{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:09:45Z","timestamp":1792390185183,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019937","name":"State Key Laboratory of Biocatalysis and Enzyme Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2020YFA0908400"],"award-info":[{"award-number":["2020YFA0908400"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Synthetic and Systems Biotechnology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.synbio.2025.04.009","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T11:18:24Z","timestamp":1744975104000},"page":"858-867","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Integration of metabolic and evolutionary processes to construct efficient xylose-utilizing strain of Zymomonas mobilis for lignocellulosic ethanol production"],"prefix":"10.1016","volume":"10","author":[{"given":"Jiyun","family":"Lou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9394-9148","authenticated-orcid":false,"given":"Shihui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.synbio.2025.04.009_bib1","article-title":"Biofuels an alternative to traditional fossil fuels: a comprehensive review","volume":"60","author":"Cherwoo","year":"2023","journal-title":"Sustain Energy Technol Assess"},{"key":"10.1016\/j.synbio.2025.04.009_bib2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13068-024-02571-9","article-title":"Biofuel production: exploring renewable energy solutions for a greener future","volume":"17","author":"El-Araby","year":"2024","journal-title":"Biotechnol Biofuels Bioprod"},{"key":"10.1016\/j.synbio.2025.04.009_bib3","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.matpr.2021.08.227","article-title":"Biofuels: an alternative to conventional fuel and energy source","volume":"48","author":"Priya","year":"2022","journal-title":"Mater Today Proc"},{"issue":"5","key":"10.1016\/j.synbio.2025.04.009_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add8835","article-title":"Big data mining, rational modification, and ancestral sequence reconstruction inferred multiple xylose isomerases for biorefinery","volume":"9","author":"Chen","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.synbio.2025.04.009_bib5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13068-021-01949-3","article-title":"Recent advances in the valorization of plant biomass","volume":"14","author":"Ning","year":"2021","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.synbio.2025.04.009_bib6","doi-asserted-by":"crossref","first-page":"9015","DOI":"10.1007\/s00253-018-9294-9","article-title":"Microbial conversion of xylose into useful bioproducts","volume":"102","author":"Jagtap","year":"2018","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.04.009_bib7","first-page":"354","article-title":"Co-utilization of xylose and glucose to produce chemicals by microorganisms","volume":"42","author":"Wang","year":"2023","journal-title":"Chem Ind Eng Prog"},{"key":"10.1016\/j.synbio.2025.04.009_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/femsyr\/fox034","article-title":"Engineering of Saccharomyces cerevisiae for the efficient co-utilization of glucose and xylose","volume":"17","author":"Hou","year":"2017","journal-title":"FEMS Yeast Res"},{"key":"10.1016\/j.synbio.2025.04.009_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cbpa.2015.09.008","article-title":"Combining C6 and C5 sugar metabolism for enhancing microbial bioconversion","volume":"29","author":"Zhang","year":"2015","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.synbio.2025.04.009_bib10","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1038\/s41589-023-01402-6","article-title":"Engineering co-utilization of glucose and xylose for chemical overproduction from lignocellulose","volume":"19","author":"Gao","year":"2023","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.synbio.2025.04.009_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/biot.202000142","article-title":"Xylose assimilation for the efficient production of biofuels and chemicals by engineered Saccharomyces cerevisiae","volume":"16","author":"Sun","year":"2021","journal-title":"Biotechnol J"},{"issue":"22","key":"10.1016\/j.synbio.2025.04.009_bib12","doi-asserted-by":"crossref","first-page":"9471","DOI":"10.1007\/s00253-018-9353-2","article-title":"Deciphering bacterial xylose metabolism and metabolic engineering of industrial microorganisms for use as efficient microbial cell factories","volume":"102","author":"Kim","year":"2018","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.04.009_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13068-020-1662-x","article-title":"Biochemical routes for uptake and conversion of xylose by microorganisms","volume":"13","author":"Zhao","year":"2020","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.synbio.2025.04.009_bib14","first-page":"122","article-title":"Systematic and evolutionary engineering of a xylose isomerase-based pathway in Saccharomyces cerevisiae for efficient conversion yields","volume":"7","author":"Lee","year":"2014","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.synbio.2025.04.009_bib15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ymben.2014.05.001","article-title":"Two-stage transcriptional reprogramming in Saccharomyces cerevisiae for optimizing ethanol production from xylose","volume":"24","author":"Cao","year":"2014","journal-title":"Metab Eng"},{"issue":"5","key":"10.1016\/j.synbio.2025.04.009_bib16","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1128\/AEM.72.5.3418-3428.2006","article-title":"Engineering of a xylose metabolic pathway in Corynebacterium glutamicum","volume":"72","author":"Kawaguchi","year":"2006","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"10.1016\/j.synbio.2025.04.009_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00253-009-2065-x","article-title":"Engineering of pentose transport in Corynebacterium glutamicum to improve simultaneous utilization of mixed sugars","volume":"85","author":"Sasaki","year":"2009","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.04.009_bib18","first-page":"2710","article-title":"Metabolic engineering for the efficient co-utilization of glucose and xylose","volume":"40","author":"Wang","year":"2024","journal-title":"Chin J Biotechnol"},{"key":"10.1016\/j.synbio.2025.04.009_bib19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.biotechadv.2014.04.009","article-title":"The transport and mediation mechanisms of the common sugars in Escherichia coli","volume":"32","author":"Luo","year":"2014","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.synbio.2025.04.009_bib20","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jbiotec.2008.02.003","article-title":"Role of xylose transporters in xylitol production from engineered Escherichia coli","volume":"134","author":"Khankal","year":"2008","journal-title":"J Biotechnol"},{"key":"10.1016\/j.synbio.2025.04.009_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13068-022-02153-7","article-title":"Machine learning and comparative genomics approaches for the discovery of xylose transporters in yeast","volume":"15","author":"Fiamenghi","year":"2022","journal-title":"Biotechnol Biofuels Bioprod"},{"key":"10.1016\/j.synbio.2025.04.009_bib22","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1073\/pnas.1323464111","article-title":"Engineering of yeast hexose transporters to transport D-xylose without inhibition by D-glucose","volume":"111","author":"Farwick","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.synbio.2025.04.009_bib23","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1002\/bit.25631","article-title":"High-throughput sequencing reveals adaptation induced mutations in pentose-fermenting strains of Zymomonas mobilis","volume":"112","author":"Dunn","year":"2015","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.synbio.2025.04.009_bib24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1475-2859-8-66","article-title":"An evolved xylose transporter from Zymomonas mobilis enhances sugar transport in Escherichia coli","volume":"8","author":"Ren","year":"2009","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.synbio.2025.04.009_bib25","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/mlf2.12021","article-title":"New xylose transporters support the simultaneous consumption of glucose and xylose in Escherichia coli","volume":"1","author":"Zhu","year":"2022","journal-title":"mLife"},{"key":"10.1016\/j.synbio.2025.04.009_bib26","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.procbio.2021.01.006","article-title":"Heterologous expression of xylose specific transporter improves xylose utilization by recombinant Zymomonas mobilis strain in presence of glucose","volume":"102","author":"Sarkar","year":"2021","journal-title":"Process Biochem"},{"key":"10.1016\/j.synbio.2025.04.009_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54897-5","article-title":"Paradigm of engineering recalcitrant non-model microorganism with dominant metabolic pathway as a biorefinery chassis","volume":"15","author":"Yan","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.synbio.2025.04.009_bib28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.34133\/bdr.0052","article-title":"Microbial cell factories in the bioeconomy era: from discovery to creation","volume":"6","author":"Yan","year":"2024","journal-title":"BioDesign Res"},{"key":"10.1016\/j.synbio.2025.04.009_bib29","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.tibtech.2024.05.005","article-title":"Efficient genome-editing tools to engineer the recalcitrant non-model industrial microorganism Zymomonas mobilis","volume":"42","author":"Geng","year":"2024","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.synbio.2025.04.009_bib30","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.synbio.2023.07.001","article-title":"Construction and application of high-quality genome-scale metabolic model of Zymomonas mobilis to guide rational design of microbial cell factories","volume":"8","author":"Wu","year":"2023","journal-title":"Synth Syst Biotechnol"},{"key":"10.1016\/j.synbio.2025.04.009_bib31","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1126\/science.267.5195.240","article-title":"Metabolic engineering of a pentose metabolism pathway in ethanologenic Zymomonas mobilis","volume":"267","author":"Zhang","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.synbio.2025.04.009_bib32","series-title":"Zymomonas pentose-sugar fermenting strains and uses thereof","author":"Zhang","year":"2003"},{"key":"10.1016\/j.synbio.2025.04.009_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.femsle.2005.01.025","article-title":"Over-expression of xylulokinase in a xylose-metabolising recombinant strain of Zymomonas mobilis","volume":"244","author":"Jeon","year":"2005","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.synbio.2025.04.009_bib34","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1007\/s10529-011-0677-6","article-title":"Discovery and characterization of a xylose reductase from Zymomonas mobilis ZM4","volume":"33","author":"Agrawal","year":"2011","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.synbio.2025.04.009_bib35","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1007\/s00253-014-5812-6","article-title":"Expression of a xylose-specific transporter improves ethanol production by metabolically engineered Zymomonas mobilis","volume":"98","author":"Dunn","year":"2014","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.04.009_bib36","doi-asserted-by":"crossref","DOI":"10.1093\/jimb\/kuab066","article-title":"Directed evolution of Zymomonas mobilis sugar facilitator Glf to overcome glucose inhibition","volume":"49","author":"Kurgan","year":"2022","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.04.009_bib37","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10295-020-02270-y","article-title":"Adaptive laboratory evolution induced novel mutations in Zymomonas mobilis ATCC ZW658: a potential platform for co-utilization of glucose and xylose","volume":"47","author":"Sarkar","year":"2020","journal-title":"J Ind Microbiol Biotechnol"},{"issue":"4","key":"10.1016\/j.synbio.2025.04.009_bib38","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/bit.23021","article-title":"Adaptation yields a highly efficient xylose-fermenting Zymomonas mobilis strain","volume":"108","author":"Agrawal","year":"2010","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.synbio.2025.04.009_bib39","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s13068-021-02082-x","article-title":"Development and characterization of efficient xylose utilization strains of Zymomonas mobilis","volume":"14","author":"Lou","year":"2021","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.synbio.2025.04.009_bib40","series-title":"Construction method of a tight regulation system for gene expression in and applications","author":"Yang","year":"2022"},{"key":"10.1016\/j.synbio.2025.04.009_bib41","doi-asserted-by":"crossref","first-page":"11461","DOI":"10.1093\/nar\/gkz940","article-title":"Characterization and repurposing of the endogenous Type I-F CRISPR-Cas system of Zymomonas mobilis for genome engineering","volume":"47","author":"Zheng","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.synbio.2025.04.009_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ab.2009.03.048","article-title":"An in vivo, label-free quick assay for xylose transport in Escherichia coli","volume":"390","author":"Chen","year":"2009","journal-title":"Anal Biochem"},{"key":"10.1016\/j.synbio.2025.04.009_bib43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.copbio.2020.10.012","article-title":"Engineering xylose metabolism in yeasts to produce biofuels and chemicals","volume":"67","author":"Lee","year":"2021","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.synbio.2025.04.009_bib44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13068-019-1360-8","article-title":"Xylose fermentation efficiency of industrial Saccharomyces cerevisiae yeast with separate or combined xylose reductase\/xylitol dehydrogenase and xylose isomerase pathways","volume":"12","author":"Cunha","year":"2019","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.synbio.2025.04.009_bib45","doi-asserted-by":"crossref","first-page":"10340","DOI":"10.1074\/jbc.M409443200","article-title":"Complete reversal of coenzyme specificity of xylitol dehydrogenase and increase of thermostability by the introduction of structural zinc","volume":"280","author":"Watanabe","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.synbio.2025.04.009_bib46","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1128\/AEM.66.8.3381-3386.2000","article-title":"Anaerobic xylose fermentation by recombinant Saccharomyces cerevisiae carrying XYL1, XYL2, and XKS1 in mineral medium chemostat cultures","volume":"66","author":"Eliasson","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.synbio.2025.04.009_bib47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13068-018-1116-x","article-title":"Complete genome sequence and the expression pattern of plasmids of the model ethanologen Zymomonas mobilis ZM4 and its xylose-utilizing derivatives 8b and 2032","volume":"11","author":"Yang","year":"2018","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.synbio.2025.04.009_bib48","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ab.2013.07.041","article-title":"An assay for functional xylose transporters in Saccharomyces cerevisiae","volume":"442","author":"Wang","year":"2013","journal-title":"Anal Biochem"},{"key":"10.1016\/j.synbio.2025.04.009_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.126878","article-title":"Cysteine supplementation enhanced inhibitor tolerance of Zymomonas mobilis for economic lignocellulosic bioethanol production","volume":"349","author":"Yan","year":"2022","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.synbio.2025.04.009_bib50","doi-asserted-by":"crossref","first-page":"546915","DOI":"10.1155\/2012\/546915","article-title":"The redox system in C. elegans, a phylogenetic approach","volume":"2012","author":"Johnston","year":"2012","journal-title":"J Toxicol"},{"key":"10.1016\/j.synbio.2025.04.009_bib51","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13068-020-01781-1","article-title":"Development and characterization of acidic-pH-tolerant mutants of Zymomonas mobilis through adaptation and next-generation sequencing-based genome resequencing and RNA-Seq","volume":"13","author":"Yang","year":"2020","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.synbio.2025.04.009_bib52","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1002\/bit.25631","article-title":"High-throughput sequencing reveals adaptation-induced mutations in pentose-fermenting strains of Zymomonas mobilis","volume":"112","author":"Dunn","year":"2015","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.synbio.2025.04.009_bib53","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1007\/s00253-012-4094-0","article-title":"Ethanol production from wood hydrolysate using genetically engineered Zymomonas mobilis","volume":"94","author":"Yanase","year":"2012","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.synbio.2025.04.009_bib54","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.3389\/fmicb.2019.02316","article-title":"Boosting ethanol productivity of Zymomonas mobilis 8b in enzymatic hydrolysate of dilute acid and ammonia pretreated corn stover through medium optimization, high cell density fermentation and cell recycling","volume":"10","author":"Li","year":"2019","journal-title":"Front Microbiol"}],"container-title":["Synthetic and Systems Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405805X25000560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405805X25000560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:40:18Z","timestamp":1762623618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405805X25000560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2405805X25000560"],"URL":"https:\/\/doi.org\/10.1016\/j.synbio.2025.04.009","relation":{},"ISSN":["2405-805X"],"issn-type":[{"value":"2405-805X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integration of metabolic and evolutionary processes to construct efficient xylose-utilizing strain of Zymomonas mobilis for lignocellulosic ethanol production","name":"articletitle","label":"Article Title"},{"value":"Synthetic and Systems Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.synbio.2025.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}