{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:34:12Z","timestamp":1773156852910,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.taap.2013.03.001","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T16:37:21Z","timestamp":1363192641000},"page":"72-80","source":"Crossref","is-referenced-by-count":67,"title":["Oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine model"],"prefix":"10.1016","volume":"269","author":[{"given":"Jin Kyeong","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Mee","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongwoo","family":"Khang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Woong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Song","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mun-Chual","family":"Rho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2013.03.001_bb0010","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/toxsci\/kfs071","article-title":"Differential gene expression responses distinguish contact and respiratory sensitizers and nonsensitizing irritants in the local lymph node assay","volume":"126","author":"Adenuga","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2013.03.001_bb0015","first-page":"424203","article-title":"The LLNA: a brief review of recent advances and limitations","author":"Anderson","year":"2011","journal-title":"J. Allergy"},{"key":"10.1016\/j.taap.2013.03.001_bb0020","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1097\/00003246-200201001-00010","article-title":"Mitogen-activated protein kinases","volume":"30","author":"Arbabi","year":"2002","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.taap.2013.03.001_bb0025","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.taap.2011.04.008","article-title":"Chrysin suppresses mast cell-mediated allergic inflammation: involvement of calcium, caspase-1 and nuclear factor-kappaB","volume":"254","author":"Bae","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.03.001_bb0030","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5021\/ad.2010.22.2.125","article-title":"Atopic dermatitis","volume":"22","author":"Bieber","year":"2010","journal-title":"Ann. Dermatol."},{"key":"10.1016\/j.taap.2013.03.001_bb0035","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.4049\/jimmunol.158.12.5934","article-title":"Impaired activation of nuclear factor-kappaB in endotoxin-tolerant rats is associated with down-regulation of chemokine gene expression and inhibition of neutrophilic lung inflammation","volume":"158","author":"Blackwell","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0040","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jaci.2009.11.027","article-title":"Recent insights into atopic dermatitis and implications for management of infectious complications","volume":"125","author":"Boguniewicz","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0045","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jep.2010.05.001","article-title":"Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation","volume":"130","author":"Boller","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2013.03.001_bb0050","first-page":"2","article-title":"Th2 cytokines and atopic dermatitis","volume":"10","author":"Brandt","year":"2011","journal-title":"J. Clin. Cell Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0055","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.intimp.2011.04.005","article-title":"DA-9601 suppresses 2, 4-dinitrochlorobenzene and dust mite extract-induced atopic dermatitis-like skin lesions","volume":"11","author":"Choi","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2013.03.001_bb0060","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jep.2011.06.043","article-title":"Suppression of dust mite extract and 2,4-dinitrochlorobenzene-induced atopic dermatitis by the water extract of Lindera obtusiloba","volume":"137","author":"Choi","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2013.03.001_bb0065","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.foodchem.2011.11.100","article-title":"Azuki bean (Vigna angularis) extract inhibits the development of experimentally induced atopic dermatitis-like skin lesions in NC\/Nga mice","volume":"132","author":"Collantes","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.taap.2013.03.001_bb0070","first-page":"381","article-title":"Effects of oleanolic acid on immune system and type I allergic reaction","volume":"10","author":"Dai","year":"1989","journal-title":"Zhongguo Yao Li Xue Bao"},{"key":"10.1016\/j.taap.2013.03.001_bb0075","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1073\/pnas.0500815102","article-title":"Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress","volume":"102","author":"Dinkova-Kostova","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2013.03.001_bb0080","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1767","article-title":"Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells","volume":"10","author":"Duhen","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0085","first-page":"3573","article-title":"Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling","volume":"119","author":"Eyerich","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2013.03.001_bb0090","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jaci.2009.12.936","article-title":"Key advances in mechanisms of asthma, allergy, and immunology in 2009","volume":"125","author":"Finkelman","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0095","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1172815","article-title":"IL-21R on T cells is critical for sustained functionality and control of chronic viral infection","volume":"324","author":"Frohlich","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.taap.2013.03.001_bb0100","doi-asserted-by":"crossref","first-page":"U574","DOI":"10.1016\/j.jaci.2011.05.016","article-title":"Lesional dendritic cells in patients with chronic atopic dermatitis and psoriasis exhibit parallel ability to activate T-cell subsets","volume":"128","author":"Fujita","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0105","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0014-2999(01)01290-0","article-title":"Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity","volume":"428","author":"Giner-Larza","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2013.03.001_bb0110","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jaci.2011.01.053","article-title":"Contrasting pathogenesis of atopic dermatitis and psoriasis\u2014part I: clinical and pathologic concepts","volume":"127","author":"Guttman-Yassky","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1749-6632.2009.05128.x","article-title":"Thymic stromal lymphopoietin","volume":"1183","author":"He","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2013.03.001_bb0120","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1111\/j.1365-2222.2003.01782.x","article-title":"Differential in vivo cytokine mRNA expression in lesional skin of intrinsic vs. extrinsic atopic dermatitis patients using semiquantitative RT-PCR","volume":"33","author":"Jeong","year":"2003","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.taap.2013.03.001_bb0125","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1398-9995.2012.02857.x","article-title":"Skin thymic stromal lymphopoietin promotes airway sensitization to inhalant house dust mites leading to allergic asthma in mice","volume":"67","author":"Jiang","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.taap.2013.03.001_bb0130","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jaci.2009.02.007","article-title":"Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization","volume":"123","author":"Jin","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0135","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.freeradbiomed.2006.10.052","article-title":"Discoidin domain receptor 1 mediates collagen-induced nitric oxide production in J774A.1 murine macrophages","volume":"42","author":"Kim","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2013.03.001_bb0140","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/jid.2011.49","article-title":"Transduced PEP-1-FK506BP ameliorates atopic dermatitis in NC\/Nga mice","volume":"131","author":"Kim","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.taap.2013.03.001_bb0145","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.fct.2003.12.001","article-title":"Extract of the seed coat of Tamarindus indica inhibits nitric oxide production by murine macrophages in vitro and in vivo","volume":"42","author":"Komutarin","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2013.03.001_bb0150","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.0906-6705.2005.00386.x","article-title":"Phytocomponents of triterpenoids, oleanolic acid and ursolic acid, regulated differently the processing of epidermal keratinocytes via PPAR-alpha pathway","volume":"15","author":"Lee","year":"2006","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.taap.2013.03.001_bb0160","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1002\/jnr.21739","article-title":"Signaling pathways of bisphenol A-induced apoptosis in hippocampal neuronal cells: role of calcium-induced reactive oxygen species, mitogen-activated protein kinases, and nuclear factor-kappaB","volume":"86","author":"Lee","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.taap.2013.03.001_bb0155","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1248\/bpb.33.230","article-title":"Effects of hydroxy pentacyclic triterpene acids from Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea pigs","volume":"33","author":"Lee","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.taap.2013.03.001_bb0165","doi-asserted-by":"crossref","first-page":"9434","DOI":"10.1016\/j.biomaterials.2011.08.042","article-title":"The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis","volume":"32","author":"Lee","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.taap.2013.03.001_bb0170","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(03)12193-9","article-title":"Atopic dermatitis","volume":"361","author":"Leung","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2013.03.001_bb0175","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1172\/JCI21060","article-title":"New insights into atopic dermatitis","volume":"113","author":"Leung","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2013.03.001_bb0180","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1128\/JVI.78.4.1665-1674.2004","article-title":"Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein\u2013Barr virus","volume":"78","author":"Nakayama","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.taap.2013.03.001_bb0005","first-page":"14006","article-title":"The murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals\/compounds, report now available. Public health service","volume":"64","author":"National Institute of Environmental Health Sciences (NIEHS)","year":"1999","journal-title":"Fed. Regist."},{"key":"10.1016\/j.taap.2013.03.001_bb0185","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.jaci.2009.03.041","article-title":"IL-22-producing \u201cT22\u201d T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells","volume":"123","author":"Nograles","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0190","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1398-9995.2008.01922.x","article-title":"New insights into the mechanism and management of allergic diseases: atopic dermatitis","volume":"64","author":"Novak","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.taap.2013.03.001_bb0195","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jaci.2009.11.019","article-title":"Dendritic cells: bridging innate and adaptive immunity in atopic dermatitis","volume":"125","author":"Novak","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0200","first-page":"88","article-title":"Inhibitory effect of oleanolic acid on 12-O-tetradecanoylphorbol-13-acetate-induced gene expression in mouse skin","volume":"45","author":"Oguro","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2013.03.001_bb0205","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/j.1398-9995.2012.02854.x","article-title":"The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC\/Nga mice","volume":"67","author":"Ohsawa","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.taap.2013.03.001_bb0210","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0065-2776(09)01203-6","article-title":"Cellular and molecular mechanisms in atopic dermatitis","volume":"102","author":"Oyoshi","year":"2009","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0215","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/jcp.22303","article-title":"Reactive oxygen species are involved in the IFN-gamma-stimulated production of Th2 chemokines in HaCaT keratinocytes","volume":"226","author":"Qi","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2013.03.001_bb0220","first-page":"540","article-title":"Immunosuppressive antimetabolites inhibit induction of contact hypersensitivity while lymphoablative drugs also prevent its expression","volume":"13","author":"Quemeneur","year":"2003","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.taap.2013.03.001_bb0225","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1600-0625.2011.01395.x","article-title":"Extended DNFB-induced contact hypersensitivity models display characteristics of chronic inflammatory dermatoses","volume":"21","author":"Rose","year":"2012","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.taap.2013.03.001_bb0230","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jconrel.2011.11.016","article-title":"Effect of oleic acid modified polymeric bilayered nanoparticles on percutaneous delivery of spantide II and ketoprofen","volume":"158","author":"Shah","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.taap.2013.03.001_bb0235","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1067\/mai.2003.1414","article-title":"Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions","volume":"111","author":"Toda","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0240","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ni.1770","article-title":"Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells","volume":"10","author":"Trifari","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0245","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1046\/j.1523-1747.2000.00115.x","article-title":"A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+ lymphocytes into lesional atopic dermatitis skin","volume":"115","author":"Vestergaard","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.taap.2013.03.001_bb0250","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1586\/1744666X.1.1.75","article-title":"Contribution of CD4(+) and CD8(+) T-cells in contact hypersensitivity and allergic contact dermatitis","volume":"1","author":"Vocanson","year":"2005","journal-title":"Expert. Rev. Clin. Immunol."},{"key":"10.1016\/j.taap.2013.03.001_bb0255","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ni.1852","article-title":"Sensing the outside world: TSLP regulates barrier immunity","volume":"11","author":"Ziegler","year":"2010","journal-title":"Nat. Immunol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13000914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13000914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T08:13:47Z","timestamp":1688112827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X13000914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0041008X13000914"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2013.03.001","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}