{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:37:23Z","timestamp":1790278643331,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.taap.2013.01.003","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T19:46:24Z","timestamp":1358538384000},"page":"209-217","source":"Crossref","is-referenced-by-count":33,"title":["Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice"],"prefix":"10.1016","volume":"267","author":[{"given":"Binoy","family":"Shivanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E.","family":"Welty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xanthi I.","family":"Couroucli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagavatula","family":"Moorthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2013.01.003_bb0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/aja.1002040204","article-title":"Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL\/6N mouse embryo","volume":"204","author":"Abbott","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.taap.2013.01.003_bb0010","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1542\/peds.2008-0526","article-title":"Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants","volume":"123","author":"Ambalavanan","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.taap.2013.01.003_bb0015","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.taap.2004.07.008","article-title":"Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD?","volume":"203","author":"Asikainen","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.01.003_bb0020","doi-asserted-by":"crossref","first-page":"28944","DOI":"10.1074\/jbc.M800685200","article-title":"The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB","volume":"283","author":"Baglole","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2013.01.003_bb0025","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1073\/pnas.77.9.5216","article-title":"Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity","volume":"77","author":"Benson","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2013.01.003_bb0030","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.siny.2010.03.009","article-title":"Hyperoxia-derived lung damage in preterm infants","volume":"15","author":"Bhandari","year":"2010","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.taap.2013.01.003_bb0035","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1515\/BC.2009.138","article-title":"The mammalian aryl hydrocarbon (Ah) receptor: from mediator of dioxin toxicity toward physiological functions in skin and liver","volume":"390","author":"Bock","year":"2009","journal-title":"Biol. Chem."},{"key":"10.1016\/j.taap.2013.01.003_bb0040","doi-asserted-by":"crossref","first-page":"8185","DOI":"10.1073\/pnas.89.17.8185","article-title":"Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor","volume":"89","author":"Burbach","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2013.01.003_bb0045","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00008571-199312000-00005","article-title":"Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL\/6 and DBA\/2 mice","volume":"3","author":"Chang","year":"1993","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.taap.2013.01.003_bb0050","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1165\/ajrcmb.26.2.4501","article-title":"Role of NRF2 in protection against hyperoxic lung injury in mice","volume":"26","author":"Cho","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2013.01.003_bb0055","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1203\/00006450-198805000-00007","article-title":"Alveolar macrophage status in bronchopulmonary dysplasia","volume":"23","author":"Clement","year":"1988","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.taap.2013.01.003_bb0060","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1749-6632.2000.tb06179.x","article-title":"Post-transcriptional regulation of lung antioxidant enzyme gene expression","volume":"899","author":"Clerch","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2013.01.003_bb0065","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1136\/thx.37.8.572","article-title":"The radial alveolar count method of Emery and Mithal: a reappraisal 1\u2014postnatal lung growth","volume":"37","author":"Cooney","year":"1982","journal-title":"Thorax"},{"key":"10.1016\/j.taap.2013.01.003_bb0070","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1124\/mol.61.3.507","article-title":"Regulation of pulmonary and hepatic cytochrome P4501A expression in the rat by hyperoxia: implications for hyperoxic lung injury","volume":"61","author":"Couroucli","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2013.01.003_bb0075","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.taap.2011.06.018","article-title":"Prenatal administration of the cytochrome P4501A inducer, beta-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: implications for bronchopulmonary dysplasia (BPD) in premature infants","volume":"256","author":"Couroucli","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.01.003_bb0080","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.freeradbiomed.2006.01.025","article-title":"BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2","volume":"40","author":"Das","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2013.01.003_bb0085","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1074\/jbc.271.7.3952","article-title":"Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex","volume":"271","author":"Emi","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"147","key":"10.1016\/j.taap.2013.01.003_bb0090","first-page":"e141","article-title":"Trends in neonatal morbidity and mortality for very low birthweight infants","volume":"196","author":"Fanaroff","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.taap.2013.01.003_bb0095","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1016\/S0021-9258(20)64358-7","article-title":"Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants","volume":"266","author":"Favreau","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2013.01.003_bb0100","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2183\/pjab.86.40","article-title":"Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli","volume":"86","author":"Fujii-Kuriyama","year":"2010","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.taap.2013.01.003_bb0105","first-page":"L810","article-title":"Antioxidant enzyme expression in rat lungs during hyperoxia","volume":"270","author":"Ho","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2013.01.003_bb0110","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1164\/rccm.200809-1522ST","article-title":"An official research policy statement of the American Thoracic Society\/European Respiratory Society: standards for quantitative assessment of lung structure","volume":"181","author":"Hsia","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.taap.2013.01.003_bb0115","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0046-8177(98)90280-5","article-title":"Pathology of arrested acinar development in postsurfactant bronchopulmonary dysplasia","volume":"29","author":"Husain","year":"1998","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.taap.2013.01.003_bb0120","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1124\/jpet.103.059766","article-title":"Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury","volume":"310","author":"Jiang","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2013.01.003_bb0125","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1203\/00006450-199912000-00007","article-title":"The new BPD: an arrest of lung development","volume":"46","author":"Jobe","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.taap.2013.01.003_bb0130","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000143721","article-title":"Injury and inflammation from resuscitation of the preterm infant","volume":"94","author":"Jobe","year":"2008","journal-title":"Neonatology"},{"key":"10.1016\/j.taap.2013.01.003_bb0135","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.freeradbiomed.2010.08.013","article-title":"Multiple roles of microsomal glutathione transferase 1 in cellular protection: a mechanistic study","volume":"49","author":"Johansson","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2013.01.003_bb0140","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1152\/jappl.1988.64.4.1376","article-title":"Genetic differences in response to pulmonary cytochrome P-450 inducers and oxygen toxicity","volume":"64","author":"Mansour","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.taap.2013.01.003_bb0145","doi-asserted-by":"crossref","first-page":"L565","DOI":"10.1152\/ajplung.90487.2008","article-title":"Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia","volume":"296","author":"McGrath-Morrow","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.taap.2013.01.003_bb0150","series-title":"Cytochromes P450","first-page":"97","author":"Moorthy","year":"2008"},{"key":"10.1016\/j.taap.2013.01.003_bb0155","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0378-4274(96)03832-5","article-title":"Induction and decline of hepatic cytochromes P4501A1 and 1A2 in rats exposed to hyperoxia are not paralleled by changes in glutathione S-transferase-alpha","volume":"90","author":"Moorthy","year":"1997","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2013.01.003_bb0160","first-page":"553","article-title":"Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole","volume":"292","author":"Moorthy","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"7","key":"10.1016\/j.taap.2013.01.003_bb0165","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.earlhumdev.2011.12.013","article-title":"Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition","volume":"88","author":"Natarajan","year":"2012","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.taap.2013.01.003_bb0170","doi-asserted-by":"crossref","first-page":"23847","DOI":"10.1074\/jbc.R400004200","article-title":"Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer","volume":"279","author":"Nebert","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2013.01.003_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0009-2797(91)90029-7","article-title":"Molecular mechanisms of quinone cytotoxicity","volume":"80","author":"O'Brien","year":"1991","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2013.01.003_bb0180","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1203\/PDR.0b013e318159af61","article-title":"Altered expressions of fibroblast growth factor receptors and alveolarization in neonatal mice exposed to 85% oxygen","volume":"62","author":"Park","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.taap.2013.01.003_bb0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0891-5849(91)90191-5","article-title":"A note on the inhibition of DT-diaphorase by dicoumarol","volume":"11","author":"Preusch","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2013.01.003_bb0190","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/10408449991349276","article-title":"Glutathione redox system in oxidative lung injury","volume":"29","author":"Rahman","year":"1999","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.taap.2013.01.003_bb0195","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1073\/pnas.87.10.3826","article-title":"Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds","volume":"87","author":"Rushmore","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2013.01.003_bb0200","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1515\/jpm.2010.108","article-title":"Oxygen and oxidative stress in bronchopulmonary dysplasia","volume":"38","author":"Saugstad","year":"2010","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.taap.2013.01.003_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2011.08.013","article-title":"Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor","author":"Shivanna","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2013.01.003_bb0210","doi-asserted-by":"crossref","DOI":"10.1124\/jpet.111.182980","article-title":"Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation, and is associated with increased expression of cytochrome P4501a enzymes","author":"Shivanna","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2013.01.003_bb0215","doi-asserted-by":"crossref","first-page":"e359","DOI":"10.1542\/peds.112.5.e359","article-title":"Cognitive and academic consequences of bronchopulmonary dysplasia and very low birth weight: 8-year-old outcomes","volume":"112","author":"Short","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.taap.2013.01.003_bb0220","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/toxsci\/kfi226","article-title":"Attenuation of hyperoxic lung injury by the CYP1A inducer beta-naphthoflavone","volume":"87","author":"Sinha","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2013.01.003_bb0225","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2353\/ajpath.2007.060391","article-title":"Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB","volume":"170","author":"Thatcher","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2013.01.003_bb0230","doi-asserted-by":"crossref","first-page":"e174","DOI":"10.1371\/journal.pbio.0030174","article-title":"Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury","volume":"3","author":"Thiel","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.taap.2013.01.003_bb0235","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/jps.20324","article-title":"Nuclear receptors and drug disposition gene regulation","volume":"94","author":"Tirona","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.taap.2013.01.003_bb0240","first-page":"175","article-title":"A low vitamin A status increases the susceptibility to cigarette smoke-induced lung emphysema in C57BL\/6J mice","volume":"62","author":"van Eijl","year":"2011","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2013.01.003_bb0245","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/ajcn\/61.5.1067","article-title":"l-cysteine and glutathione metabolism are impaired in premature infants due to cystathionase deficiency","volume":"61","author":"Vina","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.taap.2013.01.003_bb0250","first-page":"L110","article-title":"Functional and pathological effects of prolonged hyperoxia in neonatal mice","volume":"275","author":"Warner","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2013.01.003_bb0255","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1542\/peds.2010-3875","article-title":"Targeting inflammation to prevent bronchopulmonary dysplasia: can new insights be translated into therapies?","volume":"128","author":"Wright","year":"2011","journal-title":"Pediatrics"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13000161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13000161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T07:44:07Z","timestamp":1644133447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X13000161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0041008X13000161"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2013.01.003","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}