{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:32:49Z","timestamp":1791300769889,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","award":["R37 ES02710"],"award-info":[{"award-number":["R37 ES02710"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIEHS Superfund","award":["P42 ES04699"],"award-info":[{"award-number":["P42 ES04699"]}]},{"name":"West Coast Comprehensive Metabolomics Resources Core","award":["NIH\/NIDDK U24 DK097154"],"award-info":[{"award-number":["NIH\/NIDDK U24 DK097154"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32 HL86350"],"award-info":[{"award-number":["T32 HL86350"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL85727"],"award-info":[{"award-number":["HL85727"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL85844"],"award-info":[{"award-number":["HL85844"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Administration Merit Review","award":["I01 BX000576"],"award-info":[{"award-number":["I01 BX000576"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.taap.2015.03.022","type":"journal-article","created":{"date-parts":[[2015,4,5]],"date-time":"2015-04-05T16:52:10Z","timestamp":1428252730000},"page":"102-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice"],"prefix":"10.1016","volume":"286","author":[{"given":"Todd R.","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Bettaieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Kodani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipavan","family":"Chiamvimonvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawaz G.","family":"Haj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Hammock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2015.03.022_bb0005","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1369\/0022155412438104","article-title":"Decorin-TGFbeta axis in hepatic fibrosis and cirrhosis","volume":"60","author":"Baghy","year":"2012","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.taap.2015.03.022_bb0010","doi-asserted-by":"crossref","first-page":"10253","DOI":"10.1074\/jbc.M007674200","article-title":"Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation","volume":"276","author":"Balbin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2015.03.022_bb0015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2015.03.022_bb0020","doi-asserted-by":"crossref","first-page":"14189","DOI":"10.1074\/jbc.M113.458414","article-title":"Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue","volume":"288","author":"Bettaieb","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2015.03.022_bb0025","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/jgh.12366","article-title":"Regulation by resveratrol of the cellular factors mediating liver damage and regeneration after acute toxic liver injury","volume":"29","author":"Chan","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2015.03.022_bb0030","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.2119\/molmed.2011.00131","article-title":"Endoplasmic reticulum stress implicated in the development of renal fibrosis","volume":"17","author":"Chiang","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.taap.2015.03.022_bb0035","first-page":"237","article-title":"Modeling liver fibrosis in rodents","volume":"117","author":"Constandinou","year":"2005","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.taap.2015.03.022_bb0045","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1042\/CS20130003","article-title":"Role of haem oxygenase in the renoprotective effects of soluble epoxide hydrolase inhibition in diabetic spontaneously hypertensive rats","volume":"125","author":"Elmarakby","year":"2013","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.taap.2015.03.022_bb0040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1665-2681(19)31810-1","article-title":"Improvement of hepatic fibrosis by leukotriene inhibition in cholestatic rats","volume":"8","author":"El-Swefy","year":"2009","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.taap.2015.03.022_bb0050","doi-asserted-by":"crossref","first-page":"14647","DOI":"10.1074\/jbc.M112.439893","article-title":"Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses","volume":"288","author":"Fanjul-Fern\u00e1ndez","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2015.03.022_bb0055","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1038\/onc.2013.157","article-title":"Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis","volume":"33","author":"Foley","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2015.03.022_bb0060","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","article-title":"Prostaglandins and leukotrienes: advances in eicosanoid biology","volume":"294","author":"Funk","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.taap.2015.03.022_bb0065","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.taap.2015.03.022_bb0070","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jhep.2013.02.016","article-title":"Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy","volume":"59","author":"Hernandez-Gea","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2015.03.022_bb0075","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/pin.12094","article-title":"JNK1 and JNK2 regulate alpha-SMA in hepatic stellate cells during CCl4-induced fibrosis in the rat liver","volume":"63","author":"Hong","year":"2013","journal-title":"Pathol. Int."},{"key":"10.1016\/j.taap.2015.03.022_bb0080","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1124\/jpet.107.128264","article-title":"Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor","volume":"323","author":"Horrillo","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2015.03.022_bb0085","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.taap.2015.03.022_bb0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1478-3231.2005.01202.x","article-title":"Effect of celecoxib on experimental liver fibrosis in rat","volume":"26","author":"Hui","year":"2006","journal-title":"Liver Int."},{"key":"10.1016\/j.taap.2015.03.022_bb0095","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1161\/CIRCRESAHA.110.225698","article-title":"Endoplasmic reticulum stress and inflammation in obesity and diabetes","volume":"107","author":"Hummasti","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2015.03.022_bb0100","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1021\/jm070270t","article-title":"Orally bioavailable potent soluble epoxide hydrolase inhibitors","volume":"50","author":"Hwang","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.taap.2015.03.022_bb0105","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2015.03.022_bb0110","doi-asserted-by":"crossref","first-page":"758614","DOI":"10.1155\/2012\/758614","article-title":"Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats","volume":"2012","author":"Iyer","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.taap.2015.03.022_bb0115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/hep.24368","article-title":"Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice","volume":"54","author":"Ji","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2015.03.022_bb0120","doi-asserted-by":"crossref","first-page":"751854","DOI":"10.1155\/2013\/751854","article-title":"Mechanism of the inhibitory effects of eucommia ulmoides oliv. cortex extracts (EUCE) in the CCl4-induced acute liver lipid accumulation in rats","volume":"2013","author":"Jin","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.taap.2015.03.022_bb0125","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm829","article-title":"The unfolded protein response in nutrient sensing and differentiation","volume":"3","author":"Kaufman","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2015.03.022_bb0130","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1872-034X.2008.00339.x","article-title":"Effect of selective cyclooxygenase-2 inhibitor meloxicam on liver fibrosis in rats with ligated common bile ducts","volume":"38","author":"Kim","year":"2008","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.taap.2015.03.022_bb0135","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0731-7085(03)00359-5","article-title":"Determination of hydroxyproline in plasma and tissue using electrospray mass spectrometry","volume":"33","author":"Kindt","year":"2003","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.taap.2015.03.022_bb0140","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ijcard.2011.12.062","article-title":"Soluble epoxide hydrolase inhibition exerts beneficial anti-remodeling actions post-myocardial infarction","volume":"167","author":"Kompa","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.taap.2015.03.022_bb0145","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S1499-3872(14)60261-7","article-title":"Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases","volume":"13","author":"Kurzepa","year":"2014","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.taap.2015.03.022_bb0150","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.biocel.2011.06.010","article-title":"The roles of ER stress and P450 2E1 in CCl(4)-induced steatosis","volume":"43","author":"Lee","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.taap.2015.03.022_bb0155","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/BOR.0b013e3283588dbb","article-title":"The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis","volume":"24","author":"Lenna","year":"2012","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.taap.2015.03.022_bb0160","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.abb.2005.02.010","article-title":"Role of CYP2E1 activity in endoplasmic reticulum ubiquitination, proteasome association, and the unfolded protein response","volume":"436","author":"Lewis","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2015.03.022_bb0165","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.2741\/2942","article-title":"Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension","volume":"13","author":"Li","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1016\/j.taap.2015.03.022_bb0175","doi-asserted-by":"crossref","first-page":"e39165","DOI":"10.1371\/journal.pone.0039165","article-title":"Inhibition of soluble epoxide hydrolase attenuates high-fat-diet-induced hepatic steatosis by reduced systemic inflammatory status in mice","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2015.03.022_bb0170","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ejps.2012.12.013","article-title":"Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models","volume":"48","author":"Liu","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.taap.2015.03.022_bb0180","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1074\/jbc.M608057200","article-title":"Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice","volume":"282","author":"Luria","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2015.03.022_bb0185","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.fct.2013.11.017","article-title":"Hepatoprotective properties of sesamin against CCl induced oxidative stress-mediated apoptosis in mice via JNK pathway","volume":"64","author":"Ma","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2015.03.022_bb0190","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/mi.2012.105","article-title":"The ER stress transducer IRE1beta is required for airway epithelial mucin production","volume":"6","author":"Martino","year":"2013","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.taap.2015.03.022_bb0195","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.numecd.2010.10.012","article-title":"From chronic overfeeding to hepatic injury: role of endoplasmic reticulum stress and inflammation","volume":"21","author":"Mollica","year":"2011","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.taap.2015.03.022_bb0200","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jhep.2013.06.023","article-title":"Cell-specific PPARgamma deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells","volume":"59","author":"Moran-Salvador","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2015.03.022_bb0205","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1146\/annurev-pharmtox-011112-140244","article-title":"Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health","volume":"53","author":"Morisseau","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2015.03.022_bb0210","first-page":"3430","article-title":"Mechanism of hepatocyte regeneration inhibition in rats with liver fibrosis induced by lipogenic methionine-choline- deficient diet","volume":"89","author":"Mu","year":"2009","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.taap.2015.03.022_bb0220","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1101\/gad.992302","article-title":"ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats","volume":"16","author":"Nishitoh","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.taap.2015.03.022_bb0225","doi-asserted-by":"crossref","first-page":"13528","DOI":"10.1073\/pnas.1311565110","article-title":"Epoxyeicosanoids promote organ and tissue regeneration","volume":"110","author":"Panigrahy","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2015.03.022_bb0230","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2015.03.022_bb0235","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.1021\/jm100691c","article-title":"1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain","volume":"53","author":"Rose","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.taap.2015.03.022_bb0240","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","article-title":"The mammalian unfolded protein response","volume":"74","author":"Schroder","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.taap.2015.03.022_bb0245","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1073\/pnas.1221972110","article-title":"Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis","volume":"110","author":"Sirish","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2015.03.022_bb0250","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2144\/05381RV01","article-title":"Zymographic techniques for the analysis of matrix metalloproteinases and their inhibitors","volume":"38","author":"Snoek-van Beurden","year":"2005","journal-title":"Biotechniques"},{"key":"10.1016\/j.taap.2015.03.022_bb0255","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jhep.2008.04.023","article-title":"Prevention of alcoholic fatty liver and mitochondrial dysfunction in the rat by long-chain polyunsaturated fatty acids","volume":"49","author":"Song","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2015.03.022_bb0260","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.plipres.2010.07.005","article-title":"Old and new generation lipid mediators in acute inflammation and resolution","volume":"50","author":"Stables","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.taap.2015.03.022_bb0265","doi-asserted-by":"crossref","first-page":"L721","DOI":"10.1152\/ajplung.00410.2011","article-title":"Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis","volume":"302","author":"Tanjore","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.taap.2015.03.022_bb0270","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1050-1738(03)00027-6","article-title":"Overexpression of 12-lipoxygenase and cardiac fibroblast hypertrophy","volume":"13","author":"Wen","year":"2003","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.taap.2015.03.022_bb0275","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.redox.2013.10.008","article-title":"Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK","volume":"1","author":"Wu","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2015.03.022_bb0280","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.taap.2015.03.022_bb0295","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/labinvest.3700603","article-title":"Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers","volume":"87","author":"Yang","year":"2007","journal-title":"Lab. Invest."},{"key":"10.1016\/j.taap.2015.03.022_bb0290","doi-asserted-by":"crossref","first-page":"8085","DOI":"10.1021\/ac901282n","article-title":"Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry","volume":"81","author":"Yang","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.taap.2015.03.022_bb0285","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.freeradbiomed.2012.05.001","article-title":"Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients","volume":"53","author":"Yang","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2015.03.022_bb0300","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1478-3231.2008.01760.x","article-title":"The anti-inflammatory effect of celecoxib does not prevent liver fibrosis in bile duct-ligated rats","volume":"29","author":"Yu","year":"2009","journal-title":"Liver Int."},{"key":"10.1016\/j.taap.2015.03.022_bb0305","doi-asserted-by":"crossref","first-page":"312943","DOI":"10.1155\/2012\/312943","article-title":"ER stress and lipid metabolism in adipocytes","volume":"2012","author":"Zha","year":"2012","journal-title":"Biochem. Res. Int."},{"key":"10.1016\/j.taap.2015.03.022_bb0310","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/emboj.2011.52","article-title":"The unfolded protein response transducer IRE1alpha prevents ER stress-induced hepatic steatosis","volume":"30","author":"Zhang","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.taap.2015.03.022_bb0315","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1476-511X-10-81","article-title":"alpha-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes","volume":"10","author":"Zhang","year":"2011","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.taap.2015.03.022_bb0320","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1101\/gad.12.7.982","article-title":"CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum","volume":"12","author":"Zinszner","year":"1998","journal-title":"Genes Dev."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15001131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15001131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T19:54:57Z","timestamp":1566503697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X15001131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0041008X15001131"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2015.03.022","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2015.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}