{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:42:02Z","timestamp":1787640122999,"version":"build-2736575974"},"reference-count":63,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170057"],"award-info":[{"award-number":["32170057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Synthetic and Systems Biotechnology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.synbio.2025.03.012","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T05:33:21Z","timestamp":1744090401000},"page":"794-806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["A new paradigm for the regulation of A40926B0 biosynthesis"],"prefix":"10.1016","volume":"10","author":[{"given":"Yan-Qiu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Lei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Yu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6013-4068","authenticated-orcid":false,"given":"Yong-Quan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 2","key":"10.1016\/j.synbio.2025.03.012_bib1","doi-asserted-by":"crossref","first-page":"ii21","DOI":"10.1093\/jac\/dki007","article-title":"In vitro antistaphylococcal activity of dalbavancin, a novel glycopeptide","volume":"55","author":"Lopez","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.synbio.2025.03.012_bib2","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1128\/AAC.00620-06","article-title":"Bactericidal activity and resistance development profiling of dalbavancin","volume":"51","author":"Goldstein","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.synbio.2025.03.012_bib3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2146\/ajhp070255","article-title":"Dalbavancin: a new lipoglycopeptide antibiotic","volume":"65","author":"Bailey","year":"2008","journal-title":"Am J Health Syst Pharm"},{"issue":"Suppl 1","key":"10.1016\/j.synbio.2025.03.012_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0213-005X(17)30029-0","article-title":"Antimicrobial spectrum of dalbavancin. Mechanism of action and in vitro activity against Gram-positive microorganisms","volume":"35","author":"Cercenado","year":"2017","journal-title":"Enferm Infecc Microbiol Cl\u00edn"},{"key":"10.1016\/j.synbio.2025.03.012_bib5","doi-asserted-by":"crossref","first-page":"910.e1","DOI":"10.1016\/j.cmi.2020.08.025","article-title":"Dalbavancin exposure in vitro selects for dalbavancin-non-susceptible and vancomycin-intermediate strains of methicillin-resistant Staphylococcus aureus","volume":"27","author":"Werth","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.synbio.2025.03.012_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijantimicag.2009.08.020","article-title":"Evaluation of dalbavancin, tigecycline, minocycline, tetracycline, teicoplanin and vancomycin against community-associated and multidrug-resistant hospital-associated meticillin-resistant Staphylococcus aureus","volume":"35","author":"Huang","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.synbio.2025.03.012_bib7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ijantimicag.2016.04.009","article-title":"In vitro activity of dalbavancin against multidrug-resistant Staphylococcus aureus and streptococci from patients with documented infections in Europe and surrounding regions (2011-2013)","volume":"47","author":"Huband","year":"2016","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.synbio.2025.03.012_bib8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/microorganisms7080270","article-title":"Novel antibiotics for multidrug-resistant Gram-positive microorganisms","volume":"7","author":"Koulenti","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.synbio.2025.03.012_bib9","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.2147\/DDDT.S313756","article-title":"Real-world use of dalbavancin in the era of empowerment of outpatient antimicrobial treatment: a careful appraisal beyond approved indications focusing on unmet clinical needs","volume":"15","author":"Gatti","year":"2021","journal-title":"Drug Des Dev Ther"},{"key":"10.1016\/j.synbio.2025.03.012_bib10","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2165\/00003495-200464090-00001","article-title":"Glycopeptide antibiotics: from conventional molecules to new derivatives","volume":"64","author":"Van Bambeke","year":"2004","journal-title":"Drugs"},{"issue":"Suppl 2","key":"10.1016\/j.synbio.2025.03.012_bib11","doi-asserted-by":"crossref","first-page":"ii25","DOI":"10.1093\/jac\/dki008","article-title":"Human pharmacokinetics and rationale for once-weekly dosing of dalbavancin, a semi-synthetic glycopeptide","volume":"55","author":"Dorr","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.synbio.2025.03.012_bib12","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1021\/acschembio.9b00050","article-title":"Toward single-peak dalbavancin analogs through biology and chemistry","volume":"14","author":"Alt","year":"2019","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.synbio.2025.03.012_bib13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S1074-5521(03)00120-0","article-title":"The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species","volume":"10","author":"Sosio","year":"2003","journal-title":"Chem Biol"},{"key":"10.1016\/j.synbio.2025.03.012_bib14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s10295-003-0024-6","article-title":"Production of the glycopeptide antibiotic A40926 by Nonomuraea sp. ATCC 39727: influence of medium composition in batch fermentation","volume":"30","author":"Gunnarsson","year":"2003","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7164\/antibiotics.57.37","article-title":"Valine influences production and complex composition of glycopeptide antibiotic A40926 in fermentations of Nonomuraea sp. ATCC 39727","volume":"57","author":"Beltrametti","year":"2004","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.synbio.2025.03.012_bib16","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s10295-008-0392-z","article-title":"Factors influencing cell fatty acid composition and A40926 antibiotic complex production in Nonomuraea sp. ATCC 39727","volume":"35","author":"Jovetic","year":"2008","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jbiotec.2020.09.017","article-title":"Improved A40926 production from Nonomuraea gerenzanensis using the promoter engineering and the co-expression of crucial genes","volume":"324","author":"Dong","year":"2020","journal-title":"J Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib18","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1111\/1751-7915.14021","article-title":"Redirection of acyl donor metabolic flux for lipopeptide A40926B0 biosynthesis","volume":"15","author":"Xia","year":"2022","journal-title":"Microb Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1021\/sb300091d","article-title":"Transcription factor-based screens and synthetic selections for microbial small-molecule biosynthesis","volume":"2","author":"Dietrich","year":"2013","journal-title":"ACS Synth Biol"},{"key":"10.1016\/j.synbio.2025.03.012_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.mec.2021.e00170","article-title":"Analysis of metabolic network disruption in engineered microbial hosts due to enzyme promiscuity","volume":"12","author":"Porokhin","year":"2021","journal-title":"Metab Eng Commun"},{"key":"10.1016\/j.synbio.2025.03.012_bib21","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00253-014-6199-0","article-title":"Bacillus subtilis as heterologous host for the secretory production of the non-ribosomal cyclodepsipeptide enniatin","volume":"99","author":"Zobel","year":"2015","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib22","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fmicb.2020.00406","article-title":"The application of regulatory cascades in Streptomyces: yield enhancement and metabolite mining","volume":"11","author":"Xia","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.synbio.2025.03.012_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01201-20","article-title":"Impact on multiple antibiotic pathways reveals MtrA as a master regulator of antibiotic production in Streptomyces spp. and potentially in other Actinobacteria","volume":"86","author":"Zhu","year":"2020","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.synbio.2025.03.012_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02702-23","article-title":"Transcriptional regulation of the fidaxomicin gene cluster and cellular development in Actinoplanes deccanensis YP-1 by the pleiotropic regulator MtrA","volume":"11","author":"Xie","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.synbio.2025.03.012_bib25","doi-asserted-by":"crossref","first-page":"7992","DOI":"10.1074\/jbc.M114.608273","article-title":"Transcriptional regulation of the daptomycin gene cluster in Streptomyces roseosporus by an autoregulator, AtrA","volume":"290","author":"Mao","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.synbio.2025.03.012_bib26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00253-008-1545-8","article-title":"Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165","volume":"80","author":"Chen","year":"2008","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrg.2016.30","article-title":"Gene regulation: a gene-centric analysis of transcriptional cascades","volume":"17","author":"Cloney","year":"2016","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.synbio.2025.03.012_bib28","doi-asserted-by":"crossref","first-page":"8120","DOI":"10.1128\/JB.01247-07","article-title":"Phosphate-controlled regulator for t36he biosynthesis of the dalbavancin precursor A40926","volume":"189","author":"Alduina","year":"2007","journal-title":"J Bacteriol"},{"key":"10.1016\/j.synbio.2025.03.012_bib29","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.1038\/s41598-020-63257-4","article-title":"A Two-Component regulatory system with opposite effects on glycopeptide antibiotic biosynthesis and resistance","volume":"10","author":"Alduina","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.synbio.2025.03.012_bib30","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1128\/JB.00262-15","article-title":"Two master switch regulators trigger A40926 biosynthesis in Nonomuraea sp. strain ATCC 39727","volume":"197","author":"Lo Grasso","year":"2015","journal-title":"J Bacteriol"},{"key":"10.1016\/j.synbio.2025.03.012_bib31","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s41587-022-01307-0","article-title":"Prediction of protein-ligand binding affinity from sequencing data with interpretable machine learning","volume":"40","author":"Rube","year":"2022","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.tibs.2022.01.001","article-title":"Methods for the directed evolution of biomolecular interactions","volume":"47","author":"Xie","year":"2022","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.synbio.2025.03.012_bib33","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1007\/s00253-019-09949-y","article-title":"FadR1, a pathway-specific activator of fidaxomicin biosynthesis in Actinoplanes deccanensis Yp-1","volume":"103","author":"Li","year":"2019","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib34","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/jam.13512","article-title":"wblA, a pleiotropic regulatory gene modulating morphogenesis and daptomycin production in Streptomyces roseosporus","volume":"123","author":"Huang","year":"2017","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.synbio.2025.03.012_bib35","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1046\/j.1365-2958.1998.00958.x","article-title":"FtsK is an essential cell division protein that is localized to the septum and induced as part of the SOS response","volume":"29","author":"Wang","year":"1998","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.synbio.2025.03.012_bib36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0092-8674(02)00624-4","article-title":"FtsK Is a DNA motor protein that activates chromosome dimer resolution by switching the catalytic state of the XerC and XerD recombinases","volume":"108","author":"Aussel","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.synbio.2025.03.012_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01742-22","article-title":"FtsK, a DNA motor protein, coordinates the genome segregation and early cell division processes in Deinococcus radiodurans","volume":"13","author":"Mishra","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.synbio.2025.03.012_bib38","article-title":"In conditions of over-expression, WblI, a WhiB-like transcriptional regulator, has a positive impact on the weak antibiotic production of Streptomyces lividans TK24","volume":"12","author":"Yan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.synbio.2025.03.012_bib39","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1111\/1462-2920.15992","article-title":"The regulatory gene wblA is a target of the orphan response regulator OrrA in Streptomyces coelicolor","volume":"24","author":"Zhu","year":"2022","journal-title":"Environ Microbiol"},{"key":"10.1016\/j.synbio.2025.03.012_bib40","doi-asserted-by":"crossref","first-page":"26443","DOI":"10.1074\/jbc.M116.762476","article-title":"Direct involvement of the master nitrogen metabolism regulator GlnR in antibiotic biosynthesis in Streptomyces","volume":"291","author":"He","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1016\/j.synbio.2025.03.012_bib41","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1128\/JB.181.17.5433-5442.1999","article-title":"Catabolism of branched-chain alpha-keto acids in Enterococcus faecalis: the bkd gene cluster, enzymes, and metabolic route","volume":"181","author":"Ward","year":"1999","journal-title":"J Bacteriol"},{"key":"10.1016\/j.synbio.2025.03.012_bib42","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00203-007-0212-2","article-title":"Identification of the bkdAB gene cluster, a plausible source of the starter-unit for virginiamycin M production in Streptomyces virginiae","volume":"187","author":"Pulsawat","year":"2007","journal-title":"Arch Microbiol"},{"key":"10.1016\/j.synbio.2025.03.012_bib43","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/cbic.200800219","article-title":"Identification of additional players in the alternative biosynthesis pathway to isovaleryl-CoA in the myxobacterium Myxococcus xanthus","volume":"10","author":"Bode","year":"2009","journal-title":"ChemBioChem"},{"key":"10.1016\/j.synbio.2025.03.012_bib44","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1128\/JB.187.2.664-671.2005","article-title":"The bkdR gene of Streptomyces coelicolor is required for morphogenesis and antibiotic production and encodes a transcriptional regulator of a branched-chain amino acid dehydrogenase complex","volume":"187","author":"Sprusansky","year":"2005","journal-title":"J Bacteriol"},{"key":"10.1016\/j.synbio.2025.03.012_bib45","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10295-018-2011-y","article-title":"Regulatory and biosynthetic effects of the bkd gene clusters on the production of daptomycin and its analogs A21978C1-3","volume":"45","author":"Luo","year":"2018","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib46","doi-asserted-by":"crossref","DOI":"10.1128\/aem.00838-24","article-title":"Engineering of a TetR family transcriptional regulator BkdR enhances heterologous spinosad production in Streptomyces albus B4 chassis","volume":"90","author":"Wang","year":"2024","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.synbio.2025.03.012_bib47","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/mmi.14117","article-title":"The actinobacterial WhiB-like (Wbl) family of transcription factors","volume":"110","author":"Bush","year":"2018","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.synbio.2025.03.012_bib56","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0168-6445(03)00067-6","article-title":"Ammonium assimilation and nitrogen control in Corynebacterium glutamicum and its relatives: an example for new regulatory mechanisms in actinomycetes","volume":"27","author":"Burkovski","year":"2003","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.synbio.2025.03.012_bib48","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/nar\/gkz1220","article-title":"Secondary nucleotide messenger c-di-GMP exerts a global control on natural product biosynthesis in streptomycetes","volume":"48","author":"Makitrynskyy","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.synbio.2025.03.012_bib49","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1128\/JB.01789-06","article-title":"Interspecies DNA microarray analysis identifies WblA as a pleiotropic down-regulator of antibiotic biosynthesis in Streptomyces","volume":"189","author":"Kang","year":"2007","journal-title":"J Bacteriol"},{"key":"10.1016\/j.synbio.2025.03.012_bib50","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.1128\/AEM.01849-14","article-title":"WblAch, a pivotal activator of natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis L10, is positively regulated by AdpAch","volume":"80","author":"Yu","year":"2014","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.synbio.2025.03.012_bib51","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12934-016-0515-6","article-title":"Activation of a plasmid-situated type III PKS gene cluster by deletion of a wbl gene in deepsea-derived Streptomyces somaliensis SCSIO ZH66","volume":"15","author":"Huang","year":"2016","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.synbio.2025.03.012_bib52","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00253-019-10269-4","article-title":"Three transcriptional regulators positively regulate the biosynthesis of polycyclic tetramate macrolactams in Streptomyces xiamenensis 318","volume":"104","author":"Bu","year":"2020","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib53","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1021\/acssynbio.0c00114","article-title":"Construction of inducible genetic switch for the global regulator WblA to sustain both overproduction of tiancimycins and on-demand sporulation in Streptomyces sp. CB03234","volume":"9","author":"Zhang","year":"2020","journal-title":"ACS Synth Biol"},{"key":"10.1016\/j.synbio.2025.03.012_bib55","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1021\/acs.jcim.4c00013","article-title":"MOINER: a novel multiomics early integration framework for biomedical classification and biomarker discovery","volume":"64","author":"Zhang","year":"2024","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.synbio.2025.03.012_bib54","doi-asserted-by":"crossref","DOI":"10.1093\/jimb\/kuab007","article-title":"WblA, a global regulator of antibiotic biosynthesis in Streptomyces","volume":"48","author":"Nah","year":"2021","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib59","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1111\/1751-7915.14016","article-title":"Effects of dual deletion of glnR and mtrA on expression of nitrogen metabolism genes in Streptomyces venezuelae","volume":"15","author":"Zhu","year":"2022","journal-title":"Microb Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib57","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/mmi.12080","article-title":"Identification of two-component system AfsQ1\/Q2 regulon and its cross-regulation with GlnR in Streptomyces coelicolor","volume":"87","author":"Wang","year":"2013","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.synbio.2025.03.012_bib58","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/febs.14021","article-title":"Glutamine synthetase stabilizes the binding of GlnR to nitrogen fixation gene operators","volume":"284","author":"Fernandes","year":"2017","journal-title":"FEBS J"},{"key":"10.1016\/j.synbio.2025.03.012_bib60","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1128\/jb.174.3.671-681.1992","article-title":"Interaction of the Bacillus subtilis glnRA repressor with operator and promoter sequences in vivo","volume":"174","author":"Gutowski","year":"1992","journal-title":"J Bacteriol"},{"key":"10.1016\/j.synbio.2025.03.012_bib61","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.02615-19","article-title":"GlnR negatively regulates glutamate-dependent acid resistance in Lactobacillus brevis","volume":"86","author":"Gong","year":"2020","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.synbio.2025.03.012_bib62","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10295-008-0480-0","article-title":"Branched-chain amino acid catabolism provides precursors for the Type II polyketide antibiotic, actinorhodin, via pathways that are nutrient dependent","volume":"36","author":"Stirrett","year":"2009","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.03.012_bib63","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1128\/jb.175.13.3934-3940.1993","article-title":"The bkdR gene of Pseudomonas putida is required for expression of the bkd operon and encodes a protein related to Lrp of Escherichia coli","volume":"175","author":"Madhusudhan","year":"1993","journal-title":"J Bacteriol"}],"container-title":["Synthetic and Systems Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405805X2500047X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405805X2500047X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T17:58:11Z","timestamp":1757095091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405805X2500047X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2405805X2500047X"],"URL":"https:\/\/doi.org\/10.1016\/j.synbio.2025.03.012","relation":{},"ISSN":["2405-805X"],"issn-type":[{"value":"2405-805X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new paradigm for the regulation of A40926B0 biosynthesis","name":"articletitle","label":"Article Title"},{"value":"Synthetic and Systems Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.synbio.2025.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}