{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:14:15Z","timestamp":1792174455623,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES018883"],"award-info":[{"award-number":["R01ES018883"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institutes of Environmental Health Sciences","doi-asserted-by":"crossref","award":["R01ES021771"],"award-info":[{"award-number":["R01ES021771"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.taap.2015.06.008","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T02:30:42Z","timestamp":1434508242000},"page":"240-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis"],"prefix":"10.1016","volume":"287","author":[{"given":"Youn-hee","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghern","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2015.06.008_bb0005","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrc2657","article-title":"p21 in cancer: intricate networks and multiple activities","volume":"9","author":"Abbas","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.taap.2015.06.008_bb0010","author":"American Type Culture Collection (ATCC)"},{"key":"10.1016\/j.taap.2015.06.008_bb0015","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1046\/j.1432-1327.2001.02225.x","article-title":"Post-translational modifications and activation of p53 by genotoxic stresses","volume":"268","author":"Appella","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.taap.2015.06.008_bb0020","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cell.2007.08.005","article-title":"Living with p53, dying of p53","volume":"130","author":"Aylon","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.taap.2015.06.008_bb0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tox.2009.11.018","article-title":"Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid","volume":"268","author":"Chilakapati","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2015.06.008_bb0030","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cellsig.2009.11.014","article-title":"Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli","volume":"22","author":"Cox","year":"2010","journal-title":"Cell. Signal."},{"key":"10.1016\/j.taap.2015.06.008_bb0035","first-page":"639","article-title":"The role of the cyclin-dependent kinase inhibitor p21 in apoptosis","volume":"1","author":"Gartel","year":"2002","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.taap.2015.06.008_bb0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.taap.2015.06.008_bb0045","first-page":"1","article-title":"Arsenic and arsenic compounds","volume":"100C","author":"International Agency for Research on Cancer (IARC)","year":"2012","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.taap.2015.06.008_bb0050","first-page":"1","article-title":"Chromium (VI) compounds","volume":"100C","author":"International Agency for Research on Cancer (IARC)","year":"2012","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.taap.2015.06.008_bb0055","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cell.2007.02.022","article-title":"Wild-type p53: tumors can't stand it","volume":"128","author":"Kastan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.taap.2015.06.008_bb0060","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cell.2009.04.050","article-title":"Modes of p53 regulation","volume":"137","author":"Kruse","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.taap.2015.06.008_bb0065","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/BF02796396","article-title":"Clonal growth of normal adult human bronchial epithelial cells in a serum-free medium","volume":"18","author":"Lechner","year":"1982","journal-title":"In Vitro"},{"key":"10.1016\/j.taap.2015.06.008_bb0070","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1432-0436.1984.tb01361.x","article-title":"Induction of squamous differentiation of normal human bronchial epithelial cells by small amounts of serum","volume":"25","author":"Lechner","year":"1984","journal-title":"Differentiation"},{"key":"10.1016\/j.taap.2015.06.008_bb0075","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/carcin\/14.5.833","article-title":"p53 mutations in human immortalized epithelial cell lines","volume":"14","author":"Lehman","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2015.06.008_bb0080","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.taap.2007.07.017","article-title":"Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells","volume":"225","author":"Liao","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2015.06.008_bb0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.taap.2009.11.012","article-title":"Arsenite promotes centrosome abnormalities under a p53 compromised status induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)","volume":"243","author":"Liao","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2015.06.008_bb0090","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1756-8722-6-71","article-title":"Differential responses to genotoxic agents between induced pluripotent stem cells and tumor cell lines","volume":"6","author":"Lu","year":"2013","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.taap.2015.06.008_bb0095","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.2307\/4586677","article-title":"Cancer of the respiratory system in the United States chromate producing industry","volume":"63","author":"Machle","year":"1948","journal-title":"Public Health Rep."},{"key":"10.1016\/j.taap.2015.06.008_bb0100","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.4161\/cc.6.14.4503","article-title":"The role of ubiquitination in the direct mitochondrial death program of p53","volume":"6","author":"Marchenko","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.taap.2015.06.008_bb0105","article-title":"Arsenic exposure and the induction of human cancers","volume":"431287","author":"Martinez","year":"2011","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.taap.2015.06.008_bb0110","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1128\/MCB.7.2.961","article-title":"Primary structure polymorphism at amino acid residue 72 of human p53","volume":"7","author":"Matlashewski","year":"1987","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.taap.2015.06.008_bb0115","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1158\/0008-5472.CAN-09-2036","article-title":"p53 pre- and post-binding event theories revisited: stresses reveal specific and dynamic p53-binding patterns on the p21 gene promoter","volume":"69","author":"Millau","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2015.06.008_bb0120","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mrrev.2008.06.002","article-title":"P53 transcriptional activities: a general overview and some thoughts","volume":"681","author":"Millau","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2015.06.008_bb0125","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1289\/ehp.00108655","article-title":"Risk of internal cancers from arsenic in drinking water","volume":"108","author":"Morales","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2015.06.008_bb0130","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncb2641","article-title":"p53 mutations in cancer","volume":"15","author":"Muller","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.taap.2015.06.008_bb0135","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/toxsci\/kfu201","article-title":"Silencing KRAS overexpression in arsenic-transformed prostate epithelial and stem cells partially mitigates malignant phenotype","volume":"142","author":"Ngalame","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2015.06.008_bb0140","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/humu.20495","article-title":"Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database","volume":"28","author":"Petitjean","year":"2007","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.taap.2015.06.008_bb0145","doi-asserted-by":"crossref","first-page":"9027","DOI":"10.1158\/0008-5472.CAN-04-3703","article-title":"Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins","volume":"64","author":"Ramirez","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2015.06.008_bb0150","first-page":"1904","article-title":"Transformation of Human Bronchial Epithelial Cells by Infection with SV40 or Adenovirus-12 SV40 Hybrid Virus, or Transfection via Strontium Phosphate Coprecipitation with a Plasmid Containing SV40 Early Region Genes","volume":"48","author":"Reddel","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2015.06.008_bb0155","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/toxsci\/kfm153","article-title":"p53 response to arsenic exposure in epithelial cells: protein kinase B\/Akt involvement","volume":"99","author":"Sandoval","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2015.06.008_bb0160","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1093\/carcin\/15.11.2475","article-title":"Reaction of Cr(VI) with ascorbate and hydrogen peroxide generates hydroxyl radicals and causes DNA damage: role of a Cr(IV)-mediated Fenton-like reaction","volume":"15","author":"Shi","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2015.06.008_bb0165","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0092-8674(00)80416-X","article-title":"DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2","volume":"91","author":"Shieh","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.taap.2015.06.008_bb0170","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1101\/gad.14.3.289","article-title":"The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites","volume":"14","author":"Shieh","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.taap.2015.06.008_bb0175","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1093\/nar\/gkn232","article-title":"Characterization of genome-wide p53-binding sites upon stress response","volume":"36","author":"Smeenk","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2015.06.008_bb0180","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.taap.2010.03.004","article-title":"Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells","volume":"245","author":"Son","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2015.06.008_bb0185","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/oem.55.4.236","article-title":"Lung cancer mortality in nickel\/chromium platers, 1946\u20131995","volume":"55","author":"Sorahan","year":"1998","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.taap.2015.06.008_bb0190","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.taap.2012.04.003","article-title":"Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells","volume":"261","author":"Stueckle","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2015.06.008_bb0195","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2131\/jts.38.815","article-title":"Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells","volume":"38","author":"Tokumoto","year":"2013","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.taap.2015.06.008_bb0200","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nrc2012","article-title":"Regulating the p53 pathway: in vitro hypotheses, in vivo veritas","volume":"6","author":"Toledo","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.taap.2015.06.008_bb0205","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35042675","article-title":"Surfing the p53 network","volume":"408","author":"Vogelstein","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.taap.2015.06.008_bb0210","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrm2147","article-title":"p53 in health and disease","volume":"8","author":"Vousden","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2015.06.008_bb0215","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2009.04.037","article-title":"Blinded by the light: the growing complexity of p53","volume":"137","author":"Vousden","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.taap.2015.06.008_bb0220","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00204-012-0810-x","article-title":"Blockade of p53 by HIF-2\u03b1, but not HIF-1\u03b1, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells","volume":"86","author":"Xu","year":"2012","journal-title":"Arch. Toxicol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15300144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15300144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T13:37:31Z","timestamp":1652449051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X15300144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0041008X15300144"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2015.06.008","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2015.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}