{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:17:14Z","timestamp":1778660234695,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573173"],"award-info":[{"award-number":["81573173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Q3126982"],"award-info":[{"award-number":["Q3126982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["ZY32007613"],"award-info":[{"award-number":["ZY32007613"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.taap.2015.09.020","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T20:57:42Z","timestamp":1443560262000},"page":"231-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells"],"prefix":"10.1016","volume":"289","author":[{"given":"Xu","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5810-1806","authenticated-orcid":false,"given":"Dapeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiguo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanyi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunchun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7341-8238","authenticated-orcid":false,"given":"Yan","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2015.09.020_bb0005","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1093\/jnci\/94.24.1888","article-title":"Inorganic arsenite-induced malignant transformation of human prostate epithelial cells","volume":"94","author":"Achanzar","year":"2002","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.taap.2015.09.020_bb0010","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0006-291X(03)00728-9","article-title":"Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts","volume":"305","author":"Aono","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2015.09.020_bb0015","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1073\/pnas.91.10.4293","article-title":"Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase\/collagenase) to the metastatic phenotype in transformed rat embryo cells","volume":"91","author":"Bernhard","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2015.09.020_bb0020","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1001\/jama.297.8.842","article-title":"Mortality in randomized trials of antioxidant supplements for primary and secondary prevention","volume":"297","author":"Bjelakovic","year":"2007","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.taap.2015.09.020_bb0025","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1289\/ehp.7224","article-title":"Association of chromosomal alterations with arsenite-induced tumorigenicity of human HaCaT keratinocytes in nude mice","volume":"112","author":"Chain","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2015.09.020_bb0030","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1158\/0008-5472.CAN-10-0007","article-title":"Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells","volume":"70","author":"Chang","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2015.09.020_bb0035","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1165\/ajrcmb.26.2.4501","article-title":"Role of Nrf2 in protection against hyperoxic lung injury in mice","volume":"26","author":"Cho","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2015.09.020_bb0040","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0076-6879(94)38026-0","article-title":"Biological assays for cellular transformation","volume":"238","author":"Cox","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.taap.2015.09.020_bb0045","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1089\/ars.2007.1871","article-title":"Alterations of cellular redox state during NNK-induced malignant transformation and resistance to radiation","volume":"10","author":"Demizu","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2015.09.020_bb0050","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature10189","article-title":"Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis","volume":"475","author":"DeNicola","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.taap.2015.09.020_bb0055","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1289\/ehp.11464","article-title":"Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response","volume":"116","author":"Du","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2015.09.020_bb0060","first-page":"48066","article-title":"Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite","volume":"276","author":"Duyndam","year":"2001","journal-title":"J. Biolumin. Chemilumin."},{"key":"10.1016\/j.taap.2015.09.020_bb0065","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1289\/ehp.0901608","article-title":"Low level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta-cells: involvement of cellular adaptive response to oxidative stress","volume":"118","author":"Fu","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2015.09.020_bb0070","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1289\/ehp.1206178","article-title":"A population-based case\u2013control study of urinary arsenic species and squamous cell carcinoma in New Hampshire","volume":"121","author":"Gilbert-Diamond","year":"2013","journal-title":"USA. Environ. Health. Perspect."},{"key":"10.1016\/j.taap.2015.09.020_bb0075","series-title":"A Review of Human Carcinogens","first-page":"36","article-title":"Arsenic, metals, fibres, and dusts","volume":"100 C","author":"IARC","year":"2012"},{"key":"10.1016\/j.taap.2015.09.020_bb0080","doi-asserted-by":"crossref","first-page":"10292","DOI":"10.1158\/0008-5472.CAN-05-4414","article-title":"Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer","volume":"66","author":"Ivshina","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2015.09.020_bb0085","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2337\/db09-1342","article-title":"The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy","volume":"59","author":"Jiang","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.taap.2015.09.020_bb0090","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/toxsci\/kfr256","article-title":"Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells","volume":"125","author":"Jing","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2015.09.020_bb0095","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/jat.1649","article-title":"Arsenic: toxicity, oxidative stress and human disease","volume":"31","author":"Jomova","year":"2011","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.taap.2015.09.020_bb0100","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1021\/tx900343d","article-title":"Arsenic-induced carcinogenesiss, oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment","volume":"23","author":"Kitchin","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2015.09.020_bb0105","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1001\/jama.2011.1437","article-title":"Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)","volume":"306","author":"Klein","year":"2011","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.taap.2015.09.020_bb0110","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.advenzreg.2006.01.007","article-title":"Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species","volume":"46","author":"Kobayashi","year":"2006","journal-title":"Adv. Enzym. Regul."},{"key":"10.1016\/j.taap.2015.09.020_bb0115","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.phrs.2008.09.003","article-title":"Dual roles of Nrf2 in cancer","volume":"58","author":"Lau","year":"2008","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2015.09.020_bb0120","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/tox.20731","article-title":"Sodium arsenite induced reactive oxygen species generation, nuclear factor (erythroid-2 related) factor 2 activation, heme oxygenase-1 expression, and glutathione elevation in Chang human hepatocytes","volume":"28","author":"Li","year":"2013","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.taap.2015.09.020_bb0125","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1289\/ehp.0901677","article-title":"mot-2-mediated cross talk between nuclear factor-\u03baB and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells","volume":"118","author":"Li","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2015.09.020_bb0130","first-page":"24756","article-title":"Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a \u201ctethering\u201d mechanism: a two-site interaction model for the Nrf2-Keap1 complex","volume":"281","author":"McMahon","year":"2006","journal-title":"J. Biolumin. Chemilumin."},{"key":"10.1016\/j.taap.2015.09.020_bb0135","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ccr.2012.05.016","article-title":"Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming","volume":"22","author":"Mitsuishi","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.taap.2015.09.020_bb0140","doi-asserted-by":"crossref","first-page":"499","DOI":"10.7150\/ijbs.6.499","article-title":"Increased proliferation and analysis of diVerential gene expression in human Wharton's jelly-derived mesenchymal stromal cells under hypoxia","volume":"6","author":"Nekanti","year":"2010","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.taap.2015.09.020_bb0145","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.pharmtox.43.100901.140229","article-title":"Regulatory mechanisms controlling gene expression mediated by the antioxidant response element","volume":"43","author":"Nguyen","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2015.09.020_bb0150","first-page":"9873","article-title":"Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis","volume":"287","author":"Niture","year":"2012","journal-title":"J. Biolumin. Chemilumin."},{"key":"10.1016\/j.taap.2015.09.020_bb0155","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.freeradbiomed.2012.12.014","article-title":"Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance","volume":"57","author":"Niture","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2015.09.020_bb0160","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1158\/0008-5472.CAN-07-5003","article-title":"Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth","volume":"68","author":"Ohta","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2015.09.020_bb0165","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1056\/NEJM199605023341802","article-title":"Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease","volume":"334","author":"Omenn","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2015.09.020_bb0170","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.2174\/1381612043384411","article-title":"Tumor intracellular redox status and drug resistance-serendipity or a causal relationship?","volume":"10","author":"Pervaiz","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.taap.2015.09.020_bb0175","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0014-4827(03)00341-0","article-title":"Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide","volume":"290","author":"Pi","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.taap.2015.09.020_bb0180","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.freeradbiomed.2008.05.020","article-title":"Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2","volume":"45","author":"Pi","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2015.09.020_bb0185","first-page":"1904","article-title":"Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes","volume":"48","author":"Reddel","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2015.09.020_bb0190","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jlb.47.5.440","article-title":"Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2\u2032,7\u2032-dichlorofluorescin","volume":"47","author":"Rothe","year":"1990","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.taap.2015.09.020_bb0195","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/toxsci\/kfh086","article-title":"Inorganic cadmium- and arsenite-induced malignant transformation of human bladder urothelial cells","volume":"79","author":"Sens","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2015.09.020_bb0200","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1073\/pnas.0401604101","article-title":"A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl(\u2212) channel","volume":"101","author":"Shimizu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2015.09.020_bb0205","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejphar.2009.08.022","article-title":"Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide","volume":"620","author":"Shin","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2015.09.020_bb0210","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1371\/journal.pmed.0030420","article-title":"Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer","volume":"3","author":"Singh","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.taap.2015.09.020_bb0215","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1073\/pnas.191367098","article-title":"Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications","volume":"98","author":"Sorlie","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2015.09.020_bb0220","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/hed.20430","article-title":"Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas","volume":"28","author":"Stacy","year":"2006","journal-title":"Head Neck"},{"key":"10.1016\/j.taap.2015.09.020_bb0225","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1002\/ijc.28216","article-title":"Occupational exposure to arsenic and risk of nonmelanoma skin cancer in a multinational European study","volume":"133","author":"Surdu","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2015.09.020_bb0230","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?","volume":"8","author":"Trachootham","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.taap.2015.09.020_bb0235","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00204-012-0845-z","article-title":"Arsenic modulates heme oxygenase-1, interleukin-6, and vascularendothelial growth factor expression in endothelial cells: roles of ROS, NF-jB, and MAPK pathways","volume":"86","author":"Wang","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2015.09.020_bb0240","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/carcin\/bgn095","article-title":"Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2","volume":"29","author":"Wang","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2015.09.020_bb0245","doi-asserted-by":"crossref","first-page":"120144","DOI":"10.1098\/rsob.120144","article-title":"Oxidants, antioxidants and the current incurability of metastatic cancers","volume":"3","author":"Watson","year":"2013","journal-title":"Open Biol."},{"key":"10.1016\/j.taap.2015.09.020_bb0250","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2119\/2007-00090.Wen","article-title":"Malignant (neoplastic) transformation of human small airway epithelial cells induced by arsenic","volume":"14","author":"Wen","year":"2007","journal-title":"Mol. Med."},{"key":"10.1016\/j.taap.2015.09.020_bb0255","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00204-012-0810-x","article-title":"Blockade of p53 by HIF-2\u03b1, but not HIF-1\u03b1, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells","volume":"86","author":"Xu","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2015.09.020_bb0260","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.lfs.2009.02.008","article-title":"Dimethylarsine likely acts as a mouse-pulmonary tumor initiator via the production of dimethylarsine radical and\/or its peroxy radical","volume":"84","author":"Yamanaka","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2015.09.020_bb0265","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/03602530600971974","article-title":"Mechanistic studies of the Nrf2-Keap1 signaling pathway","volume":"38","author":"Zhang","year":"2006","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.taap.2015.09.020_bb0270","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1158\/1535-7163.MCT-09-0589","article-title":"Loss of kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth","volume":"9","author":"Zhang","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.taap.2015.09.020_bb0275","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1158\/0008-5472.CAN-03-3361","article-title":"Reactive oxygen species (ROS), troublemakers between nuclear factor-\u03baB(NF-\u03baB) and c-Jun NH(2)-terminal kinase (JNK)","volume":"64","author":"Zhang","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2015.09.020_bb0280","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1289\/ehp.1104580","article-title":"Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes","volume":"120","author":"Zhao","year":"2012","journal-title":"Environ. Health Perspect."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15300946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15300946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:05:11Z","timestamp":1778659511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X15300946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0041008X15300946"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2015.09.020","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2015.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}