{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:52:31Z","timestamp":1776988351513,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.taap.2006.12.028","type":"journal-article","created":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T18:39:38Z","timestamp":1168367978000},"page":"83-91","source":"Crossref","is-referenced-by-count":16,"title":["Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: Involvement of ATM pathway"],"prefix":"10.1016","volume":"220","author":[{"given":"Katsura","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Inageda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Nishitai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2006.12.028_bib1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1081\/CLT-100102425","article-title":"Vanadium","volume":"37","author":"Barceloux","year":"1999","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.taap.2006.12.028_bib2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00001622-200201000-00015","article-title":"Multiple roles of the tumor suppressor p53","volume":"14","author":"Bargonetti","year":"2002","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.taap.2006.12.028_bib3","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nrc1455","article-title":"Post-translational modification of p53 in tumorigenesis","volume":"4","author":"Bode","year":"2004","journal-title":"Nat. Rev., Cancer"},{"key":"10.1016\/j.taap.2006.12.028_bib4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.molcel.2006.01.020","article-title":"p53 ubiquitination: Mdm2 and beyond","volume":"21","author":"Brooks","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2006.12.028_bib5","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S0140-6736(02)11274-8","article-title":"Air pollution and health","volume":"360","author":"Brunekreef","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2006.12.028_bib6","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/jcb.20304","article-title":"Vanadium induces apoptosis and modulates the expressions of metallothionein, Ki-67 nuclear antigen, and p53 during 2-acetylaminofluorene-induced rat liver preneoplasia","volume":"94","author":"Chakraborty","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.taap.2006.12.028_bib7","doi-asserted-by":"crossref","first-page":"11936","DOI":"10.1073\/pnas.220252297","article-title":"Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage","volume":"97","author":"Chao","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.taap.2006.12.028_bib8","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.bbrc.2005.11.045","article-title":"Induction of COX-2 protein expression by vanadate in A549 human lung carcinoma cell line through EGF receptor and p38 MAPK-mediated pathway","volume":"339","author":"Chien","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2006.12.028_bib9","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1139\/y04-089","article-title":"Vanadium and the cardiovascular functions","volume":"82","author":"Coderre","year":"2004","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2006.12.028_bib10","doi-asserted-by":"crossref","first-page":"7002","DOI":"10.1093\/emboj\/18.24.7002","article-title":"Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2","volume":"18","author":"Dumaz","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.taap.2006.12.028_bib11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1040-8428(01)00221-9","article-title":"Vanadium in cancer treatment","volume":"42","author":"Evangelou","year":"2002","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.taap.2006.12.028_bib12","doi-asserted-by":"crossref","first-page":"31963","DOI":"10.1074\/jbc.M200082200","article-title":"Vanadate-induced expression of hypoxia-inducible factor 1\u03b1 and vascular endothelial growth factor through phosphatidylinositol 3-kinase\/Akt pathway and reactive oxygen species","volume":"277","author":"Gao","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.taap.2006.12.028_bib13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1289\/ehp.02110s1189","article-title":"Biologic effects of oil fly ash","volume":"110","author":"Ghio","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2006.12.028_bib14","doi-asserted-by":"crossref","first-page":"17885","DOI":"10.1074\/jbc.M210560200","article-title":"Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein: requirement of ATM for both apoptosis and recovery from terminal growth arrest","volume":"278","author":"Ha","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2006.12.028_bib15","doi-asserted-by":"crossref","first-page":"32516","DOI":"10.1074\/jbc.M005366200","article-title":"Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis","volume":"275","author":"Huang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2006.12.028_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1383-5718(02)00138-9","article-title":"Vanadate induces DNA strand breaks in cultured human fibroblasts at doses relevant to occupational exposure","volume":"519","author":"Ivancsits","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2006.12.028_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D","article-title":"Screening the p53 status of human cell lines using a yeast functional assay","volume":"19","author":"Jia","year":"1997","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.taap.2006.12.028_bib18","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.dnarep.2004.03.029","article-title":"DNA damage-induced activation of ATM and ATM-dependent signaling pathways","volume":"3","author":"Kurz","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.taap.2006.12.028_bib19","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1074\/jbc.M208295200","article-title":"Activation of JNK by vanadate induces a Fas-associated death domain (FADD)-dependent death of cerebellar granule progenitors in vitro","volume":"278","author":"Luo","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2006.12.028_bib20","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1006\/bbrc.2001.4700","article-title":"Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells","volume":"282","author":"Matsuoka","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2006.12.028_bib21","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/sj.cdd.4401768","article-title":"Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53","volume":"13","author":"Morita","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.taap.2006.12.028_bib22","doi-asserted-by":"crossref","first-page":"35778","DOI":"10.1074\/jbc.M004267200","article-title":"Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin","volume":"275","author":"Persons","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2006.12.028_bib23","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jama.287.9.1132","article-title":"Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution","volume":"287","author":"Pope","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.taap.2006.12.028_bib24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/toxsci\/kfg136","article-title":"Carcinogenicity of inhaled vanadium pentoxide in F344\/N rats and B6C3F1 mice","volume":"74","author":"Ress","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2006.12.028_bib25","first-page":"4375","article-title":"Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin","volume":"58","author":"Sarkaria","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2006.12.028_bib26","first-page":"4375","article-title":"Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine","volume":"59","author":"Sarkaria","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2006.12.028_bib27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrm1546","article-title":"p53: traffic cop at the crossroads of DNA repair and recombination","volume":"6","author":"Sengupta","year":"2005","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.taap.2006.12.028_bib28","doi-asserted-by":"crossref","first-page":"20444","DOI":"10.1074\/jbc.M001020200","article-title":"ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation","volume":"275","author":"She","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2006.12.028_bib29","first-page":"1604","article-title":"Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase","volume":"61","author":"She","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2006.12.028_bib30","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0092-8674(00)80416-X","article-title":"DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2","volume":"91","author":"Shieh","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.taap.2006.12.028_bib31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrc1011","article-title":"ATM and related protein kinases: safeguarding genome integrity","volume":"3","author":"Shiloh","year":"2003","journal-title":"Nat. Rev., Cancer"},{"key":"10.1016\/j.taap.2006.12.028_bib32","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1101\/gad.11.24.3471","article-title":"DNA damage induces phosphorylation of the amino terminus of p53","volume":"11","author":"Siliciano","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.taap.2006.12.028_bib33","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1158\/1055-9965.EPI-04-0899","article-title":"Transition metals in personal samples of PM2.5 and oxidative stress in human volunteers","volume":"14","author":"S\u00f8rensen","year":"2005","journal-title":"Cancer Epidemiol., Biomarkers Prev."},{"key":"10.1016\/j.taap.2006.12.028_bib34","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1007\/s00204-006-0110-4","article-title":"ATM\/ATR-related checkpoint signals mediate arsenite-induced G2\/M arrest in primary aortic endothelial cells","volume":"80","author":"Tsou","year":"2006","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2006.12.028_bib35","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/carcin\/22.5.757","article-title":"Mechanisms of Cr(VI)-induced p53 activation: the role of phosphorylation, mdm2 and ERK","volume":"22","author":"Wang","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2006.12.028_bib36","first-page":"6346","article-title":"Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts","volume":"60","author":"Yih","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2006.12.028_bib37","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/emboj\/cdg134","article-title":"Protein kinase C\u03b4 is responsible for constitutive and DNA damage-induced phosphorylation of Rad9","volume":"22","author":"Yoshida","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.taap.2006.12.028_bib38","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/abbi.2001.2464","article-title":"Vanadate-induced cell growth regulation and the role of reactive oxygen species","volume":"392","author":"Zhang","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2006.12.028_bib39","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0891-5849(03)00145-X","article-title":"Role of reactive oxygen species and MAPKs in vanadate-induced G2\/M phase arrest","volume":"34","author":"Zhang","year":"2003","journal-title":"Free Radic. Biol. Med."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X06005096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X06005096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T05:20:39Z","timestamp":1547097639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X06005096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0041008X06005096"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2006.12.028","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}