{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:09:20Z","timestamp":1768900160611,"version":"3.49.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.taap.2013.06.021","type":"journal-article","created":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T12:06:21Z","timestamp":1373285181000},"page":"797-805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Distinct mechanisms of relaxation to bioactive components from chamomile species in porcine isolated blood vessels"],"prefix":"10.1016","volume":"272","author":[{"given":"R.E.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.Y.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.C.","family":"Hobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Karania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.N.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.S.Y.","family":"Pek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Raghvani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.Y.","family":"Shee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Shikotra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Street","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.K.","family":"Heer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.P.H.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2013.06.021_bb0005","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1476-5381.2011.01649_1.x","article-title":"Guide to Receptors and Channels (GRAC), 5th Edition","volume":"164","author":"Alexander","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.021_bb0010","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00210-004-0964-z","article-title":"Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels","volume":"370","author":"Calderone","year":"2004","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.021_bb0015","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.lfs.2010.10.014","article-title":"Calcium- and phosphatidylinositol 3-kinase\/Akt-dependent activation of endothelial nitric oxide synthase by apigenin","volume":"87","author":"Chen","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2013.06.021_bb0020","first-page":"444","article-title":"Luteolin induces vasorelaxion in rat thoracic aorta via calcium and potassium channels","volume":"60","author":"Jiang","year":"2005","journal-title":"Pharmazie"},{"key":"10.1016\/j.taap.2013.06.021_bb0025","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejphar.2009.06.020","article-title":"Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress","volume":"616","author":"Jin","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.021_bb0030","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.bcp.2004.06.030","article-title":"Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure\u2013activity relationships","volume":"68","author":"Ko","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.021_bb0035","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1055\/s-2005-864133","article-title":"Mechanisms of relaxant action of luteolin in isolated guinea pig trachea","volume":"71","author":"Ko","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.taap.2013.06.021_bb0040","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00178212","article-title":"Overnight storage of the porcine isolated splenic artery enhances endothelium-dependent contractions to NG-nitro-l-arginine methyl ester without impairing endothelium-dependent dilator function","volume":"349","author":"Lot","year":"1994","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.021_bb0045","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1021\/jf800051n","article-title":"Inhibition of human cAMP-phosphodiesterase as a mechanism of the spasmolytic effect of Matricaria recutita L.","volume":"56","author":"Maschi","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.taap.2013.06.021_bb0050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1540\/jsmr.39.67","article-title":"Phosphodiesterases in the vascular system","volume":"39","author":"Matsumoto","year":"2003","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.taap.2013.06.021_bb0055","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/ptr.1900","article-title":"A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)","volume":"20","author":"McKay","year":"2006","journal-title":"Phytother. Res."},{"key":"10.1016\/j.taap.2013.06.021_bb0060","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.talanta.2010.06.057","article-title":"Development and application of UHPLC\u2013MS\/MS method for the determination of phenolic compounds in chamomile flowers and chamomile tea extracts","volume":"82","author":"Novakova","year":"2010","journal-title":"Talanta"},{"key":"10.1016\/j.taap.2013.06.021_bb0065","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/14786410802560690","article-title":"Content and composition of the essential oil of Chamomilla recutita (L.) Rauschert from some European countries","volume":"24","author":"Orav","year":"2010","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.taap.2013.06.021_bb0070","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/molecules15010270","article-title":"Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-halo-3-phenylcoumarins","volume":"15","author":"Quezada","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2013.06.021_bb0075","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1038\/sj.bjp.0702979","article-title":"\u03b12-Adrenoceptor and NPY receptor-mediated contractions of porcine isolated blood vessels: evidence for involvement of the vascular endothelium","volume":"128","author":"Roberts","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2013.06.021_bb0080","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0022-2828(08)80009-0","article-title":"Regulation of l-type calcium channels of vascular smooth muscle cells","volume":"27","author":"Xiong","year":"1995","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2013.06.021_bb0085","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.phytochem.2007.02.013","article-title":"Structure\u2013activity relationships of flavonoids for vascular relaxation in porcine coronary artery","volume":"68","author":"Xu","year":"2007","journal-title":"Phytochemistry"},{"key":"10.1016\/j.taap.2013.06.021_bb0090","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.cbi.2010.04.024","article-title":"(+\/\u2212)-Praeruptorin A enantiomers exert distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis","volume":"186","author":"Xu","year":"2010","journal-title":"Chem. Biol. Interact."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13002949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X13002949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T14:52:25Z","timestamp":1539528745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X13002949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0041008X13002949"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2013.06.021","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct mechanisms of relaxation to bioactive components from chamomile species in porcine isolated blood vessels","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2013.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}