{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:35:18Z","timestamp":1770813318305,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.taap.2009.12.035","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T09:16:33Z","timestamp":1262855793000},"page":"218-225","source":"Crossref","is-referenced-by-count":9,"title":["Transport of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2)"],"prefix":"10.1016","volume":"244","author":[{"given":"Kirill","family":"Tsirulnikov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Abuladze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myong-Chul","family":"Koag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoline","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galyna","family":"Bondar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quansheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuraly K.","family":"Avliyakulov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Dekant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kym","family":"Faull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Kurtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Pushkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2009.12.035_bib1","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR), 1993, Toxicological Profile for Trichloroethylene. U.S. Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA."},{"key":"10.1016\/j.taap.2009.12.035_bib2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.pharmtox.38.1.501","article-title":"Glutathione-dependent bioactivation of haloalkenes","volume":"38","author":"Anders","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2009.12.035_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1054-3589(08)61031-5","article-title":"Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate beta-lyase pathway","volume":"27","author":"Anders","year":"1994","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.taap.2009.12.035_bib4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0003-2697(83)90004-0","article-title":"Linear one-step assay for the determination of orthophosphate","volume":"132","author":"Bencini","year":"1983","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2009.12.035_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002040050461","article-title":"Biotransformation, excretion, and nephrotoxicity of haloalkene-derived cysteine S-conjugates","volume":"72","author":"Birner","year":"1997","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2009.12.035_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0005-2736(99)00167-4","article-title":"The multidrug resistance protein family","volume":"1461","author":"Borst","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2009.12.035_bib7","doi-asserted-by":"crossref","first-page":"15091","DOI":"10.1074\/jbc.271.25.15091","article-title":"cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats","volume":"271","author":"B\u00fcchler","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2009.12.035_bib9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1054-3589(08)61030-3","article-title":"Enzymology of cysteine S-conjugate \u03b2-lyases","volume":"27","author":"Cooper","year":"1994","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.taap.2009.12.035_bib10","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0026-895X(24)23190-4","article-title":"Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells","volume":"55","author":"Cui","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2009.12.035_bib11","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0022-3565(25)24457-3","article-title":"Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules","volume":"272","author":"Dantzler","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2009.12.035_bib12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0022-3565(24)37556-1","article-title":"Relation of cysteine conjugate nephrotoxicity to transport by the basolateral organic anion transport system in isolated S2 segments of rabbit proximal renal tubules","volume":"286","author":"Dantzler","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2009.12.035_bib13","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0278-6915(97)00084-7","article-title":"Public health implications of hazardous waste sites: finding, assessment and research","volume":"34","author":"De Rosa","year":"1996","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2009.12.035_bib14","first-page":"114","article-title":"Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate \u03b2-lyase pathway","volume":"27","author":"Dekant","year":"1994","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.taap.2009.12.035_bib15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.biopha.2005.01.005","article-title":"Pharmacological and clinical features of the multidgug resistance protein 2","volume":"59","author":"Farrel","year":"2005","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2009.12.035_bib16","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1469-7793.2001.0597h.x","article-title":"The stoichiometry of the electrogenic sodium bicarbonate cotransporter NBC1 is cell-type dependent","volume":"531","author":"Gross","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.taap.2009.12.035_bib40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1042\/bj1720057","article-title":"Studies on the orientation of brush-border membrane vesicles","volume":"172","author":"Haase","year":"1978","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2009.12.035_bib17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/oxfordjournals.jbchem.a134591","article-title":"Hepato-renal cooperation in biotransformation, membrane transport, and elimination of cysteine S-conjugates of xenobiotics","volume":"95","author":"Inoue","year":"1984","journal-title":"J. Biochem."},{"key":"10.1016\/j.taap.2009.12.035_bib41","doi-asserted-by":"crossref","first-page":"19279","DOI":"10.1016\/S0021-9258(17)30655-5","article-title":"ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane: role of ATP-dependent transport system for glutathione S-conjugates","volume":"265","author":"Ishikawa","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2009.12.035_bib18","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1124\/mol.59.5.1077","article-title":"Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2","volume":"59","author":"Ito","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2009.12.035_bib19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/1056-8719(93)90027-C","article-title":"An in vitro model of renal proximal tubule cell regeneration","volume":"29","author":"Kays","year":"1993","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.taap.2009.12.035_bib20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0022-3565(25)23734-X","article-title":"Uptake of nephrotoxic S-conjugates by isolated rat renal proximal tubular cells","volume":"248","author":"Lash","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2009.12.035_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.2001.9295","article-title":"Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-l-cysteine in primary cultures of human proximal tubule cells","volume":"177","author":"Lash","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2009.12.035_bib22","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1080\/15287390500360133","article-title":"Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione- and cytochrome P-450-derived metabolites in liver, kidney, blood, and urine","volume":"69","author":"Lash","year":"2006","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.taap.2009.12.035_bib23","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.taap.2004.10.012","article-title":"Multidrug resistance protein: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense","volume":"204","author":"Leslie","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2009.12.035_bib24","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1021\/ja01318a036","article-title":"The determination of enzyme dissociation constants","volume":"56","author":"Lineweaver","year":"1934","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.taap.2009.12.035_bib25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1124\/dmd.106.012062","article-title":"Specificity of aminoacylase III-mediated deacetylation of mercapturic acids","volume":"35","author":"Newman","year":"2007","journal-title":"Drug Metabol. Disposit."},{"key":"10.1016\/j.taap.2009.12.035_bib26","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00424-006-0109-y","article-title":"The apical conjugate efflux pump ABCC2 (Mrp2)","volume":"453","author":"Nies","year":"2007","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"10.1016\/j.taap.2009.12.035_bib27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0304-4157(95)00006-D","article-title":"Hepatobiliary secretion of organic compounds: molecular mechanisms of membrane transport","volume":"1241","author":"Oude Elferink","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2009.12.035_bib28","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.271.5252.1126","article-title":"Congenital jaundice in rats with a mutation in a multidrug resistance associated-protein gene","volume":"271","author":"Paulusma","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.taap.2009.12.035_bib30","doi-asserted-by":"crossref","first-page":"C848","DOI":"10.1152\/ajpcell.00192.2003","article-title":"Structural characterization, tissue distribution, and functional expression of murine aminoacylase III","volume":"286","author":"Pushkin","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2009.12.035_bib31","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1681\/ASN.V881213","article-title":"Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules","volume":"8","author":"Schaub","year":"1997","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.taap.2009.12.035_bib32","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.jasms.2005.08.003","article-title":"Rapid detection and identification of N-acetyl-L-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced product-ion scans on a linear ion trap mass spectrometer","volume":"16","author":"Scholz","year":"2005","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.taap.2009.12.035_bib33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/01480548608998281","article-title":"Early biological indicators of S-(1,2-dichlorovinyl)-l-cysteine nephrotoxicity in the rabbit","volume":"9","author":"Silber","year":"1986","journal-title":"Drug. Chem. Toxicol."},{"key":"10.1016\/j.taap.2009.12.035_bib34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1055\/s-2007-1007170","article-title":"Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT\/MRP2","volume":"18","author":"Suzuki","year":"1998","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.taap.2009.12.035_bib35","first-page":"F216","article-title":"Molecular pharmacology of renal organic transporters","volume":"279","author":"Van Aubel","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2009.12.035_bib36","first-page":"474","article-title":"Mechanism of nephrogenic repair response. Studies on proliferation and vimentin expression after 35S-1,2-dichlorovinyl-l-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells","volume":"66","author":"Wallin","year":"1992","journal-title":"Lab. Invest."},{"key":"10.1016\/j.taap.2009.12.035_bib37","first-page":"41","article-title":"Sulfoxidation of mercapturic acids derived from tri- and tetrachloroethylene by cytochromes P450 3A: a bioactivation reaction in addition to deacetylation and cysteine conjugate \u03b2-lyase mediated cleavage","volume":"9","author":"Werner","year":"1997","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2009.12.035_bib38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0041-008X(89)90270-6","article-title":"N-acetyl S-(1,2-dichlorovinyl)-l-cysteine produces a similar toxicity to S-(1,2-dichlorovinyl)-l-cysteine in rabbit renal slices: differential transport and metabolism","volume":"101","author":"Wolfgang","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2009.12.035_bib39","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0022-3565(24)37405-1","article-title":"Na-dependent transport of S-(1,2-dichlorovinyl)-l-cysteine by renal brush-border membrane vesicles","volume":"285","author":"Wright","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X09005420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X09005420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T15:11:46Z","timestamp":1739718706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X09005420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0041008X09005420"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2009.12.035","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}