{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:50:03Z","timestamp":1788457803505,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T00:00:00Z","timestamp":1699747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010261","name":"Fok Ying Tung Education Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011198","name":"State Key Laboratory of Drug Research, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270192"],"award-info":[{"award-number":["32270192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903526"],"award-info":[{"award-number":["81903526"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991523"],"award-info":[{"award-number":["81991523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072240"],"award-info":[{"award-number":["82072240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011199","name":"State Key Laboratory of Microbial Resources, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["SKLMR-20220704"],"award-info":[{"award-number":["SKLMR-20220704"]}],"id":[{"id":"10.13039\/501100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["SIMM2205KF"],"award-info":[{"award-number":["SIMM2205KF"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011513","name":"State Key Laboratory of Bioreactor Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003021","name":"East China University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013152","name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007956","name":"Nanjing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Synthetic and Systems Biotechnology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.synbio.2023.11.003","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T21:58:14Z","timestamp":1700690294000},"page":"749-756","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Heterologous biosynthesis of medicarpin using engineered Saccharomyces cerevisiae"],"prefix":"10.1016","volume":"8","author":[{"given":"Chujie","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5912-6108","authenticated-orcid":false,"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-6966","authenticated-orcid":false,"given":"Wei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.synbio.2023.11.003_bib1","article-title":"Metabolites of medicarpin and their distributions in rats","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.synbio.2023.11.003_bib2","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1021\/acs.jnatprod.7b00741","article-title":"Total synthesis of (+)-medicarpin","volume":"80","author":"Yang","year":"2017","journal-title":"J Nat Prod"},{"key":"10.1016\/j.synbio.2023.11.003_bib3","first-page":"786","article-title":"Determination of eight active components in Radix Hedysari by HPLC and its cluster analysis","volume":"51","author":"Liu","year":"2016","journal-title":"Acta Pharm Sin"},{"key":"10.1016\/j.synbio.2023.11.003_bib4","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1021\/jf061335o","article-title":"Quantification and stability studies on the flavonoids of Radix hedysari","volume":"54","author":"Liu","year":"2006","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.synbio.2023.11.003_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.5483\/BMBRep.2018.51.5.228","article-title":"Medicarpin induces lipolysis via activation of Protein Kinase A in brown adipocytes","volume":"51","author":"Imran","year":"2018","journal-title":"BMB Rep"},{"key":"10.1016\/j.synbio.2023.11.003_bib6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/biof.1392","article-title":"A pivotal role of AMPK signaling in medicarpin-mediated formation of brown and beige","volume":"44","author":"Imran","year":"2018","journal-title":"Biofactors"},{"key":"10.1016\/j.synbio.2023.11.003_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106299","article-title":"Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines","volume":"82","author":"Mansoori","year":"2020","journal-title":"Int Immunopharm"},{"key":"10.1016\/j.synbio.2023.11.003_bib8","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s12272-011-0603-4","article-title":"A new phenolic compound with anticancer activity from the wood of Millettia leucantha","volume":"34","author":"Rayanil","year":"2011","journal-title":"Arch Pharm Res (Seoul)"},{"key":"10.1016\/j.synbio.2023.11.003_bib9","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.phymed.2015.09.005","article-title":"Medicarpin and millepurpan, two flavonoids isolated from Medicago sativa, induce apoptosis and overcome multidrug resistance in leukemia P388 cells","volume":"22","author":"Gatouillat","year":"2015","journal-title":"Phytomedicine"},{"key":"10.1016\/j.synbio.2023.11.003_bib10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1023\/A:1010618606776","article-title":"Functional expression and subcellular localization of the Nectria haematococca Mak1 phytoalexin detoxification enzyme in transgenic tobacco","volume":"46","author":"Mundodi","year":"2001","journal-title":"Plant Mol Biol"},{"key":"10.1016\/j.synbio.2023.11.003_bib11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12272-011-0206-0","article-title":"In vitro Sortase A inhibitory and antimicrobial activity of flavonoids isolated from the roots of Sophora flavescens","volume":"34","author":"Oh","year":"2011","journal-title":"Arch Pharm Res (Seoul)"},{"key":"10.1016\/j.synbio.2023.11.003_bib12","doi-asserted-by":"crossref","first-page":"15274","DOI":"10.1021\/acsomega.1c01590","article-title":"Antigonococcal activity of (+)-medicarpin","volume":"6","author":"Williams","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.synbio.2023.11.003_bib13","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.3390\/molecules190913027","article-title":"Structures of new phenolics isolated from licorice, and the effectiveness of licorice phenolics on vancomycin-resistant Enterococci","volume":"19","author":"Eerdunbayaer","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.synbio.2023.11.003_bib14","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1248\/cpb.42.1056","article-title":"Chemical studies of Chinese licorice-roots.I. elucidation of five new flavonoid constituents from the roots of Glycyrrhiza glabra L. collected in Xinjiang","volume":"42","author":"Kitagawa","year":"1994","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.synbio.2023.11.003_bib15","first-page":"182","article-title":"Optimal temperature and salt conditions for germination of Glycyrrhiza glabra L. seed","volume":"45","author":"Zhang","year":"2017","journal-title":"Journal of Northwest A & F University Natural Science Edition"},{"key":"10.1016\/j.synbio.2023.11.003_bib16","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1039\/c2ob25722j","article-title":"Synthesis, optical resolution, absolute configuration, and osteogenic activity of cis-pterocarpans","volume":"10","author":"Goel","year":"2012","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.synbio.2023.11.003_bib17","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1039\/jr9650001034","article-title":"A synthesis of demethylhomopterocarpin","author":"Cocker","year":"1965","journal-title":"J Chem Soc"},{"key":"10.1016\/j.synbio.2023.11.003_bib18","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature12051","article-title":"High-level semi-synthetic production of the potent antimalarial artemisinin","volume":"496","author":"Paddon","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.synbio.2023.11.003_bib19","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nature04640","article-title":"Production of the antimalarial drug precursor artemisinic acid in engineered yeast","volume":"440","author":"Ro","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.synbio.2023.11.003_bib20","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.3390\/ijms16023035","article-title":"Transcriptome analysis of methyl jasmonate-elicited Panax ginseng adventitious roots to discover putative ginsenoside biosynthesis and transport genes","volume":"16","author":"Cao","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.synbio.2023.11.003_bib21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12870-015-0527-0","article-title":"Comprehensive analysis of Panax ginseng root transcriptomes","volume":"15","author":"Jayakodi","year":"2015","journal-title":"BMC Plant Biol"},{"key":"10.1016\/j.synbio.2023.11.003_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12864-015-1477-5","article-title":"Transcriptome analysis of leaves, roots and flowers of Panax notoginseng identifies genes involved in ginsenoside and alkaloid biosynthesis","volume":"16","author":"Liu","year":"2015","journal-title":"BMC Genom"},{"key":"10.1016\/j.synbio.2023.11.003_bib23","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/bab.1649","article-title":"Advances in ginsenoside biosynthesis and metabolic regulation","volume":"65","author":"Lu","year":"2018","journal-title":"Biotechnol Appl Biochem"},{"key":"10.1016\/j.synbio.2023.11.003_bib24","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2174\/1389201021666200807113723","article-title":"Ginseng omics for ginsenoside biosynthesis","volume":"22","author":"Yin","year":"2021","journal-title":"Curr Pharmaceut Biotechnol"},{"key":"10.1016\/j.synbio.2023.11.003_bib25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biotechadv.2018.11.005","article-title":"Flavonoid biosynthetic pathways in plants: versatile targets for metabolic engineering","volume":"38","author":"Nabavi","year":"2020","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.synbio.2023.11.003_bib26","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.1021\/acs.jafc.9b01329","article-title":"Metabolic engineering of Saccharomyces cerevisiae for de novo production of kaempferol","volume":"67","author":"Lyu","year":"2019","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.synbio.2023.11.003_bib27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ymben.2022.01.011","article-title":"High efficient production of plant flavonoids by microbial cell factories: challenges and opportunities","volume":"70","author":"Sun","year":"2022","journal-title":"Metab Eng"},{"key":"10.1016\/j.synbio.2023.11.003_bib28","doi-asserted-by":"crossref","first-page":"5521","DOI":"10.1021\/acs.chemrev.2c00403","article-title":"Metabolic engineering: methodologies and applications","volume":"123","author":"Volk","year":"2022","journal-title":"Chem Rev"},{"key":"10.1016\/j.synbio.2023.11.003_bib29","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/tpj.14409","article-title":"Functional specialization of UDP-glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin","volume":"99","author":"Nomura","year":"2019","journal-title":"Plant J"},{"key":"10.1016\/j.synbio.2023.11.003_bib30","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.apsb.2019.07.005","article-title":"De novo biosynthesis of liquiritin in Saccharomyces cerevisiae","volume":"10","author":"Yin","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.synbio.2023.11.003_bib31","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1038\/s41467-021-26361-1","article-title":"De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories","volume":"12","author":"Liu","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.synbio.2023.11.003_bib32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0014-5793(94)01267-9","article-title":"The 'pterocarpan synthase' of alfalfa: association and co-induction of vestitone reductase and 7,2'-dihydroxy-4'-methoxy-isoflavanol (DMI) dehydratase, the two final enzymes in medicarpin biosynthesis","volume":"356","author":"Guo","year":"1994","journal-title":"FEBS Lett"},{"key":"10.1016\/j.synbio.2023.11.003_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218148","article-title":"Utilizing PacBio Iso-Seq for novel transcript and gene discovery of abiotic stress responses in Oryza sativa L","volume":"21","author":"Schaarschmidt","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.synbio.2023.11.003_bib34","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1080\/13880209.2019.1680706","article-title":"Transcriptome sequencing of Salvia miltiorrhiza after infection by its endophytic fungi and identification of genes related to tanshinone biosynthesis","volume":"57","author":"Jiang","year":"2019","journal-title":"Pharm Biol"},{"key":"10.1016\/j.synbio.2023.11.003_bib35","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.ygeno.2018.06.004","article-title":"Genome-wide transcriptome profiling of the medicinal plant Zanthoxylum planispinum using a single-molecule direct RNA sequencing approach","volume":"111","author":"Kim","year":"2019","journal-title":"Genomics"},{"key":"10.1016\/j.synbio.2023.11.003_bib36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13007-020-00629-x","article-title":"Analysis and comprehensive comparison of PacBio and nanopore-based RNA sequencing of the Arabidopsis transcriptome","volume":"16","author":"Cui","year":"2020","journal-title":"Plant Methods"},{"key":"10.1016\/j.synbio.2023.11.003_bib37","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1046\/j.1365-313X.2003.01893.x","article-title":"Regiospecic hydroxylation of isoavones by cytochrome P450 81E enzymes from Medicago truncatula","volume":"36","author":"Liu","year":"2003","journal-title":"Plant J"},{"key":"10.1016\/j.synbio.2023.11.003_bib38","article-title":"CRISPR\/Cas9: a molecular swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae","volume":"32","author":"Mans","year":"2015","journal-title":"Yeast"},{"key":"10.1016\/j.synbio.2023.11.003_bib39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ymben.2012.01.006","article-title":"Microbial production of indolylglucosinolate through engineering of a multi-gene pathway in a versatile yeast expression platform","volume":"14","author":"Mikkelsen","year":"2012","journal-title":"Metab Eng"},{"key":"10.1016\/j.synbio.2023.11.003_bib40","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s13205-021-02646-6","article-title":"De novo RNA sequencing and analysis reveal the putative genes involved in diterpenoid biosynthesis in Aconitum vilmorinianum roots","volume":"11","author":"Li","year":"2021","journal-title":"3 Biotech"},{"key":"10.1016\/j.synbio.2023.11.003_bib41","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s12870-018-1505-0","article-title":"Comparative transcriptome analysis of roots, stems and leaves of Isodon amethystoides reveals candidate genes involved in Wangzaozins biosynthesis","volume":"18","author":"Zhao","year":"2018","journal-title":"BMC Plant Biol"},{"key":"10.1016\/j.synbio.2023.11.003_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22122155","article-title":"De novo RNA sequencing and expression analysis of Aconitum carmichaelii to analyze key genes involved in the biosynthesis of diterpene alkaloids","volume":"22","author":"Rai","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.synbio.2023.11.003_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-36316-0","article-title":"Deep sequencing and transcriptome analysis to identify genes related to biosynthesis of aristolochic acid in Asarum heterotropoides","volume":"8","author":"Wang","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.synbio.2023.11.003_bib44","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.fitote.2013.07.003","article-title":"Phytochemistry and biological properties of glabridin","volume":"90","author":"Simmler","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.synbio.2023.11.003_bib45","first-page":"161","article-title":"Determination of glabridin in cosmetic by UHPLC-MS\/MS method","volume":"51","author":"Dong","year":"2021","journal-title":"China Surfactant Detergent & Cosmetics"},{"key":"10.1016\/j.synbio.2023.11.003_bib46","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1248\/yakushi1947.111.6_311","article-title":"Phenolic constituents of licorice. IV. Correlation of phenolic constituents and licorice specimens from various sources, and inhibitory effects of licorice extracts on xanthine oxidase and monoamine oxidase","volume":"111","author":"Hatano","year":"1991","journal-title":"Yakugaku Zasshi : J Pharm Soc Jpn"},{"key":"10.1016\/j.synbio.2023.11.003_bib47","first-page":"692","article-title":"Study on the preparation technology of isoflavon glabridin from Glycyrrhiza glabra L","volume":"30","author":"Ma","year":"2007","journal-title":"Journal of Xinjiang Medical University"},{"key":"10.1016\/j.synbio.2023.11.003_bib48","first-page":"10","article-title":"The application, extraction and separation and preparation methods for glabridin","volume":"50","author":"Wang","year":"2020","journal-title":"Fine Chem Intermed"},{"key":"10.1016\/j.synbio.2023.11.003_bib49","first-page":"74","article-title":"Determination of glabridin in different species of Glycyrrhiza by HPLC","volume":"33","author":"Wang","year":"2011","journal-title":"Hubei Journal of TCM"},{"key":"10.1016\/j.synbio.2023.11.003_bib50","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.chroma.2008.07.072","article-title":"Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice)","volume":"1216","author":"Zhang","year":"2009","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.synbio.2023.11.003_bib51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/pcp\/pcg034","article-title":"cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4 '-trihydroxyisoflavanone 4 '-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway","volume":"44","author":"Akashi","year":"2003","journal-title":"Plant Cell Physiol"},{"key":"10.1016\/j.synbio.2023.11.003_bib52","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1105\/tpc.010382","article-title":"Elicitor-induced association of isoflavone O-methyltransferase with endomembranes prevents the formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis","volume":"13","author":"Liu","year":"2001","journal-title":"Plant Cell"},{"key":"10.1016\/j.synbio.2023.11.003_bib53","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/0031-9422(88)80455-2","article-title":"Flavonoid and other constituents of bauhinia manca","volume":"27","author":"Achenbach","year":"1988","journal-title":"Phytochemistry"},{"key":"10.1016\/j.synbio.2023.11.003_bib54","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/bmc.3160","article-title":"Effect of liquiritin on human intestinal bacteria growth: metabolism and modulation","volume":"28","author":"Zhang","year":"2014","journal-title":"Biomed Chromatogr"},{"key":"10.1016\/j.synbio.2023.11.003_bib55","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0003-9861(95)90019-5","article-title":"Molecular cloning and expression of alfalfa (Medicago sativa L.) vestitone reductase, the penultimate enzyme in medicarpin biosynthesis","volume":"320","author":"Guo","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.synbio.2023.11.003_bib56","doi-asserted-by":"crossref","first-page":"9775","DOI":"10.3390\/molecules16129775","article-title":"Antibacterial activity of the flavonoids from dalbergia odorifera on Ralstonia solanacearum","volume":"16","author":"Zhao","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.synbio.2023.11.003_bib57","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/pcp\/pcw213","article-title":"The missing link in leguminous pterocarpan biosynthesis is a dirigent domain-containing protein with isoflavanol dehydratase activity","volume":"58","author":"Uchida","year":"2017","journal-title":"Plant Cell Physiol"},{"key":"10.1016\/j.synbio.2023.11.003_bib58","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ces.2020.116177","article-title":"Metabolic engineering of Yarrowia lipolytica for liquiritigenin production","volume":"230","author":"Akram","year":"2021","journal-title":"Chem Eng Sci"},{"key":"10.1016\/j.synbio.2023.11.003_bib59","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.biortech.2017.06.043","article-title":"Metabolic engineering of yeast for fermentative production of flavonoids","volume":"245","author":"Rodriguez","year":"2017","journal-title":"Bioresour Technol"}],"container-title":["Synthetic and Systems Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405805X2300090X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405805X2300090X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:03:22Z","timestamp":1762506202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405805X2300090X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S2405805X2300090X"],"URL":"https:\/\/doi.org\/10.1016\/j.synbio.2023.11.003","relation":{},"ISSN":["2405-805X"],"issn-type":[{"value":"2405-805X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heterologous biosynthesis of medicarpin using engineered Saccharomyces cerevisiae","name":"articletitle","label":"Article Title"},{"value":"Synthetic and Systems Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.synbio.2023.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}