{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:23:06Z","timestamp":1793305386084,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21402241"],"award-info":[{"award-number":["21402241"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20130653"],"award-info":[{"award-number":["BK20130653"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Key Laboratory of Natural Medicines, China Pharmaceutical University","award":["SKLNMKF201407"],"award-info":[{"award-number":["SKLNMKF201407"]}]},{"name":"College Students Innovation Project for the R&D of Novel Drugs","award":["J1030830"],"award-info":[{"award-number":["J1030830"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["JKZD2013006"],"award-info":[{"award-number":["JKZD2013006"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, China"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.taap.2015.10.001","type":"journal-article","created":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T07:13:02Z","timestamp":1445065982000},"page":"142-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction"],"prefix":"10.1016","volume":"289","author":[{"given":"Yuanxue","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhou","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangjian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Saavedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2015.10.001_bb0005","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1071\/CH9950883","article-title":"Totarol: a non-conventional diterpenoid","volume":"48","author":"Bendall","year":"1995","journal-title":"Aust. J. Chem."},{"key":"10.1016\/j.taap.2015.10.001_bb0010","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/00004647-200207000-00007","article-title":"A potent protective role of lysophospholipids against global cerebral ischemia and glutamate excitotoxicity in neuronal cultures","volume":"22","author":"Blondeau","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.taap.2015.10.001_bb0015","first-page":"644","article-title":"Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics","volume":"10","author":"Candelario-Jalil","year":"2009","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.taap.2015.10.001_bb0020","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1212\/01.wnl.0000326064.42186.7e","article-title":"High plasma glutamate concentrations are associated with infarct growth in acute ischemic stroke","volume":"71","author":"Castellanos","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.taap.2015.10.001_bb0025","doi-asserted-by":"crossref","first-page":"8745","DOI":"10.1073\/pnas.96.15.8745","article-title":"Lithium activates the serine\/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons","volume":"96","author":"Chalecka-Franaszek","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2015.10.001_bb0030","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1073\/pnas.081082098","article-title":"An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen","volume":"98","author":"Chan","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2015.10.001_bb0035","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.freeradbiomed.2011.12.012","article-title":"4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2\/HO-1 axis and protects against oxidative stress-induced cell injury via acbivation of PI3K\/AKT signaling","volume":"52","author":"Chen","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2015.10.001_bb0040","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1365-2826.2010.02054.x","article-title":"Vasopressin protects hippocampal neurons in culture against nutrient deprivation or glutamate-induced apoptosis","volume":"22","author":"Chen","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.taap.2015.10.001_bb0045","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1038\/srep05531","article-title":"Nafamostat mesilate attenuates neuronal damage in a rat model of transient focal cerebral ischemia through thrombin inhibition","volume":"4","author":"Chen","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2015.10.001_bb0050","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0896-6273(88)90162-6","article-title":"Glutamate neurotoxicity and diseases of the nervous system","volume":"1","author":"Choi","year":"1988","journal-title":"Neuron"},{"key":"10.1016\/j.taap.2015.10.001_bb0055","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1210\/en.2006-0991","article-title":"Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation","volume":"148","author":"Chung","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2015.10.001_bb0060","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1055\/s-2003-42778","article-title":"In vitro antiplasmodial activity of abietane and totarane diterpenes isolated from Harpagophytum procumbens (Devil's Claw)","volume":"69","author":"Clarkson","year":"2003","journal-title":"Planta Med."},{"key":"10.1016\/j.taap.2015.10.001_bb0065","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.taap.2015.10.001_bb0070","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/S0140-6736(08)60694-7","article-title":"Stroke","volume":"371","author":"Donnan","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2015.10.001_bb0075","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1073\/pnas.96.5.2445","article-title":"Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury","volume":"96","author":"Dor\u00e9","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2015.10.001_bb0080","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.3748\/wjg.v12.i26.4149","article-title":"Antioxidant role of heme oxygenase-1 in prehepatic portal hypertensive rats","volume":"12","author":"Gonzales","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2015.10.001_bb0085","first-page":"47","article-title":"Ischemia\u2013reperfusion injury: role of oxygen-derived free radicals","volume":"548","author":"Granger","year":"1986","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"10.1016\/j.taap.2015.10.001_bb0090","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0301-0082(01)00011-9","article-title":"The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling","volume":"65","author":"Grimes","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.taap.2015.10.001_bb0095","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1046\/j.1471-4159.1995.65052016.x","article-title":"NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implication for cell death","volume":"65","author":"Gunasekar","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2015.10.001_bb0100","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.freeradbiomed.2010.01.017","article-title":"Celecoxib activates PI3K\/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium","volume":"48","author":"Hamdulay","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2015.10.001_bb0105","doi-asserted-by":"crossref","first-page":"22569","DOI":"10.1074\/jbc.274.32.22569","article-title":"Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase","volume":"274","author":"Hetman","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2015.10.001_bb0110","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.neuint.2013.01.022","article-title":"Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK\/ERK and PI3-K\/Akt\/GSK3\u03b2 pathways","volume":"62","author":"Hu","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.taap.2015.10.001_bb0115","doi-asserted-by":"crossref","first-page":"16023","DOI":"10.1074\/jbc.275.21.16023","article-title":"Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages","volume":"275","author":"Ishii","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2015.10.001_bb0120","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1089\/ars.2005.7.1664","article-title":"Molecular mechanism of nrf2 activation by oxidative stress","volume":"7","author":"Kang","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2015.10.001_bb0125","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.freeradbiomed.2009.07.035","article-title":"Nrf2: INrf2 (Keap1) signaling in oxidative stress","volume":"47","author":"Kaspar","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2015.10.001_bb0130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","article-title":"Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu. Rev. Pharmacol."},{"key":"10.1016\/j.taap.2015.10.001_bb0135","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/00004647-199905000-00005","article-title":"Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia","volume":"19","author":"Kilic","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.taap.2015.10.001_bb0140","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/ars.2010.3153","article-title":"Heme oxygenase in the regulation of vascular biology: from molecular mechanisms to therapeutic opportunities","volume":"14","author":"Kim","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2015.10.001_bb0145","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0076-6879(04)78021-0","article-title":"Unique function of the Nrf2\u2013Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes","volume":"378","author":"Kobayashi","year":"2004","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.taap.2015.10.001_bb0150","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/ars.2005.7.385","article-title":"Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation","volume":"7","author":"Kobayashi","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2015.10.001_bb0155","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neures.2009.11.009","article-title":"Cell death mechanisms in the early stages of acute glutamate neurotoxicity","volume":"66","author":"Kumar","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.taap.2015.10.001_bb0160","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1179\/1351000214Y.0000000095","article-title":"Indole acetic acid is responsible for protection against oxidative stress caused by drought in soybean plants: the role of heme oxygenase induction","volume":"19","author":"Lecube","year":"2014","journal-title":"Redox Rep."},{"key":"10.1016\/j.taap.2015.10.001_bb0165","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neurobiolaging.2013.06.020","article-title":"Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-alpha 1\/heme oxygenase-1 pathways","volume":"35","author":"Lin","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.taap.2015.10.001_bb0170","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neulet.2013.10.052","article-title":"Glimepiride attenuates A\u03b2 production via suppressing BACE1 activity in cortical neurons","volume":"557","author":"Liu","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.taap.2015.10.001_bb0175","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10571-011-9746-6","article-title":"Activation of ERK1\/2 and PI3K\/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro","volume":"32","author":"Liu","year":"2012","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.taap.2015.10.001_bb0180","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.taap.2015.10.001_bb0185","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1161\/01.STR.23.3.414","article-title":"Neuroprotective effects of SKF 10,047 in cultured rat cerebellar neurons and in gerbil global brain ischemia","volume":"23","author":"Lysko","year":"1992","journal-title":"Stroke"},{"key":"10.1016\/j.taap.2015.10.001_bb0190","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1161\/01.STR.23.11.1630","article-title":"Neuroprotective effects of carvedilol, a new antihypertensive agent, in cultured rat cerebellar neurons and in gerbil global brain ischemia","volume":"23","author":"Lysko","year":"1992","journal-title":"Stroke"},{"key":"10.1016\/j.taap.2015.10.001_bb0195","doi-asserted-by":"crossref","first-page":"8919","DOI":"10.1074\/jbc.M309660200","article-title":"Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase\/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol","volume":"279","author":"Marin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2015.10.001_bb0200","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2672.1996.tb03233.x","article-title":"Antibacterial activity of anacardic acid and toatarol, alone and in combination with methicillin, against methicillin resistant Staphylococcus aureus","volume":"80","author":"Muroi","year":"1996","journal-title":"J. Appl. Bacteriol."},{"key":"10.1016\/j.taap.2015.10.001_bb0205","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/jnr.21567","article-title":"Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta","volume":"86","author":"Nishimoto","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.taap.2015.10.001_bb0210","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/(SICI)1098-1136(199808)23:4<285::AID-GLIA1>3.0.CO;2-2","article-title":"Differential expression of superoxide dismutase isoforms in neuronal and glial compartments in the course of excitotoxically mediated neurodegeneration: relation to oxidative and nitrergic stress","volume":"23","author":"Noack","year":"1998","journal-title":"Glia"},{"key":"10.1016\/j.taap.2015.10.001_bb0215","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.brainres.2010.05.077","article-title":"Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture","volume":"1347","author":"Ohnishi","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.taap.2015.10.001_bb0220","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1471-4159.1999.721187.x","article-title":"Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice","volume":"72","author":"Panahian","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2015.10.001_bb0225","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1747-4949.2007.00089.x","article-title":"Stroke and thrombolysis in developing countries","volume":"2","author":"Pandian","year":"2007","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.taap.2015.10.001_bb0230","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/aps.2013.199","article-title":"Telmisartan protects central neurons against nutrient deprivation-induced apoptosis in vitro through activation of PPAR\u03b3 and the Akt\/GSK-3\u03b2 pathway","volume":"35","author":"Pang","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.taap.2015.10.001_bb0235","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1126\/science.8235590","article-title":"Programmed cell death and the control of cell survival: lessons from the nervous system","volume":"262","author":"Raff","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.taap.2015.10.001_bb0240","first-page":"669","article-title":"Glutamate-stimulated ROS production in neuronal cultures: interactions with lead and the cholinergic system","volume":"19","author":"Savolainen","year":"1998","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.taap.2015.10.001_bb0245","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiological importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.taap.2015.10.001_bb0250","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.freeradbiomed.2014.04.009","article-title":"Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia\u2013reperfusion injury","volume":"72","author":"Takagi","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2015.10.001_bb0255","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF03179070","article-title":"Superoxide dismutases: a physiopharmacological update","volume":"65","author":"Valdivia","year":"2009","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.taap.2015.10.001_bb0260","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neuropharm.2013.11.022","article-title":"Telmisartan ameliorates glutamate-induced neurotoxicity: roles of AT(1) receptor blockade and PPAR\u03b3 activation","volume":"79","author":"Wang","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.taap.2015.10.001_bb0265","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neuroscience.2014.11.056","article-title":"Gardenamide a attenuated cell apoptosis induced by serum deprivation insult via the ERK1\/2 and PI3K\/Akt signaling pathways","volume":"286","author":"Wang","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.taap.2015.10.001_bb0270","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0022-3565(25)38652-0","article-title":"Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions","volume":"268","author":"Watanabe","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2015.10.001_bb0275","doi-asserted-by":"crossref","first-page":"7173","DOI":"10.1021\/jm300681r","article-title":"Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c]thiophen-1(3H)-one","volume":"55","author":"Wu","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.taap.2015.10.001_bb0280","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1007\/s10886-007-9390-2","article-title":"The antifungal compound totarol of Thujopsis dolabrata var. hondai seeds selects for fungi on seedling root surfaces","volume":"33","author":"Yamaji","year":"2007","journal-title":"J. Chem. Ecol."},{"key":"10.1016\/j.taap.2015.10.001_bb0285","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/j.freeradbiomed.2011.09.007","article-title":"Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK\/Nrf2 pathway and protects against oxidative stress","volume":"51","author":"Yang","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2015.10.001_bb0290","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1527-3458.2006.00009.x","article-title":"Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury","volume":"12","author":"Yoshida","year":"2006","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.taap.2015.10.001_bb0295","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s12640-009-9014-4","article-title":"Low doses of carbon monoxide protect against experimental focal brain ischemia","volume":"15","author":"Zeynalov","year":"2009","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.taap.2015.10.001_bb0300","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s11064-013-1068-2","article-title":"Pyrroloquinoline quinine protects rat brain cortex against acute glutamate-induced neurotoxicity","volume":"38","author":"Zhang","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.taap.2015.10.001_bb0305","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainres.2012.03.065","article-title":"Neuroprotection of early and short-time applying berberine in the acute phase of cerebral ischemia: up-regulated pAkt, pGSK and pCREB, down-regulated NF-kappaB expression, ameliorated BBB permeability","volume":"1459","author":"Zhang","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.taap.2015.10.001_bb0310","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1007\/s11064-014-1356-5","article-title":"Pretreatment by evodiamine is neuroprotective in cerebral ischemia: up-regulated pAkt, pGSK3beta, down-regulated NF-kappa B expression, and ameliorated BBB permeability","volume":"39","author":"Zhao","year":"2014","journal-title":"Neurochem. Res."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15301046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15301046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:44:59Z","timestamp":1758573899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X15301046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0041008X15301046"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2015.10.001","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2015.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}