{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T19:51:05Z","timestamp":1775937065144,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education","doi-asserted-by":"crossref","award":["20100201110054"],"award-info":[{"award-number":["20100201110054"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173059"],"award-info":[{"award-number":["81173059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.taap.2015.10.021","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T06:31:20Z","timestamp":1446618680000},"page":"389-396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["H2S induces vasoconstriction of rat cerebral arteries via cAMP\/adenylyl cyclase pathway"],"prefix":"10.1016","volume":"289","author":[{"given":"Sen","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na-na","family":"Ping","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-ni","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-xiao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2015.10.021_bb0010","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/sj.bjp.0706906","article-title":"Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?","volume":"6","author":"Ali","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2015.10.021_bb0015","series-title":"Gasotransmitters: Physiology and Pathophysiology","first-page":"37","article-title":"The role of carbon monoxide as a gasotransmitter in cardiovascular and metabolic regulation","author":"Ashley","year":"2012"},{"key":"10.1016\/j.taap.2015.10.021_bb0025","first-page":"1277","article-title":"Hydrogen sulfide poisoning: review of 5years' experience","volume":"11","author":"Burnett","year":"1977","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.taap.2015.10.021_bb0030","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.vph.2010.04.004","article-title":"4-Aminopyridine-sensitive K+ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery","volume":"3-4","author":"Cheang","year":"2010","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.taap.2015.10.021_bb0035","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1152\/ajpheart.00331.2004","article-title":"Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats","volume":"5","author":"Cheng","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2015.10.021_bb0040","article-title":"Pharmacological actions of the slow release hydrogen sulfide donor GYY4137 on phenylephrine-induced tone in isolated bovine ciliary artery","volume":"350-354","author":"Chitnis","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.taap.2015.10.021_bb0045","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1053\/j.gastro.2005.07.060","article-title":"Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs","volume":"4","author":"Fiorucci","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2015.10.021_bb0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.vascn.2007.03.002","article-title":"A novel approach for the determination of contractile and calcium responses of the basilar artery employing real-time confocal laser microscopy","volume":"1","author":"Hashimoto","year":"2007","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.taap.2015.10.021_bb0065","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","article-title":"The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide","volume":"3","author":"Hosoki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2015.10.021_bb0070","doi-asserted-by":"crossref","first-page":"21903","DOI":"10.1074\/jbc.R110.128363","article-title":"Redox biochemistry of hydrogen sulfide","volume":"29","author":"Kabil","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2015.10.021_bb0075","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tox.2006.12.023","article-title":"Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: contribution to dual modulation of vascular tension","volume":"232","author":"Kubo","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2015.10.021_bb0080","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s10787-007-1590-4","article-title":"Dual modulation of the tension of isolated gastric artery and gastric mucosal circulation by hydrogen sulfide in rats","volume":"15","author":"Kubo","year":"2007","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.taap.2015.10.021_bb0085","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide","volume":"18","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.taap.2015.10.021_bb0090","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pharmthera.2009.05.005","article-title":"Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation\u2013a tale of three gases!","volume":"3","author":"Li","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2015.10.021_bb0095","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1152\/ajpcell.00105.2010","article-title":"Bicarbonate-dependent effect of hydrogen sulfide on vascular contractility in rat aortic rings","volume":"4","author":"Liu","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.taap.2015.10.021_bb0100","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0008-6363(00)00322-9","article-title":"Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C","volume":"1","author":"Mackay","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.taap.2015.10.021_bb0105","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1440-1681.1992.tb00420.x","article-title":"Assessing vascular reactivity of arteries in the small vessel myograph","volume":"12","author":"McPherson","year":"1992","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.taap.2015.10.021_bb0110","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11064-009-0085-7","article-title":"Effect of hydrogen sulfide on cyclic AMP production in isolated bovine and porcine neural retinae","volume":"3","author":"Njie-Mbye","year":"2010","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.taap.2015.10.021_bb0115","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1242\/jeb.02480","article-title":"Hydrogen sulfide as an oxygen sensor\/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation","volume":"20","author":"Olson","year":"2006","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.taap.2015.10.021_bb0120","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1152\/ajpcell.00282.2007","article-title":"H2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes","volume":"1","author":"Pan","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.taap.2015.10.021_bb0125","doi-asserted-by":"crossref","first-page":"143","DOI":"10.33549\/physiolres.932631","article-title":"The determination of optimal initial tension in rat coronary artery using wire myography","volume":"1","author":"Ping","year":"2014","journal-title":"Physiol. Res."},{"issue":"Pt 2","key":"10.1016\/j.taap.2015.10.021_bb0135","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1161\/01.HYP.37.2.767","article-title":"Workshop: hypertension and cardiovascular risk factors: role of the angiotensin II-nitric oxide interaction","volume":"2","author":"Raij","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.taap.2015.10.021_bb0140","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1152\/ajpgi.90484.2008","article-title":"H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of KATP channels","volume":"6","author":"Siebert","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.taap.2015.10.021_bb0145","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00043764-197902000-00008","article-title":"Hydrogen sulfide poisoning","volume":"2","author":"Smith","year":"1979","journal-title":"J. Occup. Med."},{"key":"10.1016\/j.taap.2015.10.021_bb0150","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00210-012-0779-2","article-title":"An investigation of the mechanisms of hydrogen sulfide-induced vasorelaxation in rat middle cerebral arteries","volume":"10","author":"Streeter","year":"2012","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.taap.2015.10.021_bb0155","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/aps.2011.51","article-title":"Vasorelaxant and antihypertensive effects of formononetin through endothelium-dependent and -independent mechanisms","volume":"8","author":"Sun","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.taap.2015.10.021_bb0160","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.phrs.2011.11.006","article-title":"NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel","volume":"2","author":"Tian","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2015.10.021_bb0165","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1161\/01.STR.17.2.202","article-title":"Characterization of beta adrenergic receptors in human cerebral arteries and alteration of the receptors after subarachnoid hemorrhage","volume":"2","author":"Tsukahara","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/j.taap.2015.10.021_bb0170","series-title":"Gasotransmitters: Physiology and Pathophysiology","first-page":"1","article-title":"Nitric oxide: biological synthesis and functions","author":"Ulrich","year":"2012"},{"key":"10.1016\/j.taap.2015.10.021_bb0175","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"13","author":"Wang","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2015.10.021_bb0180","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1152\/ajpheart.2001.281.4.H1545","article-title":"Adenylyl cyclase isoforms and signal integration in models of vascular smooth muscle cells","volume":"4","author":"Webb","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2015.10.021_bb0185","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1124\/jpet.107.133538","article-title":"Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery","volume":"2","author":"Webb","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2015.10.021_bb0190","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.bjp.0706063","article-title":"The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK","volume":"1","author":"Weber","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2015.10.021_bb0195","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener","volume":"21","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.taap.2015.10.021_bb0200","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1097\/00004872-200310000-00015","article-title":"The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase","volume":"10","author":"Zhong","year":"2003","journal-title":"J. Hypertens."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15301241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X15301241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T03:56:59Z","timestamp":1653451019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X15301241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0041008X15301241"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2015.10.021","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"H2S induces vasoconstriction of rat cerebral arteries via cAMP\/adenylyl cyclase pathway","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2015.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}