{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:58:08Z","timestamp":1785369488690,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["F.No-7-357\/2011(BSR))"],"award-info":[{"award-number":["F.No-7-357\/2011(BSR))"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.taap.2015.01.012","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T18:22:41Z","timestamp":1421950961000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"title":["Genistein modulates the expression of NF-\u03baB and MAPK (p-38 and ERK1\/2), thereby attenuating d-Galactosamine induced fulminant hepatic failure in Wistar rats"],"prefix":"10.1016","volume":"283","author":[{"given":"Ajaz A.","family":"Ganai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athar A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainul A.","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humaira","family":"Farooqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2015.01.012_bb0005","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1016\/S0021-9258(18)45614-1","article-title":"Genistein, a specific inhibitor of tyrosine-specific protein kinases","volume":"262","author":"Akiyama","year":"1987","journal-title":"J. Biol. Chem."},{"issue":"Pt 3","key":"10.1016\/j.taap.2015.01.012_bb0010","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1042\/bj3020723","article-title":"Structure of the human cyclo-oxygenase-2 gene","volume":"302","author":"Appleby","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2015.01.012_bb0015","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/1359-6101(96)00020-2","article-title":"Biological and biochemical inhibitors of the NF-kappa B\/Rel proteins and cytokine synthesis","volume":"7","author":"Beauparlant","year":"1996","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.taap.2015.01.012_bb0020","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0003-2697(76)90323-7","article-title":"Enzymatic assay for glutathione","volume":"74","author":"Brehe","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2015.01.012_bb0025","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.taap.2015.01.012_bb0030","series-title":"Wheater's Functional Histology","author":"Burkitt","year":"1993"},{"key":"10.1016\/j.taap.2015.01.012_bb0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jsbmb.2005.05.010","article-title":"Effect of phytoestrogens on gene expression of carbonic anhydrase II in rat uterus and liver","volume":"97","author":"Caldarelli","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.taap.2015.01.012_bb0040","doi-asserted-by":"crossref","first-page":"C441","DOI":"10.1152\/ajpcell.2001.280.3.C441","article-title":"IFN-gamma+LPS induction of iNOS is modulated by ERK, JNK\/SAPK, and p38(mapk) in a mouse macrophage cell line","volume":"280","author":"Chan","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.taap.2015.01.012_bb0045","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2015.01.012_bb0050","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.021908.132629","article-title":"The liver as a lymphoid organ","volume":"27","author":"Crispe","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.taap.2015.01.012_bb0055","doi-asserted-by":"crossref","DOI":"10.1007\/BFb0027661","article-title":"Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death","volume":"77\u2013106","author":"Decker","year":"1974","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2015.01.012_bb0060","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1023\/A:1018876328561","article-title":"Prognostic evaluation of early indicators in fulminant hepatic failure by multivariate analysis","volume":"43","author":"Dhiman","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.taap.2015.01.012_bb0065","series-title":"The Basis of Toxicity Testing","author":"Ecobichon","year":"1997"},{"key":"10.1016\/j.taap.2015.01.012_bb0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cbi.2014.02.006","article-title":"Glycine propionyl l-carnitine attenuates d-Galactosamine induced fulminant hepatic failure in Wistar rats","volume":"214","author":"Ganai","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2015.01.012_bb0075","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nri2423","article-title":"New regulators of NF-kappaB in inflammation","volume":"8","author":"Ghosh","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2015.01.012_bb0080","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1515\/DMDI.2000.17.1-4.261","article-title":"Promotion of health by soy isoflavones: efficacy, benefit and safety concerns","volume":"17","author":"Goldwyn","year":"2000","journal-title":"Drug Metabol. Drug Interact."},{"key":"10.1016\/j.taap.2015.01.012_bb0085","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1007\/s12272-011-1214-9","article-title":"Anti-inflammatory effect of 2-methoxy-4-vinylphenol via the suppression of NF-kappaB and MAPK activation, and acetylation of histone H3","volume":"34","author":"Jeong","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.taap.2015.01.012_bb0090","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and their crosstalk with other innate receptors in infection and immunity","volume":"34","author":"Kawai","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.taap.2015.01.012_bb0230","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00011-011-0413-7","article-title":"Indirubin-3-monoxime exhibits anti-inflammatory properties by down-regulating NF-kappaB and JNK signaling pathways in lipopolysaccharide-treated RAW264.7 cells","volume":"61","author":"Kim","year":"2012","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.taap.2015.01.012_bb0100","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/jcp.7.4.322","article-title":"Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine","volume":"7","author":"Kind","year":"1954","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.taap.2015.01.012_bb0235","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2174\/1568010043343714","article-title":"Molecular therapeutic targets in inflammation: cyclooxygenase and NF-kappaB","volume":"3","author":"Krakauer","year":"2004","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"key":"10.1016\/j.taap.2015.01.012_bb0110","doi-asserted-by":"crossref","first-page":"36381","DOI":"10.1155\/2007\/36381","article-title":"Protective role of genistein in acute liver damage induced by carbon tetrachloride","volume":"2007","author":"Kuzu","year":"2007","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.taap.2015.01.012_bb0115","doi-asserted-by":"crossref","first-page":"11911","DOI":"10.1074\/jbc.271.20.11911","article-title":"Molecular cloning and expression of an avian macrophage nitric-oxide synthase cDNA and the analysis of the genomic 5\u2032-flanking region","volume":"271","author":"Lin","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2015.01.012_bb0120","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0165-1110(95)90004-7","article-title":"Potential genotoxicity of chronically elevated nitric oxide: a review","volume":"339","author":"Liu","year":"1995","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2015.01.012_bb0240","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods (San Diego, Calif.)"},{"key":"10.1016\/j.taap.2015.01.012_bb0130","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.febslet.2004.09.002","article-title":"Indole-3-carbinol activates the cyclin-dependent kinase inhibitor p15(INK4b) gene","volume":"576","author":"Matsuzaki","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.taap.2015.01.012_bb0135","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nri2634","article-title":"Transcriptional control of the inflammatory response","volume":"9","author":"Medzhitov","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2015.01.012_bb0140","doi-asserted-by":"crossref","first-page":"3095S","DOI":"10.1093\/jn\/131.11.3095S","article-title":"Soy for breast cancer survivors: a critical review of the literature","volume":"131","author":"Messina","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.taap.2015.01.012_bb0145","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.nmd.2011.04.014","article-title":"The soy isoflavone genistein blunts nuclear factor kappa-B, MAPKs and TNF-alpha activation and ameliorates muscle function and morphology in mdx mice","volume":"21","author":"Messina","year":"2011","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.taap.2015.01.012_bb0150","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1753-0407.2009.00045.x","article-title":"Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance","volume":"1","author":"Mohamed Salih","year":"2009","journal-title":"J. Diabetes"},{"key":"10.1016\/j.taap.2015.01.012_bb0155","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1089\/jmf.2009.1359","article-title":"The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells","volume":"13","author":"Park","year":"2010","journal-title":"J. Med. Food"},{"key":"10.1016\/j.taap.2015.01.012_bb0160","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nri2655","article-title":"Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases","volume":"9","author":"Pasparakis","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2015.01.012_bb0165","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1089\/ars.2006.8.478","article-title":"NF-kappaB: a stress-regulated switch for cell survival","volume":"8","author":"Piva","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2015.01.012_bb0170","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1515\/JBCPP.2008.19.2.131","article-title":"Influence of Piper betle on hepatic marker enzymes and tissue antioxidant status in D-galactosamine-induced hepatotoxic rats","volume":"19","author":"Pushpavalli","year":"2008","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2015.01.012_bb0175","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.taap.2015.01.012_bb0180","doi-asserted-by":"crossref","first-page":"23","DOI":"10.18388\/abp.2010_2368","article-title":"Synthetic derivatives of genistein, their properties and possible applications","volume":"57","author":"Rusin","year":"2010","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.taap.2015.01.012_bb0185","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1081\/CNV-120023773","article-title":"Soy isoflavones and cancer prevention","volume":"21","author":"Sarkar","year":"2003","journal-title":"Cancer Investig."},{"key":"10.1016\/j.taap.2015.01.012_bb0190","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1196\/annals.1351.039","article-title":"Effects of anti-TNF-alpha treatment on lipid profile in patients with active rheumatoid arthritis","volume":"1069","author":"Seriolo","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2015.01.012_bb0195","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12016-008-8091-0","article-title":"Inflammatory pathways in liver homeostasis and liver injury","volume":"36","author":"Tacke","year":"2009","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.taap.2015.01.012_bb0200","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1124\/jpet.104.065151","article-title":"Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice","volume":"310","author":"Veres","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2015.01.012_bb0205","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1517\/13543784.9.9.2103","article-title":"The therapeutic potential of flavonoids","volume":"9","author":"Wang","year":"2000","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.taap.2015.01.012_bb0210","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jep.2006.04.028","article-title":"Protective effect of Lygodium flexuosum (L.) Sw. (Lygodiaceae) against D-galactosamine induced liver injury in rats","volume":"108","author":"Wills","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2015.01.012_bb0215","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0024-3205(99)00263-5","article-title":"Acteoside inhibits apoptosis in D-galactosamine and lipopolysaccharide-induced liver injury","volume":"65","author":"Xiong","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2015.01.012_bb0220","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1677\/joe.0.1760267","article-title":"The phytoestrogen genistein suppresses cell-mediated immunity in mice","volume":"176","author":"Yellayi","year":"2003","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.taap.2015.01.012_bb0225","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10787-008-8018-7","article-title":"Soy isoflavones and their bone protective effects","volume":"16","author":"Zhang","year":"2008","journal-title":"Inflammopharmacology"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15000228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15000228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T07:48:44Z","timestamp":1651045724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X15000228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0041008X15000228"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2015.01.012","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genistein modulates the expression of NF-\u03baB and MAPK (p-38 and ERK1\/2), thereby attenuating d-Galactosamine induced fulminant hepatic failure in Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2015.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}