{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:02:17Z","timestamp":1791518537478,"version":"4.3.4"},"reference-count":55,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.taap.2015.02.015","type":"journal-article","created":{"date-parts":[[2015,2,21]],"date-time":"2015-02-21T02:04:01Z","timestamp":1424484241000},"page":"152-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Paradoxically, iron overload does not potentiate doxorubicin-induced cardiotoxicity in vitro in cardiomyocytes and in vivo in mice"],"prefix":"10.1016","volume":"284","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3554-7714","authenticated-orcid":false,"given":"Charles","family":"Guenancia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hachet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Rigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Cottin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Dutartre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Rochette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Vergely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2015.02.015_bb0005","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/ajh.21487","article-title":"Deferasirox removes cardiac iron and attenuates oxidative stress in the iron-overloaded gerbil","volume":"84","author":"Al-Rousan","year":"2009","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.taap.2015.02.015_bb0010","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1139\/y11-020","article-title":"Amelioration of doxorubicin-induced cardiotoxicity by deferiprone in rats","volume":"89","author":"Ammar el","year":"2011","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2015.02.015_bb0015","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ijcard.2004.11.004","article-title":"Endurance training attenuates doxorubicin-induced cardiac oxidative damage in mice","volume":"100","author":"Ascensao","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.taap.2015.02.015_bb0020","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0008-6363(99)00040-1","article-title":"Cardiac function and cytotoxic aldehyde production in a murine model of chronic iron-overload","volume":"43","author":"Bartfay","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.taap.2015.02.015_bb0025","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000265166","article-title":"Doxorubicin cardiomyopathy","volume":"115","author":"Chatterjee","year":"2010","journal-title":"Cardiology"},{"key":"10.1016\/j.taap.2015.02.015_bb0030","doi-asserted-by":"crossref","first-page":"13738","DOI":"10.1074\/jbc.M310106200","article-title":"Doxorubicin paradoxically protects cardiomyocytes against iron-mediated toxicity: role of reactive oxygen species and ferritin","volume":"279","author":"Corna","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2015.02.015_bb0035","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s10534-009-9214-7","article-title":"Modulation of intracellular iron levels by oxidative stress implicates a novel role for iron in signal transduction","volume":"22","author":"Deb","year":"2009","journal-title":"Biometals"},{"key":"10.1016\/j.taap.2015.02.015_bb0040","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/FJC.0b013e31815571f7","article-title":"Acute administration of epirubicin induces myocardial depression in isolated rat heart and production of radical species evaluated by electron spin resonance spectroscopy","volume":"50","author":"Delemasure","year":"2007","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.taap.2015.02.015_bb0045","first-page":"23","article-title":"Cytoprotective agents for anthracyclines","volume":"23","author":"Dorr","year":"1996","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.taap.2015.02.015_bb0050","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.biochi.2011.02.015","article-title":"General oxidative stress during doxorubicin-induced cardiotoxicity in rats: absence of cardioprotection and low antioxidant efficiency of alpha-lipoic acid","volume":"94","author":"Ghibu","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.taap.2015.02.015_bb0055","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/mnfr.201400036","article-title":"Iron, oxidative stress, and redox signaling in the cardiovascular system","volume":"58","author":"Gudjoncik","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.taap.2015.02.015_bb0060","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/0006-2952(84)90340-X","article-title":"Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin\u2013iron (III) complex","volume":"33","author":"Gutteridge","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2015.02.015_bb0065","first-page":"245","article-title":"Anthracycline toxicity is potentiated by iron and inhibited by deferoxamine: studies in rat heart cells in culture","volume":"122","author":"Hershko","year":"1993","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.taap.2015.02.015_bb0070","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/eurheartj\/ehi702","article-title":"Anthracycline cardiotoxicity","volume":"27","author":"Horan","year":"2006","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.taap.2015.02.015_bb0075","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1038\/cddis.2011.65","article-title":"Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity","volume":"2","author":"Huelsenbeck","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2015.02.015_bb0080","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1365-201X.2001.00805.x","article-title":"Regional cardiac expression and concentration of natriuretic peptides in patients with severe chronic heart failure","volume":"171","author":"Hystad","year":"2001","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.taap.2015.02.015_bb0085","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI72931","article-title":"Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation","volume":"124","author":"Ichikawa","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2015.02.015_bb0090","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0024-3205(98)00617-1","article-title":"Thermal preconditioning protects rat cardiac muscle cells from doxorubicin-induced apoptosis","volume":"64","author":"Ito","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2015.02.015_bb0095","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1016\/j.ejca.2013.04.030","article-title":"Role of cardioprotective therapy for prevention of cardiotoxicity with chemotherapy: a systematic review and meta-analysis","volume":"49","author":"Kalam","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.taap.2015.02.015_bb0100","doi-asserted-by":"crossref","first-page":"H1703","DOI":"10.1152\/ajpheart.00238.2001","article-title":"Echocardiographic assessment of LV hypertrophy and function in aortic-banded mice: necropsy validation","volume":"282","author":"Liao","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2015.02.015_bb0110","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0022-2143(96)90095-5","article-title":"Role of iron in the potentiation of anthracycline cardiotoxicity: identification of heart cell mitochondria as a major site of iron\u2013anthracycline interaction","volume":"127","author":"Link","year":"1996","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.taap.2015.02.015_bb0105","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0022-2143(98)90148-2","article-title":"Mitochondrial respiratory enzymes are a major target of iron toxicity in rat heart cells","volume":"131","author":"Link","year":"1998","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.taap.2015.02.015_bb0115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0074-7696(08)61526-0","article-title":"Changes in gene expression during cardiac growth","volume":"124","author":"Lompre","year":"1991","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.taap.2015.02.015_bb0120","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00109-014-1147-0","article-title":"Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity","volume":"92","author":"Maccarinelli","year":"2014","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.taap.2015.02.015_bb0125","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/abbi.1995.1367","article-title":"Production of hydroxyl radical by iron(III)\u2013anthraquinone complexes through self-reduction and through reductive activation by the xanthine oxidase\/hypoxanthine system","volume":"321","author":"Malisza","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2015.02.015_bb0130","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10534-006-9034-y","article-title":"Short term protective effects of iron in a murine model of ischemia\/reperfusion","volume":"20","author":"Metzler","year":"2007","journal-title":"Biometals"},{"key":"10.1016\/j.taap.2015.02.015_bb0135","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1182\/blood-2003-03-0869","article-title":"Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin","volume":"102","author":"Miranda","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.taap.2015.02.015_bb0140","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00246-011-0019-4","article-title":"Establishment of secondary iron overloaded mouse model: evaluation of cardiac function and analysis according to iron concentration","volume":"32","author":"Moon","year":"2011","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.taap.2015.02.015_bb0145","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0014-5793(84)81130-8","article-title":"Hydroxyl radical production and DNA damage induced by anthracycline\u2013iron complex","volume":"172","author":"Muindi","year":"1984","journal-title":"FEBS Lett."},{"key":"10.1016\/j.taap.2015.02.015_bb0150","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.freeradbiomed.2009.11.017","article-title":"Iron induces protection and necrosis in cultured cardiomyocytes: role of reactive oxygen species and nitric oxide","volume":"48","author":"Munoz","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2015.02.015_bb0160","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1126\/science.877547","article-title":"Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response","volume":"197","author":"Myers","year":"1977","journal-title":"Science"},{"key":"10.1016\/j.taap.2015.02.015_bb0155","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1021\/bi00537a001","article-title":"Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin\u2013iron complex","volume":"21","author":"Myers","year":"1982","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.taap.2015.02.015_bb0165","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/j.jacc.2007.02.060","article-title":"Potentiation of doxorubicin cardiotoxicity by iron loading in a rodent model","volume":"49","author":"Panjrath","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.taap.2015.02.015_bb0170","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ctrv.2004.06.002","article-title":"Evaluating the role of dexrazoxane as a cardioprotectant in cancer patients receiving anthracyclines","volume":"30","author":"Pouillart","year":"2004","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.taap.2015.02.015_bb0180","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/FJC.0b013e3181865f28","article-title":"Effects of angiotensin-1 converting enzyme inhibition on oxidative stress and bradykinin receptor expression during doxorubicin-induced cardiomyopathy in rats","volume":"52","author":"Richard","year":"2008","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.taap.2015.02.015_bb0175","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1124\/jpet.111.185892","article-title":"Oxidative stress and myocardial gene alterations associated with doxorubicin-induced cardiotoxicity in rats persist for 2months after treatment cessation","volume":"339","author":"Richard","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2015.02.015_bb0185","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pharmthera.2014.09.004","article-title":"The iron-regulatory hormone hepcidin: a possible therapeutic target?","volume":"146","author":"Rochette","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2015.02.015_bb0190","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/01.CIR.58.6.1072","article-title":"Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements","volume":"58","author":"Sahn","year":"1978","journal-title":"Circulation"},{"key":"10.1016\/j.taap.2015.02.015_bb0195","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s00059-011-3470-3","article-title":"Mechanisms and management of doxorubicin cardiotoxicity","volume":"36","author":"Shi","year":"2011","journal-title":"Herz"},{"key":"10.1016\/j.taap.2015.02.015_bb0200","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S1734-1140(09)70018-0","article-title":"Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron","volume":"61","author":"Simunek","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.taap.2015.02.015_bb0205","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJM199809243391307","article-title":"Doxorubicin-induced cardiomyopathy","volume":"339","author":"Singal","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2015.02.015_bb0210","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1001\/jama.1991.03470120074036","article-title":"Cardiac toxicity 4 to 20years after completing anthracycline therapy","volume":"266","author":"Steinherz","year":"1991","journal-title":"JAMA"},{"key":"10.1016\/j.taap.2015.02.015_bb0215","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/0003-9861(86)90523-0","article-title":"Release of iron from ferritin by cardiotoxic anthracycline antibiotics","volume":"248","author":"Thomas","year":"1986","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2015.02.015_bb0220","first-page":"3722","article-title":"Cardiotoxicity of epirubicin and doxorubicin: assessment by endomyocardial biopsy","volume":"46","author":"Torti","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2015.02.015_bb0225","first-page":"CD003917","article-title":"Cardioprotective interventions for cancer patients receiving anthracyclines","author":"van Dalen","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.taap.2015.02.015_bb0230","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ygeno.2006.04.012","article-title":"Early and transient gene expression changes in pressure overload-induced cardiac hypertrophy in mice","volume":"88","author":"van den Bosch","year":"2006","journal-title":"Genomics"},{"key":"10.1016\/j.taap.2015.02.015_bb0235","doi-asserted-by":"crossref","first-page":"e76676","DOI":"10.1371\/journal.pone.0076676","article-title":"Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells","volume":"8","author":"Vavrova","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2015.02.015_bb0240","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.abb.2003.07.007","article-title":"Identification and quantification of free radicals during myocardial ischemia and reperfusion using electron paramagnetic resonance spectroscopy","volume":"420","author":"Vergely","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2015.02.015_bb0245","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.echo.2011.01.018","article-title":"The cardioprotective role of probucol against anthracycline and trastuzumab-mediated cardiotoxicity","volume":"24","author":"Walker","year":"2011","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.taap.2015.02.015_bb0250","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1365-2141.2005.05759.x","article-title":"Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies","volume":"131","author":"Wouters","year":"2005","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.taap.2015.02.015_bb0255","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1124\/mol.105.013383","article-title":"Molecular pharmacology of the interaction of anthracyclines with iron","volume":"68","author":"Xu","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2015.02.015_bb0260","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1124\/mol.107.041335","article-title":"Iron chelation by clinically relevant anthracyclines: alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and trafficking","volume":"73","author":"Xu","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2015.02.015_bb0265","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1067\/mlc.2002.127725","article-title":"Bimodal cardiac dysfunction in an animal model of iron overload","volume":"140","author":"Yang","year":"2002","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.taap.2015.02.015_bb0270","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1056\/NEJM198107163050305","article-title":"The anthracycline antineoplastic drugs","volume":"305","author":"Young","year":"1981","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2015.02.015_bb0275","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/nm.2919","article-title":"Identification of the molecular basis of doxorubicin-induced cardiotoxicity","volume":"18","author":"Zhang","year":"2012","journal-title":"Nat. Med."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15000666?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15000666?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:43:53Z","timestamp":1758573833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X15000666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S0041008X15000666"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2015.02.015","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paradoxically, iron overload does not potentiate doxorubicin-induced cardiotoxicity in vitro in cardiomyocytes and in vivo in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2015.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}