","relation":{},"ISSN":["2050-0521"],"issn-type":[{"value":"2050-0521","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Genetic Basis of Peyronie Disease: A Review","name":"articletitle","label":"Article Title"},{"value":"Sexual Medicine Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sxmr.2015.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}