{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:16:02Z","timestamp":1773292562175,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.taap.2011.12.009","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T18:19:10Z","timestamp":1324405150000},"page":"143-151","source":"Crossref","is-referenced-by-count":34,"title":["2,3,7,8-Tetrachlorodibenzo-p-dioxin treatment alters eicosanoid levels in several organs of the mouse in an aryl hydrocarbon receptor-dependent fashion"],"prefix":"10.1016","volume":"259","author":[{"given":"Peter","family":"Bui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parrisa","family":"Solaimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Hankinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2011.12.009_bb0005","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1111\/j.1476-5381.2009.00461.x","article-title":"3-Methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats","volume":"158","author":"Aboutabl","year":"2009","journal-title":"Br. J. Pharmacol."},{"issue":"32","key":"10.1016\/j.taap.2011.12.009_bb0010","doi-asserted-by":"crossref","first-page":"21599","DOI":"10.1074\/jbc.M109.003822","article-title":"Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of lyme arthritis","volume":"283","author":"Blaho","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2011.12.009_bb0015","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1515\/BC.2009.138","article-title":"The mammalian aryl hydrocarbon (Ah) receptor: from mediator of dioxin toxicity toward physiological functions in skin and liver","volume":"390","author":"Bock","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"419","key":"10.1016\/j.taap.2011.12.009_bb0020","first-page":"1471","article-title":"Transcriptomic responses to 2,3,7,8-tetrachlorodibenzi-p-dioxin (TCDD) in liver: comparison of rat and mouse","volume":"9","author":"Boutros","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.taap.2011.12.009_bb0025","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1194\/jlr.R900004-JLR200","article-title":"An integrated omics analysis of eicosanoid biology","volume":"50","author":"Buczynski","year":"2009","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.taap.2011.12.009_bb0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/toxsci\/kfn149","article-title":"Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor","volume":"106","author":"Bunger","year":"2008","journal-title":"Toxicol. Sci."},{"issue":"19","key":"10.1016\/j.taap.2011.12.009_bb0035","doi-asserted-by":"crossref","first-page":"10865","DOI":"10.1016\/S0021-9258(19)38526-6","article-title":"Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase","volume":"265","author":"Capdevilla","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"4 Pt 2","key":"10.1016\/j.taap.2011.12.009_bb0040","first-page":"R863","article-title":"Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides","volume":"271","author":"Carroll","year":"1996","journal-title":"Am. J. Physiol."},{"issue":"8","key":"10.1016\/j.taap.2011.12.009_bb0045","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1124\/dmd.32.8.840","article-title":"Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1B1","volume":"32","author":"Choudhary","year":"2004","journal-title":"Drug Metab. Dispos."},{"issue":"4","key":"10.1016\/j.taap.2011.12.009_bb0050","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1385\/CT:1:4:285","article-title":"Dioxin exposure is an environmental risk factor for ischemic heart disease","volume":"1","author":"Dalton","year":"2001","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.taap.2011.12.009_bb0055","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0378-4274(95)03387-Z","article-title":"The effects of 2,2\u2032 4,4\u2032,5,5\u2032-hexachlorobiphenyl cotreatment on the disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice","volume":"80","author":"De Jongh","year":"1995","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.taap.2011.12.009_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kfr218","article-title":"Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor","volume":"124","author":"Denison","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2011.12.009_bb0065","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.abb.2008.01.002","article-title":"Metabolismo f eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450","volume":"471","author":"Fer","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2011.12.009_bb0070","series-title":"Comparative Metabolomic and Genomic Analyses of TCDD-Elicited Metabolic Disruption in Mouse and Rat Liver","author":"Forgacs","year":"2012"},{"issue":"1","key":"10.1016\/j.taap.2011.12.009_bb0075","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2183\/pjab.86.40","article-title":"Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli","volume":"86","author":"Fujii-Kuriyama","year":"2010","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.taap.2011.12.009_bb0080","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.pa.35.040195.001515","article-title":"The aryl hydrocarbon receptor complex","volume":"35","author":"Hankinson","year":"1995","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2011.12.009_bb0085","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1021\/tx7003294","article-title":"Hepatic transcriptional networks induced by exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin","volume":"20","author":"Hayes","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2011.12.009_bb0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1124\/jpet.107.130336","article-title":"20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-\u03baB activation and the production of inflammatory cytokines in human endothelial cells","volume":"324","author":"Ishizuka","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.taap.2011.12.009_bb0095","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jbiosc.2009.04.015","article-title":"High-throughput evaluation of aryl hydrocarbon receptor-binding sites selected via chromatin immunoprecipitation-based screening in Hepa-1c1c7 cells stimulated with 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"108","author":"Kinehara","year":"2009","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.taap.2011.12.009_bb0100","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.bbalip.2006.08.001","article-title":"Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s","volume":"1761","author":"Kita","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2011.12.009_bb0105","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbapap.2010.09.009","article-title":"Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids","volume":"1814","author":"Konkel","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.taap.2011.12.009_bb0110","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/toxsci\/kfq236","article-title":"Automated dose\u2013response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL\/6 Mice","volume":"118","author":"Kopec","year":"2010","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.taap.2011.12.009_bb0115","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/toxsci\/kfq218","article-title":"Cytochrome P4501A1 is required for vasuclar dysfunction and hypertension induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"117","author":"Kopf","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2011.12.009_bb0120","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/03602530600632063","article-title":"The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases","volume":"38","author":"Korashy","year":"2006","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.taap.2011.12.009_bb0125","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.freeradbiomed.2010.02.010","article-title":"Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation","volume":"48","author":"Kubala","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.taap.2011.12.009_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1998.8468","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin induction of cytochrome P450-dependent arachidonic acid metabolism in mouse liver microsomes: evidence for species-specific differences in responses","volume":"153","author":"Lee","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.taap.2011.12.009_bb0135","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1751-7133.2010.00209.x","article-title":"Use of metabolomic profiling in the study of arachidonic acid metabolism in cardiovascular disease","volume":"17","author":"Li","year":"2011","journal-title":"Congest. Heart Fail."},{"key":"10.1016\/j.taap.2011.12.009_bb0140","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1039\/c1mb05057e","article-title":"Metabolomic analysis of liver and skeletal muscle tissues in C57BL\/6J and DBA\/2J mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"7","author":"Lin","year":"2011","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.taap.2011.12.009_bb0145","first-page":"231","article-title":"The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways","volume":"99","author":"Ma","year":"2009","journal-title":"EXS"},{"issue":"52","key":"10.1016\/j.taap.2011.12.009_bb0150","doi-asserted-by":"crossref","first-page":"36061","DOI":"10.1074\/jbc.R800053200","article-title":"Endogenous functions of the aryl hydrocarbon receptor (AHR): intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology","volume":"283","author":"Nebert","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.taap.2011.12.009_bb0155","first-page":"447","article-title":"Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis","volume":"2","author":"Norwood","year":"2010","journal-title":"Am. J. Transl. Res."},{"issue":"12","key":"10.1016\/j.taap.2011.12.009_bb0160","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1073\/pnas.0809613106","article-title":"The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology","volume":"106","author":"Nukaya","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"46","key":"10.1016\/j.taap.2011.12.009_bb0165","doi-asserted-by":"crossref","first-page":"35599","DOI":"10.1074\/jbc.M110.132043","article-title":"The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes","volume":"285","author":"Nukaya","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.taap.2011.12.009_bb0170","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/toxsci\/kfq305","article-title":"Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver","volume":"118","author":"Nukaya","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2011.12.009_bb0175","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/01.RES.83.9.932","article-title":"Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation","volume":"83","author":"Oltman","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2011.12.009_bb0180","series-title":"Role of the AHR and its Structure in TCDD Toxicity","author":"Pohjanvirta","year":"2011"},{"key":"10.1016\/j.taap.2011.12.009_bb0185","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/03602530600570107","article-title":"CYP1A in TCDD Toxicity and in Physiology-with Particular Reference to CYP Dependent Arachidonic Acid Metabolism and Other Endogenous Substrates","volume":"38","author":"Rifkind","year":"2006","journal-title":"Drug Metab. Rev."},{"issue":"2","key":"10.1016\/j.taap.2011.12.009_bb0190","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/abbi.1998.0651","article-title":"Arachidonic acid metabolism in the marine fish Stenotomus chrysops (Scup) and the effects of cytochrome P450 1A Inducers","volume":"353","author":"Schlezinger","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"issue":"13","key":"10.1016\/j.taap.2011.12.009_bb0195","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1073\/pnas.93.13.6731","article-title":"Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development","volume":"93","author":"Schmidt","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2011.12.009_bb0200","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.bcp.2003.12.023","article-title":"Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxiyeicosatetraenoic acid","volume":"67","author":"Schwarz","year":"2004","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.taap.2011.12.009_bb0205","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/taap.2001.9131","article-title":"The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells","volume":"171","author":"Slim","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2011.12.009_bb0210","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/taap.2001.9167","article-title":"Protection of the Cyp1a2 (\u2212\/\u2212) Null Mouse against Uroporphyria and Hepatic Injury Following Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin","volume":"173","author":"Smith","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"S1","key":"10.1016\/j.taap.2011.12.009_bb0260","first-page":"S171","article-title":"The long Winding Road toward Understanding the Molecular Mechanisms for B-Cell Suppression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin","volume":"120","author":"Sulentic","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2011.12.009_bb0225","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1124\/mol.105.018705","article-title":"Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries","volume":"69","author":"Tijet","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2011.12.009_bb0230","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.taap.2004.01.014","article-title":"Cyp1a1 (\u2212\/\u2212) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria","volume":"196","author":"Uno","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.taap.2011.12.009_bb0235","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/abbi.1997.0555","article-title":"Modulation of Prostaglandin H Synthase-2 mRNA Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mice","volume":"352","author":"Vogel","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.taap.2011.12.009_bb0240","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/10590500903310047","article-title":"An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology","volume":"27","author":"White","year":"2009","journal-title":"J. Environ. Sci. Health C"},{"issue":"19","key":"10.1016\/j.taap.2011.12.009_bb0245","doi-asserted-by":"crossref","first-page":"8085","DOI":"10.1021\/ac901282n","article-title":"Quantitative Profiling Method for Oxylipin Metabolome by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry","volume":"81","author":"Yang","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.taap.2011.12.009_bb0250","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1080\/01926230701618516","article-title":"A Critical Comparison of Murine Pathology and Epidemiological Data of TCDD, PCB126, and PeCDF","volume":"35","author":"Yoshizawa","year":"2007","journal-title":"Toxicol. Pathol."},{"issue":"39","key":"10.1016\/j.taap.2011.12.009_bb0255","doi-asserted-by":"crossref","first-page":"36059","DOI":"10.1074\/jbc.R100030200","article-title":"Epoxygenase Pathways of Arachidonic Acid Metabolism","volume":"276","author":"Zeldin","year":"2001","journal-title":"J. Biol. Chem."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X11004662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X11004662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T04:52:34Z","timestamp":1640062354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X11004662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0041008X11004662"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2011.12.009","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}