{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:40:02Z","timestamp":1778838002988,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2012R1A5A2A28671860"],"award-info":[{"award-number":["2012R1A5A2A28671860"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002583","name":"Gyeongsang National University","doi-asserted-by":"publisher","award":["RPP-2012-011"],"award-info":[{"award-number":["RPP-2012-011"]}],"id":[{"id":"10.13039\/501100002583","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.taap.2015.12.025","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T16:46:34Z","timestamp":1451580394000},"page":"30-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The role of heme oxygenase-1 in drug metabolizing dysfunction in the alcoholic fatty liver exposed to ischemic injury"],"prefix":"10.1016","volume":"292","author":[{"given":"Sang Won","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Woo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-4005","authenticated-orcid":false,"given":"Sun-Mee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2015.12.025_bb0005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.toxlet.2013.03.018","article-title":"Posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by methylmercury in HepG2 cells: a role of heme oxygenase-1","volume":"219","author":"Amara","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2015.12.025_bb0010","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1124\/dmd.111.042564","article-title":"Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes","volume":"40","author":"Anwar-Mohamed","year":"2012","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.taap.2015.12.025_bb0015","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1038\/cddis.2010.29","article-title":"Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia\u2013reperfusion","volume":"1","author":"Ben Mosbah","year":"2010","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2015.12.025_bb0020","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10495-013-0814-x","article-title":"Induction of heme oxygenase-1 protects mouse liver from apoptotic ischemia\/reperfusion injury","volume":"18","author":"Ben-Ari","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.taap.2015.12.025_bb0025","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0003-2697(76)90323-7","article-title":"Enzymatic assay for glutathione","volume":"74","author":"Brehe","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2015.12.025_bb0030","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1161\/01.STR.25.3.639","article-title":"Effect of carbon monoxide on rabbit cerebral arteries","volume":"25","author":"Brian","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.taap.2015.12.025_bb0035","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.taap.2015.12.025_bb0040","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1016\/0006-2952(85)90355-7","article-title":"Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450","volume":"34","author":"Burke","year":"1985","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2015.12.025_bb0045","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.intimp.2015.08.039","article-title":"Protective effects of protostemonine on LPS\/GalN-induced acute liver failure: roles of increased hepatic expression of heme oxygenase-1","volume":"29","author":"Cheng","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2015.12.025_bb0050","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/BF02977778","article-title":"Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia\/reperfusion","volume":"30","author":"Cho","year":"2007","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.taap.2015.12.025_bb0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1165\/ajrcmb.15.1.8679227","article-title":"Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury","volume":"15","author":"Choi","year":"1996","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2015.12.025_bb0060","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/hep.24279","article-title":"The contribution of endoplasmic reticulum stress to liver diseases","volume":"53","author":"Dara","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2015.12.025_bb0065","doi-asserted-by":"crossref","first-page":"10161","DOI":"10.1128\/MCB.24.23.10161-10168.2004","article-title":"Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2","volume":"24","author":"Deng","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.taap.2015.12.025_bb0070","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1210\/en.2013-1667","article-title":"Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation","volume":"155","author":"Dong","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2015.12.025_bb0075","first-page":"255","article-title":"Carbon monoxide and vascular cell function","volume":"2","author":"Durante","year":"1998","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.taap.2015.12.025_bb0080","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/toxsci\/59.1.169","article-title":"High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes","volume":"59","author":"Enomoto","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2015.12.025_bb0085","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/ar.20715","article-title":"Hepatic microcirculation in fatty liver disease","volume":"291","author":"Farrell","year":"2008","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.taap.2015.12.025_bb0090","doi-asserted-by":"crossref","first-page":"E101","DOI":"10.1208\/aapsj080112","article-title":"Cytochrome P450s and other enzymes in drug metabolism and toxicity","volume":"8","author":"Guengerich","year":"2006","journal-title":"AAPS J."},{"key":"10.1016\/j.taap.2015.12.025_bb0095","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0003-9861(71)90304-3","article-title":"Cytochrome P-450 as a microsomal peroxidase utilizing a lipid peroxide substrate","volume":"147","author":"Hrycay","year":"1971","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2015.12.025_bb0100","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0006-2952(99)00137-9","article-title":"Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of delta-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats","volume":"58","author":"Iba","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2015.12.025_bb0105","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1749-6632.2011.06121.x","article-title":"The role of carbon monoxide in metabolic disease","volume":"1229","author":"Joe","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2015.12.025_bb0110","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1046\/j.1523-1755.2003.00882.x","article-title":"Preconditioning with tin-protoporphyrin IX attenuates ischemia\/reperfusion injury in the rat kidney","volume":"63","author":"Kaizu","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.taap.2015.12.025_bb0115","doi-asserted-by":"crossref","first-page":"H3193","DOI":"10.1152\/ajpheart.00274.2007","article-title":"Carbon monoxide and Ca2+-activated K+ channels in cerebral arteriolar responses to glutamate and hypoxia in newborn pigs","volume":"293","author":"Kanu","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2015.12.025_bb0120","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/01.shk.0000180616.13941.7d","article-title":"Chronic ethanol sensitizes the liver to endotoxin via effects on endothelial nitric oxide synthase regulation","volume":"24","author":"Karaa","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.taap.2015.12.025_bb0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF00225252","article-title":"Function and induction of the microsomal heme oxygenase","volume":"53-54","author":"Kikuchi","year":"1983","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.taap.2015.12.025_bb0130","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1111\/j.1742-4658.2011.08148.x","article-title":"Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction","volume":"278","author":"Kim","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.taap.2015.12.025_bb0135","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.lfs.2011.10.003","article-title":"Protective effect of heme oxygenase-1 induction against hepatic injury in alcoholic steatotic liver exposed to cold ischemia\/reperfusion","volume":"90","author":"Kim","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2015.12.025_bb0140","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1080\/09168451.2014.910105","article-title":"Ascorbic acid deficiency decreases hepatic cytochrome P-450, especially CYP2B1\/2B2, and simultaneously induces heme oxygenase-1 gene expression in scurvy-prone ODS rats","volume":"78","author":"Kobayashi","year":"2014","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.taap.2015.12.025_bb0145","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/SLA.0000000000000287","article-title":"Nrf2 activation protects the liver from ischemia\/reperfusion injury in mice","volume":"260","author":"Kudoh","year":"2014","journal-title":"Ann. Surg."},{"key":"10.1016\/j.taap.2015.12.025_bb0150","first-page":"991","article-title":"Microsomal ethanol-oxidizing system (MEOS): the first 30years (1968\u20131998)\u2014a review","volume":"23","author":"Lieber","year":"1999","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.taap.2015.12.025_bb0155","first-page":"197","article-title":"Liquid diet technique of ethanol administration: 1989 update","volume":"24","author":"Lieber","year":"1989","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.taap.2015.12.025_bb0160","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0076-6879(96)68049-5","article-title":"Carbon monoxide and nitric oxide homology: differential modulation of heme oxygenases in brain and detection of protein and activity","volume":"268","author":"Maines","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.taap.2015.12.025_bb0165","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","article-title":"The heme oxygenase system: a regulator of second messenger gases","volume":"37","author":"Maines","year":"1997","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2015.12.025_bb0170","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","article-title":"Endoplasmic reticulum stress in liver disease","volume":"54","author":"Malhi","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2015.12.025_bb0175","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1089\/ars.2007.1782","article-title":"Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?","volume":"9","author":"Malhotra","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2015.12.025_bb0180","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3109\/03602532.2011.577781","article-title":"Drug metabolism alterations in nonalcoholic fatty liver disease","volume":"43","author":"Merrell","year":"2011","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.taap.2015.12.025_bb0185","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1111\/j.1600-6143.2012.04288.x","article-title":"Liver defatting: an alternative approach to enable steatotic liver transplantation","volume":"12","author":"Nativ","year":"2012","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.taap.2015.12.025_bb0190","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature","volume":"239","author":"Omura","year":"1964","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2015.12.025_bb0195","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1139\/cjpp-2014-0174","article-title":"Effect of curcumin on hepatic heme oxygenase 1 expression in high fat diet fed rats: is there a triangular relationship?","volume":"92","author":"Oner-Iyidogan","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2015.12.025_bb0200","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1097\/00004647-199712000-00009","article-title":"Vasodilator effects on canine basilar artery induced by intracisternal interleukin-1 beta","volume":"17","author":"Osuka","year":"1997","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.taap.2015.12.025_bb0205","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1152\/physrev.1999.79.3.683","article-title":"Signal transduction from the endoplasmic reticulum to the cell nucleus","volume":"79","author":"Pahl","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.taap.2015.12.025_bb0210","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jss.2014.09.021","article-title":"Role of Kupffer cells in ischemic injury in alcoholic fatty liver","volume":"194","author":"Park","year":"2015","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.taap.2015.12.025_bb0215","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1079\/BJN19900112","article-title":"Mixed function oxidases in response to different types of dietary lipids in rats","volume":"63","author":"Saito","year":"1990","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.taap.2015.12.025_bb0220","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0026-895X(25)14748-2","article-title":"Spectral studies of drug interaction with hepatic microsomal cytochrome","volume":"3","author":"Schenkman","year":"1967","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2015.12.025_bb0225","doi-asserted-by":"crossref","first-page":"15289","DOI":"10.3748\/wjg.v20.i41.15289","article-title":"N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia\u2013reperfusion injury","volume":"20","author":"Sun","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2015.12.025_bb0230","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ejphar.2014.06.006","article-title":"Treatment with baicalein attenuates methionine\u2013choline deficient diet-induced non-alcoholic steatohepatitis in rats","volume":"738","author":"Xin","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2015.12.025_bb0235","doi-asserted-by":"crossref","first-page":"G1318","DOI":"10.1152\/ajpgi.00555.2007","article-title":"The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage","volume":"296","author":"Yao","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.taap.2015.12.025_bb0240","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1089\/ars.2009.2873","article-title":"Protective role of heme oxygenase-1 against liver damage caused by hepatic ischemia and reperfusion in rats","volume":"13","author":"Yun","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2015.12.025_bb0245","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.freeradbiomed.2013.12.014","article-title":"Impaired autophagy contributes to hepatocellular damage during ischemia\/reperfusion: heme oxygenase-1 as a possible regulator","volume":"68","author":"Yun","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2015.12.025_bb0250","doi-asserted-by":"crossref","first-page":"142736","DOI":"10.1155\/2015\/142736","article-title":"Agaricoglycerides protect against hepatic ischemia\/reperfusion injury by attenuating inflammatory response, oxidative stress, and expression of NF-kappaB","volume":"2015","author":"Zhao","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.taap.2015.12.025_bb0255","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbagen.2013.09.018","article-title":"Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis","volume":"1840","author":"Zhou","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2015.12.025_bb0260","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1101\/lm.6.1.63","article-title":"On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus","volume":"6","author":"Zhuo","year":"1999","journal-title":"Learn. Mem."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X1530171X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X1530171X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:01:10Z","timestamp":1748736070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X1530171X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":52,"alternative-id":["S0041008X1530171X"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2015.12.025","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of heme oxygenase-1 in drug metabolizing dysfunction in the alcoholic fatty liver exposed to ischemic injury","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2015.12.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}