{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:25:48Z","timestamp":1767374748545},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.taap.2006.06.002","type":"journal-article","created":{"date-parts":[[2006,6,11]],"date-time":"2006-06-11T12:00:42Z","timestamp":1150027242000},"page":"319-330","source":"Crossref","is-referenced-by-count":17,"title":["Changes in gene expression in human renal proximal tubule cells exposed to low concentrations of S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene"],"prefix":"10.1016","volume":"216","author":[{"given":"Edward A.","family":"Lock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy L.","family":"Barth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott W.","family":"Argraves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick G.","family":"Schnellmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2006.06.002_bib1","first-page":"F77","article-title":"Regulation of glycolytic metabolism during long-term primary culture of renal proximal tubule cells","volume":"262","author":"Aleo","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2006.06.002_bib2","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1093\/bioinformatics\/btg325","article-title":"The MUSC DNA microarray database","volume":"19","author":"Argraves","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.taap.2006.06.002_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/10408440091159202","article-title":"Renal toxicity and carcinogenicity of trichloroethylene: key results, mechanisms, and controversies","volume":"30","author":"Bruning","year":"2000","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.taap.2006.06.002_bib4","doi-asserted-by":"crossref","first-page":"8207","DOI":"10.1016\/S0021-9258(18)42428-3","article-title":"Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and dithiothreitol","volume":"267","author":"Chen","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2006.06.002_bib5","first-page":"F274","article-title":"Nephrotoxicant inhibition of renal proximal tubule cell regeneration","volume":"269","author":"Counts","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2006.06.002_bib6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0167-4889(93)90034-M","article-title":"Effect of glucose and insulin deprivation on differentiation and carbohydrate metabolism of rabbit proximal tubular cells in primary culture","volume":"1177","author":"Courjault","year":"1993","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.taap.2006.06.002_bib7","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1681\/ASN.V5111949","article-title":"Consecutive use of hormonally defined serum-free media to establish highly differentiated human renal proximal tubule cells in primary culture","volume":"5","author":"Courjault-Gautier","year":"1995","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.taap.2006.06.002_bib8","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/toxsci\/53.2.458","article-title":"metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-l-cysteine in freshly isolated human proximal tubular cells","volume":"53","author":"Cummings","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2006.06.002_bib9","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/rcm.1890","article-title":"Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry","volume":"19","author":"Delinsky","year":"2005","journal-title":"Rapid Comm. Mass Spectrom."},{"key":"10.1016\/j.taap.2006.06.002_bib10","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ki.1984.28","article-title":"Tissue culture of human kidney epithelial cells of proximal tubule origin","volume":"25","author":"Detrisac","year":"1984","journal-title":"Kidney Int."},{"key":"10.1016\/j.taap.2006.06.002_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0300-483X(00)00156-6","article-title":"Trichloroethylene induced vitamin B12 and folate deficiency leads to increased formic acid excretion in the rat","volume":"146","author":"Dow","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2006.06.002_bib12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/oem.2003.007153","article-title":"Biological monitoring of kidney function among workers occupationally exposed to trichloroethylene","volume":"61","author":"Green","year":"2004","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.taap.2006.06.002_bib13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0041-008X(91)90330-H","article-title":"Role of lipid peroxidation in renal proximal tubule cell death induced by haloalkene cysteine conjugates","volume":"107","author":"Groves","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2006.06.002_bib14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1523-1755.2002.00433.x","article-title":"Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury","volume":"62","author":"Han","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.taap.2006.06.002_bib15","first-page":"283","article-title":"Isolation and culture of human renal cortical cells with characteristics of proximal tubules","volume":"107","author":"Hawksworth","year":"2005","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.taap.2006.06.002_bib16","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/BF02634355","article-title":"Serum-free culture and characterization of renal epithelial cells isolated from human fetal kidneys of varying gestational age","volume":"30A","author":"Hazen-Martin","year":"1994","journal-title":"In vitro Cell Dev. Biol."},{"key":"10.1016\/j.taap.2006.06.002_bib17","doi-asserted-by":"crossref","first-page":"F552","DOI":"10.1152\/ajprenal.00285.2002","article-title":"Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury","volume":"286","author":"Ichimura","year":"2004","journal-title":"Am. J. Renal Physiol."},{"key":"10.1016\/j.taap.2006.06.002_bib18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/taap.1995.1108","article-title":"Regeneration of renal proximal tubule cells in primary culture following toxicant injury: response to growth factors","volume":"132","author":"Kays","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2006.06.002_bib19","first-page":"285","article-title":"Proximal tubule characteristics of cultured human renal cortex epithelium","volume":"113","author":"Kempson","year":"1989","journal-title":"J. Lab.Clin. Med."},{"key":"10.1016\/j.taap.2006.06.002_bib20","doi-asserted-by":"crossref","first-page":"F175","DOI":"10.1152\/ajprenal.00418.2004","article-title":"Molecular mechanism of enhanced renal cell division in protection against S-(1,2-dichlorovinyl)-l-cysteine-induced renal failure and death","volume":"289","author":"Korrapti","year":"2005","journal-title":"Am. J. Renal. Physiol."},{"key":"10.1016\/j.taap.2006.06.002_bib21","first-page":"549","article-title":"Mechanism of S-(1,2-dichlorovinyl)-l-cysteine and S-(1,2-dichlorovinyl)-l-homocysteine-induced renal mitochondrial toxicity","volume":"32","author":"Lash","year":"1987","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2006.06.002_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1289\/ehp.00108s2177","article-title":"Metabolism of trichloroethylene","volume":"108","author":"Lash","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2006.06.002_bib23","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1289\/ehp.00108s2225","article-title":"Modes of action of trichloroethylene for kidney tumorigenesis","volume":"108","author":"Lash","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2006.06.002_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.2001.9295","article-title":"Apoptosis, necrosis and cell proliferation induced by S-(1,2-dichlorovinyl)-l-cysteine in primary cultures of human proximal tubular cells","volume":"177","author":"Lash","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2006.06.002_bib25","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1124\/jpet.102.046185","article-title":"Roles of necrosis, apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorvinyl)-l-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells","volume":"305","author":"Lash","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2006.06.002_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.taap.2004.09.023","article-title":"Molecular markers of trichloroethylene-induced toxicity in human kidney cells","volume":"206","author":"Lash","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2006.06.002_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1073\/pnas.011404098","article-title":"Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection","volume":"98","author":"Li","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.taap.2006.06.002_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2001-2-8-research0032","article-title":"Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application","volume":"2","author":"Li","year":"2001","journal-title":"Genome Biol."},{"key":"10.1016\/j.taap.2006.06.002_bib29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/nar\/gkg121","article-title":"Netaffx: Affymetrix probe sets and annotations","volume":"31","author":"Liu","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2006.06.002_bib30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/10408440490265210","article-title":"Chemically induced renal tubule tumors in the laboratory rat and mouse: review of the NCI\/NTP database and categorization of renal carcinogens based on mechanistic information","volume":"34","author":"Lock","year":"2004","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.taap.2006.06.002_bib31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/toxsci\/kfj107","article-title":"Trichloroethylene: mechanisms of renal toxicity and renal cancer and relevance to risk assessment","volume":"91","author":"Lock","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2006.06.002_bib32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00204-003-0459-6","article-title":"Renal cysteine conjugate C-S lyase mediated toxicity of halogenated alkenes in primary cultures of human and rat proximal tubular cells","volume":"77","author":"McGoldrick","year":"2003","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2006.06.002_bib33","first-page":"F810","article-title":"Coordination of the cell cycle is an important determinant of the syndrome of acute renal failure","volume":"283","author":"Megyesi","year":"2002","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2006.06.002_bib34","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1124\/mol.60.6.1226","article-title":"Interactions between collagen IV and collagen-binding integrins in renal cell repair after sublethal injury","volume":"60","author":"Nony","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2006.06.002_bib35","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1124\/jpet.102.035022","article-title":"Mechanisms of renal cell repair and regeneration after acute renal failure","volume":"304","author":"Nony","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2006.06.002_bib36","doi-asserted-by":"crossref","first-page":"F443","DOI":"10.1152\/ajprenal.2001.281.3.F443","article-title":"Collagen IV promotes repair of renal cell physiological functions after toxicant injury","volume":"281","author":"Nony","year":"2001","journal-title":"Am. J. Renal Physiol."},{"key":"10.1016\/j.taap.2006.06.002_bib37","doi-asserted-by":"crossref","first-page":"C1053","DOI":"10.1152\/ajpcell.1995.268.4.C1053","article-title":"Improved culture conditions stimulate gluconeogenesis in primary cultures of renal proximal tubule cells","volume":"268","author":"Nowak","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2006.06.002_bib38","doi-asserted-by":"crossref","first-page":"C2072","DOI":"10.1152\/ajpcell.1996.271.6.C2072","article-title":"l-ascorbic acid regulates growth and metabolism of renal cells in culture","volume":"271","author":"Nowak","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2006.06.002_bib39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/taap.1997.8166","article-title":"Renal cell regeneration following oxidant exposure: inhibition by TGF-beta1 and stimulation by ascorbic acid","volume":"145","author":"Nowak","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2006.06.002_bib40","first-page":"F509","article-title":"Recovery of cellular functions following oxidant injury","volume":"274","author":"Nowak","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2006.06.002_bib41","first-page":"F228","article-title":"Differential effects of EGF on repair of cellular functions after dichlorovinyl-l-cysteine-induced injury","volume":"276","author":"Nowak","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2006.06.002_bib42","series-title":"Methods in Toxicology.","first-page":"128","article-title":"Measurement of oxygen consumption","author":"Schnellmann","year":"1994"},{"key":"10.1016\/j.taap.2006.06.002_bib43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1289\/ehp.00108s2159","article-title":"Trichloroethylene health risk\u2014State of the science","volume":"108","author":"Scott","year":"2000","journal-title":"Environ. Health. Perspect."},{"key":"10.1016\/j.taap.2006.06.002_bib44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2006.06.002_bib45","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0009-2797(85)80137-X","article-title":"Activation of chloroform and related trihalomethanes to free radical intermediates in isolated hepatocytes and in the rat liver in vivo as detected by ESP-Spin trapping technique","volume":"55","author":"Tomasi","year":"1985","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.taap.2006.06.002_bib46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0014-4827(91)90123-C","article-title":"Biochemical, functional and morphological characterization of a primary culture of rabbit proximal tubule cells","volume":"194","author":"Toutain","year":"1991","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.taap.2006.06.002_bib47","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0022-5347(17)48932-4","article-title":"Isolation, culture and characterization of human renal tubular cells","volume":"133","author":"Trifillis","year":"1985","journal-title":"J. Urol."},{"key":"10.1016\/j.taap.2006.06.002_bib48","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/toxsci\/kfg111","article-title":"Role of tissue repair in survival from S-(1,2-dichlorovinyl)-l-cysteine-induced acute renal tubular necrosis in the mouse","volume":"74","author":"Vaidya","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2006.06.002_bib49","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0041-008X(02)00080-7","article-title":"Renal injury and repair following S-1, 2 dichlorovinyl-l-cysteine administration to mice","volume":"188","author":"Vaidya","year":"2003","journal-title":"Toxicol Appl. Pharmacol."},{"key":"10.1016\/j.taap.2006.06.002_bib50","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1080\/01926230390241945","article-title":"Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1\/2 pathway","volume":"31","author":"Vaidya","year":"2003","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.taap.2006.06.002_bib51","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0378-4274(93)90053-Z","article-title":"Enhanced expression of the protooncogenes c-myc and c-fos in normal and malignant renal growth","volume":"67","author":"Vamvakas","year":"1993","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2006.06.002_bib52","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1289\/ehp.00108s2161","article-title":"Trichloroethylene and cancer: epidemiologic evidence","volume":"108","author":"Wartenberg","year":"2000","journal-title":"Environ. Health Perspect."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X06001992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X06001992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T20:05:56Z","timestamp":1707077156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X06001992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0041008X06001992"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2006.06.002","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}