{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:54:30Z","timestamp":1767963270106,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.taap.2012.11.017","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:50:47Z","timestamp":1354150247000},"page":"470-480","source":"Crossref","is-referenced-by-count":26,"title":["Liver proteomics in progressive alcoholic steatosis"],"prefix":"10.1016","volume":"266","author":[{"given":"Harshica","family":"Fernando","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Wiktorowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kizhake V.","family":"Soman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhupendra S.","family":"Kaphalia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Firoze","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.A.","family":"Shakeel Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2012.11.017_bb0005","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1521-6918(03)00053-2","article-title":"Advances in alcoholic liver disease","volume":"17","author":"Arteel","year":"2003","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.taap.2012.11.017_bb0010","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1002\/pmic.200700368","article-title":"Identification of proteins to predict the molecular basis for the observed gender susceptibility in a rat model of alcoholic steatohepatitis by 2-D gel proteomics","volume":"8","author":"Banerjee","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.taap.2012.11.017_bb0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/hep.23271","article-title":"Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease","volume":"51","author":"Bell","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2012.11.017_bb0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000090175","article-title":"Treatment of alcoholic liver disease","volume":"23","author":"Bergheim","year":"2005","journal-title":"Dig. Dis."},{"key":"10.1016\/j.taap.2012.11.017_bb0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1752-8062.2011.00377.x","article-title":"Discovery proteomics and nonparametric modeling pipeline in the development of a candidate biomarker panel for dengue hemorrhagic fever","volume":"5","author":"Brasier","year":"2012","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.taap.2012.11.017_bb0030","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1476-511X-10-60","article-title":"High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway","volume":"10","author":"Bravo","year":"2011","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.taap.2012.11.017_bb0035","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jprot.2011.03.030","article-title":"Advances in top-down proteomics for disease biomarker discovery","volume":"74","author":"Calligaris","year":"2011","journal-title":"J. Proteomics"},{"key":"10.1016\/j.taap.2012.11.017_bb0040","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jhep.2009.12.003","article-title":"TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I","volume":"52","author":"Ciuclan","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2012.11.017_bb0045","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.4049\/jimmunol.181.4.2330","article-title":"Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, d-dopachrome tautomerase","volume":"181","author":"Coleman","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2012.11.017_bb0050","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \u201chits\u201d?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2012.11.017_bb0055","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1111\/j.1530-0277.2010.01283.x","article-title":"(1)H and (31)P NMR lipidome of ethanol-induced fatty liver","volume":"34","author":"Fernando","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.taap.2012.11.017_bb0060","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.taap.2011.05.022","article-title":"Lipidomic changes in rat liver after long-term exposure to ethanol","volume":"255","author":"Fernando","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2012.11.017_bb0065","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.taap.2012.07.026","article-title":"Hepatic lipid profiling of deer mice fed ethanol using (1)H and (31)P NMR spectroscopy: a dose-dependent subchronic study","volume":"264","author":"Fernando","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2012.11.017_bb0070","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/j.1530-0277.2010.01169.x","article-title":"Future prospects for biomarkers of alcohol consumption and alcohol-induced disorders","volume":"34","author":"Freeman","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.taap.2012.11.017_bb0075","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.biopsych.2010.01.028","article-title":"Classification of alcohol abuse by plasma protein biomarkers","volume":"68","author":"Freeman","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.taap.2012.11.017_bb0080","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0741-8329(02)00205-7","article-title":"Alcoholic hepatitis: inflammatory cell-mediated hepatocellular injury","volume":"27","author":"French","year":"2002","journal-title":"Alcohol"},{"key":"10.1016\/j.taap.2012.11.017_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1214\/aos\/1176347963","article-title":"Multivariate adaptive regression splines","volume":"19","author":"Friedman","year":"1991","journal-title":"Ann. Stat."},{"key":"10.1016\/j.taap.2012.11.017_bb0090","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3233\/JAD-2005-8403","article-title":"Biomarkers for Alzheimer's disease\u2014clinical needs and application","volume":"8","author":"Galasko","year":"2005","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.taap.2012.11.017_bb0095","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1055\/s-0031-1272867","article-title":"Evolving concepts in lung carcinogenesis","volume":"32","author":"Gomperts","year":"2011","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1016\/j.taap.2012.11.017_bb0100","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/1355621021000005991","article-title":"Assay of salsolinol in peripheral blood mononuclear cells of alcoholics and healthy subjects by gas chromatography\u2013mass spectrometry","volume":"7","author":"Haber","year":"2002","journal-title":"Addict. Biol."},{"key":"10.1016\/j.taap.2012.11.017_bb0105","first-page":"15","article-title":"Biological markers in alcoholism","author":"Helander","year":"2003","journal-title":"J. Neural. Transm. Suppl."},{"key":"10.1016\/j.taap.2012.11.017_bb0115","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1046\/j.1432-1033.2003.03559.x","article-title":"Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle","volume":"270","author":"Husson","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.taap.2012.11.017_bb0120","doi-asserted-by":"crossref","first-page":"e33402","DOI":"10.1371\/journal.pone.0033402","article-title":"The action of d-dopachrome tautomerase as an adipokine in adipocyte lipid metabolism","volume":"7","author":"Iwata","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2012.11.017_bb0125","doi-asserted-by":"crossref","first-page":"216450","DOI":"10.1155\/2012\/216450","article-title":"Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries","volume":"2012","author":"Ji","year":"2012","journal-title":"Biochem. Res. Int."},{"key":"10.1016\/j.taap.2012.11.017_bb0130","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/elps.201000428","article-title":"Proteomic approaches in myeloid leukemia","volume":"32","author":"Kanaujiya","year":"2011","journal-title":"Electrophoresis"},{"key":"10.1016\/j.taap.2012.11.017_bb0135","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1055\/s-2001-12932","article-title":"Animal models of steatosis","volume":"21","author":"Koteish","year":"2001","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.taap.2012.11.017_bb0140","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1053\/bega.2002.0332","article-title":"Animal models of steatohepatitis","volume":"16","author":"Koteish","year":"2002","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.taap.2012.11.017_bb0145","first-page":"197","article-title":"Liquid diet technique of ethanol administration: 1989 update","volume":"24","author":"Lieber","year":"1989","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.taap.2012.11.017_bb0150","doi-asserted-by":"crossref","first-page":"G257","DOI":"10.1152\/ajpgi.00304.2001","article-title":"Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-alpha","volume":"282","author":"Liu","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.taap.2012.11.017_bb0155","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","article-title":"Alcoholic hepatitis","volume":"360","author":"Lucey","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2012.11.017_bb0160","series-title":"Salford Systems","author":"MARS User Manua","year":"2001"},{"key":"10.1016\/j.taap.2012.11.017_bb0165","doi-asserted-by":"crossref","first-page":"E577","DOI":"10.1073\/pnas.1102941108","article-title":"The d-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)","volume":"108","author":"Merk","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2012.11.017_bb0170","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.3390\/ijerph7051872","article-title":"Molecular basis and current treatment for alcoholic liver disease","volume":"7","author":"Miranda-Mendez","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.taap.2012.11.017_bb0175","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.alcohol.2004.08.005","article-title":"Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease","volume":"34","author":"Nanji","year":"2004","journal-title":"Alcohol"},{"key":"10.1016\/j.taap.2012.11.017_bb0180","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/01.ALC.0000113410.60985.0E","article-title":"High-throughput proteomics for alcohol research","volume":"28","author":"Neuhold","year":"2004","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.taap.2012.11.017_bb0185","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1021\/pr800905w","article-title":"Liver proteome analysis in a rodent model of alcoholic steatosis","volume":"8","author":"Newton","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.taap.2012.11.017_bb0190","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.gcb.2010.06.004","article-title":"Progression from isolated steatosis to steatohepatitis and fibrosis in nonalcoholic fatty liver disease","volume":"35","author":"Pais","year":"2011","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.taap.2012.11.017_bb0195","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.freeradbiomed.2005.02.026","article-title":"Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling","volume":"38","author":"Rhee","year":"2005","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.taap.2012.11.017_bb0200","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/prca.200900119","article-title":"Non-alcoholic fatty liver disease proteomics","volume":"4","author":"Rodriguez-Suarez","year":"2010","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.taap.2012.11.017_bb0205","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.taap.2012.11.017_bb0210","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0140-6736(95)91685-7","article-title":"Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver","volume":"346","author":"Teli","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2012.11.017_bb0215","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1164\/rccm.201010-1623OC","article-title":"Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease","volume":"183","author":"Verrills","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.taap.2012.11.017_bb0220","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1172\/JCI11596","article-title":"Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways","volume":"107","author":"Werstuck","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2012.11.017_bb0225","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0074-7742(04)61008-7","article-title":"Proteomics and alcoholism","volume":"61","author":"Witzmann","year":"2004","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.taap.2012.11.017_bb0230","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0968-0004(02)00003-8","article-title":"Structure, mechanism and regulation of peroxiredoxins","volume":"28","author":"Wood","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.taap.2012.11.017_bb0235","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0741-8329(99)00076-2","article-title":"Ethyl glucuronide: a marker of recent alcohol consumption with clinical and forensic implications","volume":"20","author":"Wurst","year":"2000","journal-title":"Alcohol"},{"key":"10.1016\/j.taap.2012.11.017_bb0240","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/hep.20838","article-title":"A genomic and proteomic study of the spectrum of nonalcoholic fatty liver disease","volume":"42","author":"Younossi","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2012.11.017_bb0245","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1021\/ac991363o","article-title":"ProFound: an expert system for protein identification using mass spectrometric peptide mapping information","volume":"72","author":"Zhang","year":"2000","journal-title":"Anal. Chem."},{"key":"10.1016\/j.taap.2012.11.017_bb0250","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/omi.2010.0061","article-title":"Upregulated and downregulated proteins in hepatocellular carcinoma: a systematic review of proteomic profiling studies","volume":"15","author":"Zhihua","year":"2011","journal-title":"OMICS"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X12005066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X12005066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T23:26:54Z","timestamp":1540078014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X12005066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0041008X12005066"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2012.11.017","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}