{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:35:34Z","timestamp":1791894934916,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.taap.2013.05.002","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T11:46:30Z","timestamp":1368099990000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["An in vitro investigation of endocrine disrupting effects of the mycotoxin alternariol"],"prefix":"10.1016","volume":"271","author":[{"given":"Caroline","family":"Frizzell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Ndossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shewit","family":"Kalayou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar S.","family":"Eriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Verhaegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"S\u00f8rlie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Ropstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2013.05.002_bb0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/1098-2744(200102)30:2<88::AID-MC1017>3.0.CO;2-E","article-title":"Signal transduction through the Ras\/Erk pathway is essential for the mycoestrogen zearalenone-induced cell-cycle progression in MCF-7 cells","volume":"30","author":"Ahamed","year":"2001","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.taap.2013.05.002_bb0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1541-4337.2009.00094.x","article-title":"Mycotoxins in food and feed: present status and future concerns","volume":"9","author":"Bhat","year":"2010","journal-title":"Comp. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.taap.2013.05.002_bb0015","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.toxlet.2006.01.001","article-title":"Mutagenicity of the mycotoxin alternariol in cultured mammalian cells","volume":"164","author":"Brugger","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2013.05.002_bb0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12550-009-0022-2","article-title":"Absorption and metabolism of the mycotoxins alternariol and alternariol-9-methyl ether in Caco-2 cells in vitro","volume":"25","author":"Burkhardt","year":"2009","journal-title":"Mycotoxin Res."},{"key":"10.1016\/j.taap.2013.05.002_bb0025","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/mnfr.201000487","article-title":"Oxidative metabolism of the mycotoxins alternariol and alternariol-9-methyl ether in precision-cut rat liver slices in vitro","volume":"55","author":"Burkhardt","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.taap.2013.05.002_bb0030","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.2903\/j.efsa.2011.2407","article-title":"Scientific opinion on the risks for animal and public health related to the presence of Alternaria toxins in feed and food","volume":"9","author":"EFSA (European Food Safety Authority) Panel on Contaminants in the Food Chain","year":"2011","journal-title":"EFSA J."},{"key":"10.1016\/j.taap.2013.05.002_bb0035","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s12550-010-0063-6","article-title":"Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1","volume":"26","author":"Fehr","year":"2010","journal-title":"Mycotoxin Res."},{"key":"10.1016\/j.taap.2013.05.002_bb0040","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.toxlet.2011.07.015","article-title":"Endocrine disrupting effects of zearalenone, alpha- and beta-zearalenol at the level of nuclear receptor binding and steroidogenesis","volume":"206","author":"Frizzell","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2013.05.002_bb0045","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.toxlet.2012.12.018","article-title":"Endocrine disrupting effects of ochratoxin A at the level of nuclear receptor activation and steroidogenesis","volume":"217","author":"Frizzell","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2013.05.002_bb0050","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.taap.2007.07.013","article-title":"Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds","volume":"225","author":"Gracia","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.05.002_bb0055","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/toxsci\/kfh191","article-title":"Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR","volume":"81","author":"Hilscherova","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2013.05.002_bb0060","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/j.1460-2075.1990.tb08280.x","article-title":"Two distinct estrogen-regulated promotors generate transcripts encoding the two functionally different human-progesterone receptor form-A and form-B","volume":"9","author":"Kastner","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.taap.2013.05.002_bb0065","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1289\/ehp.96104s4715","article-title":"Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop. Environ","volume":"104","author":"Kavlock","year":"1996","journal-title":"Health Perspect."},{"key":"10.1016\/j.taap.2013.05.002_bb0070","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.fct.2005.08.013","article-title":"Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells","volume":"44","author":"Lehmann","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2013.05.002_bb0075","first-page":"394","article-title":"Etiological role of Alternaria alternata in human esophageal cancer","volume":"105","author":"Liu","year":"1992","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.taap.2013.05.002_bb0080","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.taap.2013.05.002_bb0085","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ijc.21891","article-title":"Sex differences in risk of lung cancer: expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts","volume":"119","author":"Mollerup","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2013.05.002_bb0090","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.toxlet.2012.09.005","article-title":"An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins","volume":"214","author":"Ndossi","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2013.05.002_bb0095","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3920\/WMJ2008.x013","article-title":"Alternaria mycotoxins: an overview of chemical characterization, producers, toxicity, analysis and occurrence in foodstuffs","volume":"1","author":"Ostry","year":"2008","journal-title":"World Mycotoxin J."},{"key":"10.1016\/j.taap.2013.05.002_bb0100","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1210\/er.2003-0030","article-title":"Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones","volume":"25","author":"Payne","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.taap.2013.05.002_bb0105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1289\/ehp.730487","article-title":"Toxicity of metabolites produced by the \u201cAlternaria\u201d","volume":"4","author":"Pero","year":"1973","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2013.05.002_bb0110","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/BF02951512","article-title":"Alternaria toxins: DNA strand-breaking activity in mammalian cells in vitro","volume":"23","author":"Pfeiffer","year":"2007","journal-title":"Mycotoxin Res."},{"key":"10.1016\/j.taap.2013.05.002_bb0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12550-008-0001-z","article-title":"Glucuronidation of the mycotoxins alternariol and alternariol-9-methyl ether in vitro: chemical structures of glucuronides and activities of human UDP-glucuronosyltransferase isoforms","volume":"25","author":"Pfeiffer","year":"2009","journal-title":"Mycotoxin Res."},{"key":"10.1016\/j.taap.2013.05.002_bb0120","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mce.2003.12.020","article-title":"Adrenocortical cell lines","volume":"228","author":"Rainey","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.taap.2013.05.002_bb0130","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1093\/jaoac\/84.6.1809","article-title":"Analysis of agricultural commodities and foods for Alternaria mycotoxins","volume":"84","author":"Scott","year":"2001","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.taap.2013.05.002_bb0125","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/BF02956778","article-title":"Analysis of wines, grape juices and cranberry juices for Alternaria toxins","volume":"22","author":"Scott","year":"2006","journal-title":"Mycotoxin Res."},{"key":"10.1016\/j.taap.2013.05.002_bb0135","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/03602530701498828","article-title":"Transcriptional regulation of adrenocortical steroidogenic gene expression","volume":"39","author":"Sewer","year":"2007","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.taap.2013.05.002_bb0140","first-page":"342","article-title":"Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis","volume":"15","author":"Simpson","year":"1994","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.taap.2013.05.002_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2012.09.001","article-title":"Mechanisms involved in alternariol-induced cell cycle arrest","volume":"738\u2013739","author":"Solhaug","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2013.05.002_bb0150","first-page":"221","article-title":"Regulation of the acute production of steroids in steroidogenic cells","volume":"17","author":"Stocco","year":"1996","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.taap.2013.05.002_bb0155","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/01635580903191577","article-title":"Effects of nutrition relevant mixtures of phytoestrogens on steroidogenesis, aromatase, estrogen, and androgen activity","volume":"62","author":"Taxvig","year":"2009","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.taap.2013.05.002_bb0160","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.toxlet.2009.01.014","article-title":"The mycotoxins alternariol and alternariol methyl ether negatively affect progesterone synthesis in porcine granulosa cells in vitro","volume":"186","author":"Tiemann","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2013.05.002_bb0165","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00216-003-2217-2","article-title":"Use of reporter cell lines for detection of endocrine-disrupter activity","volume":"378","author":"Willemsen","year":"2004","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.taap.2013.05.002_bb0170","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.toxlet.2008.08.005","article-title":"Influence of alternariol (AOH) on regulator proteins of cap-dependent translation in porcine endometrial cells","volume":"182","author":"Wollenhaupt","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2013.05.002_bb0175","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1021\/es048679k","article-title":"Quantitative RT-PCR methods for evaluating toxicant-induced effects on steroidogenesis using the H295R cell line","volume":"39","author":"Zhang","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2013.05.002_bb0180","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.scitotenv.2011.01.055","article-title":"In vitro steroidogenic effects of mixtures of persistent organic pollutants (POPs) extracted from burbot (Lota lota) caught in two Norwegian lakes","volume":"409","author":"Zimmer","year":"2011","journal-title":"Sci. Total Environ."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13001919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13001919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T14:11:16Z","timestamp":1595772676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X13001919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0041008X13001919"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2013.05.002","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An in vitro investigation of endocrine disrupting effects of the mycotoxin alternariol","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2013.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}