{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:57:06Z","timestamp":1792277826634,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.taap.2008.12.009","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T10:11:21Z","timestamp":1230199881000},"page":"253-260","source":"Crossref","is-referenced-by-count":48,"title":["Prodigiosin down-regulates survivin to facilitate paclitaxel sensitization in human breast carcinoma cell lines"],"prefix":"10.1016","volume":"235","author":[{"given":"Tsing-Fen","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ta","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Show-Mei","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Chang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Lin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Hsing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ju","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo-Shu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Che","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2008.12.009_bib1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrc968","article-title":"Validating survivin as a cancer therapeutic target","volume":"3","author":"Altieri","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.taap.2008.12.009_bib2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ceb.2006.08.015","article-title":"The case for survivin as a regulator or microtubule dynamics and cell-death decisions","volume":"18","author":"Altieri","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.taap.2008.12.009_bib3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nrc2293","article-title":"Survivin, cancer networks and pathway-directed drug discovery","volume":"8","author":"Altieri","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.taap.2008.12.009_bib4","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1182\/blood-2004-12-4704","article-title":"Regulation of survivin expression through Bcr-Abl\/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells","volume":"107","author":"Carter","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.taap.2008.12.009_bib5","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1242\/jcs.00612","article-title":"Survivin is required for stable checkpoint activation in taxol-treated HeLa cells","volume":"116","author":"Carvalho","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.taap.2008.12.009_bib6","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/sj.cgt.7700752","article-title":"Cancer-specific activation of the survivin promoter and its potential use in gene therapy","volume":"11","author":"Chen","year":"2004","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.taap.2008.12.009_bib7","first-page":"CD004421","article-title":"Taxanes for adjuvant treatment of early breast cancer","volume":"17","author":"Ferguson","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.taap.2008.12.009_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2007.06.054","article-title":"Mechanisms of prodigiosin cytotoxicity in human neuroblastoma cell lines","volume":"572","author":"Francisco","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2008.12.009_bib9","doi-asserted-by":"crossref","first-page":"11737","DOI":"10.1073\/pnas.191388598","article-title":"Resistance to taxol in lung cancer cells associated with increased microtubule dynamics","volume":"98","author":"Gon\u00e7alves","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2008.12.009_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1158\/1078-0432.CCR-04-1752","article-title":"Persistent activation of Stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells","volume":"12","author":"Gritsko","year":"2006","journal-title":"Clin. Cancer Res.,"},{"key":"10.1016\/j.taap.2008.12.009_bib11","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1056\/NEJMoa071167","article-title":"HER2 and response to paclitaxel in node-positive breast cancer","volume":"357","author":"Hayes","year":"2007","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.taap.2008.12.009_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.taap.2007.08.007","article-title":"Undecylprodigiosin selectively induces apoptosis in human breast carcinoma cells independent of p53","volume":"225","author":"Ho","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2008.12.009_bib13","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1074\/jbc.M106643200","article-title":"Transcriptional repression of the anti-apoptotic survivin gene by wild type p53","volume":"277","author":"Hoffman","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2008.12.009_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3322\/CA.2007.0010","article-title":"Cancer statistics","volume":"58","author":"Jemal","year":"2008","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.taap.2008.12.009_bib15","doi-asserted-by":"crossref","first-page":"40511","DOI":"10.1074\/jbc.M404496200","article-title":"Aberrant regulation of survivin by the RB\/E2F family of proteins","volume":"279","author":"Jiang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2008.12.009_bib16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","article-title":"Microtubules as a target for anticancer drugs","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.taap.2008.12.009_bib17","doi-asserted-by":"crossref","first-page":"19273","DOI":"10.1074\/jbc.M610350200","article-title":"Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer","volume":"282","author":"Kaneko","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2008.12.009_bib18","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1271\/bbb.80064","article-title":"Cycloprodigiosin hydrochloride activates the Ras-PI3K-Akt pathway and suppresses protein synthesis inhibitor-induced apoptosis in PC12 cells","volume":"72","author":"Kawauchi","year":"2008","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.taap.2008.12.009_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0140-6736(03)13910-4","article-title":"Survivin and molecular pathogenesis of colorectal cancer","volume":"362","author":"Kim","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2008.12.009_bib20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1042\/0264-6021:3440305","article-title":"Transcriptional analysis of human survivin gene expression","volume":"344","author":"Li","year":"1999","journal-title":"Biochem. J.,"},{"key":"10.1016\/j.taap.2008.12.009_bib21","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/jcp.20634","article-title":"Survivin study: an update of \u201cwhat is the next wave\u201d?","volume":"208","author":"Li","year":"2006","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.taap.2008.12.009_bib22","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bcp.2005.05.028","article-title":"Combination of cyclooxygenase-2 inhibitors and oxaliplatin increases the growth inhibition and death in human colon cancer cells","volume":"70","author":"Lin","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2008.12.009_bib23","doi-asserted-by":"crossref","first-page":"15196","DOI":"10.1074\/jbc.M310947200","article-title":"Induction of survivin expression by taxol (paclitaxel) is an early event, which is independent of taxol-mediated G2\/M arrest","volume":"279","author":"Ling","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2008.12.009_bib24","first-page":"96","article-title":"Taxanes, microtubules and chemoresistant breast cancer","volume":"1785","author":"McGrogan","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2008.12.009_bib25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00520-002-0405-9","article-title":"Managing taxane toxicities","volume":"11","author":"Markman","year":"2003","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.taap.2008.12.009_bib26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/PPO.0b013e318074dc6f","article-title":"Breast cancer chemotherapy","volume":"13","author":"McArthur","year":"2007","journal-title":"Cancer J."},{"key":"10.1016\/j.taap.2008.12.009_bib27","unstructured":"NCI, 2008. On-line at: http:\/\/seer.cancer.gov\/statfacts\/html\/breast.html."},{"key":"10.1016\/j.taap.2008.12.009_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1349-7006.2007.00637.x","article-title":"Oxaliplatin induces mitotic catastrophe and apoptosis in esophageal cancer cells","volume":"99","author":"Ngan","year":"2008","journal-title":"Cancer Sci."},{"key":"10.1016\/j.taap.2008.12.009_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1535-6108(02)00084-3","article-title":"A p34cdc2 survival checkpoint in cancer","volume":"2","author":"O'Connor","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.taap.2008.12.009_bib31","first-page":"2805","article-title":"A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy","volume":"60","author":"Olie","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2008.12.009_bib32","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/sj.onc.1207071","article-title":"Ribozyme-mediated inhibition of survivin expression increases spontaneous and drug-induced apoptosis and decreases the tumorigenic potential of human prostate cancer cells","volume":"23","author":"Pennati","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2008.12.009_bib33","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1158\/1535-7163.MCT-05-0022","article-title":"Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation","volume":"4","author":"Pennati","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.taap.2008.12.009_bib34","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/carcin\/bgm047","article-title":"Targeting survivin in cancer therapy: fulfilled promises and open questions","volume":"28","author":"Pennati","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2008.12.009_bib35","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/leu.2008.175","article-title":"BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells","volume":"22","author":"P\u00e9rez-Gal\u00e1n","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.taap.2008.12.009_bib36","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0006-2952(03)00496-9","article-title":"The prodigiosins, proapoptotic drugs with anticancer properties","volume":"66","author":"P\u00e9rez-Tom\u00e1s","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2008.12.009_bib37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ccr.2005.03.035","article-title":"Rational design of shepherdin, a novel anticancer agent","volume":"7","author":"Plescia","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.taap.2008.12.009_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1476-4598-5-19","article-title":"Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo","volume":"5","author":"Pyrko","year":"2006","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.taap.2008.12.009_bib39","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0006-2952(01)00850-4","article-title":"Activation of protein kinase C for protection of cells against apoptosis induced by the immunosuppressor prodigiosin","volume":"63","author":"Ramoneda","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2008.12.009_bib40","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.2165\/00003495-200464160-00008","article-title":"Paclitaxel: as adjuvant or neoadjuvant therapy in early breast cancer","volume":"64","author":"Simpson","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.taap.2008.12.009_bib41","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1263\/jbb.101.157","article-title":"Purification and characterization of prodigiosin produced by integrated bioreactor from Serratia sp","volume":"101","author":"Song","year":"2006","journal-title":"KH-95. J. Biosci. Bioeng."},{"key":"10.1016\/j.taap.2008.12.009_bib42","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.bcp.2004.05.056","article-title":"Mitochondria-mediated apoptosis operating irrespective of multidrug resistance in breast cancer cells by the anticancer agent prodigiosin","volume":"68","author":"Soto-Cerrato","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2008.12.009_bib43","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.bcp.2007.07.016","article-title":"The anticancer agent prodigiosin induces p21WAF1\/CIP1 expression via transforming growth factor-beta receptor pathway","volume":"74","author":"Soto-Cerrato","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2008.12.009_bib44","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1158\/1535-7163.MCT-06-0266","article-title":"Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3\u03b2 activity in human breast cancer cells","volume":"6","author":"Soto-Cerrato","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.taap.2008.12.009_bib45","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/ijc.23183","article-title":"Transcriptional regulation of human survivin by early growth response (Egr)-1 transcription factor","volume":"122","author":"Wagner","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2008.12.009_bib46","first-page":"230","article-title":"Suppression of survivin phosphorylaion on Thr34 by flavopiridol enhances tumor cell apoptosis","volume":"63","author":"Wall","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2008.12.009_bib47","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1263\/jbb.99.616","article-title":"Enhanced production of prodigiosin-like pigment from Serratia marcescens SM\u0394R by medium improvement and oil-supplementation strategies","volume":"99","author":"Wei","year":"2005","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.taap.2008.12.009_bib48","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1263\/jbb.100.466","article-title":"Enhanced undecylprodigiosin production from Serratia marcescens SS-1 by medium formulation and amino-acid supplementation","volume":"100","author":"Wei","year":"2005","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.taap.2008.12.009_bib49","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nrmicro1531","article-title":"The biosynthesis and regulation of bacterial prodiginines","volume":"4","author":"Williamson","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.taap.2008.12.009_bib50","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbrc.2007.02.140","article-title":"Sp1 and Sp3 regulate basal transcription of the survivin gene","volume":"356","author":"Xu","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2008.12.009_bib51","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1111\/j.1349-7006.2008.00870.x","article-title":"Cancer cells survive with survivin","volume":"99","author":"Yamamoto","year":"2008","journal-title":"Cancer Sci."},{"key":"10.1016\/j.taap.2008.12.009_bib52","first-page":"6815","article-title":"Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implications for cancer specific therapy","volume":"63","author":"Yang","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2008.12.009_bib53","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1007\/s00018-002-8518-3","article-title":"Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer","volume":"59","author":"Zaffaroni","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.taap.2008.12.009_bib54","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bcp.2004.08.037","article-title":"Antimetastatic effect of prodigiosin through inhibition of tumor invasion","volume":"69","author":"Zhang","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2008.12.009_bib55","doi-asserted-by":"crossref","first-page":"8708","DOI":"10.1158\/0008-5472.CAN-04-2538","article-title":"Survivin deregulation in \u03b2-tubulin mutant ovarian cancer cells underlies their compromised mitotic response to taxol","volume":"64","author":"Zhou","year":"2004","journal-title":"Cancer Res."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X08005206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X08005206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T14:00:25Z","timestamp":1709820025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X08005206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0041008X08005206"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2008.12.009","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}