{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:33:13Z","timestamp":1773675193605,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.taap.2013.01.024","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T18:06:33Z","timestamp":1360778793000},"page":"99-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Diclofenac enhances proinflammatory cytokine-induced phagocytosis of cultured microglia via nitric oxide production"],"prefix":"10.1016","volume":"268","author":[{"given":"Hiroki","family":"Kakita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mineyoshi","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Nagaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Asai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Hamed","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mieko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyofumi","family":"Asai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2013.01.024_bb0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1046\/j.0022-3042.2001.00675.x","article-title":"Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitirite production","volume":"80","author":"Bal-Price","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2013.01.024_bb0010","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1056\/NEJM199905063401801","article-title":"Reye's syndrome in the United States from 1981 through 1997","volume":"340","author":"Belay","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2013.01.024_bb0015","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1161\/STROKEAHA.109.557439","article-title":"NCX1 expression and functional activity increase in microglia invading the infarct core","volume":"40","author":"Boscia","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.taap.2013.01.024_bb0020","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s12035-010-8105-9","article-title":"Inflammatory neurodegeneration and mechanisms of microglial killing of neurons","volume":"41","author":"Brown","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.taap.2013.01.024_bb0025","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: active sensor and versatile effector cells in the normal and pathologic brain","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.taap.2013.01.024_bb0030","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1111\/j.1471-4159.2008.05553.x","article-title":"Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases","volume":"106","author":"Harrigan","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2013.01.024_bb0035","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cyto.2011.01.006","article-title":"Serum and cerebrospinal fluid cytokine profile of patients with 2009 pandemic H1N1 influenza virus-associated encephalopathy","volume":"54","author":"Hasegawa","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.taap.2013.01.024_bb0040","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1124\/jpet.300.2.367","article-title":"Cyclooxygenase-2\u201310years later","volume":"300","author":"Hinz","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2013.01.024_bb0045","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.taap.2009.04.014","article-title":"Diclofenac enhances proinflammatory cytokine-induced nitric oxide production through NF-kappaB signaling in cultured astrocytes","volume":"238","author":"Kakita","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.01.024_bb0050","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1099\/vir.0.81670-0","article-title":"Analysis of gene-expression profiles by oligonucleotide microarray in children with influenza","volume":"87","author":"Kawada","year":"2006","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.taap.2013.01.024_bb0055","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11064-005-2604-5","article-title":"Nitrite\/nitrate (NOx) and zinc concentrations in influenza-associated encephalopathy in children with different sequela","volume":"30","author":"Kawashima","year":"2005","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.taap.2013.01.024_bb0060","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/nature05704","article-title":"UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis","volume":"446","author":"Koizumi","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.taap.2013.01.024_bb0065","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/jnr.20671","article-title":"Lipopolysaccharide and proinflammatory cytokines require different states to induce nitric oxide production","volume":"82","author":"Kozuka","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.taap.2013.01.024_bb0070","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.neuroscience.2006.10.040","article-title":"Multiple inhibitory pathways for lipopolysaccharide and pro-inflammatory cytokine-induced nitric oxide production in cultured astrocytes","volume":"144","author":"Kozuka","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.taap.2013.01.024_bb0075","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: a sensor for pathological events in the CNS","volume":"19","author":"Kreutzberg","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.taap.2013.01.024_bb0090","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1523\/JNEUROSCI.0099-06.2006","article-title":"The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology","volume":"26","author":"Meyer","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.taap.2013.01.024_bb0080","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-0404.2007.00809.x","article-title":"Acute encephalopathy associated influenza and other viral infections","volume":"115","author":"Mizuguchi","year":"2007","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.taap.2013.01.024_bb0085","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1086\/341407","article-title":"Encephalitis and encephalopathy associated with an influenza epidemic in Japan","volume":"35","author":"Morishima","year":"2002","journal-title":"Clin. Infect."},{"key":"10.1016\/j.taap.2013.01.024_bb0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2010.01.086","article-title":"Prostaglandin E2 reduces amyloid beta-induced phagocytosis in cultured rat microglia","volume":"1323","author":"Nagano","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.taap.2013.01.024_bb0100","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.1523\/JNEUROSCI.21-19-07526.2001","article-title":"Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice","volume":"21","author":"Nakanishi","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.taap.2013.01.024_bb0105","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.4049\/jimmunol.1003600","article-title":"Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death","volume":"186","author":"Neher","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2013.01.024_bb0110","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/brain\/awn109","article-title":"Debris clearance by microglia: an essential link between degeneration and regeneration","volume":"132","author":"Neumann","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.taap.2013.01.024_bb0115","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/gut.25.6.673","article-title":"Hepatotoxicity to sodium valproate","volume":"25","author":"Powell-Jackson","year":"1984","journal-title":"Gut"},{"key":"10.1016\/j.taap.2013.01.024_bb0120","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2165\/00148581-200709030-00008","article-title":"Aspirin and Reye syndrome: a review of the evidence","volume":"9","author":"Schr\u00f6r","year":"2007","journal-title":"Paediatr. Drugs"},{"key":"10.1016\/j.taap.2013.01.024_bb0125","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/glia.22337","article-title":"Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis","volume":"60","author":"Uesugi","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.taap.2013.01.024_bb0135","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00281-009-0180-5","article-title":"Role of microglia in neuronal degeneration and regeneration","volume":"31","author":"Walter","year":"2009","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.taap.2013.01.024_bb0130","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/WCO.0b013e328338f6c9","article-title":"Acute encephalopathy and encephalitis caused by influenza virus infection","volume":"23","author":"Wang","year":"2010","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.taap.2013.01.024_bb0140","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s11064-007-9543-2","article-title":"Increased nitric oxide production and GFAP expression in the brains of influenza A\/NWS virus infected mice","volume":"33","author":"Watanabe","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.taap.2013.01.024_bb0145","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1742-2094-8-38","article-title":"Specific PKC isoforms regulate LPS-stimulated iNOS induction in murine microglial cells","volume":"8","author":"Wen","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.taap.2013.01.024_bb0150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jns.2005.11.029","article-title":"Diagnostic and predictive value of CSFd-ROM level in influenza virus-associated encephalopathy","volume":"243","author":"Yamanaka","year":"2006","journal-title":"J. Neurol. Sci."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13000537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13000537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:42:12Z","timestamp":1758573732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X13000537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0041008X13000537"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2013.01.024","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diclofenac enhances proinflammatory cytokine-induced phagocytosis of cultured microglia via nitric oxide production","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2013.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}