{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:00:07Z","timestamp":1792015207750,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.taap.2007.03.018","type":"journal-article","created":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T11:17:53Z","timestamp":1175080673000},"page":"339-348","source":"Crossref","is-referenced-by-count":137,"title":["Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL\/6 mice"],"prefix":"10.1016","volume":"221","author":[{"given":"Anna A.","family":"Shvedova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena R.","family":"Kisin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley R.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Gorelik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaram","family":"Arepalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Castranova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hong","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia Y.","family":"Tyurina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim D.","family":"Oury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerian E.","family":"Kagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2007.03.018_bib1","first-page":"51","article-title":"Analytical characterization of single wall carbon nanotubes","volume":"V1","author":"Arepalli","year":"2004","journal-title":"Encycl. Nanosci. Nanotechnol."},{"key":"10.1016\/j.taap.2007.03.018_bib2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jcpa.2005.04.004","article-title":"Effect of dietary supplementation with vitamin E and stocking density on macrophage recruitment and giant cell formation in the teleost fish, Piaractus mesopotamicus","volume":"133","author":"Belo","year":"2005","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.taap.2007.03.018_bib3","series-title":"NIOSH Manual of Analytical Methods (NMAM 5040)","article-title":"Elemental carbon. Monitoring of diesel exhaust particulate in the workplace","volume":"vol. 2003\u20132154","author":"Birch","year":"2003"},{"key":"10.1016\/j.taap.2007.03.018_bib4","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.1016\/S0021-9258(18)38102-X","article-title":"Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C","volume":"266","author":"Boscoboinik","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2007.03.018_bib5","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1116\/1.1380721","article-title":"Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: a parametric study","volume":"19","author":"Bronikowski","year":"2001","journal-title":"J. Vac. Sci. Technol."},{"key":"10.1016\/j.taap.2007.03.018_bib6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0003-9861(83)90145-5","article-title":"Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?","volume":"221","author":"Burton","year":"1983","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2007.03.018_bib7","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1073\/pnas.92.14.6264","article-title":"Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia","volume":"92","author":"Carlsson","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.taap.2007.03.018_bib8","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1098\/rsta.2004.1438","article-title":"Carbon nanotube electron sources and applications","volume":"362","author":"de Jonge","year":"2004","journal-title":"Philos. Trans. A Math. Phys. Eng. Sci."},{"key":"10.1016\/j.taap.2007.03.018_bib9","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1098\/rsta.2004.1430","article-title":"Electronic, thermal and mechanical properties of carbon nanotubes","volume":"362","author":"Dresselhaus","year":"2004","journal-title":"Philos. Trans. Ser. A Math. Phys. Eng. Sci."},{"key":"10.1016\/j.taap.2007.03.018_bib10","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1006\/bbrc.2000.3327","article-title":"Purification and characterization of extracellular superoxide dismutase in mouse lung","volume":"275","author":"Fattman","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2007.03.018_bib11","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0891-5849(01)00699-2","article-title":"Altered expression of extracellular superoxide dismutase in mouse lung after bleomycin treatment","volume":"31","author":"Fattman","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2007.03.018_bib12","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0891-5849(03)00275-2","article-title":"Extracellular superoxide dismutase in biology and medicine","volume":"35","author":"Fattman","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2007.03.018_bib13","unstructured":"Gorelik, O., Nikolaev, P., Arepalli, S., 2000. Purification procedures for single-walled carbon nanotubes. NASA contractor report, NASA\/CR-2000-208926."},{"key":"10.1016\/j.taap.2007.03.018_bib14","first-page":"1","article-title":"In situ assessment of oxidant and nitrogenic stress in bleomycin pulmonary fibrosis","volume":"24","author":"Inghilleri","year":"2005","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.taap.2007.03.018_bib15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4065\/81.2.205","article-title":"Pharmacological therapy for acute respiratory distress syndrome","volume":"81","author":"Jain","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.taap.2007.03.018_bib16","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1021\/es048729l","article-title":"Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene","volume":"39","author":"Jia","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2007.03.018_bib17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01002772","article-title":"Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections","volume":"11","author":"Junqueira","year":"1979","journal-title":"Histochem. J."},{"key":"10.1016\/j.taap.2007.03.018_bib18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1749-6632.1989.tb14913.x","article-title":"Tocopherol stabilizes membrane against phospholipase A, free fatty acids, and lysophospholipids","volume":"570","author":"Kagan","year":"1989","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.taap.2007.03.018_bib19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0076-6879(94)34099-4","article-title":"Light-induced generation of vitamin E radicals: assessing vitamin E regeneration","volume":"234","author":"Kagan","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.taap.2007.03.018_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(00)01707-5","article-title":"Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis","volume":"477","author":"Kagan","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.taap.2007.03.018_bib21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1749-6632.2002.tb02093.x","article-title":"Toward mechanism-based antioxidant interventions: lessons from natural antioxidants","volume":"959","author":"Kagan","year":"2002","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.taap.2007.03.018_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0076-6879(02)52016-4","article-title":"Peroxidation of phosphatidylserine in mechanisms of apoptotic signaling","volume":"352","author":"Kagan","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.taap.2007.03.018_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.toxlet.2006.02.001","article-title":"Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron","volume":"165","author":"Kagan","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2007.03.018_bib24","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1164\/rccm.200212-1479SO","article-title":"Superoxide dismutases in the lung and human lung diseases","volume":"167","author":"Kinnula","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.taap.2007.03.018_bib25","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0003-2697(86)90203-4","article-title":"Simultaneous determination of tocopherols, ubiquinols and ubiquinones in blood, plasma, tissue homogenates and subcellular fractions","volume":"157","author":"Lang","year":"1986","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2007.03.018_bib26","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1097\/01.jom.0000188561.75578.bf","article-title":"Asthma, genes, and air pollution","volume":"47","author":"McCunney","year":"2005","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.taap.2007.03.018_bib27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.taap.2005.01.008","article-title":"Respiratory toxicity of multi-wall carbon nanotubes","volume":"207","author":"Muller","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2007.03.018_bib28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00063198-200101000-00004","article-title":"The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress","volume":"7","author":"Nel","year":"2001","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.taap.2007.03.018_bib29","doi-asserted-by":"crossref","first-page":"22152","DOI":"10.1074\/jbc.M401180200","article-title":"The intracellular proteolytic processing of extracellular superoxide dismutase (EC-SOD) is a two-step event","volume":"279","author":"Olsen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2007.03.018_bib30","doi-asserted-by":"crossref","first-page":"L777","DOI":"10.1152\/ajplung.00011.2002","article-title":"Depletion of pulmonary EC-SOD after exposure to hyperoxia","volume":"283","author":"Oury","year":"2002","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.taap.2007.03.018_bib31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3181\/00379727-200-43433","article-title":"Interactions among antioxidants in health and disease: vitamin E and its redox cycle","volume":"200","author":"Packer","year":"1992","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.taap.2007.03.018_bib32","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1080\/15287390306417","article-title":"Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynx","volume":"66","author":"Rao","year":"2003","journal-title":"J. Toxicol. Environ. Health, Part A"},{"key":"10.1016\/j.taap.2007.03.018_bib33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1165\/rcmb.4899","article-title":"Vitamin E reduces transendothelial migration of neutrophils and prevents lung injury in endotoxin-induced airway inflammation","volume":"28","author":"Rocksen","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2007.03.018_bib34","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0891-5849(01)00523-8","article-title":"Immunological dysregulation of lung cells in response to vitamin E deficiency","volume":"30","author":"Sabat","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2007.03.018_bib35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.rmed.2004.07.005","article-title":"The interrelationship between markers of inflammation and oxidative stress in chronic obstructive pulmonary disease: modulation by inhaled steroids and antioxidant","volume":"99","author":"Sadowska","year":"2005","journal-title":"Respir. Med."},{"key":"10.1016\/j.taap.2007.03.018_bib36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrd796","article-title":"SOD mimetics are coming of age","volume":"1","author":"Salvemini","year":"2002","journal-title":"Nat. Rev., Drug Discov."},{"key":"10.1016\/j.taap.2007.03.018_bib37","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.abb.2003.12.009","article-title":"Enhanced inflammatory responses in alpha-tocopherol transfer protein null mice","volume":"423","author":"Schock","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2007.03.018_bib38","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0300-483X(02)00188-9","article-title":"Metal working fluids: sub-chronic effects on pulmonary functions in B6C3F1 mice given vitamin E deficient and sufficient diets","volume":"177","author":"Shvedova","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2007.03.018_bib39","series-title":"Proc. Soc. Free Rad Research Meeting, European Section, June 26\u201329, 2003","first-page":"91","article-title":"Exposure of human bronchial epithelial cells to carbon nanotubes causes oxidative stress and cytotoxicity","author":"Shvedova","year":"2004"},{"key":"10.1016\/j.taap.2007.03.018_bib40","doi-asserted-by":"crossref","first-page":"L698","DOI":"10.1152\/ajplung.00084.2005","article-title":"Unusual inflammatory and fibrogenic pulmonary responses to single walled carbon nanotubes in mice","volume":"289","author":"Shvedova","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.taap.2007.03.018_bib41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.nutr.24.012003.132446","article-title":"Vitamin E, oxidative stress and inflammation","volume":"25","author":"Singh","year":"2005","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.taap.2007.03.018_bib42","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1109\/TNB.2005.850478","article-title":"Carbon nanotubes for biomedical applications","volume":"4","author":"Sinha","year":"2005","journal-title":"IEEE Trans. Nanobioscience"},{"key":"10.1016\/j.taap.2007.03.018_bib43","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1152\/japplphysiol.00480.2004","article-title":"Redistribution of pulmonary EC-SOD after exposure to asbestos","volume":"97","author":"Tan","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.taap.2007.03.018_bib44","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1165\/rcmb.2005-0471OC","article-title":"Matrix metalloproteinases promote inflammation and fibrosis in asbestos-induced lung injury in mice","volume":"35","author":"Tan","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2007.03.018_bib45","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1165\/rcmb.2005-0212OC","article-title":"Inflammatory cells as a source of airspace extracellular superoxide dismutase after pulmonary injury","volume":"34","author":"Tan","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2007.03.018_bib46","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0262-1746(87)90036-9","article-title":"Effects of selenium, vitamin E and vitamin C on human prostacyclin and thromboxane synthesis in vitro","volume":"26","author":"Toivanen","year":"1987","journal-title":"Prostaglandins Leukot. Med."},{"key":"10.1016\/j.taap.2007.03.018_bib47","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1046\/j.1365-2362.2000.00642.x","article-title":"Decreased antioxidant defence in individuals infected by the human immunodeficiency virus","volume":"30","author":"Treitinger","year":"2000","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.taap.2007.03.018_bib48","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0899-9007(02)00945-0","article-title":"Opportunities for nutritional amelioration of radiation-induced cellular damage","volume":"18","author":"Turner","year":"2002","journal-title":"Nutrition"},{"key":"10.1016\/j.taap.2007.03.018_bib49","series-title":"Quantitative Stereology","author":"Underwood","year":"1970"},{"key":"10.1016\/j.taap.2007.03.018_bib50","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1177\/000456329102800514","article-title":"Measurement of malondialdehyde in plasma by high performance liquid chromatography with fluorimetric detection","volume":"28","author":"Young","year":"1991","journal-title":"Ann. Clin. Biochem."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X07001378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X07001378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T21:24:53Z","timestamp":1628717093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X07001378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0041008X07001378"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2007.03.018","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}