{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:48:27Z","timestamp":1791089307156,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.taap.2012.06.005","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T05:55:27Z","timestamp":1339998927000},"page":"148-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"title":["Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos"],"prefix":"10.1016","volume":"263","author":[{"given":"Jeong Eun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Chul","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Chul","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2012.06.005_bb0005","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1038\/sj.onc.1203128","article-title":"Role of redox potential and reactive oxygen species in stress signaling","volume":"18","author":"Adler","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2012.06.005_bb0010","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10072-010-0216-6","article-title":"Protective effects of heme oxygenase-1 against MPP+-induced cytotoxicity in PC12 cells","volume":"31","author":"Bae","year":"2010","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.taap.2012.06.005_bb0015","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/FJC.0b013e318046f34a","article-title":"Effects of p38 MAPK inhibitor on angiotensin II-dependent hypertension, organ damage, and superoxide anion production","volume":"49","author":"Bao","year":"2007","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.taap.2012.06.005_bb0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuro.2004.07.004","article-title":"Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells","volume":"26","author":"Barlow","year":"2005","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.taap.2012.06.005_bb0025","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11064-010-0311-3","article-title":"Chlorpyrifos induced region specific vulnerability in rat CNS and modulation by age and cold stress: an interactive study","volume":"36","author":"Basha","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.taap.2012.06.005_bb0030","doi-asserted-by":"crossref","first-page":"13681","DOI":"10.1073\/pnas.251194298","article-title":"SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase","volume":"20","author":"Bennett","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2012.06.005_bb0035","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0006-2952(02)01174-7","article-title":"Glutathione, iron and Parkinson's disease","volume":"64","author":"Bharath","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2012.06.005_bb0040","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neuint.2008.12.003","article-title":"Catalpol attenuates nitric oxide increase via ERK signing pathways induced by rotenone in mesencephalic neurons","volume":"54","author":"Bi","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.taap.2012.06.005_bb0045","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.taap.2008.05.014","article-title":"Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat","volume":"231","author":"Black","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2012.06.005_bb0050","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1046\/j.1471-4159.2001.00689.x","article-title":"Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease","volume":"6","author":"Bogdanov","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2012.06.005_bb0055","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1089\/ars.2005.7.649","article-title":"Toxicity of redox cycling pesticides in primary mesencephalic cultures","volume":"7","author":"Bonneh-Barkay","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2012.06.005_bb0060","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/toxsci\/kfh038","article-title":"Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK\/JNK MAP kinases","volume":"78","author":"Caughlan","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2012.06.005_bb0065","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1046\/j.1471-4159.2000.0750304.x","article-title":"Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death","volume":"75","author":"Chen","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2012.06.005_bb0070","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1460-9568.2008.06590.x","article-title":"Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades","volume":"29","author":"Chen","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.taap.2012.06.005_bb0075","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jnr.20681","article-title":"Cultured astrocytes from heme oxygenase-1 knockout mice are more vulnerable to heme-mediated oxidative injury","volume":"82","author":"Chen-Roetling","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.taap.2012.06.005_bb0080","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1083\/jcb.201009132","article-title":"Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model","volume":"192","author":"Choi","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.taap.2012.06.005_bb0085","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1471-4159.1992.tb09789.x","article-title":"Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement","volume":"58","author":"Cleeter","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2012.06.005_bb0090","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0092-8674(00)00116-1","article-title":"Signal transduction by the JNK group of MAP kinases","volume":"103","author":"Davis","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.taap.2012.06.005_bb0095","doi-asserted-by":"crossref","first-page":"H3524","DOI":"10.1152\/ajpheart.00919.2007","article-title":"p38 and ERK1\/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis","volume":"293","author":"Dhingra","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2012.06.005_bb0100","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.neuro.2006.05.012","article-title":"Paraquat exposure as an etiological factor of Parkinson's disease","volume":"27","author":"Dinis-Oliveira","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.taap.2012.06.005_bb0105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0890-6238(02)00121-1","article-title":"Developmental toxicity study of chlorpyrifos in rats","volume":"17","author":"Farag","year":"2003","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2012.06.005_bb0110","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.210504","article-title":"The biology of oxygen radicals","volume":"201","author":"Fridovich","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.taap.2012.06.005_bb0115","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1523\/JNEUROSCI.18-06-02040.1998","article-title":"Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity","volume":"18","author":"Gonzalez-Zulueta","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.taap.2012.06.005_bb0120","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1212\/WNL.50.5.1346","article-title":"The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living","volume":"50","author":"Gorell","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.taap.2012.06.005_bb0125","doi-asserted-by":"crossref","first-page":"27020","DOI":"10.1074\/jbc.M701108200","article-title":"Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3\/6-independent and -dependent mechanisms","volume":"14","author":"Gills","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2012.06.005_bb0130","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/15376520490429175","article-title":"Brain regional heterogeneity and toxicological mechanisms of organophosphates and carbamates","volume":"14","author":"Gupta","year":"2004","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.taap.2012.06.005_bb0135","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1046\/j.1471-4159.1994.63051987.x","article-title":"Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease","volume":"63","author":"Hartley","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2012.06.005_bb0140","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1196\/annals.1306.012","article-title":"Redox-active metals, oxidative stress, and Alzheimer's disease pathology","volume":"1012","author":"Huang","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2012.06.005_bb0145","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/jnr.20444","article-title":"Heme oxygenase-1 activity after excitotoxic injury: immunohistocymical localization of bilirubin in neurons and astrocytes and deleterious effects of heme oxygenase inhibition on neuronal survival after kainite treatment","volume":"80","author":"Huang","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.taap.2012.06.005_bb0150","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0006-291X(90)90498-C","article-title":"1-methyl-4-phenylpyridinium (MPP+) induces NADA-dependent superoxide formation and enhances NADA-dependent lipid peroxidation in bovine heart submitochondrial particles","volume":"170","author":"Hasegawa","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2012.06.005_bb0155","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1523\/JNEUROSCI.4922-05.2006","article-title":"Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1\/2 and phosphatidylinositol-3 kinase pathways","volume":"26","author":"Hsuan","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.taap.2012.06.005_bb0160","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1002\/ana.410440712","article-title":"Understanding cell death in Parkinson's disease","volume":"44","author":"Jenner","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.taap.2012.06.005_bb0165","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.tox.2005.03.007","article-title":"Doxorubicin hapatotoxicity and hepatic free radical metabolism in rats: the effects of vitamine E and catechin","volume":"211","author":"Kalender","year":"2005","journal-title":"Toxocology"},{"key":"10.1016\/j.taap.2012.06.005_bb0170","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/abbi.1996.9727","article-title":"Changes of energy metabolism induced by 1-methyl-4-phenylpyridinium (MPP+)-releted compounds in rat pheochromocytoma PC12 cells","volume":"337","author":"Kang","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2012.06.005_bb0175","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1078\/0940-2993-00236","article-title":"Protective role of melatonin and combination of vitamin C and vitamin E on lung toxicity induced by chlorpyrifos-ethyl in rats","volume":"54","author":"Karaoz","year":"2002","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.taap.2012.06.005_bb0180","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/S0891-5849(01)00726-2","article-title":"Dieldrin induced oxidative stress and neurocheminal changes contribute to apoptotic cell death in dopaminergic cells","volume":"31","author":"Kitazawa","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2012.06.005_bb0185","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1006\/nbdi.1998.0191","article-title":"Manganese superoxide dismutase overexpression attenuates MPTP toxicity","volume":"5","author":"Klivenyl","year":"1998","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.taap.2012.06.005_bb0190","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neulet.2007.03.049","article-title":"Ethanol-induced oxidative stress is mediated by p38 MAPK pathway in mouse hippocampal cells","volume":"419","author":"Ku","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.taap.2012.06.005_bb0195","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pbb.2004.03.006","article-title":"Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson's disease","volume":"78","author":"Kurosaki","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.taap.2012.06.005_bb0200","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pestbp.2008.09.004","article-title":"Lipid peroxidation and oxidative stress in rat erythrocytes induced by chlorpyrifos and the protective effect of zinc","volume":"93","author":"Mansour","year":"2009","journal-title":"Pestic. Biochem. Phys."},{"key":"10.1016\/j.taap.2012.06.005_bb0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.pestbp.2009.04.001","article-title":"Chlorpyrifos induced alterations in the levels of hydrogen peroxide, nitrate and nitrite in rat brain and liver","volume":"94","author":"Mehta","year":"2009","journal-title":"Pestic. Biochem. Phys."},{"key":"10.1016\/j.taap.2012.06.005_bb0210","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0301-0082(99)00042-8","article-title":"JNK and p38 stress kinases\u2014degenerative effectors of signal-transduction-cascades in the nervous system","volume":"61","author":"Mielke","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.taap.2012.06.005_bb0215","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0022-510X(95)00336-Z","article-title":"Histochemical detection of apoptosis in Parkinson's disease","volume":"137","author":"Mochizuki","year":"1996","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.taap.2012.06.005_bb0220","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.taap.2005.04.009","article-title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine","volume":"209","author":"Molina-Jim\u00e9nez","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2012.06.005_bb0225","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neures.2004.11.008","article-title":"Neural mechanisms underlying motor dysfunction as detected by the tail suspension test in MPTP-treated C57BL\/6 mice","volume":"51","author":"Mori","year":"2005","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.taap.2012.06.005_bb0230","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.toxlet.2007.11.003","article-title":"Long-term monoamine changes in the striatum and nucleus accumbens after acute chlorpyrifos exposure","volume":"176","author":"Morno","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2012.06.005_bb0235","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1161\/01.STR.28.9.1797","article-title":"Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice","volume":"28","author":"Murakami","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.taap.2012.06.005_bb0240","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/toxsci\/kfh089","article-title":"Rotenone-induced apoptosis is mediate by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells","volume":"79","author":"Newhouse","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2012.06.005_bb0245","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1749-6632.1996.tb39064.x","article-title":"Oxidative stress and Parkinson's disease","volume":"786","author":"Owen","year":"1996","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.taap.2012.06.005_bb0250","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1073\/pnas.0609874104","article-title":"Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease","volume":"104","author":"Perier","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2012.06.005_bb0255","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1523\/JNEUROSCI.12-05-01658.1992","article-title":"Transgenic mice with increase Cu\/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity","volume":"12","author":"Prezdborski","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.taap.2012.06.005_bb0260","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.taap.2004.11.003","article-title":"Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos","volume":"206","author":"Quia","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2012.06.005_bb0265","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1383-5718(02)00033-5","article-title":"Assessment of genotoxic effects of chlorpyrifos and acephate by comet assay in mice leucocytes","volume":"516","author":"Rahman","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2012.06.005_bb0270","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1111\/j.1471-4159.1991.tb11409.x","article-title":"Interaction of 1-methyl-4-phenylpyridinium ion (MPP) and its analogs with the rotenone\/piericidin binding site of NADH dehydrogenase","volume":"56","author":"Ramsay","year":"1991","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2012.06.005_bb0275","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.freeradbiomed.2006.12.004","article-title":"Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and \u2010independent action","volume":"42","author":"Saito","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2012.06.005_bb0280","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.tox.2007.10.020","article-title":"Characterization of chlorpyrifos-induced apoptosis in placental cells","volume":"244","author":"Saulsbury","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2012.06.005_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2008.12.026","article-title":"Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells","volume":"259","author":"Saulsbury","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2012.06.005_bb0290","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(89)92366-0","article-title":"Mitochondrial complex I deficiency in Parkinson's disease","volume":"1","author":"Schapira","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2012.06.005_bb0295","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/j.freeradbiomed.2004.09.015","article-title":"Heme oxygenase expression in human central nervous system disorders","volume":"37","author":"Schipper","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2012.06.005_bb0300","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/exnr.2002.8072","article-title":"Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and \u03b1-synuclein aggregation","volume":"179","author":"Sherer","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.taap.2012.06.005_bb0305","doi-asserted-by":"crossref","first-page":"10756","DOI":"10.1523\/JNEUROSCI.23-34-10756.2003","article-title":"Mechanism of toxicity in rotenone models of Parkinson's disease","volume":"23","author":"Sherer","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.taap.2012.06.005_bb0310","doi-asserted-by":"crossref","first-page":"7365","DOI":"10.1016\/S0021-9258(18)53184-7","article-title":"Regulation of heme oxygenase and metallothionein gene expression by the heme analogs, cobalt-, and tinprotoporphyrin","volume":"268","author":"Smith","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2012.06.005_bb0315","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1074\/jbc.275.8.5395","article-title":"Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau","volume":"275","author":"Takeda","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2012.06.005_bb0320","doi-asserted-by":"crossref","first-page":"19603","DOI":"10.1074\/jbc.M209359200","article-title":"Reversible glutathionylation of complex I increases mitochondrial superoxide formation","author":"Taylor","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2012.06.005_bb0325","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1749-6632.2002.tb04498.x","article-title":"Chromaffin cells as models of endocrine cells and neurons","volume":"971","author":"Tischler","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2012.06.005_bb0330","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pestbp.2006.11.002","article-title":"In vivo chlorpyrifos oxidative stress: attenuation by antioxidant vitamins","volume":"88","author":"Verma","year":"2007","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.taap.2012.06.005_bb0335","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jns.2009.06.034","article-title":"JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease","volume":"15","author":"Wang","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.taap.2012.06.005_bb0340","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.yexcr.2004.02.001","article-title":"The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib","volume":"295","author":"Yu","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.taap.2012.06.005_bb0345","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0891-5849(02)00905-X","article-title":"Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression","volume":"33","author":"Zelko","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2012.06.005_bb0350","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/nbdi.2000.0319","article-title":"Oxidative stress and genetics in the pathogenesis of Parkinson's disease","volume":"7","author":"Zhang","year":"2000","journal-title":"Neurobiol. Dis."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X12002645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X12002645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:41:02Z","timestamp":1758573662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X12002645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":70,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0041008X12002645"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2012.06.005","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2012.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2012 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}