{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:15:59Z","timestamp":1770740159128,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.taap.2014.08.001","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T05:31:39Z","timestamp":1407735099000},"page":"207-215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A:diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: a link to amelioration of fatty liver"],"prefix":"10.1016","volume":"280","author":[{"given":"Xiaomang","family":"Xing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsu","family":"Chonan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johji","family":"Yamahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2014.08.001_bb0005","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ng0697-197","article-title":"Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats","volume":"16","author":"Aitman","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.taap.2014.08.001_bb0010","doi-asserted-by":"crossref","first-page":"484590","DOI":"10.1093\/ecam\/nep052","article-title":"Preventive effects of Salacia reticulata on obesity and metabolic disorders in TSOD mice","volume":"2011","author":"Akase","year":"2011","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.taap.2014.08.001_bb0015","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/sj.jhh.1002148","article-title":"Hypertension and fatty liver: guilty by association?","volume":"21","author":"Brookes","year":"2007","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.taap.2014.08.001_bb0020","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/CS20120151","article-title":"Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1\u03b1 in a rat model","volume":"124","author":"Burgue\u00f1o","year":"2013","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.taap.2014.08.001_bb0025","doi-asserted-by":"crossref","first-page":"38870","DOI":"10.1074\/jbc.M106219200","article-title":"Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members","volume":"276","author":"Cases","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2014.08.001_bb0030","doi-asserted-by":"crossref","first-page":"22678","DOI":"10.1074\/jbc.M704213200","article-title":"Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance","volume":"282","author":"Choi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2014.08.001_bb0035","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/ajcn\/85.6.1511","article-title":"Mechanisms for the acute effect of fructose on postprandial lipemia","volume":"85","author":"Chong","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.taap.2014.08.001_bb0040","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.taap.2012.01.015","article-title":"Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative\/nitrosative stress via Nrf2-NF\u03baB pathways","volume":"260","author":"Das","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2014.08.001_bb0045","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/gut.2003.027086","article-title":"Increased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: role of insulin resistance","volume":"53","author":"Donati","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.taap.2014.08.001_bb0050","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1210\/en.2012-1725","article-title":"The role of the carbohydrate response element-binding protein in male fructose-fed rats","volume":"154","author":"Erion","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2014.08.001_bb0055","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nm1025","article-title":"PPARs and the complex journey to obesity","volume":"10","author":"Evans","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.taap.2014.08.001_bb0060","doi-asserted-by":"crossref","first-page":"570948","DOI":"10.1155\/2012\/570948","article-title":"Treatment with ginger ameliorates fructose-induced fatty liver and hypertriglyceridemia in rats: modulation of the hepatic carbohydrate response element binding protein-mediated pathway","volume":"2012","author":"Gao","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.taap.2014.08.001_bb0065","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.nut.2006.05.006","article-title":"Fructose-enriched diet modifies antioxidant status and lipid metabolism in spontaneously hypertensive rats","volume":"22","author":"Girard","year":"2006","journal-title":"Nutrition"},{"key":"10.1016\/j.taap.2014.08.001_bb0070","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/mnfr.201100392","article-title":"Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters","volume":"55","author":"Guo","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.taap.2014.08.001_bb0075","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.taap.2005.05.003","article-title":"Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: activation of PPAR-alpha","volume":"210","author":"Huang","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2014.08.001_bb0080","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.taap.2005.07.020","article-title":"Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes","volume":"210","author":"Huang","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2014.08.001_bb0085","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/MOL.0b013e3282feea85","article-title":"Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism","volume":"19","author":"Hussain","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.taap.2014.08.001_bb0090","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1872-034X.2011.00920.x","article-title":"Spontaneously hypertensive rats develop pronounced hepatic steatosis induced by choline-deficient diet: evidence for hypertension as a potential enhancer in non-alcoholic steatohepatitis","volume":"42","author":"Ikuta","year":"2012","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.taap.2014.08.001_bb0095","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1073\/pnas.1103451108","article-title":"Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2","volume":"108","author":"Jornayvaz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2014.08.001_bb0100","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1042\/CS20080306","article-title":"The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans","volume":"116","author":"Kantartzis","year":"2009","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.taap.2014.08.001_bb0105","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1017\/S0007114509991978","article-title":"The protective role of amla (Emblica officinalis Gaertn.) against fructose-induced metabolic syndrome in a rat model","volume":"103","author":"Kim","year":"2010","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.taap.2014.08.001_bb0110","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.lfs.2008.03.005","article-title":"Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity","volume":"82","author":"Li","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2014.08.001_bb0115","doi-asserted-by":"crossref","first-page":"e90137","DOI":"10.1371\/journal.pone.0090137","article-title":"Dual mode action of mangiferin in mouse liver under high fat diet","volume":"9","author":"Lim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2014.08.001_bb0120","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jep.2013.10.020","article-title":"Modulation of hepatic sterol regulatory element-binding protein-1c-mediated gene expression contributes to Salacia oblonga root-elicited improvement of fructose-induced fatty liver in rats","volume":"150","author":"Liu","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2014.08.001_bb0125","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1248\/bpb.24.1091","article-title":"The suppressive effect of mangiferin with exercise on blood lipids in type 2 diabetes","volume":"24","author":"Miura","year":"2001","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.taap.2014.08.001_bb0130","doi-asserted-by":"crossref","first-page":"25164","DOI":"10.1074\/jbc.M402781200","article-title":"Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms","volume":"279","author":"Miyazaki","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2014.08.001_bb0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cmet.2007.05.005","article-title":"Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver","volume":"6","author":"Monetti","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2014.08.001_bb0140","doi-asserted-by":"crossref","first-page":"e30782","DOI":"10.1371\/journal.pone.0030782","article-title":"Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK","volume":"7","author":"Niu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2014.08.001_bb0145","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1053\/jhep.2002.30690","article-title":"Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association","volume":"35","author":"Pagano","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2014.08.001_bb0150","doi-asserted-by":"crossref","first-page":"E28","DOI":"10.1152\/ajpendo.90897.2008","article-title":"Biochemical and physiological function of stearoyl-CoA desaturase","volume":"297","author":"Paton","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2014.08.001_bb0155","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI34275","article-title":"Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice","volume":"118","author":"Postic","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2014.08.001_bb0160","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s003350010273","article-title":"Identification of a mutation in ADD1\/SREBP-1 in the spontaneously hypertensive rat","volume":"12","author":"Pravenec","year":"2001","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.taap.2014.08.001_bb0165","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/HYPERTENSIONAHA.107.100743","article-title":"Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat","volume":"51","author":"Pravenec","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.taap.2014.08.001_bb0170","doi-asserted-by":"crossref","first-page":"420979","DOI":"10.1155\/2013\/420979","article-title":"Role of renin-angiotensin system and oxidative stress on vascular inflammation in insulin resistence model","volume":"2013","author":"Renna","year":"2013","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.taap.2014.08.001_bb0175","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1254\/jphs.FP0070619","article-title":"Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution","volume":"105","author":"Saiki","year":"2007","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.taap.2014.08.001_bb0180","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1152\/ajpendo.90949.2008","article-title":"Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism","volume":"297","author":"Shi","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2014.08.001_bb0185","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s11745-013-3839-6","article-title":"Increased lipid synthesis and decreased \u03b2-oxidation in the liver of SHR\/NDmcr-cp (cp\/cp) rats, an animal model of metabolic syndrome","volume":"48","author":"Tanaka","year":"2013","journal-title":"Lipids"},{"key":"10.1016\/j.taap.2014.08.001_bb0190","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/hep.21655","article-title":"Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis","volume":"45","author":"Yamaguchi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2014.08.001_bb0195","doi-asserted-by":"crossref","first-page":"21506","DOI":"10.1074\/jbc.M412989200","article-title":"Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1","volume":"280","author":"Yamazaki","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2014.08.001_bb0200","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/hep.20783","article-title":"Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice","volume":"42","author":"Yu","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2014.08.001_bb0205","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00125-003-1073-0","article-title":"Insulin signaling pathways in aorta and muscle from two animal models of insulin resistance\u2013the obese middle-aged and the spontaneously hypertensive rats","volume":"46","author":"Zecchin","year":"2003","journal-title":"Diabetologia"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X14002932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X14002932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T19:14:56Z","timestamp":1565723696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X14002932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0041008X14002932"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2014.08.001","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A:diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: a link to amelioration of fatty liver","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2014.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}