{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:17:41Z","timestamp":1791443861647,"version":"4.3.3"},"reference-count":54,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["58213"],"award-info":[{"award-number":["58213"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.taap.2014.06.017","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T20:00:44Z","timestamp":1404417644000},"page":"391-400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Methamidophos alters sperm function and DNA at different stages of spermatogenesis in mice"],"prefix":"10.1016","volume":"279","author":[{"given":"Mayrut","family":"Uri\u00f3stegui-Acosta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Hern\u00e1ndez-Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"S\u00e1nchez-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belem","family":"Pi\u00f1a-Guzm\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Rafael-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Sol\u00eds-Heredia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Mart\u00ednez-Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betzabet","family":"Quintanilla-Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2014.06.017_bb0005","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1515\/znc-1987-1-205","article-title":"Cytogenetic effects of the insecticide methamidophos in mouse bone marrow and cultured mouse spleen cells","volume":"42","author":"Amer","year":"1987","journal-title":"Z. Naturforsch. C."},{"key":"10.1016\/j.taap.2014.06.017_bb0010","author":"AMIFAC","year":"2013"},{"key":"10.1016\/j.taap.2014.06.017_bb0015","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1095\/biolreprod42.2.317","article-title":"Acrosome biogenesis begins during meiosis: evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during guinea pig spermatogenesis","volume":"42","author":"Anakwe","year":"1990","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.taap.2014.06.017_bb0020","series-title":"Encyclopedia of Reproduction","first-page":"597","article-title":"Encyclopedia of reproduction","author":"Bedford","year":"1999"},{"key":"10.1016\/j.taap.2014.06.017_bb0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0890-6238(99)00062-3","article-title":"In vitro fertilization after in vivo treatment of rats with three reproductive toxicants","volume":"14","author":"Berger","year":"2000","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2014.06.017_bb0030","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/humrep\/deq082","article-title":"Exposure to organophosphate pesticides and male hormone profile in floriculturist of the state of Morelos, Mexico","volume":"25","author":"Blanco-Mu\u00f1oz","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.taap.2014.06.017_bb0035","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.fertnstert.2013.01.124","article-title":"Epigenetic disorders and male subfertility","volume":"99","author":"Boissonnas","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.taap.2014.06.017_bb0040","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1006\/taap.2000.8933","article-title":"Paternal effects from methamidophos administration in mice","volume":"165","author":"Burruel","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2014.06.017_bb0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10815-012-9715-0","article-title":"Epigenetics and its role in male infertility","volume":"29","author":"Dada","year":"2012","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.taap.2014.06.017_bb0050","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1093\/humrep\/17.12.3122","article-title":"Sperm DNA quality predicts intrauterine insemination outcome: a prospective cohort study","volume":"17","author":"Duran","year":"2002","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.taap.2014.06.017_bb0055","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2014.06.017_bb0060","series-title":"Organophosphorous pesticides: Organic and Biological Chemistry","first-page":"387","author":"Eto","year":"1974"},{"key":"10.1016\/j.taap.2014.06.017_bb0065","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/em.2850210208","article-title":"Effects of methyl methanesulfonate on mouse sperm chromatin structure and testicular cell kinetics","volume":"21","author":"Evenson","year":"1993","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.taap.2014.06.017_bb0070","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1439-0272.2010.01113.x","article-title":"Evaluation of male-mediated reproductive toxic effects of methamidophos in the mouse","volume":"44","author":"Farag","year":"2012","journal-title":"Andrologia"},{"key":"10.1016\/j.taap.2014.06.017_bb0075","first-page":"73","article-title":"Plasma membrane structure and remodelling during sperm maturation in the epididymis","volume":"53","author":"Jones","year":"1998","journal-title":"J. Reprod. Fertil. Suppl."},{"key":"10.1016\/j.taap.2014.06.017_bb0080","first-page":"40","article-title":"Male reproductive toxic effects of carbendazim: hitherto unreported targets in testis","volume":"40","author":"Kadalmani","year":"2002","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.taap.2014.06.017_bb0085","doi-asserted-by":"crossref","first-page":"321213","DOI":"10.1155\/2013\/321213","article-title":"Acetylcholinesterase as a biomarker in environmental and occupational medicine: new insights and future perspectives","volume":"2013","author":"Lionetto","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.taap.2014.06.017_bb0090","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tox.2013.02.005","article-title":"Environmental and occupational pesticide exposure and human sperm parameters: a systematic review","volume":"307","author":"Martenies","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2014.06.017_bb0095","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0165-1218(92)90045-2","article-title":"Methyl parathion-induced sperm shape abnormalities in mouse","volume":"280","author":"Mathew","year":"1992","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2014.06.017_bb0105","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1289\/ehp.7234","article-title":"The relationship of urinary metabolites of carbaryl\/naphthalene and chlorpyrifos with human semen quality","volume":"112","author":"Meeker","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2014.06.017_bb0110","article-title":"Oxidative and genetic damage in germinal and mononuclear mouse cells by methyl-parathion exposure in mice","volume":"510","author":"Monroy-Per\u00e9z","year":"2012","journal-title":"Toxicologist"},{"key":"10.1016\/j.taap.2014.06.017_bb0115","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/sj.jes.7500550","article-title":"Method for determination of acephate, methamidophos, omethoate, dimethoate, ethylenethiourea and propylenethiourea in human urine using high-performance liquid chromatography\u2013atmospheric pressure chemical ionization tandem mass spectrometry","volume":"17","author":"Montesano","year":"2007","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.taap.2014.06.017_bb0120","series-title":"Chemicals","article-title":"Reconsideration of approvals and registrations related to methamidophos. Review scope document","author":"NRA","year":"2002"},{"key":"10.1016\/j.taap.2014.06.017_bb0125","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/095530099140311","article-title":"DNA damage and repair in individual cells: applications of the comet assay in radiobiology","volume":"75","author":"Olive","year":"1999","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.taap.2014.06.017_bb0135","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1097\/00043764-199812000-00002","article-title":"Reproductive hormone profile among pesticide factory workers","volume":"40","author":"Padungtod","year":"1998","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.taap.2014.06.017_bb0130","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/(SICI)1097-0274(199908)36:2<230::AID-AJIM2>3.0.CO;2-6","article-title":"Sperm aneuploidy among Chinese pesticide factory workers: scoring by the FISH method","volume":"36","author":"Padungtod","year":"1999","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.taap.2014.06.017_bb0140","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1097\/00043764-200010000-00004","article-title":"Occupational pesticide exposure and semen quality among Chinese workers","volume":"42","author":"Padungtod","year":"2000","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.taap.2014.06.017_bb0145","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1530\/rep.0.1210239","article-title":"A comparative study of sperm production in two species of Australian arid zone rodents (Pseudomys australis, Notomys alexis) with marked differences in testis size","volume":"121","author":"Peirce","year":"2001","journal-title":"Reproduction"},{"key":"10.1016\/j.taap.2014.06.017_bb0150","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.taap.2008.02.021","article-title":"PON1Q192R genetic polymorphism modifies organophosphorous pesticide effects on semen quality and DNA integrity in agricultural workers from Southern Mexico","volume":"230","author":"P\u00e9rez-Herrera","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2014.06.017_bb0155","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/humupd\/dmm039","article-title":"Effects of environmental and occupational pesticide exposure on human sperm: a systematic review","volume":"14","author":"Perry","year":"2008","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.taap.2014.06.017_bb0165","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.taap.2004.06.028","article-title":"Diazinon alters sperm chromatin structure in mice by phosphorylating nuclear protamines","volume":"202","author":"Pi\u00f1a-Guzm\u00e1n","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2014.06.017_bb0170","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.taap.2006.05.001","article-title":"Genetic damage caused by methyl-parathion in mouse spermatozoa is related to oxidative stress","volume":"216","author":"Pi\u00f1a-Guzm\u00e1n","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2014.06.017_bb0160","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.taap.2009.05.008","article-title":"Methyl-parathion decreases sperm function and fertilization capacity after targeting spermatocytes and maturing spermatozoa","volume":"238","author":"Pi\u00f1a-Guzm\u00e1n","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2014.06.017_bb0185","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1289\/ehp.011091237","article-title":"Organophosphorous pesticide exposure increases the frequency of sperm sex null aneuploidy","volume":"109","author":"Recio","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2014.06.017_bb0180","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1289\/ehp.7374","article-title":"Pesticide exposure alters follicle-stimulating hormone levels in Mexican agricultural workers","volume":"113","author":"Recio","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2014.06.017_bb0175","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/jat.1321","article-title":"Organophosphorus pesticide exposure decreases sperm quality: association between sperm parameters and urinary pesticide levels","volume":"28","author":"Recio","year":"2008","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.taap.2014.06.017_bb0190","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1021\/bi00232a015","article-title":"J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential","volume":"30","author":"Reers","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.taap.2014.06.017_bb0195","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/JOM.0b013e318215fbf2","article-title":"Hematological, biochemical effects, and self-reported symptoms in pesticide retailers","volume":"53","author":"Rojas-Garc\u00eda","year":"2011","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.taap.2014.06.017_bb0200","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.taap.2003.11.023","article-title":"Organophosphorous pesticide exposure alters sperm chromatin structure in Mexican agricultural workers","volume":"196","author":"S\u00e1nchez-Pe\u00f1a","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2014.06.017_bb0205","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.ecoenv.2008.04.022","article-title":"Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on the mouse testis","volume":"72","author":"Sarabia","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2014.06.017_bb0210","first-page":"521","article-title":"Adducts in sperm protamine and DNA vs. mutation frequency","volume":"372","author":"Sega","year":"1991","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.taap.2014.06.017_bb0215","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/molehr\/3.8.677","article-title":"gamma-Aminobutyric acid (GABA) induces the acrosome reaction in human spermatozoa","volume":"3","author":"Shi","year":"1997","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.taap.2014.06.017_bb0220","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.taap.2014.06.017_bb0225","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1095\/biolreprod56.3.602","article-title":"Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro","volume":"56","author":"Sun","year":"1997","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.taap.2014.06.017_bb0230","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jat.1518","article-title":"Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry","volume":"30","author":"Tacal","year":"2010","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.taap.2014.06.017_bb0235","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1021\/bi00024a002","article-title":"Biochemical characterization of a glycosylphosphatidylinositol-linked hyaluronidase on mouse sperm","volume":"34","author":"Thaler","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.taap.2014.06.017_bb5000","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/j.1939-4640.1997.tb02432.x","article-title":"The human acrosome reaction is highly sensitive to inhibition by cyclodiene insecticides","volume":"18","author":"Turner","year":"1997","journal-title":"J. Androl."},{"issue":"Suppl. 2","key":"10.1016\/j.taap.2014.06.017_bb0240","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0015-0282(03)00983-X","article-title":"Alterations in mitochondria membrane potential and oxidative stress in infertile men: a prospective observational study","volume":"80","author":"Wang","year":"2003","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.taap.2014.06.017_bb0245","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.theriogenology.2009.04.016","article-title":"Beta-cypermethrin impairs reproductive function in male mice by inducing oxidative stress","volume":"72","author":"Wang","year":"2009","journal-title":"Theriogenology"},{"key":"10.1016\/j.taap.2014.06.017_bb0250","series-title":"World Health Organization. Laboratory Manual for the Examination and Processing of Human Semen","author":"WHO","year":"2010"},{"key":"10.1016\/j.taap.2014.06.017_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-1110(83)90014-3","article-title":"An evaluation of the mouse sperm morphology test and other sperm tests in nonhuman mammals. A report of the U.S. Environmental Protection Agency Gene-Tox Program","volume":"115","author":"Wyrobek","year":"1983","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2014.06.017_bb0265","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1179\/oeh.2006.12.4.355","article-title":"Semen quality and reproductive sex hormone levels in Peruvian pesticide sprayers","volume":"12","author":"Yucra","year":"2006","journal-title":"Int. J. Occup. Environ. Health"},{"key":"10.1016\/j.taap.2014.06.017_bb0260","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1476-069X-7-59","article-title":"Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters","volume":"7","author":"Yucra","year":"2008","journal-title":"Environ. Health"},{"key":"10.1016\/j.taap.2014.06.017_bb0270","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1515\/znc-1987-1-204","article-title":"Methylation of guanine in vivo by the organophosphorus insecticide methamidophos","volume":"42","author":"Zayed","year":"1987","journal-title":"Z. Naturforsch. C"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X14002464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X14002464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:44:50Z","timestamp":1758573890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X14002464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0041008X14002464"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2014.06.017","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methamidophos alters sperm function and DNA at different stages of spermatogenesis in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2014.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}