{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:52:17Z","timestamp":1789786337822,"version":"4.0.1"},"reference-count":80,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.taap.2013.01.027","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T02:38:05Z","timestamp":1361846285000},"page":"264-277","source":"Crossref","is-referenced-by-count":38,"title":["Persistent fibrosis in the liver of choline-deficient and iron-supplemented l-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation"],"prefix":"10.1016","volume":"268","author":[{"given":"Ayano","family":"Takeuchi-Yorimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Noto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Miyamae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2013.01.027_bb0005","first-page":"1333","article-title":"Reversibility of hepatic fibrosis in experimentally induced cholestasis in rat","volume":"137","author":"Abdel-Aziz","year":"1990","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2013.01.027_bb0010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00418-009-0563-7","article-title":"Peroxisomes and reactive oxygen species, a lasting challenge","volume":"131","author":"Angermuller","year":"2009","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.taap.2013.01.027_bb0015","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/bjc.1995.429","article-title":"Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver","volume":"72","author":"Arteel","year":"1995","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.taap.2013.01.027_bb0020","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1046\/j.1432-1327.1998.2530743.x","article-title":"Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state","volume":"253","author":"Arteel","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.taap.2013.01.027_bb0025","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1124\/dmd.105.008185","article-title":"Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan)","volume":"34","author":"Baldwin","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.taap.2013.01.027_bb0030","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.clinbiochem.2007.02.006","article-title":"Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis","volume":"40","author":"Baskol","year":"2007","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.taap.2013.01.027_bb0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2013.01.027_bb0040","doi-asserted-by":"crossref","first-page":"744","DOI":"10.2353\/ajpath.2010.090667","article-title":"Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis","volume":"176","author":"Behari","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2013.01.027_bb0045","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jss.2007.12.784","article-title":"Steatosis reversibly increases hepatocyte sensitivity to hypoxia\u2013reoxygenation injury","volume":"152","author":"Berthiaume","year":"2009","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.taap.2013.01.027_bb0050","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0163-7258(01)00129-2","article-title":"Oxidative stress and vascular smooth muscle cell function in liver disease","volume":"89","author":"Bomzon","year":"2001","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2013.01.027_bb0055","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.biomaterials.2008.11.040","article-title":"Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component","volume":"30","author":"Brown","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.taap.2013.01.027_bb0060","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.taap.2013.01.027_bb0065","first-page":"1399","article-title":"Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation","volume":"22","author":"Buchman","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2013.01.027_bb0070","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0002-9440(10)65501-0","article-title":"Synaptophysin: a novel marker for human and rat hepatic stellate cells","volume":"155","author":"Cassiman","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2013.01.027_bb0075","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0168-8278(01)00260-4","article-title":"Hepatic stellate cell\/myofibroblast subpopulations in fibrotic human and rat livers","volume":"36","author":"Cassiman","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2013.01.027_bb0080","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/bjc.1990.408","article-title":"Distribution of pimonidazole and RSU 1069 in tumour and normal tissues","volume":"62","author":"Cobb","year":"1990","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.taap.2013.01.027_bb0085","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1478-3231.2009.02015.x","article-title":"Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes","volume":"29","author":"Copple","year":"2009","journal-title":"Liver Int."},{"key":"10.1016\/j.taap.2013.01.027_bb0090","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/MOG.0b013e32834e7b4b","article-title":"Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression","volume":"28","author":"Corbin","year":"2012","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.taap.2013.01.027_bb0095","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1478-3231.2010.02369.x","article-title":"Angiogenesis in chronic liver disease and its complications","volume":"31","author":"Coulon","year":"2011","journal-title":"Liver Int."},{"key":"10.1016\/j.taap.2013.01.027_bb0100","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.jhep.2012.07.003","article-title":"Phenotyping the effect of diet on non-alcoholic fatty liver disease","volume":"57","author":"de Wit","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2013.01.027_bb0105","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1055\/s-2007-991515","article-title":"Hepatic microvasculature in liver injury","volume":"27","author":"DeLeve","year":"2007","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.taap.2013.01.027_bb0110","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/carcin\/23.2.245","article-title":"Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide","volume":"23","author":"Denda","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2013.01.027_bb0115","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1002\/hep.20974","article-title":"Reversal of hepatic fibrosis\u2014fact or fantasy?","volume":"43","author":"Friedman","year":"2006","journal-title":"Hepatology"},{"issue":"Suppl. 1","key":"10.1016\/j.taap.2013.01.027_bb0120","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1111\/j.1530-0277.2008.00756.x","article-title":"Nitric oxide plays a crucial role in the development\/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model","volume":"34","author":"Fujita","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.taap.2013.01.027_bb0125","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/01.LAB.0000021135.87203.92","article-title":"Hypoxia and an angiogenic response in the partially obstructed rat bladder","volume":"82","author":"Ghafar","year":"2002","journal-title":"Lab. Invest."},{"key":"10.1016\/j.taap.2013.01.027_bb0130","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/hep.21595","article-title":"Progression of fibrosis in advanced chronic hepatitis C: evaluation by morphometric image analysis","volume":"45","author":"Goodman","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2013.01.027_bb0135","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/10715769900301221","article-title":"Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies","volume":"31","author":"Halliwell","year":"1999","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.taap.2013.01.027_bb0140","doi-asserted-by":"crossref","first-page":"194829","DOI":"10.1155\/2012\/194829","article-title":"Bisphenol A induces hepatotoxicity through oxidative stress in rat model","volume":"2012","author":"Hassan","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.taap.2013.01.027_bb0145","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF01324802","article-title":"The hepatic stellate (Ito) cell: its role in human liver disease","volume":"430","author":"Hautekeete","year":"1997","journal-title":"Virchows Arch."},{"key":"10.1016\/j.taap.2013.01.027_bb0150","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/carcin\/21.5.983","article-title":"Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondria","volume":"21","author":"Hensley","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2013.01.027_bb0155","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","article-title":"The myofibroblast: one function, multiple origins","volume":"170","author":"Hinz","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2013.01.027_bb0160","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1365-2559.2006.02416.x","article-title":"Histological assessment of non-alcoholic fatty liver disease","volume":"49","author":"Hubscher","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.taap.2013.01.027_bb0165","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI1018","article-title":"Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors","volume":"102","author":"Iredale","year":"1998","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.taap.2013.01.027_bb0170","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2013.01.027_bb0175","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1053\/j.gastro.2004.03.009","article-title":"Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking","volume":"126","author":"Issa","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2013.01.027_bb0180","first-page":"532","article-title":"Enhanced expression of CD34 messenger RNA by developing endothelial cells of mice","volume":"72","author":"Ito","year":"1995","journal-title":"Lab. Invest."},{"key":"10.1016\/j.taap.2013.01.027_bb0185","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2011.04.099","article-title":"Cu\/Zn superoxide dismutase is differentially regulated in period gene-mutant mice","volume":"409","author":"Jang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2013.01.027_bb0190","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1517\/17425255.1.4.671","article-title":"CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury","volume":"1","author":"Jimenez-Lopez","year":"2005","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.taap.2013.01.027_bb0195","first-page":"444","article-title":"Vascular endothelial growth factor (VEGF)\u2014part 1: in physiology and pathophysiology","volume":"62","author":"Kajdaniuk","year":"2011","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.taap.2013.01.027_bb0200","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jhep.2007.03.020","article-title":"Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model","volume":"47","author":"Kamada","year":"2007","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2013.01.027_bb0205","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2013.01.027_bb0210","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10753-007-9053-z","article-title":"The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet","volume":"31","author":"Koca","year":"2008","journal-title":"Inflammation"},{"key":"10.1016\/j.taap.2013.01.027_bb0215","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/hep.23797","article-title":"High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis","volume":"52","author":"Kohli","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2013.01.027_bb0220","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.taap.2013.01.027_bb0225","first-page":"G1069","article-title":"Nitric oxide. IV. Determinants of nitric oxide protection and toxicity in liver","volume":"276","author":"Li","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2013.01.027_bb0230","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1152\/physrev.1997.77.2.517","article-title":"Cytochrome P-4502E1: its physiological and pathological role","volume":"77","author":"Lieber","year":"1997","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.taap.2013.01.027_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hepres.2003.08.001","article-title":"CYP2E1: from ASH to NASH","volume":"28","author":"Lieber","year":"2004","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.taap.2013.01.027_bb0240","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1440-1746.1995.tb01365.x","article-title":"CD34 expression in endothelial cells of small hepatocellular carcinoma: its correlation with tumour progression and angiographic findings","volume":"10","author":"Maeda","year":"1995","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2013.01.027_bb0245","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.dld.2012.09.002","article-title":"The pro-inflammatory action of tumour necrosis factor-alpha in non-alcoholic steatohepatitis is independent of the NSMAF gene product","volume":"45","author":"Mas","year":"2013","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.taap.2013.01.027_bb0250","first-page":"472","article-title":"Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis","volume":"3","author":"Matsunami","year":"2010","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.taap.2013.01.027_bb0255","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0016-5085(99)70506-8","article-title":"Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity","volume":"116","author":"Matteoni","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2013.01.027_bb0260","doi-asserted-by":"crossref","first-page":"G582","DOI":"10.1152\/ajpgi.90368.2008","article-title":"Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice","volume":"296","author":"Moon","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.taap.2013.01.027_bb0265","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/labinvest.2009.123","article-title":"Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine\u2013choline-deficient diet","volume":"90","author":"Mu","year":"2010","journal-title":"Lab. Invest."},{"key":"10.1016\/j.taap.2013.01.027_bb0270","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0006-2952(98)00220-2","article-title":"Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride","volume":"56","author":"Muriel","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2013.01.027_bb0275","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00795-003-0228-x","article-title":"Differentiation and function of Kupffer cells","volume":"37","author":"Naito","year":"2004","journal-title":"Med. Electron Microsc."},{"key":"10.1016\/j.taap.2013.01.027_bb0280","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1046\/j.1440-1827.1999.00990.x","article-title":"Endogenous liver carcinogenesis in the rat","volume":"49","author":"Nakae","year":"1999","journal-title":"Pathol. Int."},{"key":"10.1016\/j.taap.2013.01.027_bb0285","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1111\/j.1349-7006.1990.tb02515.x","article-title":"Production of both 8-hydroxydeoxyguanosine in liver DNA and gamma-glutamyltransferase-positive hepatocellular lesions in rats given a choline-deficient, L-amino acid-defined diet","volume":"81","author":"Nakae","year":"1990","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.taap.2013.01.027_bb0290","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/path.3005","article-title":"The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cells","volume":"226","author":"Novo","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.taap.2013.01.027_bb0295","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/10715760100300761","article-title":"The mechanisms for nitration and nitrotyrosine formation in vitro and in vivo: impact of diet","volume":"35","author":"Oldreive","year":"2001","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.taap.2013.01.027_bb0300","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/hep.510260325","article-title":"Partial cloning of rat CD34 cDNA and expression during stem cell-dependent liver regeneration in the adult rat","volume":"26","author":"Omori","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2013.01.027_bb0305","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.gastro.2006.10.014","article-title":"Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis","volume":"132","author":"Ota","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2013.01.027_bb0310","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3748\/wjg.v16.i3.281","article-title":"Hypoxia, angiogenesis and liver fibrogenesis in the progression of chronic liver diseases","volume":"16","author":"Paternostro","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2013.01.027_bb0315","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1053\/gast.2002.33023","article-title":"Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C","volume":"122","author":"Poynard","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2013.01.027_bb0320","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/labinvest.3700030","article-title":"Portal tract fibrogenesis in the liver","volume":"84","author":"Ramadori","year":"2004","journal-title":"Lab. Invest."},{"key":"10.1016\/j.taap.2013.01.027_bb0325","doi-asserted-by":"crossref","first-page":"d808","DOI":"10.2741\/reeves","article-title":"Activation of hepatic stellate cells\u2014a key issue in liver fibrosis","volume":"7","author":"Reeves","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.taap.2013.01.027_bb0330","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1053\/gast.2001.27126","article-title":"Nonalcoholic steatohepatitis","volume":"121","author":"Reid","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2013.01.027_bb0335","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2011.10.003","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis","volume":"52","author":"Rolo","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2013.01.027_bb0340","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1478-3231.2005.01213.x","article-title":"Expression of oxidative stress-related molecules in circulating leukocytes and urine in patients with chronic viral hepatitis","volume":"26","author":"Saeki","year":"2006","journal-title":"Liver Int."},{"key":"10.1016\/j.taap.2013.01.027_bb0345","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1472-6882-11-48","article-title":"Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat","volume":"11","author":"Sahreen","year":"2011","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.taap.2013.01.027_bb0350","first-page":"1233","article-title":"Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers","volume":"138","author":"Schmitt-Graff","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2013.01.027_bb0355","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF01607161","article-title":"Modulation of perisinusoidal cell cytoskeletal features during experimental hepatic fibrosis","volume":"422","author":"Schmitt-Graff","year":"1993","journal-title":"Virchows Arch. A Pathol. Anat. Histopathol."},{"key":"10.1016\/j.taap.2013.01.027_bb0360","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.humpath.2006.07.007","article-title":"Direct and indirect evidence for the reversibility of cirrhosis","volume":"37","author":"Serpaggi","year":"2006","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.taap.2013.01.027_bb0365","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/gut.2005.071118","article-title":"Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice","volume":"55","author":"Tomita","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.taap.2013.01.027_bb0370","doi-asserted-by":"crossref","first-page":"27043","DOI":"10.1074\/jbc.273.42.27043","article-title":"Biochemical and evolutionary significance of phospholipid methylation","volume":"273","author":"Walkey","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2013.01.027_bb0375","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/ijc.23995","article-title":"Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats","volume":"124","author":"Wang","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2013.01.027_bb0380","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.5858\/2000-124-1599-ROHC","article-title":"Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis","volume":"124","author":"Wanless","year":"2000","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.taap.2013.01.027_bb0385","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.taap.2013.01.027_bb0390","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jep.2011.03.053","article-title":"Investigation of the \u201cdose\u2013time-response\u201d relationships of rhubarb on carbon tetrachloride-induced liver injury in rats","volume":"135","author":"Xing","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2013.01.027_bb0395","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1096\/fasebj.5.7.2010061","article-title":"Choline, an essential nutrient for humans","volume":"5","author":"Zeisel","year":"1991","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2013.01.027_bb0400","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0016-5085(92)90850-X","article-title":"Reversibility of secondary biliary fibrosis by biliodigestive anastomosis in the rat","volume":"103","author":"Zimmermann","year":"1992","journal-title":"Gastroenterology"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13000586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13000586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T13:06:33Z","timestamp":1644411993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X13000586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0041008X13000586"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2013.01.027","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}