{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:51:51Z","timestamp":1769550711736,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.taap.2013.06.017","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T07:31:26Z","timestamp":1372231886000},"page":"542-550","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Involvement of HIF-2\u03b1-mediated inflammation in arsenite-induced transformation of human bronchial epithelial cells"],"prefix":"10.1016","volume":"272","author":[{"given":"Yuan","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bairu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qizhan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2013.06.017_bb0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semcancer.2011.12.005","article-title":"Cancer-related inflammation: common themes and therapeutic opportunities","volume":"22","author":"Balkwill","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.taap.2013.06.017_bb0010","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10555-007-9084-9","article-title":"Bladder cancer angiogenesis and metastasis \u2014 translation from murine model to clinical trial","volume":"26","author":"Black","year":"2007","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.taap.2013.06.017_bb0015","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/toxsci\/kfn208","article-title":"Nickel and the microbial toxin, MALP-2, stimulate proangiogenic mediators from human lung fibroblasts via a HIF-1alpha and COX-2-mediated pathway","volume":"107","author":"Brant","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2013.06.017_bb0020","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.4049\/jimmunol.0803851","article-title":"Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease","volume":"183","author":"Brereton","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2013.06.017_bb0025","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00018-011-0876-2","article-title":"NFkappaB and HIF display synergistic behaviour during hypoxic inflammation","volume":"69","author":"Bruning","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.taap.2013.06.017_bb0030","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1001\/jama.292.24.2984","article-title":"Ingested arsenic, cigarette smoking, and lung cancer risk: a follow-up study in arseniasis-endemic areas in Taiwan","volume":"292","author":"Chen","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.taap.2013.06.017_bb0035","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/carcin\/bgs159","article-title":"Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke carcinogen","volume":"33","author":"Chen","year":"2012","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2013.06.017_bb0040","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/toxsci\/kfr310","article-title":"An NF-kappaB-independent and Erk1\/2-dependent mechanism controls CXCL8\/IL-8 responses of airway epithelial cells to cadmium","volume":"125","author":"Cormet-Boyaka","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2013.06.017_bb0045","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/S1357-2725(02)00048-1","article-title":"Asthma: the importance of epithelial mesenchymal communication in pathogenesis. Inflammation and the airway epithelium in asthma","volume":"34","author":"Davies","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.taap.2013.06.017_bb0050","first-page":"6189","article-title":"Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing","volume":"60","author":"Elson","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2013.06.017_bb0055","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.taap.2009.12.029","article-title":"Low level exposure to monomethyl arsonous acid-induced the over-production of inflammation-related cytokines and the activation of cell signals associated with tumor progression in a urothelial cell model","volume":"244","author":"Escudero-Lourdes","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.017_bb0060","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.taap.2011.10.002","article-title":"Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells","volume":"258","author":"Escudero-Lourdes","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.017_bb0065","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/j.freeradbiomed.2011.08.023","article-title":"Opposite effects of HIF-1alpha and HIF-2alpha on the regulation of IL-8 expression in endothelial cells","volume":"51","author":"Florczyk","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2013.06.017_bb0070","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1371\/journal.pgen.0030207","article-title":"Activation of inflammation\/NF-kappaB signaling in infants born to arsenic-exposed mothers","volume":"3","author":"Fry","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.taap.2013.06.017_bb0075","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.taap.2009.01.003","article-title":"Manganese (II) induces chemical hypoxia by inhibiting HIF-prolyl hydroxylase: implication in manganese-induced pulmonary inflammation","volume":"235","author":"Han","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.017_bb0080","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.4049\/jimmunol.181.4.2772","article-title":"Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6","volume":"181","author":"Hollins","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2013.06.017_bb0085","first-page":"269","article-title":"Some drinking-water disinfectants and contaminants, including arsenic. Monographs on chloramine, chloral and chloral hydrate, dichloroacetic acid, trichloroacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone","volume":"84","author":"IARC","year":"2004","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.taap.2013.06.017_bb0095","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00109-010-0706-2","article-title":"At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop","volume":"89","author":"Kaluz","year":"2011","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.taap.2013.06.017_bb0100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/1066896911436274","article-title":"Significance of the correlation between the expression of interleukin 6 and clinical features in patients with non-small cell lung cancer","volume":"20","author":"Koh","year":"2012","journal-title":"Int. J. Surg. Pathol."},{"key":"10.1016\/j.taap.2013.06.017_bb0105","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.pharmtox.47.120505.105144","article-title":"Arsenic: signal transduction, transcription factor, and biotransformation involved in cellular response and toxicity","volume":"47","author":"Kumagai","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2013.06.017_bb0110","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.ejca.2010.01.031","article-title":"Constitutive HIF-1 activity in malignant melanoma","volume":"46","author":"Kuphal","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.taap.2013.06.017_bb0115","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/toxsci\/kfr305","article-title":"The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells","volume":"125","author":"Lau","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2013.06.017_bb0120","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1289\/ehp.0901677","article-title":"mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells","volume":"118","author":"Li","year":"2010","journal-title":"Environ. Heal. Perspect."},{"key":"10.1016\/j.taap.2013.06.017_bb0125","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.taap.2007.07.017","article-title":"Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells","volume":"225","author":"Liao","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.017_bb0130","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1172\/JCI31537","article-title":"A cytokine-mediated link between innate immunity, inflammation, and cancer","volume":"117","author":"Lin","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2013.06.017_bb0135","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.taap.2013.06.017_bb0140","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1038\/onc.2008.275","article-title":"Cytokine-based transformation of immune surveillance into tumor-promoting inflammation","volume":"27","author":"Mumm","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2013.06.017_bb0145","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.intimp.2012.01.008","article-title":"Arsenic decreases RXRalpha-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes","volume":"12","author":"Noreault-Conti","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2013.06.017_bb0150","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1097\/JTO.0b013e3181f387e4","article-title":"The role of inflammation in the pathogenesis of non-small cell lung cancer","volume":"5","author":"O'Callaghan","year":"2010","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.taap.2013.06.017_bb0155","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1615\/JEnvironPatholToxicolOncol.v30.i2.50","article-title":"Vernolide-A inhibits radiation-induced hypoxia-mediated tumor angiogenesis by regulating HIF-1alpha, MMP-2, MMP-9, and VEGF","volume":"30","author":"Pratheeshkumar","year":"2011","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.taap.2013.06.017_bb0160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-3-540-37696-5_5","article-title":"Cytokines are a therapeutic target for the prevention of inflammation-induced cancers","volume":"174","author":"Rose-John","year":"2007","journal-title":"Recent Results Cancer Res."},{"key":"10.1016\/j.taap.2013.06.017_bb0165","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1002\/art.30451","article-title":"Interleukin-6 plays an essential role in hypoxia-inducible factor 2alpha-induced experimental osteoarthritic cartilage destruction in mice","volume":"63","author":"Ryu","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.taap.2013.06.017_bb0170","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/toxsci\/kfq155","article-title":"Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation","volume":"116","author":"Saini","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2013.06.017_bb0175","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1289\/ehp.6332","article-title":"Arsenic exposure accelerates atherogenesis in apolipoprotein E(\u2212\/\u2212) mice","volume":"111","author":"Simeonova","year":"2003","journal-title":"Environ. Heal. Perspect."},{"key":"10.1016\/j.taap.2013.06.017_bb0180","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pharmthera.2009.06.004","article-title":"Inflammatory mechanisms and treatment of obstructive airway diseases with neutrophilic bronchitis","volume":"124","author":"Simpson","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2013.06.017_bb0185","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.taap.2009.10.014","article-title":"Adverse health effects due to arsenic exposure: modification by dietary supplementation of jaggery in mice","volume":"242","author":"Singh","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.017_bb0190","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4161\/cbt.8.1.7079","article-title":"Inflammation, but not hypoxia, mediated HIF-1alpha activation depends on COX-2","volume":"8","author":"Stasinopoulos","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.taap.2013.06.017_bb0195","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.taap.2012.04.003","article-title":"Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells","volume":"261","author":"Stueckle","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.017_bb0200","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.mrrev.2006.02.001","article-title":"Arsenic in the aetiology of cancer","volume":"612","author":"Tapio","year":"2006","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2013.06.017_bb0205","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/jb\/mvq129","article-title":"Inhibitory effect of extracellular histidine on cobalt-induced HIF-1alpha expression","volume":"149","author":"Torii","year":"2011","journal-title":"J. Biochem."},{"key":"10.1016\/j.taap.2013.06.017_bb0210","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.20040624","article-title":"Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity","volume":"201","author":"Walmsley","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.taap.2013.06.017_bb0215","doi-asserted-by":"crossref","first-page":"10112","DOI":"10.1158\/0008-5472.CAN-10-0775","article-title":"IL-17 enhances tumor development in carcinogen-induced skin cancer","volume":"70","author":"Wang","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2013.06.017_bb0220","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cyto.2012.04.020","article-title":"Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells","volume":"59","author":"Wang","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.taap.2013.06.017_bb0225","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2012.04.013","article-title":"Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion","volume":"59","author":"Wang","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.taap.2013.06.017_bb0230","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2119\/2007-00090.Wen","article-title":"Neoplastic transformation of human small airway epithelial cells induced by arsenic","volume":"14","author":"Wen","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.taap.2013.06.017_bb0235","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3181\/0710-RM-269","article-title":"High dietary fat exacerbates arsenic-induced liver fibrosis in mice","volume":"233","author":"Wu","year":"2008","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.taap.2013.06.017_bb0240","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.taap.2012.11.014","article-title":"The accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells","volume":"266","author":"Xu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.017_bb0245","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00204-012-0810-x","article-title":"Blockade of p53 by HIF-2alpha, but not HIF-1alpha, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells","volume":"86","author":"Xu","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2013.06.017_bb0250","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.taap.2008.11.002","article-title":"c-Jun\/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells","volume":"235","author":"Zhang","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13002901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13002901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T21:28:58Z","timestamp":1539552538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X13002901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0041008X13002901"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2013.06.017","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of HIF-2\u03b1-mediated inflammation in arsenite-induced transformation of human bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2013.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2013 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}