{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:16:47Z","timestamp":1785860207870,"version":"3.56.0"},"reference-count":113,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Normal sexual activity is an important determinant of quality of life. Unfortunately, several chronic health disorders are associated with an impaired sexual function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To provide coverage of the current literature on prevalence and pathophysiology of sexual dysfunction in patients with gastrointestinal and liver disorders<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Comprehensive review of the literature on the prevalence of sexual dysfunction in chronic gastrointestinal and liver disorders, assessing the underlying mechanism (s) was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Many gastrointestinal disorders, either functional or organic, are associated with some degree of sexual dysfunction. The main pathogenic mechanisms are: (i) the disease itself causing fatigue, anxiety or depression with a potential alteration of self-esteem; (ii) worry of transmitting a potential infectious agent through sexual activity; (iii) alteration of the endocrine mechanisms which are necessary for normal sexual functioning; (iv) chronic pro- inflammatory conditions which may cause endothelial dysfunction and abnormal vascular responses; (v) iatrogenic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on this review, a thorough evaluation of sexual function through validated questionnaires and\/or psychological interviews with patients with chronic gastrointestinal disorders should be part of the clinical assessment in order to timely diagnose and possibly treat sexual dysfunction in this clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.sxmr.2021.02.002","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T04:51:52Z","timestamp":1627966312000},"page":"620-631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Sexual Dysfunction in Patients With Chronic Gastrointestinal and Liver Diseases: A neglected Issue"],"prefix":"10.1093","volume":"10","author":[{"given":"Lorenzo","family":"Romano","sequence":"first","affiliation":[{"name":"Department of Neurosciences , Naples , Italy"},{"name":"Reproductive Sciences and Odontostomatology, University of Naples \"Federico II\" , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Granata","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina di Precisione , Napoli , Italy"},{"name":"Hepato-Gastroenterology Unit, Universit\u00e0 della Campania Luigi Vanvitelli , Napoli , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Fusco","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialized Surgery, Urology Unit , Naples , Italy"},{"name":"University of Campania 'Luigi Vanvitelli' , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Department of Neurosciences , Naples , Italy"},{"name":"Reproductive Sciences and Odontostomatology, University of Naples \"Federico II\" , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Cerbone","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina di Precisione , Napoli , Italy"},{"name":"Hepato-Gastroenterology Unit, Universit\u00e0 della Campania Luigi Vanvitelli , Napoli , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kateryna","family":"Priadko","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina di Precisione , Napoli , Italy"},{"name":"Hepato-Gastroenterology Unit, Universit\u00e0 della Campania Luigi Vanvitelli , Napoli , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Sciorio","sequence":"additional","affiliation":[{"name":"UOC di Urologia ASST Manzoni , Lecco , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Mirone","sequence":"additional","affiliation":[{"name":"Department of Neurosciences , Naples , Italy"},{"name":"Reproductive Sciences and Odontostomatology, University of Naples \"Federico II\" , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Romano","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina di Precisione , Napoli , Italy"},{"name":"Hepato-Gastroenterology Unit, Universit\u00e0 della Campania Luigi Vanvitelli , Napoli , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"2023041308074135700_","article-title":"Defining sexual health. 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