{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:12:23Z","timestamp":1793884343396,"version":"4.7.0"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PGC2018-094919-B-C21"],"award-info":[{"award-number":["PGC2018-094919-B-C21"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017008","name":"Cancer Research UK Manchester Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sexual Medicine Reviews"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.sxmr.2022.07.001","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T18:11:43Z","timestamp":1665079903000},"page":"481-492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Orgasm and Related Disorders Depend on Neural Inhibition Combined With Neural Excitation"],"prefix":"10.1093","volume":"10","author":[{"given":"Barry R.","family":"Komisaruk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cruz","family":"Rodriguez del Cerro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"Suppl 1","key":"10.1016\/j.sxmr.2022.07.001_bib0001","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1038\/sj.bjp.0706443","article-title":"GABA and glycine as neurotransmitters: a brief history","volume":"147","author":"Bowery","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0002","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0304-3959(85)90164-2","article-title":"Elevation of pain threshold by vaginal stimulation in women","volume":"21","author":"Whipple","year":"1985","journal-title":"Pain"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0003","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3389\/fnmol.2019.00168","article-title":"From hiring to firing: activation of inhibitory neurons and their recruitment in behavior","volume":"12","author":"Swanson","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0004","doi-asserted-by":"crossref","first-page":"13722","DOI":"10.1038\/ncomms13722","article-title":"Dendritic excitation-inhibition balance shapes cerebellar output during motor behaviour","volume":"7","author":"Jelitai","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0005","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/cne.901870304","article-title":"The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation","volume":"187","author":"Basbaum","year":"1979","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0006","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/0024-3205(86)90164-5","article-title":"Nociceptive responses to altered GABAergic activity at the spinal cord","volume":"39","author":"Roberts","year":"1986","journal-title":"Life Sci"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0007","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/bs.pmbts.2014.11.008","article-title":"Synaptic inhibition and disinhibition in the spinal dorsal horn","volume":"131","author":"Prescott","year":"2015","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0008","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/physrev.00025.2008","article-title":"Models and mechanisms of hyperalgesia and allodynia","volume":"89","author":"Sandk\u00fchler","year":"2009","journal-title":"Physiol Rev"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0009","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00424-014-1532-0","article-title":"Mechanical allodynia","volume":"467","author":"Lolignier","year":"2015","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0010","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jsxm.2021.01.172","volume":"18","author":"Goldstein","year":"2021","journal-title":"J Sex Med"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0011","unstructured":"Kaplan HS. Sexual desire disorders: dysfunctional regulation of sexual motivation. New York, NY: Brunner\/Mazel, Inc; 1995"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0012","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1743-6109.2008.01177.x","article-title":"The sexual tipping point: a mind\/body model for sexual medicine","volume":"6","author":"Perelman","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0013","unstructured":"Parish SJ, Hahn SR. The Epidemiology and Diagnosis of Hypoactive Sexual Desire Disorder and Causes of HSDD: Situational, Depression, Drugs, Chronic Illnesses, and Hormonal Depletion. In: Lipshultz, L. I., Pastuszak, A. W., Goldstein, A. T., Giraldi, A.,"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0014","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/00224490902747222","article-title":"The dual control model: current status and future directions","volume":"46","author":"Bancroft","year":"2009","journal-title":"J Sex Res"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0015","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1743-6109.2012.02984.x","article-title":"Toward personalized sexual medicine (part 1): integrating the \"dual control model\" into differential drug treatments for hypoactive sexual desire disorder and female sexual arousal disorder","volume":"10","author":"Bloemers","year":"2013","journal-title":"J Sex Med"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0016","doi-asserted-by":"crossref","first-page":"563","DOI":"10.21037\/tau.2016.07.05","article-title":"Psychosexual therapy for delayed ejaculation based on the sexual tipping point model","volume":"5","author":"Perelman","year":"2016","journal-title":"Translational andrology and urology"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0017","first-page":"1","article-title":"Aspects of stimulation and organization inapproach\/withdrawal processes underlying vertebrate behavioral development","volume":"1","author":"Schneirla","year":"1965"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0018","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1152\/jn.1963.26.6.1003","article-title":"Single-cell responses in striate cortex of kittens deprived of vision in one eye","volume":"26","author":"Wiesel","year":"1963","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0019","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nrn3680","article-title":"Wallerian degeneration: an emerging axon death pathway linking injury and disease","volume":"15","author":"Conforti","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0020","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.rxeng.2022.01.001","article-title":"Imaging secondary neuronal degeneration","volume":"64","author":"Montoya-Filardi","year":"2022","journal-title":"Radiologia (Engl Ed)"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0021","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1177\/1545968310368534","article-title":"Severe degeneration of peripheral motor axons after spinal cord injury: a European multicenter study in 345 patients","volume":"24","author":"Van De Meent","year":"2010","journal-title":"Neurorehabil Neuronal Repair"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0022","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0361-9230(89)90125-1","article-title":"Transsynaptic degeneration of motoneurones caudal to spinal cord lesions","volume":"22","author":"Eidelberg","year":"1989","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0023","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(90)91164-E","article-title":"Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine","volume":"42","author":"Sugimoto","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0024","series-title":"Phantoms in the brain: human nature and the architecture of the mind","author":"Ramachandran","year":"1998"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0025","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1037\/h0024290","article-title":"A biological theory of reinforcement","volume":"74","author":"Glickman","year":"1967","journal-title":"Psychological review"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0026","series-title":"El cerebro afectivo","author":"Del Cerro","year":"2017"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0027","first-page":"318","article-title":"Some theoretical implications from animal behaviour studies for the psycho-analytic concepts of instinct, energy, and drive","volume":"41","author":"Kaufman","year":"1960","journal-title":"Int J Psycho-Anal"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0028","series-title":"The art of loving: an enquiry into the nature of love","author":"Fromm","year":"1956"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0029","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1542\/peds.62.3.277","article-title":"Excessive masturbation of childhood: a symptom of tactile deprivation?","volume":"62","author":"McCray","year":"1978","journal-title":"Pediatrics"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0030","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/NMD.0b013e3181b9760b","article-title":"The psychotomimetic effects of short-term sensory deprivation","volume":"197","author":"Mason","year":"2009","journal-title":"J Nerv Ment Dis"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0031","first-page":"107","article-title":"Visceral-Somatic Integration in Behavior Cognition, and \u201cPsychosomatic\u201d Disease","volume":"12","author":"Komisaruk","year":"1982"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0032","series-title":"Psychobiology and human disease","author":"Weiner","year":"1977"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0033","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1097\/PSY.0b013e31816ffc39","article-title":"Alexithymia and somatization in general population","volume":"70","author":"Mattila","year":"2008","journal-title":"Psychosom Med"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0034","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.paid.2016.05.364","article-title":"The alexithymia, cognitive emotion regulation, and physical symptoms in Iranian asthmatic patients","volume":"101","author":"Khosravani","year":"2016","journal-title":"Pers Individual Differences"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0035","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.nec.2018.12.002","article-title":"Intrathecal baclofen infusion for the treatment of movement disorders","volume":"30","author":"Lake","year":"2019","journal-title":"Neurosurg Clin N Am"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0036","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1210\/endo-93-3-548","article-title":"Lordosis reflex intensity in rats in relation to the estrous cycle, ovariectomy, estrogen administration and mating behavior","volume":"93","author":"Komisaruk","year":"1973","journal-title":"Endocrinology"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0037","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0006-8993(94)91365-X","article-title":"Momentary analgesia produced by copulation in female rats","volume":"656","author":"G\u00f3mora","year":"1994","journal-title":"Brain Res"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0038","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0006-8993(91)91713-B","article-title":"Analgesia is produced by uterocervical mechanostimulation in rats: roles of afferent nerves and implications for analgesia of pregnancy and parturition","volume":"566","author":"Gintzler","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0039","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0020-7489(90)90036-I","article-title":"Sensory thresholds during the antepartum, intrapartum and postpartum periods","volume":"27","author":"Whipple","year":"1990","journal-title":"Int J Nurs Stud"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0040","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.yhbeh.2015.07.004","article-title":"Environmental prenatal stress eliminates brain and maternal behavioral sex differences and alters hormone levels in female rats","volume":"73","author":"Del Cerro","year":"2015","journal-title":"Horm Behav"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0041","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1037\/0033-295X.104.3.572","article-title":"Cortical dynamics of lateral inhibition: metacontrast masking","volume":"104","author":"Francis","year":"1997","journal-title":"Psychol Rev"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0042","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168963","article-title":"Retinal Lateral Inhibition Provides the Biological Basis of Long-Range Spatial Induction","volume":"11","author":"Yeonan-Kim","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0043","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/FBP.0000000000000529","article-title":"Pain and stress: functional evidence that supra-spinal mechanisms involved in pain-induced analgesia mediate stress-induced analgesia","volume":"31","author":"Tobaldini","year":"2020","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0044","series-title":"Functions of the nervous system Vol. 1: autonomic functions","author":"Monnier","year":"1968"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0045","series-title":"Society for Neuroscience Annual Conference. 235.06\/DD10","article-title":"fMRI representation of erotic vs non-erotic genital self- stimulation; attenuation during the post-orgasmic refractory period in men","author":"Allen","year":"2016"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0046","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/01614576.1998.11074222","article-title":"Male multiple ejaculatory orgasms: a case study","volume":"23","author":"Whipple","year":"1998","journal-title":"J Sex Educ Ther"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0047","first-page":"349","article-title":"Opakovan\u00fd orgasmus u zen [Multiple orgasms in women]","volume":"89","author":"Kratochv\u00edl","year":"1993","journal-title":"Cesk Psychiatr"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0048","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.sxmr.2015.12.004","article-title":"Multiple orgasms in men-what we know so far","volume":"4","author":"Wibowo","year":"2016","journal-title":"Sex Med Rev"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0049","series-title":"Sexual behavior in the human female","author":"Kinsey","year":"1953"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF01541349","article-title":"Voluntary vaginal musculature contractions as an enhancer of sexual arousal","volume":"14","author":"Mess\u00e9","year":"1985","journal-title":"Arch Sex Behav"},{"issue":"Suppl 1","key":"10.1016\/j.sxmr.2022.07.001_bib0051","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/00926230252851230","article-title":"Neurophysiology and pharmacology of female genital sexual response","volume":"28","author":"Giuliano","year":"2002","journal-title":"J Sex Marital Ther"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0052","first-page":"173","article-title":"Women's orgasm","volume":"15","author":"Meston","year":"2004","journal-title":"Annu Rev Sex Res"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0053","doi-asserted-by":"crossref","first-page":"32578","DOI":"10.3402\/snp.v6.32578","article-title":"The whole versus the sum of some of the parts: toward resolving the apparent controversy of clitoral versus vaginal orgasms","volume":"6","author":"Pfaus","year":"2016","journal-title":"Socio Affect Neurosci Psychol"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0054","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/00224499.2018.1531367","article-title":"Body movement is associated with orgasm during vaginal intercourse in women","volume":"56","author":"Bischof-Campbell","year":"2019","journal-title":"J Sex Res"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0055","series-title":"The Waking Brain","author":"Magoun","year":"1958"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0056","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF01542242","article-title":"Written descriptions of orgasm: a study of sex differences","volume":"5","author":"Vance","year":"1976","journal-title":"Arch Sex Behav"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0057","series-title":"The science of orgasm","author":"Komisaruk","year":"2006"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0058","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1152\/jn.00979.2001","article-title":"Windup of flexion reflexes in chronic human spinal cord injury: a marker for neuronal plateau potentials?","volume":"89","author":"Hornby","year":"2003","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0059","doi-asserted-by":"crossref","first-page":"6146","DOI":"10.3390\/ijms20246146","article-title":"Windup of nociceptive flexion reflex depends on synaptic and intrinsic properties of dorsal horn neurons in adult rats","volume":"20","author":"Aby","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0060","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1136\/jnnp.56.5.548","article-title":"Anorgasmia in anterior spinal cord syndrome","volume":"56","author":"Beri\u0107","year":"1993","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0061","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.brainresrev.2007.05.010","article-title":"The somatosensory system, with emphasis on structures important for pain","volume":"55","author":"Willis","year":"2007","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0062","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0987-7053(00)00227-6","article-title":"Functional imaging of brain responses to pain. A review and meta-analysis (2000)","volume":"30","author":"Peyron","year":"2000","journal-title":"Neurophysiol Clin"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0063","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.brainres.2004.07.029","article-title":"Brain activation during vaginocervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by the vagus nerves","volume":"1024","author":"Komisaruk","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0064","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.jsxm.2017.08.014","article-title":"Brain Activity Unique to Orgasm in Women: An fMRI Analysis","volume":"14","author":"Wise","year":"2017","journal-title":"J Sex Med"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0065","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0304-3959(83)90205-1","article-title":"Spinal cord monoamines modulate the antinociceptive effects of vaginal stimulation in rats","volume":"16","author":"Steinman","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0066","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01542589","article-title":"Physiological correlates of imagery-induced orgasm in women","volume":"21","author":"Whipple","year":"1992","journal-title":"Arch Sex Behav"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0067","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/1073858417734530","article-title":"GABA-from inhibition to cognition: emerging concepts","volume":"24","author":"Schmidt-Wilcke","year":"2018","journal-title":"Neuroscientist"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0068","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jsxm.2022.03.217","article-title":"Functional magnetic resonance imaging studies in sexual medicine: a primer","volume":"19","author":"Mills-Finnerty","year":"2022","journal-title":"J Sex Med"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0069","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/14681994.2011.649252","article-title":"Non-genital orgasms","volume":"26","author":"Komisaruk","year":"2011","journal-title":"Sexual and Relationship Therapy"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0070","series-title":"Diagnostic and statisticalmanual of mental disorders DSM 4 TR (text revision)","year":"2003"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0071","series-title":"Diagnostic and statistical manual of mental disorders, Fifth edition","first-page":"433","year":"2013"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0072","unstructured":"Scheaffer H. Female Orgasmic Disorder DSM-5 302.73 (F52.31). Therapedia. 2022. Available at: https:\/\/www.theravive.com\/therapedia\/female-orgasmic-disorder-dsm-5-302.73-(f52.31)"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0073","article-title":"DSM-5 changes in diagnostic criteria of sexual dysfunctions","volume":"2","author":"IsHak","year":"2013","journal-title":"Reprod Sys Sex Disord"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0074","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11930-016-0066-1","article-title":"Why the sexual tipping point model?","volume":"8","author":"Perelman","year":"2016","journal-title":"Curr Sex Health Rep"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0075","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11930-018-0148-3","article-title":"Why the Sexual Tipping Point is a \u201cvariable switch model\u201d","volume":"10","author":"Perelman","year":"2018","journal-title":"Curr Sex Health Rep"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0076","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/j.1743-6109.2009.01309.x","article-title":"Pathways of sexual desire","volume":"6","author":"Pfaus","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0077","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.clinpsy.3.022806.091507","article-title":"Sexual dysfunctions in women","volume":"3","author":"Meston","year":"2007","journal-title":"Annu Rev Clin Psychol"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0078","unstructured":"Goldstein I. Orgasmic Anhedonia (PDOD). Available at: https:\/\/www.sandiegosexualmedicine.com\/female-issues\/orgasmic-anhedonia-pdod. Accessed August 24, 2022."},{"key":"10.1016\/j.sxmr.2022.07.001_bib0079","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.apnu.2013.02.001","article-title":"Anhedonia: a concept analysis","volume":"27","author":"Ho","year":"2013","journal-title":"Arch Psychiatr Nurs"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0080","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1743-6109.2011.02533.x","article-title":"Specificity of anhedonic depression and anxious arousal with sexual problems among sexually healthy young adults","volume":"9","author":"Kalmbach","year":"2012","journal-title":"J Sex Med"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0081","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2021.102825","article-title":"neuronal mapping of anhedonia across psychiatric diagnoses: A transdiagnostic neuroimaging analysis","volume":"32","author":"Schaub","year":"2021","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0082","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.biopsych.2005.05.019","article-title":"The neuronal correlates of anhedonia in major depressive disorder","volume":"58","author":"Keedwell","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0083","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.741794","article-title":"Pharmacological Characterization of Toludesvenlafaxine as a Triple Reuptake Inhibitor","volume":"12","author":"Zhu","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0084","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pnpbp.2019.01.002","article-title":"Pharmacological interventions targeting anhedonia in patients with major depressive disorder: a systematic review","volume":"92","author":"Cao","year":"2019","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0085","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1177\/0269881113494104","article-title":"Anhedonia revisited: is there a role for dopamine-targeting drugs for depression?","volume":"27","author":"Argyropoulos","year":"2013","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0086","doi-asserted-by":"crossref","first-page":"291","DOI":"10.31887\/DCNS.2008.10.3\/pgorwood","article-title":"Neurobiological mechanisms of anhedonia","volume":"10","author":"Gorwood","year":"2008","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0087","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1111\/jsm.12980","article-title":"Effect of Vortioxetine vs. Escitalopram on Sexual Functioning in Adults with Well-Treated Major Depressive Disorder Experiencing SSRI-Induced Sexual Dysfunction","volume":"12","author":"Jacobsen","year":"2015","journal-title":"J Sex Med"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0088","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.sxmr.2019.09.002","article-title":"Management options for premature ejaculation and delayed ejaculation in men","volume":"8","author":"Martin-Tuite","year":"2020","journal-title":"Sex Med Rev"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0089","first-page":"8","article-title":"Persistent genital arousal disorder: what it is and what it isn't","volume":"40","author":"Leiblum","year":"2006","journal-title":"Contemp Sex"},{"key":"10.1016\/j.sxmr.2022.07.001_bib0090","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1111\/j.1743-6109.2012.02765.x","article-title":"Prevalence of sacral spinal (Tarlov) cysts in persistent genital arousal disorder","volume":"9","author":"Komisaruk","year":"2012","journal-title":"J Sex Med"}],"container-title":["Sexual Medicine Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2050052122000634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2050052122000634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T14:38:23Z","timestamp":1672756703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2050052122000634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":90,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S2050052122000634"],"URL":"https:\/\/doi.org\/10.1016\/j.sxmr.2022.07.001","relation":{},"ISSN":["2050-0521"],"issn-type":[{"value":"2050-0521","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Orgasm and Related Disorders Depend on Neural Inhibition Combined With Neural Excitation","name":"articletitle","label":"Article Title"},{"value":"Sexual Medicine Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sxmr.2022.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022, International Society of Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}