{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:34:03Z","timestamp":1760204043539},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.taap.2004.09.001","type":"journal-article","created":{"date-parts":[[2004,12,15]],"date-time":"2004-12-15T14:28:51Z","timestamp":1103120931000},"page":"187-195","source":"Crossref","is-referenced-by-count":9,"title":["Hepatic arachidonic acid metabolism is disrupted after hexachlorobenzene treatment"],"prefix":"10.1016","volume":"204","author":[{"given":"Silvia C.","family":"Billi de Catabbi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Faletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor C.","family":"San Mart\u00edn de Viale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana C.","family":"Coch\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2004.09.001_bib1","series-title":"Toxicological Profile for Chlorinated Dibenzo-p-Dioxins","year":"1998"},{"key":"10.1016\/j.taap.2004.09.001_bib2","series-title":"Toxicological Profile for Hexachlorobenzene","year":"2002"},{"key":"10.1016\/j.taap.2004.09.001_bib3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S1357-2725(96)00096-9","article-title":"Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria","volume":"29","author":"Billi de Catabbi","year":"1997","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.taap.2004.09.001_bib4","first-page":"165","article-title":"Heme metabolism after discontinued hexachlorobenzene administration in rats: possible irreversible changes and biomarker for hexachlorobenzene persistence","volume":"127","author":"Billi de Catabbi","year":"2000","journal-title":"Comp. Biochem. Physiol., C: Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2004.09.001_bib5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0300-483X(00)00234-1","article-title":"Hexachlorobenzene-induced alterations on neutral and acidic sphingomyelinases and serine palmitoyltransferase activities. A time course study in two strains of rats","volume":"149","author":"Billi de Catabbi","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2004.09.001_bib6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0300-483X(87)90019-9","article-title":"Comparison of hexachlorobenzene-induced alterations of microsomal membrane composition and monooxygenase activity in male and female rats","volume":"45","author":"Cantoni","year":"1987","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2004.09.001_bib7","doi-asserted-by":"crossref","first-page":"10865","DOI":"10.1016\/S0021-9258(19)38526-6","article-title":"Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase","volume":"265","author":"Capdevila","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2004.09.001_bib8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-2275(20)32049-6","article-title":"Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase","volume":"41","author":"Capdevila","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.taap.2004.09.001_bib9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0013-9351(79)90001-X","article-title":"Hexachlorobenzene (HCB): a review","volume":"20","author":"Courtney","year":"1979","journal-title":"Environ. Res."},{"key":"10.1016\/j.taap.2004.09.001_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1055\/s-2007-1007142","article-title":"Porphyria cutanea tarda","volume":"18","author":"Elder","year":"1998","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.taap.2004.09.001_bib11","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1182\/blood.V78.7.1781.1781","article-title":"Chloroquine attenuates hemorrhagic shock-induced suppression of Kupffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin release","volume":"78","author":"Ertel","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.taap.2004.09.001_bib12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/niox.1999.0231","article-title":"Activity of ovarian nitric oxide synthase (NOs) during ovulatory process in the rat: relationship with prostaglandins (PGs) production","volume":"3","author":"Faletti","year":"1999","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.taap.2004.09.001_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S1388-1981(02)00208-1","article-title":"Phospholipase C inhibitors and prostaglandins differentially regulate phosphatidylcholine synthesis in rat renal papilla. Evidence of compartmental regulation of CTP:phosphocholine cytidylyltransferase and CDP-choline:1,2-diacylglycerolcholinephosphotransferase","volume":"1583","author":"Fernandez-Tom\u00e9","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2004.09.001_bib14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0952-3278(93)90097-G","article-title":"Relationship between factors influencing Na+-K+-ATPase activity and eicosanoid production from 14C-arachidonic acid in spayed rat uterus","volume":"48","author":"Franchi","year":"1993","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.taap.2004.09.001_bib15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/scdb.1997.0151","article-title":"Phospholipases A2","volume":"8","author":"Gij\u00f3n","year":"1997","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.taap.2004.09.001_bib16","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1053\/jhep.2002.32487","article-title":"Uroporphyria in mice: thresholds for hepatic CYP 1A2 and iron","volume":"35","author":"Gorman","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2004.09.001_bib17","doi-asserted-by":"crossref","first-page":"7561","DOI":"10.1016\/S0021-9258(20)89484-8","article-title":"Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties","volume":"266","author":"Karara","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2004.09.001_bib18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0003-2697(84)90144-1","article-title":"An alternative 7-ethoxyresorufin O-deethylase activity assay: a continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity","volume":"140","author":"Klotz","year":"1984","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2004.09.001_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0006-2952(82)90229-5","article-title":"The role of possible membrane damage in porphyria cutanea tarda: a spin label study of rat liver cell membranes","volume":"31","author":"K\u00f3sz\u00f3","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2004.09.001_bib20","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1016\/S0021-9258(18)42801-3","article-title":"Purification and properties of a cytochrome P450 arachidonic acid epoxygenase from rabbit renal cortex","volume":"267","author":"Laethem","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2004.09.001_bib21","series-title":"Biochemical Toxicology: A Practical Approach","first-page":"183","article-title":"Preparation and characterization of microsomal fractions for studies on xenobiotic metabolism","author":"Lake","year":"1987"},{"key":"10.1016\/j.taap.2004.09.001_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1998.8468","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin induction of cytochrome P450-dependent arachidonic acid metabolism in mouse liver microsomes: evidence for species-specific differences in responses","volume":"153","author":"Lee","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2004.09.001_bib23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0006-2952(03)00241-7","article-title":"Tryptophan metabolism via serotonin in rats with hexachlorobenzene experimental porphyria","volume":"66","author":"Llamb\u00edas","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2004.09.001_bib24","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/0005-2760(85)90114-6","article-title":"Effects of antimalarial drugs on phospholipase A and lysophospholipase activities in plasma membrane, mitochondrial, microsomal and cytosolic subcellular fractions of rat liver","volume":"835","author":"Loffler","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2004.09.001_bib25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"249","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2004.09.001_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/taap.1997.8157","article-title":"Studies on the mechanism of uroporphyrinogen decarboxylase inhibition in hexachlorobenzene-induced porphyria in the female rat","volume":"145","author":"Mylchreest","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2004.09.001_bib27","doi-asserted-by":"crossref","first-page":"19503","DOI":"10.1016\/S0021-9258(18)41804-2","article-title":"\u03b2-Naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase","volume":"267","author":"Nakai","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2004.09.001_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0009-8981(02)00276-0","article-title":"Human hereditary hepatic porphyries","volume":"325","author":"Nordmann","year":"2002","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.taap.2004.09.001_bib29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0049-3848(02)00036-1","article-title":"Cationic amphiphilic drugs and platelet phospholipase A2 (cPLA2)","volume":"105","author":"Nos\u00e1l","year":"2002","journal-title":"Thromb. Res."},{"key":"10.1016\/j.taap.2004.09.001_bib30","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0006-2952(97)00417-6","article-title":"Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin","volume":"54","author":"Puga","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2004.09.001_bib31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1023\/A:1006902212598","article-title":"Purification and characterization of the hepatic CYP2C and 3A isozymes from phenobarbitone pretreated rhesus monkey","volume":"198","author":"Ramana","year":"1999","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.taap.2004.09.001_bib32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0300-483X(97)00165-0","article-title":"Hexachlorobenzene-induced alterations of rat hepatic microsomal membrane function","volume":"125","author":"Randi","year":"1998","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2004.09.001_bib33","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/0006-291X(90)91573-B","article-title":"Arachidonic acid metabolism by dioxin-induced cytochrome P-450: a new hypothesis on the role of P-450 in dioxin toxicity","volume":"172","author":"Rifkind","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2004.09.001_bib34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0009-8981(70)90155-5","article-title":"Experimental porphyria induced in rats by hexachlorobenzene. A study of the porphyrin excreted by urine","volume":"28","author":"San Martin de Viale","year":"1970","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.taap.2004.09.001_bib35","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1042\/bj1680393","article-title":"Porphyrins and porphyrinogen carboxy-lyase in hexachlorobenzene-induced porphyria","volume":"168","author":"San Mart\u00edn de Viale","year":"1977","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2004.09.001_bib36","first-page":"1025","article-title":"An update on eicosanoids and inhibitors of cyclooxygenase enzyme systems","volume":"35","author":"Sharma","year":"1997","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.taap.2004.09.001_bib37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/bj3300149","article-title":"Uroporphyria produced in mice by iron and 5-aminolevulinic acid does not occur in Cyp1a2(\u2212\/\u2212) null mutant mice","volume":"330","author":"Sinclair","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2004.09.001_bib38","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0308-2261(21)00183-1","article-title":"Drugs and porphyria","volume":"9","author":"Smith","year":"1980","journal-title":"Clin. Haematol."},{"key":"10.1016\/j.taap.2004.09.001_bib39","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/0006-2952(90)90236-E","article-title":"Sex-linked hepatic uroporphyria and the induction of cytochromes P450IA in rats caused by hexachlorobenzene and polyhalogenated biphenyls","volume":"40","author":"Smith","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2004.09.001_bib40","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/abbi.2000.1844","article-title":"fMLP-induced arachidonic acid release in db-cAMP-differentiated HL-60 cells is independent of phosphatidylinositol-4,5-bisphosphate-specific phospholipase C activation and cytosolic phospholipase A2 activation","volume":"378","author":"Sternfeld","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2004.09.001_bib41","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/0006-2952(86)90587-3","article-title":"Metabolism of the \u201cmixed\u201d cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes","volume":"35","author":"Stewart","year":"1986","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2004.09.001_bib42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tox.2003.12.014","article-title":"Glycogen metabolism and glucose transport in experimental porphyria","volume":"197","author":"Taira","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2004.09.001_bib43","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/bj3190385","article-title":"Vitamin E potentiates arachidonate release and phospholipase A2 activity in rat heart myoblastic cells","volume":"319","author":"Tran","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2004.09.001_bib44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/abbi.1997.0555","article-title":"Modulation of prostaglandin H synthase-2 mRNA expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice","volume":"351","author":"Vogel","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2004.09.001_bib45","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1093\/carcin\/21.12.2267","article-title":"Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: possible c-Src-mediated pathway","volume":"21","author":"Vogel","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2004.09.001_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/carcin\/21.1.15","article-title":"Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"21","author":"W\u00f6lfle","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2004.09.001_bib47","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1006\/abio.1999.4053","article-title":"Group-specific assays that distinguish between the four major types of mammalian phospholipase A2","volume":"269","author":"Yang","year":"1999","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2004.09.001_bib48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1389200033336892","article-title":"Kidney CYP450 enzymes: biological actions beyond drug metabolism","volume":"4","author":"Zhao","year":"2003","journal-title":"Curr. Drug Metab."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X04004193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X04004193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T12:17:20Z","timestamp":1625141840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X04004193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0041008X04004193"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2004.09.001","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}