{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:08:27Z","timestamp":1791839307264,"version":"4.3.4"},"reference-count":106,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["101000441"],"award-info":[{"award-number":["101000441"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["FWF W1224"],"award-info":[{"award-number":["FWF W1224"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["- DOI 10.55776\/M2891"],"award-info":[{"award-number":["- DOI 10.55776\/M2891"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["- DOI 10.55776\/I6795"],"award-info":[{"award-number":["- DOI 10.55776\/I6795"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004955","name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015053","name":"Amt der N\u00d6 Landesregierung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019730","name":"Technology Agency of the City of Vienna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012416","name":"Bundesministerium f\u00fcr Digitalisierung und Wirtschaftsstandort","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007945","name":"Steirische Wirtschaftsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011035","name":"Standortagentur Tirol","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Synthetic and Systems Biotechnology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.synbio.2024.03.003","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T12:56:06Z","timestamp":1710161766000},"page":"322-329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Single carbon metabolism \u2013 A new paradigm for microbial bioprocesses?"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-6002","authenticated-orcid":false,"given":"Michael","family":"Baumschabl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-2039","authenticated-orcid":false,"given":"\u00d6zge","family":"Ata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diethard","family":"Mattanovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.synbio.2024.03.003_bib1","unstructured":"US Department of Commerce NGML. n.d. Global monitoring laboratory - carbon cycle greenhouse gases.."},{"key":"10.1016\/j.synbio.2024.03.003_bib2","series-title":"Report of the conference of the parties on its twenty-first session, held in Paris from 30 november to 13 december 2015, addendum-part two: action taken by the conference of the parties","year":"2015"},{"key":"10.1016\/j.synbio.2024.03.003_bib3","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.respol.2018.10.001","article-title":"Biotechnology as a new techno-economic paradigm that will help drive the world economy and mitigate climate change","volume":"48","author":"Tylecote","year":"2019","journal-title":"Res Pol"},{"key":"10.1016\/j.synbio.2024.03.003_bib4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jbiotec.2016.07.022","article-title":"The flexible feedstock concept in Industrial Biotechnology: metabolic engineering of Escherichia coli, Corynebacterium glutamicum, Pseudomonas, Bacillus and yeast strains for access to alternative carbon sources","volume":"234","author":"Wendisch","year":"2016","journal-title":"J Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11274-016-2060-1","article-title":"Updates on industrial production of amino acids using Corynebacterium glutamicum","volume":"32","author":"Wendisch","year":"2016","journal-title":"World J Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib6","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.ijhydene.2021.10.122","article-title":"A comprehensive review on lignocellulosic biomass biorefinery for sustainable biofuel production","volume":"47","author":"Rodionova","year":"2022","journal-title":"Int J Hydrogen Energy"},{"key":"10.1016\/j.synbio.2024.03.003_bib7","series-title":"Ullmann's encyclopedia of industrial chemistry","article-title":"Methanol","author":"Ott","year":"2012"},{"key":"10.1016\/j.synbio.2024.03.003_bib8","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.matpr.2021.12.164","article-title":"Life cycle assessment of methanol production by natural gas route","volume":"57","author":"Sutar","year":"2022","journal-title":"Mater Today Proc"},{"key":"10.1016\/j.synbio.2024.03.003_bib9","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.apenergy.2015.07.067","article-title":"Methanol synthesis using captured CO2 as raw material: techno-economic and environmental assessment","volume":"161","author":"P\u00e9rez-Fortes","year":"2016","journal-title":"Appl Energy"},{"key":"10.1016\/j.synbio.2024.03.003_bib10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jcou.2018.02.007","article-title":"Improving methanol synthesis from carbon-free H2 and captured CO2: a techno-economic and environmental evaluation","volume":"24","author":"Szima","year":"2018","journal-title":"J CO2 Util"},{"key":"10.1016\/j.synbio.2024.03.003_bib11","doi-asserted-by":"crossref","first-page":"25929","DOI":"10.1016\/j.ijhydene.2022.01.124","article-title":"Economic accounting and high-tech strategy for sustainable production: a case study of methanol production from CO2 hydrogenation","volume":"47","author":"Su","year":"2022","journal-title":"Int J Hydrogen Energy"},{"key":"10.1016\/j.synbio.2024.03.003_bib12","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1021\/acs.iecr.7b03514","article-title":"General techno-economic analysis of CO2 electrolysis systems","volume":"57","author":"Jouny","year":"2018","journal-title":"Ind Eng Chem Res"},{"key":"10.1016\/j.synbio.2024.03.003_bib13","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/ce\/zkac007","article-title":"Analysis of routes for electrochemical conversion of CO2 to methanol","volume":"6","author":"Li","year":"2022","journal-title":"Clean Energy"},{"key":"10.1016\/j.synbio.2024.03.003_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3184\/003685011X13044430633960","article-title":"How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathway","volume":"94","author":"Anthony","year":"2011","journal-title":"Sci Prog"},{"key":"10.1016\/j.synbio.2024.03.003_bib15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1271\/bbb.70.10","article-title":"The physiological role of the ribulose monophosphate pathway in bacteria and archaea","volume":"70","author":"Kato","year":"2006","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.synbio.2024.03.003_bib16","article-title":"Systems-level organization of yeast methylotrophic lifestyle","volume":"13:80","author":"Ru\u00dfmayer","year":"2015","journal-title":"BMC Biol"},{"key":"10.1016\/j.synbio.2024.03.003_bib17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.copbio.2015.01.007","article-title":"Synthetic methylotrophy: engineering the production of biofuels and chemicals based on the biology of aerobic methanol utilization","volume":"33","author":"Whitaker","year":"2015","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib18","doi-asserted-by":"crossref","first-page":"102685","DOI":"10.1016\/j.copbio.2022.102685","article-title":"Methylotrophs: from C1 compounds to food","volume":"75","author":"Sakarika","year":"2022","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib19","article-title":"Advances in Komagataella phaffii engineering for the production of renewable chemicals and proteins","volume":"8:575","author":"Carneiro","year":"2022","journal-title":"Fermentation"},{"key":"10.1016\/j.synbio.2024.03.003_bib20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2217\/fmb.12.133","article-title":"Pichia pastoris: protein production host and model organism for biomedical research","volume":"8","author":"Gasser","year":"2013","journal-title":"Future Microbiol"},{"key":"10.1016\/j.synbio.2024.03.003_bib21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fbioe.2019.00094","article-title":"Advances in using Hansenula polymorpha as chassis for recombinant protein production","volume":"7","author":"Manfr\u00e3o-Netto","year":"2019","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12864-015-1393-8","article-title":"Pichia pastoris regulates its gene-specific response to different carbon sources at the transcriptional, rather than the translational, level","volume":"16","author":"Prielhofer","year":"2015","journal-title":"BMC Genom"},{"key":"10.1016\/j.synbio.2024.03.003_bib23","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.nbt.2012.11.010","article-title":"Regulation of Pichia pastoris promoters and its consequences for protein production","volume":"30","author":"Vogl","year":"2013","journal-title":"N Biotech"},{"key":"10.1016\/j.synbio.2024.03.003_bib24","doi-asserted-by":"crossref","first-page":"7754","DOI":"10.1038\/s41467-023-43610-7","article-title":"The oxygen-tolerant reductive glycine pathway assimilates methanol, formate and CO2 in the yeast Komagataella phaffii","volume":"14","author":"Mitic","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.synbio.2024.03.003_bib25","doi-asserted-by":"crossref","first-page":"foab009","DOI":"10.1093\/femsyr\/foab009","article-title":"Beyond alcohol oxidase: the methylotrophic yeast Komagataella phaffii utilizes methanol also with its native alcohol dehydrogenase Adh2","volume":"21","author":"Zavec","year":"2021","journal-title":"FEMS Yeast Res"},{"key":"10.1016\/j.synbio.2024.03.003_bib26","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/bit.27303","article-title":"Characterization of methanol utilization negative Pichia pastoris for secreted protein production: new cultivation strategies for current and future applications","volume":"117","author":"Zavec","year":"2020","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.synbio.2024.03.003_bib27","doi-asserted-by":"crossref","first-page":"1050740","DOI":"10.3389\/fbioe.2022.1050740","article-title":"Developing methylotrophic microbial platforms for a methanol-based bioindustry","volume":"10","author":"Singh","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.tibtech.2008.10.009","article-title":"Methanol-based industrial biotechnology: current status and future perspectives of methylotrophic bacteria","volume":"27","author":"Schrader","year":"2009","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib29","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ymben.2014.12.008","article-title":"Engineering Escherichia coli for methanol conversion","volume":"28","author":"M\u00fcller","year":"2015","journal-title":"Metab Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib30","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2020.07.010","article-title":"Converting Escherichia coli to a synthetic methylotroph growing solely on methanol","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.synbio.2024.03.003_bib31","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1038\/s41467-022-32744-9","article-title":"Generation of an Escherichia coli strain growing on methanol via the ribulose monophosphate cycle","volume":"13","author":"Keller","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.synbio.2024.03.003_bib32","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1038\/s41467-020-19235-5","article-title":"Methanol-dependent Escherichia coli strains with a complete ribulose monophosphate cycle","volume":"11","author":"Keller","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.synbio.2024.03.003_bib33","article-title":"Methanol-essential growth of Escherichia coli","volume":"9:1508","author":"Meyer","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.synbio.2024.03.003_bib34","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.biortech.2017.05.100","article-title":"Metabolic construction strategies for direct methanol utilization in Saccharomyces cerevisiae","volume":"245","author":"Dai","year":"2017","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.synbio.2024.03.003_bib35","article-title":"Adaptive laboratory evolution of native methanol assimilation in Saccharomyces cerevisiae","volume":"11:5564","author":"Espinosa","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.synbio.2024.03.003_bib36","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1021\/acssynbio.2c00110","article-title":"Toward methanol-based biomanufacturing: emerging strategies for engineering synthetic methylotrophy in Saccharomyces cerevisiae","volume":"11","author":"Kelso","year":"2022","journal-title":"ACS Synth Biol"},{"key":"10.1016\/j.synbio.2024.03.003_bib37","article-title":"Adaptive laboratory evolution enhances methanol tolerance and conversion in engineered Corynebacterium glutamicum","volume":"3:217","author":"Wang","year":"2020","journal-title":"Commun Biol"},{"key":"10.1016\/j.synbio.2024.03.003_bib38","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ymben.2018.07.011","article-title":"Engineering Corynebacterium glutamicum for methanol-dependent growth and glutamate production","volume":"49","author":"Tuyishime","year":"2018","journal-title":"Metab Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib39","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1128\/AEM.03110-14","article-title":"Metabolic engineering of Corynebacterium glutamicum for methanol metabolism","volume":"81","author":"Witthoff","year":"2015","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.synbio.2024.03.003_bib40","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1128\/JB.00228-08","article-title":"Formate as the main branch point for methylotrophic metabolism in Methylobacterium extorquens AM1","volume":"190","author":"Crowther","year":"2008","journal-title":"J Bacteriol"},{"key":"10.1016\/j.synbio.2024.03.003_bib41","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev.micro.091208.073600","article-title":"The expanding world of methylotrophic metabolism","volume":"63","author":"Chistoserdova","year":"2009","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.synbio.2024.03.003_bib42","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1038\/s41467-020-18906-7","article-title":"The reductive glycine pathway allows autotrophic growth of Desulfovibrio desulfuricans","volume":"11","author":"S\u00e1nchez-Andrea","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.synbio.2024.03.003_bib43","doi-asserted-by":"crossref","first-page":"7516","DOI":"10.1073\/pnas.1912289117","article-title":"Functional cooperation of the glycine synthasereductase and Wood-Ljungdahl pathways for autotrophic growth of Clostridium drakei","volume":"117","author":"Song","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.synbio.2024.03.003_bib44","doi-asserted-by":"crossref","DOI":"10.1007\/s00216-023-04786-5","article-title":"Tailored extraction and ion mobility-mass spectrometry enables isotopologue analysis of tetrahydrofolate vitamers","author":"Mitic","year":"2023","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.synbio.2024.03.003_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2023.123811","article-title":"Electrochemical reduction of CO2 into formate\/formic acid: a review of cell design and operation","volume":"316","author":"Ewis","year":"2023","journal-title":"Sep Purif Technol"},{"key":"10.1016\/j.synbio.2024.03.003_bib46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cogsc.2019.01.005","article-title":"Recent advances in industrial CO2 electroreduction","volume":"16","author":"S\u00e1nchez","year":"2019","journal-title":"Curr Opin Green Sustainable Chem"},{"key":"10.1016\/j.synbio.2024.03.003_bib47","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41589-020-0473-5","article-title":"Growth of E. coli on formate and methanol via the reductive glycine pathway","volume":"16","author":"Kim","year":"2020","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.synbio.2024.03.003_bib48","doi-asserted-by":"crossref","first-page":"1091899","DOI":"10.3389\/fbioe.2023.1091899","article-title":"coli as a formatotrophic platform for bioproduction via the reductive glycine pathway","volume":"11","author":"Kim","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib49","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ymben.2023.02.004","article-title":"Paving the way for synthetic C1 - metabolism in Pseudomonas putida through the reductive glycine pathway","volume":"76","author":"Bruinsma","year":"2023","journal-title":"Metab Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib50","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ymben.2022.10.008","article-title":"Integrated rational and evolutionary engineering of genome-reduced Pseudomonas putida strains promotes synthetic formate assimilation","volume":"74","author":"Turlin","year":"2022","journal-title":"Metab Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ymben.2023.11.007","article-title":"Engineering and evolution of the complete Reductive Glycine Pathway in Saccharomyces cerevisiae for formate and CO2 assimilation","volume":"81","author":"Bysani","year":"2024","journal-title":"Metab Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib52","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1021\/ja01636a012","article-title":"The path of carbon in photosynthesis. XXI. The cyclic regeneration of carbon dioxide acceptor 1","volume":"76","author":"Bassham","year":"1954","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.synbio.2024.03.003_bib53","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1073\/pnas.55.4.928","article-title":"A new ferredoxin-dependent carbon reduction cycle in a photosynthetic bacterium","volume":"55","author":"Evans","year":"1966","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.synbio.2024.03.003_bib54","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev.mi.40.100186.002215","article-title":"The autotrophic pathway of acetate synthesis in acetogenic bacteria","volume":"40","author":"Ljungdhal","year":"1986","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.synbio.2024.03.003_bib55","doi-asserted-by":"crossref","first-page":"20277","DOI":"10.1074\/jbc.M201030200","article-title":"A bicyclic autotrophic CO2 fixation pathway in Chloroflexus aurantiacus","volume":"277","author":"Herter","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.synbio.2024.03.003_bib56","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1126\/science.1149976","article-title":"A 3-hydroxypropionate\/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in archaea","volume":"318","author":"Berg","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.synbio.2024.03.003_bib57","doi-asserted-by":"crossref","first-page":"7851","DOI":"10.1073\/pnas.0801043105","article-title":"A dicarboxylate\/4-hydroxybutyrate autotrophic carbon assimilation cycle in the hyperthermophilic Archaeum Ignicoccus hospitalis","volume":"105","author":"Huber","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.synbio.2024.03.003_bib58","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.biortech.2018.02.039","article-title":"Sequestration and utilization of carbon dioxide by chemical and biological methods for biofuels and biomaterials by chemoautotrophs: opportunities and challenges","volume":"256","author":"Thakur","year":"2018","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.synbio.2024.03.003_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.rser.2021.111852","article-title":"Continuous cultivation of microalgae in photobioreactors as a source of renewable energy: current status and future challenges","volume":"154","author":"Peter","year":"2022","journal-title":"Renew Sustain Energy Rev"},{"key":"10.1016\/j.synbio.2024.03.003_bib60","article-title":"Gas Fermentation-A flexible platform for commercial scale production of low-carbon-fuels and chemicals from waste and renewable feedstocks","volume":"11:694","author":"Liew","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.synbio.2024.03.003_bib61","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.copbio.2017.12.021","article-title":"Technologies for the bioconversion of methane into more valuable products","volume":"50","author":"Cantera","year":"2018","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib62","article-title":"Recent trends in methane to bioproduct conversion by methanotrophs","volume":"53:107861","author":"G\u0119sicka","year":"2021","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.synbio.2024.03.003_bib63","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jenvman.2016.07.064","article-title":"Valorization of CH4 emissions into high-added-value products: assessing the production of ectoine coupled with CH4 abatement","volume":"182","author":"Cantera","year":"2016","journal-title":"J Environ Manag"},{"key":"10.1016\/j.synbio.2024.03.003_bib64","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41587-021-01195-w","article-title":"Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale","volume":"40","author":"Liew","year":"2022","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib65","doi-asserted-by":"crossref","first-page":"8777","DOI":"10.3390\/ijms21228777","article-title":"Microbial upgrading of acetate into value-added products\u2014examining microbial diversity, bioenergetic constraints and metabolic engineering approaches","volume":"21","author":"Kutscha","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.synbio.2024.03.003_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2020.124573","article-title":"Blending industrial blast furnace gas with H2 enables Acetobacterium woodii to efficiently co-utilize CO, CO2 and H2","volume":"323","author":"Novak","year":"2021","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.synbio.2024.03.003_bib67","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13068-020-01816-7","article-title":"Microbial upgrading of acetate into 2,3-butanediol and acetoin by E. coli W","volume":"13","author":"Novak","year":"2020","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.synbio.2024.03.003_bib68","doi-asserted-by":"crossref","first-page":"8889","DOI":"10.1073\/pnas.0907176107","article-title":"Design and analysis of synthetic carbon fixation pathways","volume":"107","author":"Bar-Even","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.synbio.2024.03.003_bib69","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3389\/fbioe.2019.00446","article-title":"Synthetic biology applied to carbon conservative and carbon dioxide recycling pathways","volume":"7","author":"Fran\u00e7ois","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib70","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jare.2022.07.011","article-title":"Natural carbon fixation and advances in synthetic engineering for redesigning and creating new fixation pathways","volume":"47","author":"Santos Correa","year":"2023","journal-title":"J Adv Res"},{"key":"10.1016\/j.synbio.2024.03.003_bib71","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ymben.2019.09.001","article-title":"Systematic design and in vitro validation of novel one-carbon assimilation pathways","volume":"56","author":"Yang","year":"2019","journal-title":"Metab Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib72","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cell.2016.05.064","article-title":"Sugar synthesis from CO2 in Escherichia coli","volume":"166","author":"Antonovsky","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.synbio.2024.03.003_bib73","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ymben.2021.11.007","article-title":"Adaptive laboratory evolution and reverse engineering enhances autotrophic growth in Pichia pastoris","volume":"69","author":"Gassler","year":"2022","journal-title":"Metab Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib74","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41587-019-0363-0","article-title":"The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO2","volume":"38","author":"Gassler","year":"2020","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib75","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cell.2019.11.009","article-title":"Conversion of Escherichia coli to generate all biomass carbon from CO2","volume":"179","author":"Gleizer","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.synbio.2024.03.003_bib76","article-title":"The genetic basis for the adaptation of E. coli to sugar synthesis from CO2","volume":"8:1709","author":"Herz","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.synbio.2024.03.003_bib77","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2211827119","article-title":"Conversion of CO2 into organic acids by engineered autotrophic yeast","volume":"119","author":"Baumschabl","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.synbio.2024.03.003_bib78","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.egypro.2019.02.183","article-title":"Commercially important bioproducts from microalgae and their current applications-A review","volume":"160","author":"Mobin","year":"2019","journal-title":"Energy Proc"},{"key":"10.1016\/j.synbio.2024.03.003_bib79","article-title":"Versatile applications of cyanobacteria in biotechnology","volume":"10:2318","author":"\u017byma\u0144czyk-Duda","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.synbio.2024.03.003_bib80","doi-asserted-by":"crossref","DOI":"10.1088\/1757-899X\/1142\/1\/012004","article-title":"Evolution of photobioreactors: a review based on microalgal perspective","volume":"1142","author":"Ahmad","year":"2021","journal-title":"IOP Conf Ser Mater Sci Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.algal.2019.101433","article-title":"Light management technologies for increasing algal photobioreactor efficiency","volume":"39","author":"Nwoba","year":"2019","journal-title":"Algal Res"},{"key":"10.1016\/j.synbio.2024.03.003_bib82","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1093\/nar\/gkr874","article-title":"EQuilibrator - the biochemical thermodynamics calculator","volume":"40","author":"Flamholz","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.synbio.2024.03.003_bib83","doi-asserted-by":"crossref","first-page":"711550","DOI":"10.3389\/fspas.2021.711550","article-title":"Towards a biomanufactory on mars","volume":"8","author":"Berliner","year":"2021","journal-title":"Front Astron Sp Sci"},{"key":"10.1016\/j.synbio.2024.03.003_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.128948","article-title":"Strategies to overcome mass transfer limitations of hydrogen during anaerobic gaseous fermentations: a comprehensive review","volume":"377","author":"Ale Enriquez","year":"2023","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.synbio.2024.03.003_bib85","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/10643389.2019.1631991","article-title":"Current achievements and the future direction of electrochemical CO2 reduction: a short review","volume":"50","author":"Lee","year":"2020","journal-title":"Crit Rev Environ Sci Technol"},{"key":"10.1016\/j.synbio.2024.03.003_bib86","doi-asserted-by":"crossref","first-page":"7950","DOI":"10.1038\/s41467-023-43762-6","article-title":"Accelerating CO2 electrochemical conversion towards industrial implementation","volume":"14","author":"Segets","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.synbio.2024.03.003_bib87","article-title":"Can we decarbonise methanol production by direct electrochemical CO2 reduction?","volume":"10:e202300068","author":"Sheppard","year":"2023","journal-title":"Chemelectrochem"},{"key":"10.1016\/j.synbio.2024.03.003_bib88","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1021\/acssuschemeng.2c05390","article-title":"Syngas from what? Comparative life-cycle assessment for syngas production from biomass, CO2, and steel mill off-gases","volume":"11","author":"Bachmann","year":"2023","journal-title":"ACS Sustainable Chem Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib89","article-title":"The potential of CO2-based production cycles in biotechnology to fight the climate crisis","volume":"14:6978","author":"Bachleitner","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.synbio.2024.03.003_bib90","article-title":"Recent advances in heterogeneous electroreduction of CO2 on copper-based catalysts","volume":"12:860","author":"Wu","year":"2022","journal-title":"Catalysts"},{"key":"10.1016\/j.synbio.2024.03.003_bib91","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1754-6834-7-99","article-title":"Exploring metabolic engineering design principles for the photosynthetic production of lactic acid by Synechocystis sp. PCC6803","volume":"7","author":"Angermayr","year":"2014","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.synbio.2024.03.003_bib92","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ymben.2021.06.010","article-title":"Engineering Cupriavidus necator H16 for the autotrophic production of (R)-1,3-butanediol","volume":"67","author":"Gascoyne","year":"2021","journal-title":"Metab Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.139668","article-title":"Bioconversion of carbon dioxide to succinate by Citrobacter","volume":"452","author":"Jin","year":"2023","journal-title":"Chem Eng J"},{"key":"10.1016\/j.synbio.2024.03.003_bib94","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jbiotec.2014.03.005","article-title":"Selective enhancement of autotrophic acetate production with genetically modified Acetobacterium woodii","volume":"178","author":"Straub","year":"2014","journal-title":"J Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib95","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s00253-022-11770-z","article-title":"Autotrophic lactate production from H2 + CO2 using recombinant and fluorescent FAST-tagged Acetobacterium woodii strains","volume":"106","author":"Mook","year":"2022","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib96","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13068-021-01966-2","article-title":"Production of the biocommodities butanol and acetone from methanol with fluorescent FAST-tagged proteins using metabolically engineered strains of Eubacterium limosum","volume":"14","author":"Flaiz","year":"2021","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.synbio.2024.03.003_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.125485","article-title":"Autotrophic (C1-gas) versus heterotrophic (fructose) accumulation of acetic acid and ethanol in Clostridium aceticum","volume":"337","author":"Arslan","year":"2021","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.synbio.2024.03.003_bib98","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ymben.2023.06.015","article-title":"Engineering the biological conversion of formate into crotonate in Cupriavidus necator","volume":"79","author":"Collas","year":"2023","journal-title":"Metab Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib99","doi-asserted-by":"crossref","first-page":"719","DOI":"10.9713\/kcer.2016.54.5.719","article-title":"Formatotrophic production of poly-\u03b2-hydroxybutyric acid (PHB) from Methylobacterium sp. using formate as the sole carbon and energy source","volume":"54","author":"Cho","year":"2016","journal-title":"Korean Chem Eng Res"},{"key":"10.1016\/j.synbio.2024.03.003_bib100","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s10295-018-2035-3","article-title":"A modular approach for high-flux lactic acid production from methane in an industrial medium using engineered Methylomicrobium buryatense 5GB1","volume":"45","author":"Garg","year":"2018","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbiotec.2006.06.003","article-title":"Enhancement of l-lysine production in methylotroph Methylophilus methylotrophus by introducing a mutant LysE exporter","volume":"127","author":"Gunji","year":"2006","journal-title":"J Biotechnol"},{"key":"10.1016\/j.synbio.2024.03.003_bib102","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1021\/acssuschemeng.3c00410","article-title":"Efficient bioproduction of 3-hydroxypropionic acid from methanol by a synthetic yeast cell factory","volume":"11","author":"Wu","year":"2023","journal-title":"ACS Sustainable Chem Eng"},{"key":"10.1016\/j.synbio.2024.03.003_bib103","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/bit.27575","article-title":"Metabolic engineering of Pichia pastoris for malic acid production from methanol","volume":"118","author":"Guo","year":"2021","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.synbio.2024.03.003_bib104","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2201711119","article-title":"Methanol biotransformation toward high-level production of fatty acid derivatives by engineering the industrial yeast Pichia pastoris","volume":"119","author":"Cai","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.synbio.2024.03.003_bib105","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s42255-022-00601-0","article-title":"Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol","volume":"4","author":"Gao","year":"2022","journal-title":"Nat Metab"},{"key":"10.1016\/j.synbio.2024.03.003_bib106","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1021\/acssynbio.1c00235","article-title":"Metabolic engineering of gas-fermenting Clostridium ljungdahlii for efficient Co-production of isopropanol, 3-hydroxybutyrate, and ethanol","volume":"10","author":"Jia","year":"2021","journal-title":"ACS Synth Biol"}],"container-title":["Synthetic and Systems Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405805X24000371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405805X24000371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:20:48Z","timestamp":1778523648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405805X24000371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":106,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S2405805X24000371"],"URL":"https:\/\/doi.org\/10.1016\/j.synbio.2024.03.003","relation":{},"ISSN":["2405-805X"],"issn-type":[{"value":"2405-805X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single carbon metabolism \u2013 A new paradigm for microbial bioprocesses?","name":"articletitle","label":"Article Title"},{"value":"Synthetic and Systems Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.synbio.2024.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}