{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:26:18Z","timestamp":1791919578610,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.taap.2006.11.012","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T19:15:55Z","timestamp":1163704555000},"page":"265-273","source":"Crossref","is-referenced-by-count":47,"title":["Paroxetine-induced apoptosis in human osteosarcoma cells: Activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation"],"prefix":"10.1016","volume":"218","author":[{"given":"Chiang-Ting","family":"Chou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Ren","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2006.11.012_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0022-5347(01)67288-4","article-title":"Growth-inhibitory effects of serotonin uptake inhibitors on human prostate carcinoma cell lines","volume":"154","author":"Abdul","year":"1995","journal-title":"J. Urol."},{"key":"10.1016\/j.taap.2006.11.012_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1079\/BJN2001489","article-title":"Pancreatic islet insulin secretion and metabolism in adult rats malnourished during neonatal life","volume":"87","author":"Barbosa","year":"2002","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.taap.2006.11.012_bib3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/BJ20051265","article-title":"Bcl-2 overexpression prevents calcium overload and subsequent apoptosis in dystrophic myotubes","volume":"395","author":"Basset","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2006.11.012_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biochi.2004.10.018","article-title":"The role of MAPKs in adipocyte differentiation and obesity","volume":"87","author":"Bost","year":"2005","journal-title":"Biochimie"},{"key":"10.1016\/j.taap.2006.11.012_bib5","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1111\/j.1368-5031.2005.00681.x","article-title":"Clinical effects of pharmacological variations in selective serotonin reuptake inhibitors: an overview","volume":"59","author":"Carrasco","year":"2005","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.taap.2006.11.012_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/excr.2000.4836","article-title":"Serine\/threonine protein kinases and apoptosis","volume":"256","author":"Cross","year":"2000","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.taap.2006.11.012_bib7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.taap.2006.11.012_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1006935114624","article-title":"TNF-alpha induced altered signaling mechanism in human neutrophil","volume":"197","author":"Das","year":"1999","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.taap.2006.11.012_bib9","doi-asserted-by":"crossref","first-page":"8543","DOI":"10.1038\/sj.onc.1207107","article-title":"A decade of caspases","volume":"22","author":"Degterev","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2006.11.012_bib10","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.cellsig.2005.05.020","article-title":"The regulatory mechanisms of export trafficking of G protein-coupled receptors","volume":"17","author":"Duvernay","year":"2005","journal-title":"Cell. Signalling"},{"key":"10.1016\/j.taap.2006.11.012_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0952-3278(02)00277-6","article-title":"Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells","volume":"68","author":"Dziak","year":"2003","journal-title":"Prostaglandins, Leukotrienes Essent. Fatty Acids"},{"key":"10.1016\/j.taap.2006.11.012_bib12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1745-7270.2005.00076.x","article-title":"Regulation of EGF-induced ERK\/MAPK activation and EGFR internalization by G protein-coupled receptor kinase 2","volume":"37","author":"Gao","year":"2005","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.taap.2006.11.012_bib13","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1176\/appi.ajp.159.10.1702","article-title":"Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine","volume":"159","author":"Gilmor","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.taap.2006.11.012_bib14","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2006.11.012_bib15","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.taap.2006.11.012_bib16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.nurx.2005.12.007","article-title":"Advances in the treatment of depression","volume":"3","author":"Holtzheimer","year":"2006","journal-title":"NeuroRx"},{"key":"10.1016\/j.taap.2006.11.012_bib17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1742-7843.2004.950304.x","article-title":"Effect of nortriptyline on intracellular Ca2+ handling and proliferation in human osteosarcoma cells","volume":"95","author":"Hsu","year":"2004","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2006.11.012_bib18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000073663","article-title":"Effect of the antidepressant desipramine on cytosolic Ca2+ movement and proliferation in human osteosarcoma cells","volume":"69","author":"Jan","year":"2003","journal-title":"Pharmacology"},{"key":"10.1016\/j.taap.2006.11.012_bib19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.yjmcc.2006.01.021","article-title":"Asymmetric dimethylarginine induces apoptosis via p38 MAPK\/caspase-3-dependent signaling pathway in endothelial cells","volume":"40","author":"Jiang","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2006.11.012_bib20","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO;2-J","article-title":"Apoptosis\u2014its significance in cancer and cancer therapy","volume":"73","author":"Kerr","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/j.taap.2006.11.012_bib21","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm1263","article-title":"Caspase-independent cell death","volume":"11","author":"Kroemer","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.taap.2006.11.012_bib22","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1172\/JCI26252","article-title":"Caspases: pharmacological manipulation of cell death","volume":"115","author":"Lavrik","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2006.11.012_bib23","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/S0006-2952(01)00622-0","article-title":"Mechanisms of histamine-induced intracellular Ca2+ release and extracellular Ca2+ entry in MG63 human osteosarcoma cells","volume":"61","author":"Lee","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2006.11.012_bib24","first-page":"201","article-title":"Role of MAPKs and NF-kappaB in diosgenin-induced megakaryocytic differentiation and subsequent apoptosis in HEL cells","volume":"28","author":"Leger","year":"2006","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.taap.2006.11.012_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1385\/JMN:27:1:029","article-title":"Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement","volume":"27","author":"Levkovitz","year":"2005","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.taap.2006.11.012_bib26","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.bbrc.2004.04.201","article-title":"Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation","volume":"319","author":"Liu","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2006.11.012_bib27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000057317","article-title":"Integration of signals from receptor tyrosine kinases and g protein-coupled receptors","volume":"11","author":"Lowes","year":"2002","journal-title":"NeuroSignals"},{"key":"10.1016\/j.taap.2006.11.012_bib28","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/bbrc.1998.9131","article-title":"Thymic lymphomas are resistant to Nur77-mediated apoptosis","volume":"249","author":"Matuszyk","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2006.11.012_bib29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0092-8674(00)81874-7","article-title":"Apoptosis by death factor","volume":"88","author":"Nagata","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.taap.2006.11.012_bib30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ejphar.2004.11.046","article-title":"Involvement of reactive oxygen species and stress-activated MAPKs in satratoxin H-induced apoptosis","volume":"507","author":"Nusuetrong","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2006.11.012_bib31","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/PL00000747","article-title":"Differential stimulation of signaling pathways initiated by Edg-2 in response to lysophosphatidic acid or sphingosine-1-phosphate","volume":"57","author":"Peyruchaud","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.taap.2006.11.012_bib32","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1046\/j.0953-816X.2000.01352.x","article-title":"Differential induction of NF-kappaB activity and neural cell death by antidepressants in vitro","volume":"12","author":"Post","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.taap.2006.11.012_bib33","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1023\/A:1023781114568","article-title":"Role of MAP kinase in tumor progression and invasion","volume":"22","author":"Reddy","year":"2003","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.taap.2006.11.012_bib34","first-page":"231","article-title":"Calcium-dependent proliferation of NG108-15 neuroblastoma cells","volume":"23","author":"Rouzaire-Dubois","year":"2004","journal-title":"Gen. Physiol Biophys."},{"key":"10.1016\/j.taap.2006.11.012_bib35","first-page":"187","article-title":"A historical review of cellular calcium handling, with emphasis on mitochondria","volume":"70","author":"Saris","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.taap.2006.11.012_bib36","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1128\/MCB.19.4.2435","article-title":"Mitogen-activated protein kinases: specific messages from ubiquitous messengers","volume":"19","author":"Schaeffer","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.taap.2006.11.012_bib37","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1182\/blood-2002-07-2044","article-title":"Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells","volume":"101","author":"Serafeim","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.taap.2006.11.012_bib38","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bcp.2005.12.018","article-title":"Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathways","volume":"71","author":"Shimizu","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2006.11.012_bib39","first-page":"161","article-title":"Estimation of apoptosis in C6 glioma cells treated with antidepressants","volume":"46","author":"Spanova","year":"1997","journal-title":"Physiol. Res."},{"key":"10.1016\/j.taap.2006.11.012_bib40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2165\/00002512-200219040-00004","article-title":"Clinically significant drug interactions with antidepressants in the elderly","volume":"19","author":"Spina","year":"2002","journal-title":"Drugs Aging"},{"key":"10.1016\/j.taap.2006.11.012_bib41","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0167-4838(99)00281-2","article-title":"Caspases-controlling intracellular signals by protease zymogen activation","volume":"1477","author":"Stennicke","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2006.11.012_bib42","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0047-6374(02)00025-8","article-title":"Cell signaling in aging and apoptosis","volume":"123","author":"Suh","year":"2002","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.taap.2006.11.012_bib43","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1073\/pnas.87.7.2466","article-title":"Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2+-ATPase","volume":"87","author":"Thastrup","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.taap.2006.11.012_bib44","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1345\/aph.1D352","article-title":"Serotonin syndrome with elevated paroxetine concentrations","volume":"38","author":"Velez","year":"2004","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.taap.2006.11.012_bib45","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/sj.onc.1207556","article-title":"Mitogen-activated protein kinases in apoptosis regulation","volume":"23","author":"Wada","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2006.11.012_bib46","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2165\/00003495-200262040-00010","article-title":"Paroxetine: an update of its use in psychiatric disorders in adults","volume":"62","author":"Wagstaff","year":"2002","journal-title":"Drugs"},{"key":"10.1016\/j.taap.2006.11.012_bib47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.abb.2004.08.001","article-title":"Redox active calcium ion channels and cell death","volume":"434","author":"Waring","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2006.11.012_bib48","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj20030312","article-title":"Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+","volume":"374","author":"Werry","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2006.11.012_bib49","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.18388\/abp.2000_3957","article-title":"The DFF40\/CAD endonuclease and its role in apoptosis","volume":"47","author":"Widlak","year":"2000","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.taap.2006.11.012_bib51","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.2042-7158.1996.tb05889.x","article-title":"The tricyclic antidepressants clomipramine and citalopram induce apoptosis in cultured human lymphocytes","volume":"48","author":"Xia","year":"1996","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.taap.2006.11.012_bib52","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/(SICI)1522-7146(1996)11:4<203::AID-JBT6>3.0.CO;2-O","article-title":"Dysregulation of bcl-2, c-myc, and Fas expression during tricyclic antidepressant-induced apoptosis in human peripheral lymphocytes","volume":"11","author":"Xia","year":"1996","journal-title":"J. Biochem. Toxicol."},{"key":"10.1016\/j.taap.2006.11.012_bib53","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0192-0561(97)00020-9","article-title":"Tricyclic antidepressants induce apoptosis in human T lymphocytes","volume":"19","author":"Xia","year":"1997","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.taap.2006.11.012_bib50","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/(SICI)1099-0461(1999)13:6<338::AID-JBT8>3.0.CO;2-7","article-title":"The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation","volume":"13","author":"Xia","year":"1999","journal-title":"J. Biochem. Mol. Toxicol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X06004273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X06004273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T20:12:05Z","timestamp":1628107925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X06004273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0041008X06004273"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2006.11.012","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}